{"id":3410,"date":"2026-04-12T09:38:57","date_gmt":"2026-04-12T00:38:57","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=3410"},"modified":"2026-04-12T09:38:58","modified_gmt":"2026-04-12T00:38:58","slug":"post-3410","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-3410\/","title":{"rendered":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u6cbb\u7642\uff08\u751f\u7269\u88fd\u5264\u4f7f\u7528\u6642\uff09\u306e\u85ac\u5264\u5909\u66f4\u6642\u306e\u6ce8\u610f\u70b9\uff1a\u751f\u7269\u5b66\u7684\u88fd\u5264\u306e\u300c\u5207\u308a\u66ff\u3048\u6642\u306e\u8003\u616e\u70b9\u300d\u3068\u300c\u751f\u7269\u88fd\u5264\u5358\u5264\u7642\u6cd5\u306b\u304a\u3051\u308b\u975eTNF\u963b\u5bb3\u85ac\u306e\u512a\u4f4d\u6027\u300d"},"content":{"rendered":"\n

\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff08RA\uff09\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\uff08bDMARDs\uff09\u306f\u5287\u7684\u306a\u52b9\u679c\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u304c\u3001\u6700\u521d\u306b\u9078\u629e\u3057\u305f\u85ac\u5264\u304c\u5341\u5206\u306a\u52b9\u679c\u3092\u767a\u63ee\u3057\u306a\u3044\u5834\u5408\u3084\u3001\u526f\u4f5c\u7528\u306a\u3069\u306e\u7406\u7531\u3067\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\uff08MTX\uff09\u3092\u4f75\u7528\u3067\u304d\u306a\u3044\u5834\u5408\u306e\u6cbb\u7642\u9078\u629e\u306f\u3001\u4e88\u5f8c\u3092\u5de6\u53f3\u3059\u308b\u6975\u3081\u3066\u91cd\u8981\u306a\u5224\u65ad\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305a\u3001\u6700\u521d\u306eTNF\u963b\u5bb3\u85ac<\/strong>\uff08\u30a2\u30c0\u30ea\u30e0\u30de\u30d6\u3084\u30a8\u30bf\u30cd\u30eb\u30bb\u30d7\u30c8\u306a\u3069\uff09\u3067\u52b9\u679c\u304c\u4e0d\u5341\u5206\u3060\u3063\u305f\u969b\u3001\u6b21\u306b\u3069\u306e\u85ac\u5264\u3092\u9078\u3076\u3079\u304d\u304b\u3068\u3044\u3046\u554f\u984c\u3067\u3059\u30022016\u5e74\u306bJAMA\u8a8c\u3067\u767a\u8868\u3055\u308c\u305f\u81e8\u5e8a\u8a66\u9a13\uff08RCT\uff09\u306b\u3088\u308b\u3068\u30012\u7a2e\u985e\u76ee\u306eTNF\u963b\u5bb3\u85ac\u3078\u5207\u308a\u66ff\u3048\u308b\u3088\u308a\u3082\u3001\u975eTNF\u963b\u5bb3\u85ac<\/strong>\uff08\u30a2\u30af\u30c6\u30e0\u30e9\u3001\u30aa\u30ec\u30f3\u30b7\u30a2\u3001\u30ea\u30c4\u30ad\u30b5\u30f3\u306a\u3069\uff09\u3078\u5909\u66f4\u3057\u305f\u65b9\u304c\u300124\u9031\u5f8c\u306e\u6cbb\u7642\u53cd\u5fdc\u6027\uff08EULAR good or moderate response\uff09\u306b\u304a\u3044\u3066\u6709\u610f\u306b\u512a\u308c\u305f\u6210\u7e3e\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u3084\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u306b\u5927\u304d\u306a\u5dee\u306f\u306a\u304f\u3001\u6cbb\u7642\u6210\u7e3e\u306e\u5411\u4e0a\u3092\u76ee\u6307\u3059\u4e0a\u3067\u3001\u7570\u306a\u308b\u4f5c\u7528\u6a5f\u5e8f\u3092\u6301\u3064\u85ac\u5264\u3078\u306e\u6226\u7565\u7684\u306a\u300c\u5207\u308a\u66ff\u3048<\/strong>\u300d\u306f\u3001\u975e\u5e38\u306b\u6709\u52b9\u306a\u624b\u6bb5\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092MTX\u4f75\u7528\u306a\u304f\u5358\u5264\uff08\u5358\u72ec\uff09\u3067\u7528\u3044\u308b\u5834\u5408\u3001TNF\u963b\u5bb3\u85ac\u3088\u308a\u3082IL-6\u963b\u5bb3\u85ac<\/strong>\uff08\u30a2\u30af\u30c6\u30e0\u30e9\u3084\u30b1\u30d6\u30b6\u30e9\uff09\u306e\u65b9\u304c\u300124\u9031\u5f8c\u306e\u5bdb\u89e3\u9054\u6210\u7387\u3084ACR50\u9054\u6210\u7387\u306b\u304a\u3044\u3066\u660e\u3089\u304b\u306b\u512a\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8eab\u4f53\u6a5f\u80fd\u306e\u6539\u5584\u6307\u6a19\uff08HAQ-DI\uff09\u306b\u304a\u3044\u3066\u3082IL-6\u963b\u5bb3\u85ac\u306e\u512a\u4f4d\u6027\u304c\u8a8d\u3081\u3089\u308c\u3066\u304a\u308a\u3001MTX\u304c\u4f7f\u3048\u306a\u3044\u72b6\u6cc1\u4e0b\u3067\u6a5f\u80fd\u7684\u5bdb\u89e3\u3092\u76ee\u6307\u3059\u306b\u306f\u3001\u307e\u305aIL-6\u963b\u5bb3\u85ac\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u5f53\u9662\u3067\u306f\u3001\u3053\u308c\u3089\u6700\u65b0\u306e\u5b66\u8853\u7684\u6839\u62e0\u306b\u57fa\u3065\u304d\u3001\u85ac\u5264\u306e\u30b3\u30b9\u30c8<\/strong>\u3084\u60a3\u8005\u69d8\u306e\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u3092\u7dcf\u5408\u7684\u306b\u8003\u616e\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u5358\u306b\u75db\u307f\u3092\u53d6\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u9577\u671f\u7684\u306b\u95a2\u7bc0\u306e\u7834\u58ca\u3092\u9632\u304e\u3001\u65e5\u5e38\u751f\u6d3b\u306e\u8cea\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306e\u6700\u9069\u306a\u6cbb\u7642\u30d7\u30e9\u30f3\u3092\u63d0\u6848\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u75c7\u72b6\u306e\u80cc\u666f\u306b\u3042\u308b\u300c\u4f53\u306e\u4ed5\u7d44\u307f\u300d\u307e\u3067\u4e01\u5be7\u306b\u8aac\u660e\u3057\u306a\u304c\u3089\u3001\u5185\u79d1\u30fb\u30ea\u30a6\u30de\u30c1\u30fb\u81a0\u539f\u75c5\u8a3a\u7642\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u300c\u306a\u305c\u3053\u306e\u75c7\u72b6\u304c\u8d77\u304d\u308b\u306e\u304b\u300d\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3092\u5927\u5207\u306b\u3057\u3066\u3044\u307e\u3059\u3002 \u67cf\u5e02\u30fb\u6211\u5b6b\u5b50\u5e02\u5468\u8fba\u3067\u3001\u95a2\u7bc0\u75db\u3084\u539f\u56e0\u306e\u5206\u304b\u3089\u306a\u3044\u4f53\u8abf\u4e0d\u826f\u306b\u304a\u60a9\u307f\u306e\u65b9\u306f\u3001\u3069\u3046\u305e\u304a\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff08RA\uff09\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\uff08bDMARDs\uff09\u306f\u5287\u7684\u306a\u52b9\u679c\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u304c\u3001\u6700\u521d\u306b\u9078\u629e\u3057\u305f\u85ac\u5264\u304c\u5341\u5206\u306a\u52b9\u679c\u3092\u767a\u63ee\u3057\u306a\u3044\u5834\u5408\u3084\u3001\u526f\u4f5c\u7528\u306a\u3069\u306e\u7406…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40,9],"class_list":["post-3410","post","type-post","status-publish","format-standard","hentry","category-40","category-9"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/comments?post=3410"}],"version-history":[{"count":2,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3410\/revisions"}],"predecessor-version":[{"id":3424,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3410\/revisions\/3424"}],"wp:attachment":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/media?parent=3410"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/categories?post=3410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}