{"id":3539,"date":"2026-04-18T08:15:42","date_gmt":"2026-04-17T23:15:42","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=3539"},"modified":"2026-04-18T08:15:43","modified_gmt":"2026-04-17T23:15:43","slug":"post-3539","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-3539\/","title":{"rendered":"\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u6cbb\u7642\u306b\u304a\u3051\u308b\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\uff1aAURORA 1\u8a66\u9a13\uff08\u7b2c3\u76f8\u81e8\u5e8a\u8a66\u9a13\uff09\u306e\u89e3\u6790"},"content":{"rendered":"\n<p>\u6d3b\u52d5\u6027\u30eb\u30fc\u30d7\u30b9\u814e\u708e\uff08LN\uff09\u306f\u3001\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u60a3\u8005\u306e\u7d0420\uff05\u304c\u8a3a\u65ad\u5f8c10\u5e74\u4ee5\u5185\u306b\u672b\u671f\u814e\u4e0d\u5168\uff08ESKD\uff09\u3078\u9032\u884c\u3059\u308b\u91cd\u7be4\u306a\u5408\u4f75\u75c7\u3067\u3059\u3002\u6cbb\u7642\u306e\u4e3b\u773c\u306f\u814e\u6a5f\u80fd\u306e\u4fdd\u6301\u3068\u6b7b\u4ea1\u7387\u306e\u4f4e\u4e0b\u306b\u3042\u308a\u3001\u7279\u306b\u6cbb\u7642\u958b\u59cb\u5f8c6\u301c12\u30f6\u6708\u4ee5\u5185\u306e\u65e9\u671f\u306e\u86cb\u767d\u5c3f\u6e1b\u5c11\u304c\u9577\u671f\u4e88\u5f8c\u306e\u6700\u826f\u306e\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u65b0\u898f\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\u963b\u5bb3\u85ac\uff08CNI\uff09\u3067\u3042\u308b<strong>\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3<\/strong>\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3057\u305f\u56fd\u969b\u5171\u540c\u7b2c3\u76f8\u8a66\u9a13\u300cAURORA 1\u300d\u306e\u7d50\u679c\u306b\u57fa\u3065\u304d\u3001\u305d\u306e\u81e8\u5e8a\u7684\u610f\u7fa9\u3092\u8003\u5bdf\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u3010PICO\uff1a\u81e8\u5e8a\u8a66\u9a13\u306e\u69cb\u6210\u3011<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>P\uff08Population\uff09<\/strong>: \u30a2\u30e1\u30ea\u30ab\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\uff08ACR\uff09\u57fa\u6e96\u3092\u6e80\u305f\u3059SLE\u60a3\u8005\u306e\u3046\u3061\u3001\u751f\u691c\u3067Class III\u3001IV\u3001V\uff08\u5358\u72ec\u307e\u305f\u306f\u6df7\u5408\uff09\u306e\u6d3b\u52d5\u6027LN\u3092\u78ba\u8a8d\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eUPCR\u22671.5 mg\/mg\uff08\u7d14\u7c8b\u306aClass V\u306f\u22672 mg\/mg\uff09\u3001eGFR\uff1e45 mL\/min\/1.73 m\u00b2\u306e\u60a3\u8005\u8a08357\u540d\u3002<\/li>\n\n\n\n<li><strong>I\uff08Intervention\uff09<\/strong>: \u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\uff0823.7 mg 1\u65e52\u56de\uff09\uff0b \u30df\u30b3\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u30e2\u30d5\u30a7\u30c1\u30eb\uff08MMF 2g\/\u65e5\uff09\uff0b \u30b9\u30c6\u30ed\u30a4\u30c9\u6025\u901f\u6e1b\u91cf\uff0816\u9031\u76ee\u307e\u3067\u306b2.5 mg\/\u65e5\u307e\u3067\u6e1b\u91cf\uff09\u3002<\/li>\n\n\n\n<li><strong>C\uff08Comparison\uff09<\/strong>: \u30d7\u30e9\u30bb\u30dc \uff0b MMF\uff082g\/\u65e5\uff09\uff0b \u30b9\u30c6\u30ed\u30a4\u30c9\u6025\u901f\u6e1b\u91cf\u3002<\/li>\n\n\n\n<li><strong>O\uff08Outcome\uff09<\/strong>: 52\u9031\u6642\u70b9\u306e\u5b8c\u5168\u814e\u53cd\u5fdc\uff08CRR\uff09\u9054\u6210\u7387\u3002CRR\u306e\u5b9a\u7fa9\u306f\u3001\u2460UPCR\u22660.5 mg\/mg\u3001\u2461eGFR\u306e\u5b89\u5b9a\uff08\u226760 mL\/min\/1.73 m\u00b2\u307e\u305f\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6bd420\uff05\u4ee5\u5185\u306e\u4f4e\u4e0b\uff09\u3001\u2462\u30ec\u30b9\u30ad\u30e5\u30fc\u85ac\u4e0d\u4f7f\u7528\u3001\u2463\u4f4e\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u7dad\u6301\uff08\u903144\u301c52\u3067\u30d7\u30ec\u30c9\u30cb\u30be\u30f3\u63db\u7b9710mg\u4ee5\u4e0b\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u3010\u4e3b\u8981\u306a\u8a66\u9a13\u7d50\u679c\u3011<\/strong><\/p>\n\n\n\n<p>\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b52\u9031\u6642\u70b9\u306eCRR\u9054\u6210\u7387\u306f\u3001\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u7fa4\u3067<strong>41\uff05\uff0873\/179\u540d\uff09<\/strong>\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067<strong>23\uff05\uff0840\/178\u540d\uff09<\/strong><strong>29\u65e5<\/strong>\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306763\u65e5\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4 2.05, p&lt;0.001\uff09\u3067\u3042\u308a\u3001\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306e\u8fc5\u901f\u306a\u6297\u86cb\u767d\u5c3f\u4f5c\u7528\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p>\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\uff08SAE\uff09\u306e\u767a\u751f\u7387\u306f\u4e21\u7fa4\u3068\u308221\uff05\u3067\u540c\u7b49\u3067\u3042\u3063\u305f\u3002\u611f\u67d3\u75c7\u95a2\u9023\u306eSAE\uff08\u4e3b\u306b\u80ba\u708e\uff09\u3082\u4e21\u7fa4\u30674\uff05\u3068\u5747\u8861\u3057\u3066\u304a\u308a\u3001\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306e\u8ffd\u52a0\u306b\u3088\u308b\u904e\u5ea6\u306a\u514d\u75ab\u6291\u5236\u30ea\u30b9\u30af\u306e\u5897\u5927\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u7fa4\u306e\u6b7b\u4ea1\u306f1\u540d\uff08&lt;1%\uff09\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306f5\u540d\uff083%\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<p><strong>\u3010\u533b\u5b66\u7684\u8003\u5bdf\u3068\u81e8\u5e8a\u7684\u610f\u7fa9\u3011<\/strong><\/p>\n\n\n\n<p>\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306f\u3001\u5f93\u6765\u306eCNI\u3068\u6bd4\u8f03\u3057\u3066\u5b89\u5b9a\u3057\u305f\u85ac\u7269\u52d5\u614b\u3092\u6709\u3057\u3001\u6cbb\u7642\u85ac\u7269\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff08TDM\uff09\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u5229\u70b9\u304c\u3042\u308b\u3002\u4f5c\u7528\u6a5f\u5e8f\u3068\u3057\u3066\u306f\u3001T\u7d30\u80de\u6d3b\u6027\u5316\u306e\u6291\u5236\uff08IL-2\u8ee2\u5199\u963b\u5bb3\uff09\u306b\u52a0\u3048\u3001\u30dd\u30c9\u30b5\u30a4\u30c8\uff08\u8db3\u7d30\u80de\uff09\u5185\u306e\u30b7\u30ca\u30d7\u30c8\u30dd\u30b8\u30f3\u3092\u5b89\u5b9a\u5316\u3055\u305b\u3001\u30a2\u30af\u30c1\u30f3\u9aa8\u683c\u306e\u5d29\u58ca\u3092\u9632\u3050\u76f4\u63a5\u7684\u306a\u8db3\u7d30\u80de\u4fdd\u8b77\u4f5c\u7528\u3092\u4f75\u305b\u6301\u3064\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002 \u672c\u8a66\u9a13\u306e\u610f\u7fa9\u306f\u3001\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\u66dd\u9732\u91cf\u3092\u6700\u5c0f\u5316\u3057\u3064\u3064\u3001\u65e9\u671f\u306e\u814e\u53cd\u5fdc\u9054\u6210\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u300d\u4e09\u5264\u4f75\u7528\u7642\u6cd5\u306e\u6709\u7528\u6027\u3092\u5927\u898f\u6a21\u306a\u591a\u65bd\u8a2d\u5171\u540c\u8a66\u9a13\u3067\u8a3c\u660e\u3057\u305f\u70b9\u306b\u3042\u308b\u3002\u7279\u306b\u3001\u591a\u69d8\u306a\u4eba\u7a2e\u3092\u542b\u3080\u96c6\u56e3\u3067\u4e00\u8cab\u3057\u305f\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u73fe\u4ee3\u306eLN\u5c0e\u5165\u7642\u6cd5\u306b\u304a\u3051\u308b\u6a19\u6e96\u7684\u306a\u9078\u629e\u80a2\u3068\u3057\u3066\u306e\u5730\u4f4d\u3092\u78ba\u7acb\u3057\u305f\u3068\u8a00\u3048\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"429\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-21.jpg\" alt=\"\" class=\"wp-image-3541\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-21.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-21-400x215.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"431\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-22.jpg\" alt=\"\" class=\"wp-image-3542\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-22.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-22-400x216.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"433\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-23.jpg\" alt=\"\" class=\"wp-image-3543\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-23.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-23-400x217.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"437\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-24.jpg\" alt=\"\" class=\"wp-image-3544\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-24.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-24-400x219.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"432\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-25.jpg\" alt=\"\" class=\"wp-image-3545\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-25.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-25-400x216.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"435\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-26.jpg\" alt=\"\" class=\"wp-image-3546\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-26.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-26-400x218.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"431\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-27.jpg\" alt=\"\" class=\"wp-image-3547\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-27.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-27-400x216.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"436\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-28.jpg\" alt=\"\" class=\"wp-image-3548\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-28.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-28-400x218.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"445\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-29.jpg\" alt=\"\" class=\"wp-image-3549\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-29.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-29-400x223.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>Lancet<\/em> 2021; 397: 2070\u201380. doi: 10.1016\/S0140-6736(21)00578-X<\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>\u6d3b\u52d5\u6027\u30eb\u30fc\u30d7\u30b9\u814e\u708e\uff08LN\uff09\u306f\u3001\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u60a3\u8005\u306e\u7d0420\uff05\u304c\u8a3a\u65ad\u5f8c10\u5e74\u4ee5\u5185\u306b\u672b\u671f\u814e\u4e0d\u5168\uff08ESKD\uff09\u3078\u9032\u884c\u3059\u308b\u91cd\u7be4\u306a\u5408\u4f75\u75c7\u3067\u3059\u3002\u6cbb\u7642\u306e\u4e3b\u773c\u306f\u814e&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[49,1],"class_list":["post-3539","post","type-post","status-publish","format-standard","hentry","category-lancet","category-medical_science"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/comments?post=3539"}],"version-history":[{"count":2,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3539\/revisions"}],"predecessor-version":[{"id":3550,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3539\/revisions\/3550"}],"wp:attachment":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/media?parent=3539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/categories?post=3539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}