{"id":3551,"date":"2026-04-18T10:10:09","date_gmt":"2026-04-18T01:10:09","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=3551"},"modified":"2026-04-18T12:04:00","modified_gmt":"2026-04-18T03:04:00","slug":"post-3551","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-3551\/","title":{"rendered":"\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u306b\u304a\u3051\u308b\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306e\u9577\u671f\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\uff1a\u7b2c3\u76f8AURORA 1\/2\u8a66\u9a13\u306e3\u5e74\u9593\u8ffd\u8de1\u89e3\u6790"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u30eb\u30fc\u30d7\u30b9\u814e\u708e\uff08LN\uff09\u6cbb\u7642\u306b\u304a\u3051\u308b\u81f3\u4e0a\u547d\u984c\u306f\u3001\u672b\u671f\u814e\u4e0d\u5168\uff08ESKD\uff09\u3078\u306e\u9032\u884c\u3092\u963b\u6b62\u3059\u308b\u305f\u3081\u306e\u300c\u65e9\u671f\u304b\u3064\u6301\u7d9a\u7684\u306a\u86cb\u767d\u5c3f\u306e\u6e1b\u5c11\u300d\u3068\u300c\u9577\u671f\u7684\u306a\u814e\u6a5f\u80fd\uff08eGFR\uff09\u306e\u4fdd\u6301\u300d\u3067\u3059\u3002\u65b0\u898f\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\u963b\u5bb3\u85ac\uff08CNI\uff09\u3067\u3042\u308b\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306f\u3001\u30dd\u30c9\u30b5\u30a4\u30c8\u306e\u30b7\u30ca\u30d7\u30c8\u30dd\u30b8\u30f3\u3092\u5b89\u5b9a\u5316\u3055\u305b\u308b\u76f4\u63a5\u7684\u306a\u8db3\u7d30\u80de\u4fdd\u8b77\u4f5c\u7528\u3068\u3001T\u7d30\u80de\u6d3b\u6027\u5316\u6291\u5236\u3068\u3044\u3046\u30c7\u30e5\u30a2\u30eb\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6709\u3057\u3001\u304b\u3064\u8840\u4e2d\u6fc3\u5ea6\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff08TDM\uff09\u3092\u4e0d\u8981\u3068\u3059\u308b\u6b21\u4e16\u4ee3\u306e\u6cbb\u7642\u85ac\u3067\u3059\u30021\u5e74\u9593\u306eAURORA 1\u8a66\u9a13\u306b\u7d9a\u304f2\u5e74\u9593\u306e\u7d99\u7d9a\u8a66\u9a13\u300cAURORA 2\u300d\u3092\u542b\u3081\u305f\u3001\u8a083\u5e74\u9593\u306e\u7d71\u5408\u7684\u81e8\u5e8a\u77e5\u898b\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u3010PICO\uff1a\u7b2c3\u76f8AURORA 1\/2\u7d99\u7d9a\u8a66\u9a13\u306e\u69cb\u6210\u3011<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>P\uff08Population\uff09<\/strong>: AURORA 1\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u305f\u6d3b\u52d5\u6027LN\u60a3\u8005\uff08Class III, IV, V\uff09\u306e\u3046\u3061\u3001\u7d99\u7d9a\u7684\u306a\u514d\u75ab\u6291\u5236\u7642\u6cd5\u304c\u5fc5\u8981\u3068\u5224\u65ad\u3055\u308c\u305f216\u540d\u3002<\/li>\n\n\n\n<li><strong>I\uff08Intervention\uff09<\/strong>: \u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\uff0823.7 mg 1\u65e52\u56de\uff09\uff0b \u30df\u30b3\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u30e2\u30d5\u30a7\u30c1\u30eb\uff08MMF\uff09\uff0b \u4f4e\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\u3002<\/li>\n\n\n\n<li><strong>C\uff08Comparison\uff09<\/strong>: \u30d7\u30e9\u30bb\u30dc \uff0b MMF \uff0b \u4f4e\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\uff08\u5bfe\u7167\u7fa4\uff09\u3002<\/li>\n\n\n\n<li><strong>O\uff08Outcome\uff09<\/strong>:\n<ul class=\"wp-block-list\">\n<li><strong>\u5b89\u5168\u6027\uff08Primary\uff09<\/strong>: 36\u30f6\u6708\u9593\u306e\u6709\u5bb3\u4e8b\u8c61\uff08AE\uff09\u3001\u751f\u5316\u5b66\u7684\u30fb\u8840\u6db2\u5b66\u7684\u8a55\u4fa1\u3002<\/li>\n\n\n\n<li><strong>\u6709\u52b9\u6027\uff08Secondary\uff09<\/strong>: \u5b8c\u5168\u814e\u53cd\u5fdc\uff08CRR\uff09\u9054\u6210\u7387\u3001UPCR\u63a8\u79fb\u3001eGFR\u30b9\u30ed\u30fc\u30d7\uff08\u814e\u6a5f\u80fd\u306e\u7d4c\u6642\u7684\u5909\u5316\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u3010\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\uff1a3\u5e74\u9593\u306e\u89e3\u6790\u7d50\u679c\u3011<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. \u6709\u52b9\u6027\u306e\u6301\u7d9a\u3068CRR\u9054\u6210\u7387\u306e\u512a\u4f4d\u6027<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">36\u30f6\u6708\uff083\u5e74\u9593\uff09\u6642\u70b9\u306b\u304a\u3051\u308bCRR\u9054\u6210\u7387\u306f\u3001\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u7fa4 <strong>50.9%<\/strong> \u306b\u5bfe\u3057\u3001\u5bfe\u7167\u7fa4 <strong>39.0%<\/strong> \u3067\u3042\u308a\u3001\u9577\u671f\u306b\u308f\u305f\u308b\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306e\u6cbb\u7642\u512a\u4f4d\u6027\u304c\u7dad\u6301\u3055\u308c\u305f\uff08\u30aa\u30c3\u30ba\u6bd4 1.74; 95% CI 1.00\u20133.03\uff09\u3002\u5c3f\u86cb\u767d\uff08UPCR\uff09\u306e\u5927\u5e45\u306a\u6e1b\u5c11\u306f3\u5e74\u9593\u306b\u308f\u305f\u3063\u3066\u6301\u7d9a\u3057\u3001\u7279\u306b\u6cbb\u7642\u958b\u59cb12\u30f6\u6708\u4ee5\u964d\u306e\u5b89\u5b9a\u3057\u305f\u5bdb\u89e3\u7dad\u6301\u304c\u3001\u5c06\u6765\u306e\u814e\u4fdd\u8b77\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. \u814e\u6a5f\u80fd\u306e\u9577\u671f\u5b89\u5b9a\u6027\uff08eGFR\u30b9\u30ed\u30fc\u30d7\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u8a66\u9a13\u306e\u7279\u7b46\u3059\u3079\u304d\u77e5\u898b\u306f\u3001\u814e\u6a5f\u80fd\u306e\u9577\u671f\u7684\u4e88\u5f8c\u3092\u793a\u3059eGFR\u30b9\u30ed\u30fc\u30d7\u3067\u3042\u308b\u3002AURORA 2\u671f\u9593\uff0812\u30f6\u6708\u301c36\u30f6\u6708\uff09\u306b\u304a\u3051\u308beGFR\u306e\u5e74\u9593\u5909\u5316\u7387\u306f\u3001\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u7fa4\u3067 <strong>-0.2 mL\/min\/1.73 m\u00b2<\/strong> \u3068\u307b\u307c\u6a2a\u3070\u3044\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u5bfe\u7167\u7fa4\u3067\u306f <strong>-5.4 mL\/min\/1.73 m\u00b2<\/strong> \u3068\u6709\u610f\u306a\u4f4e\u4e0b\u3092\u8a8d\u3081\u305f\u3002\u3053\u308c\u306f\u3001\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u304cLN\u306e\u81ea\u7136\u7d4c\u904e\u306b\u4f34\u3046\u814e\u6a5f\u80fd\u60aa\u5316\u3092\u6291\u5236\u3057\u3001\u9577\u671f\u9593\u306e\u814e\u5b9f\u8cea\u4fdd\u8b77\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u3092\u793a\u3059\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. \u9577\u671f\u5b89\u5168\u6027\u3068\u5fcd\u5bb9\u6027<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\u5e74\u9593\u306e\u9577\u671f\u6295\u4e0e\u306b\u304a\u3044\u3066\u3082\u3001\u65b0\u305f\u306a\u5b89\u5168\u6027\u306e\u61f8\u5ff5\uff08Safety Signal\uff09\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002CNI\u7279\u6709\u306e\u8840\u884c\u52d5\u614b\u7684\u5f71\u97ff\u3067\u3042\u308b\u300ceGFR\u4f4e\u4e0b\u300d\u3084\u300c\u9ad8\u8840\u5727\u300d\u306e\u5831\u544a\u306f\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u7fa4\u3067\u3084\u3084\u591a\u304b\u3063\u305f\u304c\uff08GFR\u4f4e\u4e0b\uff1a10.3% vs 5.0%\uff09\u3001\u3053\u308c\u3089\u306f\u7528\u91cf\u8abf\u7bc0\u306b\u3088\u308a\u7ba1\u7406\u53ef\u80fd\u3067\u3042\u308a\u3001\u5e73\u5747eGFR\u5024\u306f3\u5e74\u9593\u3092\u901a\u3058\u3066\u6b63\u5e38\u7bc4\u56f2\u5185\u3067\u5b89\u5b9a\u3057\u3066\u3044\u305f\u3002\u307e\u305f\u3001\u8102\u8cea\u3001\u8840\u7cd6\u3001\u96fb\u89e3\u8cea\u3078\u306e\u5f71\u97ff\u3082\u6975\u3081\u3066\u9650\u5b9a\u7684\u3067\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u3010\u7d50\u8ad6\u3011<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3001MMF\u3001\u4f4e\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\u306b\u3088\u308b\u4e09\u5264\u4f75\u7528\u7642\u6cd5\u306f\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u7d2f\u7a4d\u66dd\u9732\u91cf\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3064\u3064\u3001\u8fc5\u901f\u304b\u3064\u6301\u7d9a\u7684\u306a\u5c3f\u86cb\u767d\u6e1b\u5c11\u3092\u9054\u6210\u3059\u308b\u30023\u5e74\u9593\u306e\u30c7\u30fc\u30bf\u306f\u3001\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u304c\u9577\u671f\u7684\u306a\u814e\u6a5f\u80fd\u3092\u5b89\u5b9a\u3055\u305b\u3001LN\u60a3\u8005\u306e\u4e88\u5f8c\u3092\u6539\u5584\u3059\u308b\u300c\u6a19\u6e96\u6cbb\u7642\uff08SoC\uff09\u300d\u3068\u3057\u3066\u306e\u5730\u4f4d\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-30.jpg\" alt=\"\" class=\"wp-image-3552\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-30.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-30-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-31.jpg\" alt=\"\" class=\"wp-image-3553\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-31.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-31-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-32.jpg\" alt=\"\" class=\"wp-image-3554\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-32.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-32-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-33.jpg\" alt=\"\" class=\"wp-image-3555\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-33.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-33-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-34.jpg\" alt=\"\" class=\"wp-image-3556\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-34.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-34-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-35.jpg\" alt=\"\" class=\"wp-image-3557\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-35.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-35-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-36.jpg\" alt=\"\" class=\"wp-image-3558\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-36.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-36-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-37.jpg\" alt=\"\" class=\"wp-image-3559\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-37.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-37-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-38.jpg\" alt=\"\" class=\"wp-image-3560\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-38.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-38-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-39.jpg\" alt=\"\" class=\"wp-image-3561\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-39.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-39-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-40.jpg\" alt=\"\" class=\"wp-image-3562\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-40.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-40-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><em>Arthritis &amp; Rheumatology<\/em> 2024; 76(1): 59\u201367. doi: 10.1002\/art.42657.<\/p>\n<\/blockquote>\n\n\n\n<p 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