{"id":3565,"date":"2026-04-18T12:28:37","date_gmt":"2026-04-18T03:28:37","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=3565"},"modified":"2026-04-18T12:28:37","modified_gmt":"2026-04-18T03:28:37","slug":"post-3565","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-3565\/","title":{"rendered":"\u30a2\u30b8\u30a2\u4eba\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u60a3\u8005\u306b\u304a\u3051\u308b\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306e\u9577\u671f\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\uff1aAURORA 1\/2\u4e8b\u5f8c\u89e3\u6790"},"content":{"rendered":"\n<p>\u30eb\u30fc\u30d7\u30b9\u814e\u708e\uff08LN\uff09\u306f\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u306e\u91cd\u5927\u306a\u81d3\u5668\u75c5\u5909\u3067\u3042\u308a\u3001\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u6b27\u5dde\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u814e\u75c5\u5909\u306e\u5408\u4f75\u7387\u304c\u9ad8\u304f\uff0821\uff5e65%\uff09\u3001\u91cd\u75c7\u5316\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u65b0\u898f\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\u963b\u5bb3\u85ac\uff08CNI\uff09\u3067\u3042\u308b\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\uff08VCS\uff09\u306e\u30a2\u30b8\u30a2\u4eba\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3051\u308b3\u5e74\u9593\u306e\u9577\u671f\u6210\u7e3e\u3092\u307e\u3068\u3081\u305f\u3082\u306e\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u3010PICO\u3011<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>P\uff08Patient\uff09<\/strong>: AURORA 1\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u3001AURORA 2\u7d99\u7d9a\u8a66\u9a13\u306b\u53c2\u52a0\u3057\u305f\u30a2\u30b8\u30a2\u4eba\u306e\u6d3b\u52d5\u6027LN\u60a3\u8005\uff08\u8a0860\u540d\uff1aVCS\u7fa430\u540d\u3001\u5bfe\u7167\u7fa430\u540d\uff09\u3002<\/li>\n\n\n\n<li><strong>I\uff08Intervention\uff09<\/strong>: VCS\uff0823.7 mg BID\uff09\uff0b \u30df\u30b3\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u30e2\u30d5\u30a7\u30c1\u30eb\uff08MMF 2g\/\u65e5\uff09\uff0b \u4f4e\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\uff08\u6025\u901f\u6e1b\u91cf\u30d7\u30ed\u30c8\u30b3\u30eb\uff09\u3002<\/li>\n\n\n\n<li><strong>C\uff08Comparison\uff09<\/strong>: \u30d7\u30e9\u30bb\u30dc \uff0b MMF \uff0b \u4f4e\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\u3002<\/li>\n\n\n\n<li><strong>O\uff08Outcome\uff09<\/strong>: 3\u5e74\u9593\u306e\u9577\u671f\u5b89\u5168\u6027\u3001\u86cb\u767d\u5c3f\u6e1b\u5c11\u7387\uff08UPCR \u2264 0.5 mg\/mg\u9054\u6210\u7387\uff09\u304a\u3088\u3073\u5b8c\u5168\u814e\u53cd\u5fdc\uff08CRR\uff09\u9054\u6210\u7387\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u3010\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8981\u7d04\u3011<\/strong><\/p>\n\n\n\n<p><strong>1. \u86cb\u767d\u5c3f\u6e1b\u5c11\u306e\u901f\u52b9\u6027\u3068\u6301\u7d9a\u6027<\/strong> 3\u5e74\u9593\u306e\u89b3\u5bdf\u671f\u9593\u306b\u304a\u3044\u3066\u3001UPCR \u2264 0.5 mg\/mg\u3092\u9054\u6210\u3057\u305f\u5272\u5408\u306fVCS\u7fa4\u3067<strong>90.0%6.3\u30f6\u6708<\/strong>\u3067\u3042\u308a\u3001\u5bfe\u7167\u7fa4\u306e<strong>26.7<\/strong>\u30f6\u6708\u3068\u6bd4\u8f03\u3057\u3066\u9855\u8457\u306b\u77ed\u7e2e\u3057\u3066\u3044\u308b\uff08HR 3.02, P=.001\uff09\u3002\u307e\u305f\u300150%\u4ee5\u4e0a\u306e\u86cb\u767d\u5c3f\u6e1b\u5c11\uff08PRR\uff09\u3082VCS\u7fa4\u3067\u306f\u5168\u4f8b\uff08100%\uff09\u304c\u9054\u6210\u3057\u3001\u305d\u306e\u4e2d\u592e\u5024\u306f\u308f\u305a\u304b<strong>1.0<\/strong>\u30f6\u6708\u3002<\/p>\n\n\n\n<p><strong>2. \u9577\u671f\u814e\u53cd\u5fdc\uff08CRR\uff09\u306e\u9054\u6210\u7387<\/strong> 36\u30f6\u6708\u6642\u70b9\u3067\u306eCRR\u9054\u6210\u7387\u306fVCS\u7fa4\u3067<strong>66.7%<\/strong>\u3001\u5bfe\u7167\u7fa4\u306733.3%\u3067\u3042\u308a\u3001\u9577\u671f\u306b\u308f\u305f\u308b\u9ad8\u3044\u6cbb\u7642\u53cd\u5fdc\u6027\u304c\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\uff08OR 3.97, P=.019\uff09\u3002\u30a2\u30b8\u30a2\u4eba\u306e\u5bfe\u7167\u7fa4\u3067\u306fUPCR\u76ee\u6a19\u9054\u6210\u306b\u7d0427\u30f6\u6708\u3092\u8981\u3057\u3066\u304a\u308a\u3001\u6a19\u6e96\u6cbb\u7642\u306e\u307f\u3067\u306f\u53cd\u5fdc\u304c\u9045\u308c\u308b\u50be\u5411\u304c\u3042\u308b\u4e2d\u3067\u3001VCS\u306e\u4f75\u7528\u304c\u6975\u3081\u3066\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p><strong>3. \u5b89\u5168\u6027\u3068\u5fcd\u5bb9\u6027<\/strong> \u6709\u5bb3\u4e8b\u8c61\uff08AE\uff09\u306e\u767a\u751f\u7387\u306f\u4e21\u7fa4\u3067\u540c\u7b49\uff08VCS\u7fa4 93.3% vs \u5bfe\u7167\u7fa4 100.0%\uff09\u3002CNI\u95a2\u9023\u306eAE\u3068\u3057\u3066\u3001eGFR\u4f4e\u4e0b\uff0826.7% vs 6.7%\uff09\u3084\u9ad8\u8840\u5727\uff0833.3% vs 10.0%\uff09\u306e\u767a\u73fe\u7387\u306fVCS\u7fa4\u3067\u9ad8\u304b\u3063\u305f\u3082\u306e\u306e\u3001AE\u306b\u3088\u308b\u6295\u4e0e\u4e2d\u6b62\u7387\u306fVCS\u7fa4\u3067\u4f4e\u304f\uff083.3% vs 26.7%\uff09\u3001\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u3092\u793a\u3057\u305f\u3002\u307e\u305f\u3001\u30a2\u30b8\u30a2\u4eba\u3067\u61f8\u5ff5\u3055\u308c\u308b\u5e2f\u72b6\u75b1\u75b9\u306e\u767a\u73fe\u7387\u306f\u4e21\u7fa4\u3067\u5dee\u306f\u306a\u304f\uff0813.3% vs 16.7%\uff09\u3001VCS\u4f7f\u7528\u306b\u3088\u308b\u904e\u5ea6\u306a\u30ea\u30b9\u30af\u5897\u5927\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p><strong>\u3010\u7d50\u8ad6\u3011<\/strong><\/p>\n\n\n\n<p>\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306f\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3044\u3066\u3082\u30013\u5e74\u9593\u306b\u308f\u305f\u308a\u814e\u6a5f\u80fd\u3092\u4fdd\u6301\u3057\u3064\u3064\u3001\u8fc5\u901f\u304b\u3064\u6301\u7d9a\u7684\u306a\u86cb\u767d\u5c3f\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002\u8840\u4e2d\u6fc3\u5ea6\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff08TDM\uff09\u3092\u4e0d\u8981\u3068\u3057\u3001\u4f4e\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\u4e0b\u3067\u9ad8\u3044\u5bdb\u89e3\u7387\u3092\u7dad\u6301\u3067\u304d\u308b\u672c\u85ac\u5264\u306f\u3001\u30a2\u30b8\u30a2\u4ebaLN\u8a3a\u7642\u306e\u91cd\u8981\u306a\u9078\u629e\u80a2\u3068\u306a\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-41.jpg\" alt=\"\" class=\"wp-image-3566\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-41.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-41-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-42.jpg\" alt=\"\" class=\"wp-image-3567\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-42.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-42-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-43.jpg\" alt=\"\" class=\"wp-image-3568\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-43.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-43-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-44.jpg\" alt=\"\" class=\"wp-image-3569\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-44.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-44-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-45.jpg\" alt=\"\" class=\"wp-image-3570\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-45.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-45-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-46.jpg\" alt=\"\" class=\"wp-image-3571\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-46.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-46-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-47.jpg\" alt=\"\" class=\"wp-image-3572\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-47.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-47-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-48.jpg\" alt=\"\" class=\"wp-image-3573\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-48.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-48-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-49.jpg\" alt=\"\" class=\"wp-image-3574\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-49.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-49-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-50.jpg\" alt=\"\" class=\"wp-image-3575\" style=\"aspect-ratio:1.7897717341909323;width:800px;height:auto\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-50.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-50-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-51.jpg\" alt=\"\" class=\"wp-image-3576\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-51.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-51-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-52.jpg\" alt=\"\" class=\"wp-image-3577\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-52.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-52-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-53.jpg\" alt=\"\" class=\"wp-image-3578\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-53.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-53-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>Modern Rheumatology<\/em>. 2025;00(00):1\u20137. doi:10.1093\/mr\/roaf121.<\/p>\n<\/blockquote>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30eb\u30fc\u30d7\u30b9\u814e\u708e\uff08LN\uff09\u306f\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u306e\u91cd\u5927\u306a\u81d3\u5668\u75c5\u5909\u3067\u3042\u308a\u3001\u30a2\u30b8\u30a2\u4eba\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u6b27\u5dde\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u814e\u75c5\u5909\u306e\u5408\u4f75\u7387\u304c\u9ad8\u304f\uff0821\uff5e65%\uff09\u3001\u91cd\u75c7\u5316&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"class_list":["post-3565","post","type-post","status-publish","format-standard","hentry","category-50"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/comments?post=3565"}],"version-history":[{"count":1,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3565\/revisions"}],"predecessor-version":[{"id":3579,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3565\/revisions\/3579"}],"wp:attachment":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/media?parent=3565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/categories?post=3565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}