{"id":3596,"date":"2026-04-18T14:02:51","date_gmt":"2026-04-18T05:02:51","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=3596"},"modified":"2026-04-18T14:02:51","modified_gmt":"2026-04-18T05:02:51","slug":"post-3596","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-3596\/","title":{"rendered":"\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306b\u304a\u3051\u308b\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u306e\u5305\u62ec\u7684\u89e3\u6790\uff1aCYP3A\u304a\u3088\u3073P-\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4ecb\u3057\u305f\u5f71\u97ff"},"content":{"rendered":"\n<p>\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\uff08Voclosporin: VCS\uff09\u306f\u3001\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3A\uff08CsA\uff09\u306e\u30a2\u30df\u30ce\u9178-1\u9818\u57df\u306b\u5358\u4e00\u70ad\u7d20\u5ef6\u9577\u3092\u65bd\u3057\u305f\u65b0\u898f\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\u963b\u5bb3\u85ac\uff08CNI\uff09\u3067\u3042\u308b\u3002\u3053\u306e\u69cb\u9020\u6539\u5909\u306b\u3088\u308a\u3001CN\u3078\u306e\u7d50\u5408\u80fd\u5411\u4e0a\uff08\u9ad8\u529b\u4fa1\uff09\u3068\u4ee3\u8b1d\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u5909\u66f4\u304c\u9054\u6210\u3055\u308c\u3001CsA\u3068\u6bd4\u8f03\u3057\u3066\u4f4e\u7528\u91cf\u3067\u306e\u6295\u4e0e\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u308b\u3002VCS\u306e\u4ee3\u8b1d\u306f\u3001\u305d\u306e99\uff05\u4ee5\u4e0a\u304c\u809d\u81d3\u306e\u30b7\u30c8\u30af\u30ed\u30e0P450 3A\uff08CYP3A\uff09\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306b\u3088\u308b\u4ee3\u8b1d\u304a\u3088\u3073\u80c6\u6c41\u6392\u6cc4\u306b\u4f9d\u5b58\u3057\u3066\u304a\u308a\u3001\u540c\u6642\u306bP-\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff08P-gp\uff09\u306e\u57fa\u8cea\u304b\u3064\u963b\u5bb3\u5264\u3068\u3057\u3066\u306e\u7279\u6027\u3082\u6709\u3059\u308b\u3002\u4ee5\u4e0b\u306b\u3001\u5065\u5eb7\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f5\u3064\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u57fa\u3065\u304fDDI\u89e3\u6790\u7d50\u679c\u3092\u8ff0\u3079\u308b\u3002<\/p>\n\n\n\n<p><strong>\u3010\u81e8\u5e8a\u85ac\u7406\u5b66\u7684\u89e3\u6790\u7d50\u679c\u3011<\/strong><\/p>\n\n\n\n<p><strong>1. CYP3A\u3092\u4ecb\u3057\u305f\u76f8\u4e92\u4f5c\u7528<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5f37\u56fa\u306a\u963b\u5bb3\uff08\u30b1\u30c8\u30b3\u30ca\u30be\u30fc\u30eb\u4f75\u7528\uff09<\/strong>: \u5f37\u529b\u306aCYP3A\u963b\u5bb3\u5264\u3067\u3042\u308b\u30b1\u30c8\u30b3\u30ca\u30be\u30fc\u30eb\uff08400 mg QD\uff09\u306e\u5b9a\u5e38\u72b6\u614b\u4e0b\u306b\u304a\u3044\u3066\u3001VCS\u306e<em>Cmax<\/em>\u200b\u306f<strong>6.4\u500d<\/strong>\u3001AUC(0\u201312)\u306f<strong>18\u500d<\/strong>\u3078\u3068\u8457\u660e\u306b\u4e0a\u6607\u3057\u305f\u3002\u3053\u306e\u8d85\u6cbb\u7642\u57df\u306e\u8840\u4e2d\u6fc3\u5ea6\u4e0a\u6607\u306b\u4f34\u3044\u3001\u4e00\u90e8\u306e\u88ab\u9a13\u8005\u3067<strong>\u53ef\u9006\u7684<\/strong>\u306a\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u5024\u306e\u4e0a\u6607\uff08\u5e73\u574788\uff05\u5897\uff09\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002<\/li>\n\n\n\n<li><strong>\u5f37\u56fa\u306a\u8a98\u5c0e\uff08\u30ea\u30d5\u30a1\u30f3\u30d4\u30f3\u4f75\u7528\uff09<\/strong>: \u5f37\u529b\u306aCYP3A\u8a98\u5c0e\u5264\u3067\u3042\u308b\u30ea\u30d5\u30a1\u30f3\u30d4\u30f3\uff08600 mg QD\uff09\u306e\u6295\u4e0e\u5f8c\u3067\u306f\u3001VCS\u306e<em>C<\/em><em>ma<\/em><em>x<\/em>\u200b\u306f\u7d0470\uff05\u6e1b\u3001AUC\u306f\u7d04<strong>90\uff05\u6e1b<\/strong>\uff080.1\u500d\uff09\u3068\u306a\u308a\u3001\u6d88\u5931\u534a\u6e1b\u671f\u306f5\u6642\u9593\u304b\u30891\u6642\u9593\u672a\u6e80\u3078\u3068\u6fc0\u6e1b\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>CYP3A\u57fa\u8cea\u3078\u306e\u5f71\u97ff\uff08\u30df\u30c0\u30be\u30e9\u30e0\u4f75\u7528\uff09<\/strong>: VCS\u306f<em>in vitro<\/em>\u3067CYP3A\u306e\u7af6\u5408\u7684\u963b\u5bb3\u5264\u3068\u3055\u308c\u308b\u304c\u3001\u81e8\u5e8a\u7528\u91cf\uff080.4 mg\/kg Q12H\uff09\u306e\u5b9a\u5e38\u72b6\u614b\u4e0b\u306b\u304a\u3044\u3066\u3001CYP3A\u57fa\u8cea\u3067\u3042\u308b\u30df\u30c0\u30be\u30e9\u30e0\u306e\u66dd\u9732\u91cf\uff08AUC\uff09\u306b\u6709\u610f\u306a\u5909\u5316\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>2. P-\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff08P-gp\uff09\u3092\u4ecb\u3057\u305f\u76f8\u4e92\u4f5c\u7528<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>P-gp\u963b\u5bb3\uff08\u30d9\u30e9\u30d1\u30df\u30eb\u4f75\u7528\uff09<\/strong>: P-gp\u963b\u5bb3\u5264\u3067\u3042\u308b\u30d9\u30e9\u30d1\u30df\u30eb\u306e\u4f75\u7528\u306b\u3088\u308a\u3001VCS\u306e<em>C<\/em><em>ma<\/em><em>x<\/em>\u200b\u306f2.1\u500d\u3001AUC\u306f2.7\u500d\u306b\u4e0a\u6607\u3057\u305f\u3002\u3053\u308c\u306f\u4e3b\u306b\u6d88\u5316\u7ba1\u306b\u304a\u3051\u308bP-gp\u4ecb\u5728\u6027\u306e\u6392\u51fa\u6291\u5236\u306b\u3088\u308b\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\u306e\u5411\u4e0a\u306b\u8d77\u56e0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>P-gp\u57fa\u8cea\u3078\u306e\u5f71\u97ff\uff08\u30b8\u30b4\u30ad\u30b7\u30f3\u4f75\u7528\uff09<\/strong>: VCS\u306fP-gp\u57fa\u8cea\u3067\u3042\u308b\u30b8\u30b4\u30ad\u30b7\u30f3\u306e<em>C<\/em><em>ma<\/em><em>x<\/em>\u200b\u309250\uff05\u3001AUC\u309225\uff05\u4e0a\u6607\u3055\u305b\u305f\u3002\u4e00\u65b9\u3001\u30b8\u30b4\u30ad\u30b7\u30f3\u306e\u814e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306b\u5909\u5316\u306f\u306a\u304f\u3001VCS\u306b\u3088\u308bP-gp\u963b\u5bb3\u306f\u4e3b\u306b\u6d88\u5316\u7ba1\u30ec\u30d9\u30eb\u3067\u306e\u5438\u53ce\u904e\u7a0b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u3010\u7d50\u8ad6\u3068\u81e8\u5e8a\u7684\u63a8\u5968\u4e8b\u9805\u3011<\/strong><\/p>\n\n\n\n<p>VCS\u306f\u5f37\u529b\u306aCYP3A\u8abf\u7bc0\u5264\u3068\u306e\u4f75\u7528\u306b\u3088\u308a\u5287\u7684\u306a\u66dd\u9732\u91cf\u5909\u5316\u3092\u5448\u3059\u308b\u305f\u3081\u3001<strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-luminous-vivid-orange-color\">\u5f37\u529b\u306aCYP3A\u963b\u5bb3\u5264\uff08\u30b1\u30c8\u30b3\u30ca\u30be\u30fc\u30eb\u7b49\uff09\u304a\u3088\u3073\u8a98\u5c0e\u5264\uff08\u30ea\u30d5\u30a1\u30f3\u30d4\u30f3\u7b49\uff09\u3068\u306e\u4f75\u7528\u306f\u7981\u5fcc<\/mark><\/strong>\u3068\u8003\u3048\u308b\u3079\u304d\u3067\u3042\u308b\u3002\u4e00\u65b9\u3067\u3001VCS\u81ea\u8eab\u306f\u81e8\u5e8a\u7528\u91cf\u306b\u304a\u3044\u3066CYP3A\u57fa\u8cea\u306e\u4ee3\u8b1d\u3092\u963b\u5bb3\u3057\u306a\u3044\u305f\u3081\u3001\u591a\u5264\u4f75\u7528\u6642\u306b\u304a\u3051\u308b\u4ed6\u306eCYP3A\u4ee3\u8b1d\u85ac\uff08\u30df\u30c0\u30be\u30e9\u30e0\u7b49\uff09\u306e\u7528\u91cf\u8abf\u7bc0\u306f\u4e0d\u8981\u3067\u3042\u308b\u3002P-gp\u306b\u95a2\u3057\u3066\u306f\u3001VCS\u304c\u963b\u5bb3\u5264\u304a\u3088\u3073\u57fa\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u305f\u3081\u3001P-gp\u57fa\u8cea\uff08\u30b8\u30b4\u30ad\u30b7\u30f3\u7b49\uff09\u3084\u963b\u5bb3\u5264\uff08\u30d9\u30e9\u30d1\u30df\u30eb\u7b49\uff09\u3068\u306e\u4f75\u7528\u6642\u306b\u306f\u3001\u9069\u5207\u306a\u8840\u4e2d\u6fc3\u5ea6\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3068\u5b89\u5168\u6027\u76e3\u8996\uff08TDM\u306e\u691c\u8a0e\uff09\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-68.jpg\" alt=\"\" class=\"wp-image-3597\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-68.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-68-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-69.jpg\" alt=\"\" class=\"wp-image-3598\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-69.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-69-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-70.jpg\" alt=\"\" class=\"wp-image-3599\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-70.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-70-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-71.jpg\" alt=\"\" class=\"wp-image-3600\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-71.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-71-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-72.jpg\" alt=\"\" class=\"wp-image-3601\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-72.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-72-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-73.jpg\" alt=\"\" class=\"wp-image-3602\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-73.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-73-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-74.jpg\" alt=\"\" class=\"wp-image-3603\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-74.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-74-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-75.jpg\" alt=\"\" class=\"wp-image-3604\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-75.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-75-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-76.jpg\" alt=\"\" class=\"wp-image-3605\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-76.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/04\/image-21-76-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>British Journal of Clinical Pharmacology<\/em>. 2014;77(6):1039-1050. doi:10.1111\/bcp.12284.<\/p>\n<\/blockquote>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30dc\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\uff08Voclosporin: VCS\uff09\u306f\u3001\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3A\uff08CsA\uff09\u306e\u30a2\u30df\u30ce\u9178-1\u9818\u57df\u306b\u5358\u4e00\u70ad\u7d20\u5ef6\u9577\u3092\u65bd\u3057\u305f\u65b0\u898f\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\u963b\u5bb3\u85ac\uff08CNI\uff09\u3067\u3042&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"class_list":["post-3596","post","type-post","status-publish","format-standard","hentry","category-50"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/comments?post=3596"}],"version-history":[{"count":1,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3596\/revisions"}],"predecessor-version":[{"id":3606,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/3596\/revisions\/3606"}],"wp:attachment":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/media?parent=3596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/categories?post=3596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}