{"id":3750,"date":"2026-04-24T15:36:36","date_gmt":"2026-04-24T06:36:36","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=3750"},"modified":"2026-04-24T15:36:36","modified_gmt":"2026-04-24T06:36:36","slug":"post-3750","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-3750\/","title":{"rendered":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068\u30ea\u30f3\u30d1\u816b\uff08LPD\uff09\u306e\u30ea\u30b9\u30af\uff5c\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\uff08MTX\uff09\u4f7f\u7528\u4e2d\u306e\u6ce8\u610f\u70b9\u3068\u65e9\u671f\u767a\u898b\u306e\u30b5\u30a4\u30f3\u3010\u67cf\u30fb\u6211\u5b6b\u5b50\u306e\u30ea\u30a6\u30de\u30c1\u5c02\u9580\u5916\u6765\u3011"},"content":{"rendered":"\n<p>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff08RA\uff09\u306e\u60a3\u8005\u3055\u3093\u306f\u3001\u75c5\u6c17\u305d\u306e\u3082\u306e\u306b\u3088\u308b\u514d\u75ab\u306e\u4e71\u308c\u3084\u3001\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\uff08MTX\uff09\u306a\u3069\u306e\u514d\u75ab\u6291\u5236\u5264\u306e\u4f7f\u7528\u306b\u3088\u308a\u3001\u300c\u30ea\u30f3\u30d1\u5897\u6b96\u6027\u75be\u60a3\uff08LPD\uff09\u300d\u3068\u3044\u3046\u8840\u6db2\u306e\u75c5\u6c17\uff08\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306a\u3069\uff09\u3092\u5408\u4f75\u3059\u308b\u30ea\u30b9\u30af\u304c\u4e00\u822c\u306e\u65b9\u3088\u308a\u9ad8\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306bMTX\u3092\u670d\u7528\u4e2d\u306b\u767a\u75c7\u3059\u308b\u3082\u306e\u306f\u300cMTX\u95a2\u9023LPD\u300d\u3068\u547c\u3070\u308c\u3001\u30ea\u30a6\u30de\u30c1\u6cbb\u7642\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u306a\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u3068\u306a\u308a\u307e\u3059,\u3002<\/p>\n\n\n\n<p><strong>\u65e9\u671f\u767a\u898b\u306e\u305f\u3081\u306e\u300cB\u75c7\u72b6\u300d\u3068\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8<\/strong><\/p>\n\n\n\n<p>LPD\u3092\u65e9\u671f\u306b\u898b\u3064\u3051\u308b\u305f\u3081\u306b\u306f\u3001\u3054\u81ea\u8eab\u3067\u306e\u4f53\u8abf\u5909\u5316\u306e\u89b3\u5bdf\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002\u4ee5\u4e0b\u306e\u30b5\u30a4\u30f3\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u3059\u3050\u306b\u4e3b\u6cbb\u533b\u3078\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044,\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30f3\u30d1\u7bc0\u306e\u816b\u308c<\/strong>: \u9996\u3001\u8107\u306e\u4e0b\u3001\u8db3\u306e\u4ed8\u3051\u6839\u306a\u3069\u306b\u30b3\u30ea\u30b3\u30ea\u3068\u3057\u305f\u3057\u3053\u308a\u304c\u306a\u3044\u304b\u3002<\/li>\n\n\n\n<li><strong>B\u75c7\u72b6<\/strong>: \u539f\u56e0\u4e0d\u660e\u306e\u300c38\u5ea6\u4ee5\u4e0a\u306e\u767a\u71b1\u300d\u300c10%\u4ee5\u4e0a\u306e\u4f53\u91cd\u6e1b\u5c11\u300d\u300c\u3072\u3069\u3044\u5bdd\u6c57\u300d\u306e3\u3064\u3092\u6307\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8840\u6db2\u691c\u67fb\u306e\u7570\u5e38<\/strong>: \u30ea\u30a6\u30de\u30c1\u304c\u843d\u3061\u7740\u3044\u3066\u3044\u308b\u306e\u306b\u3001\u30ea\u30f3\u30d1\u7403\u304c\u6e1b\u3063\u305f\u308a\u3001LDH\u3084CRP\u3068\u3044\u3046\u6570\u5024\u304c\u4e0a\u304c\u3063\u305f\u308a\u3057\u305f\u5834\u5408\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u30ea\u30b9\u30af\u8981\u56e0\u3068\u6cbb\u7642\u306e\u8003\u3048\u65b9<\/strong><\/p>\n\n\n\n<p>LPD\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306f\u3001\u5e74\u9f62\u3084\u30ea\u30a6\u30de\u30c1\u306e\u75be\u60a3\u6d3b\u52d5\u6027\u304c\u9ad8\u3044\u3053\u3068\u3001MTX\u306e\u91cf\uff08\u90318mg\u8d85\uff09\u306a\u3069\u304c\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002 \u3082\u3057LPD\u304c\u7591\u308f\u308c\u305f\u5834\u5408\u3001\u307e\u305a\u306f\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u308bMTX\u306a\u3069\u306e\u85ac\u3092\u4e2d\u6b62\u3057\u307e\u3059\u3002MTX\u95a2\u9023LPD\u306e\u5834\u5408\u3001\u7d047\u5272\u306e\u65b9\u304c\u300c\u85ac\u3092\u6b62\u3081\u308b\u3060\u3051\u300d\u3067\u75c5\u5909\u304c\u81ea\u7136\u306b\u5c0f\u3055\u304f\u306a\u308b\uff08\u81ea\u7136\u9000\u7e2e\uff09\u3068\u3044\u3046\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u904e\u5ea6\u306b\u6050\u308c\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u5c02\u9580\u533b\u306b\u3088\u308b\u9069\u5207\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3068\u7d20\u65e9\u3044\u5bfe\u5fdc\u304c\u3001\u5b89\u5168\u306a\u30ea\u30a6\u30de\u30c1\u6cbb\u7642\u3092\u7d99\u7d9a\u3059\u308b\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>LPD\u304c\u81ea\u7136\u9000\u7e2e\u3057\u305f\u5f8c\u306e\u518d\u767a\u7387\u3084\u6ce8\u610f\u70b9<\/strong><\/p>\n\n\n\n<p>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff08RA\uff09\u60a3\u8005\u306b\u304a\u3051\u308b\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u95a2\u9023\u30ea\u30f3\u30d1\u5897\u6b96\u6027\u75be\u60a3\uff08MTX-LPD\uff09\u306f\u3001\u539f\u56e0\u85ac\u5264\u306e\u4e2d\u6b62\u306e\u307f\u3067\u7d047\u5272\u304c\u81ea\u7136\u9000\u7e2e\uff08spontaneous regression\uff09\u3092\u8a8d\u3081\u307e\u3059\u304c\u3001\u305d\u306e\u5f8c\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u306f\u4ee5\u4e0b\u306e\u518d\u767a\u7387\u3084\u6ce8\u610f\u70b9\u306b\u7559\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u81ea\u7136\u9000\u7e2e\u5f8c\u306e\u518d\u767a\u7387<\/strong><\/p>\n\n\n\n<p>LPD\u304c\u4e00\u5ea6\u81ea\u7136\u9000\u7e2e\u3057\u305f\u5f8c\u306e5\u5e74\u518d\u767a\u7387\u306f25\uff05\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9000\u7e2e\u3057\u305f\u304b\u3089\u3068\u3044\u3063\u3066\u5b8c\u6cbb\u3068\u65ad\u5b9a\u305b\u305a\u3001\u9577\u671f\u7684\u306a\u7d4c\u904e\u89b3\u5bdf\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>2. \u6cbb\u7642\u518d\u958b\u306b\u95a2\u3059\u308b\u6ce8\u610f\u70b9<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MTX\u306e\u518d\u6295\u4e0e\u7981\u6b62<\/strong>: MTX-LPD\u306e\u65e2\u5f80\u304c\u3042\u308b\u5834\u5408\u3001\u539f\u5247\u3068\u3057\u3066<strong>MTX\u306e\u518d\u6295\u4e0e\u306f\u63a8\u5968\u3055\u308c\u307e\u305b\u3093<\/strong>\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u306e\u85ac\u5264<\/strong>: MTX\u4ee5\u5916\u306eLPD\uff08\u4ed6\u306e\u514d\u75ab\u6291\u5236\u5264\u306a\u3069\u306b\u95a2\u9023\u3059\u308b\u3082\u306e\uff09\u306b\u3064\u3044\u3066\u306f\u3001\u518d\u6295\u4e0e\u306b\u95a2\u3059\u308b\u660e\u78ba\u306a\u7d50\u8ad6\u306f\u51fa\u3066\u304a\u3089\u305a\u3001\u500b\u3005\u306e\u75c7\u4f8b\u306b\u5fdc\u3058\u305f\u614e\u91cd\u306a\u5224\u65ad\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u7d4c\u904e\u89b3\u5bdf\u306b\u304a\u3051\u308b\u533b\u5b66\u7684\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8<\/strong><\/p>\n\n\n\n<p>\u518d\u767a\u3084\u518d\u71c3\u3092\u65e9\u671f\u306b\u5bdf\u77e5\u3059\u308b\u305f\u3081\u3001\u4ee5\u4e0b\u306e\u9805\u76ee\u3092\u91cd\u70b9\u7684\u306b\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7406\u5b66\u7684\u6240\u898b\u306e\u7d99\u7d9a\u78ba\u8a8d<\/strong>: \u9838\u90e8\u3001\u814b\u7aa9\u3001\u9f20\u5f84\u90e8\u3068\u3044\u3063\u305f\u30ea\u30f3\u30d1\u7bc0\u816b\u8139\u306e\u6709\u7121\u3092\u5b9a\u671f\u7684\u306b\u89e6\u8a3a\u3057\u307e\u3059\u3002\u307e\u305f\u3001MTX-LPD\u306f\u7bc0\u5916\u75c5\u5909\uff08\u53e3\u8154\u3001\u54bd\u982d\u7c98\u819c\u3001\u6d88\u5316\u7ba1\u3001\u76ae\u819a\u3001\u76ae\u4e0b\u7d44\u7e54\u306a\u3069\uff09\u3082\u591a\u3044\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u90e8\u4f4d\u306e\u7570\u5909\u306b\u3082\u6ce8\u610f\u3092\u6255\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>B\u75c7\u72b6\u306e\u76e3\u8996<\/strong>: \u4ee5\u4e0b\u306e\u300cB\u75c7\u72b6\u300d\u304c\u3044\u305a\u308c\u304b\u4e00\u3064\u3067\u3082\u51fa\u73fe\u3057\u305f\u5834\u5408\u306f\u3001\u518d\u71c3\u306e\u7591\u3044\u3092\u6301\u3063\u3066\u7cbe\u67fb\u3092\u884c\u3044\u307e\u3059\u3002\n<ul class=\"wp-block-list\">\n<li>38\u2103\u4ee5\u4e0a\u306e\u767a\u71b1<\/li>\n\n\n\n<li>10\uff05\u4ee5\u4e0a\u306e\u4f53\u91cd\u6e1b\u5c11<\/li>\n\n\n\n<li>\u76d7\u6c57\uff08\u3072\u3069\u3044\u5bdd\u6c57\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u8840\u6db2\u6307\u6a19\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7<\/strong>:\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30f3\u30d1\u7403\u6570<\/strong>: MTX\u4e2d\u6b62\u5f8c\u306b\u30ea\u30f3\u30d1\u7403\u6570\uff08\u7279\u306bTh1\u7d30\u80de\u3084\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u30e1\u30e2\u30ea\u30fcCD8\u7d30\u80de\uff09\u304c\u56de\u5fa9\u3059\u308b\u75c7\u4f8b\u306f\u4e88\u5f8c\u304c\u826f\u3044\u50be\u5411\u306b\u3042\u308a\u307e\u3059\u304c\u3001<strong>\u30ea\u30f3\u30d1\u7403\u306e\u56de\u5fa9\u304c\u898b\u3089\u308c\u306a\u3044\u75c7\u4f8b\u306f\u81ea\u7136\u9000\u7e2e\u3057\u306a\u3044\u3001\u3042\u308b\u3044\u306f\u518d\u71c3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044<\/strong>\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u30fb\u816b\u760d\u30de\u30fc\u30ab\u30fc<\/strong>: RA\u306e\u75be\u60a3\u6d3b\u52d5\u6027\u304c\u5b89\u5b9a\u3057\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001<strong>sIL-2R\u306e\u4e0a\u6607\u3001LDH\u306e\u4e0a\u6607\u3001CRP\u306e\u4e0a\u6607\u3001\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11<\/strong>\u304c\u8a8d\u3081\u3089\u308c\u308b\u5834\u5408\u306f\u3001LPD\u306e\u518d\u71c3\u3092\u5f37\u304f\u7591\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u81ea\u7136\u9000\u7e2e\u306f\u3001\u514d\u75ab\u6291\u5236\u306e\u89e3\u9664\u306b\u3088\u308b\u514d\u75ab\u76e3\u8996\u6a5f\u69cb\u306e\u56de\u5fa9\uff08\u514d\u75ab\u7cfbT\u7d30\u80de\u306e\u56de\u5fa9\uff09\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u30d0\u30e9\u30f3\u30b9\u306f\u7e4a\u7d30\u3067\u3042\u308a\u3001\u4e00\u5b9a\u306e\u78ba\u7387\u3067\u518d\u767a\u304c\u8d77\u3053\u308a\u5f97\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u53b3\u5bc6\u306a\u7ba1\u7406\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<figure 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