{"id":523,"date":"2025-10-25T13:00:00","date_gmt":"2025-10-25T04:00:00","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=523"},"modified":"2025-10-25T13:00:00","modified_gmt":"2025-10-25T04:00:00","slug":"post-523","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-523\/","title":{"rendered":"\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u306e\u76ae\u819a\u786c\u5316\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u85ac\u306e\u30a8\u30d3\u30c7\u30f3\u30b9"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u73fe\u5728\u3001\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u306e\u6839\u6cbb\u7684\u6cbb\u7642\u6cd5\u306f\u306a\u304f\u3001\u75c7\u72b6\u3092\u7de9\u548c\u3059\u308b\u305f\u3081\u306e\u5bfe\u75c7\u7642\u6cd5\u304c\u4e2d\u5fc3\u3068\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3069\u306e\u3088\u3046\u306a\u85ac\u304c\u3069\u306e\u3088\u3046\u306b\u4f5c\u7528\u3059\u308b\u306e\u304b\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u7a4d\u307f\u4e0a\u3052\u3089\u308c\u3066\u304a\u308a\u3001\u628a\u63e1\u3057\u3066\u304a\u304f\u3053\u3068\u306f\u91cd\u8981\u3067\u3059\u3002\u307e\u305a\u300c\u76ae\u819a\u786c\u5316\u300d\u306b\u5bfe\u3059\u308b\u5404\u85ac\u5264\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u5171\u6709\u3057\u3066\u304a\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u25a0PSL<\/p>\n\n\n\n

\u30fb35\u4f8b\u306eSSc\u3092\u5bfe\u8c61\u3068\u3057\u305fRCT\u3002<\/p>\n\n\n\n

\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u9759\u6ce8\u30d1\u30eb\u30b9\u7642\u6cd5100mg\/\u6708\u30016\u304b\u6708\u9593\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u6bd4\u8f03\u691c\u8a0e\u3002<\/p>\n\n\n\n

\u6cbb\u7642\u7fa4\u3067\u306fmRSS\u304c28.5\u00b112.2\u219225.8\u00b112.8\u306b\u4f4e\u4e0b<\/p>\n\n\n\n

\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306fmRSS\u304c30.6\u00b113.2\u219234.7\u00b110\u306b\u5897\u52a0\u3057\u305f\u3002<\/p>\n\n\n\n

\u30fb\u65e9\u671f\u306e\u6d6e\u816b\u6027\u786c\u5316\u3092\u5448\u3057\u6025\u901f\u306b\u9032\u884c\u3057\u3066\u3044\u308b23\u4f8b\u306b\u5bfe\u3057\u3066\u4f4e\u7528\u91cf\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u6295\u4e0e\u3057\u305f\u75c7\u4f8b\u5831\u544a<\/p>\n\n\n\n

mRSS\u304c20.3\u00b19.3\u304b\u30891\u5e74\u5f8c\u306b12.8\u00b17.0\u306b\u4f4e\u4e0b\u3057\u305f\u3002<\/p>\n\n\n\n

\u521d\u671f\u306ePSL\u6295\u4e0e\u91cf\u306f20\uff5e30mg\/\u65e5\u304c\u76ee\u5b89\u3068\u3055\u308c\u30012\uff5e4\u9031\u7d9a\u3051\u305f\u5f8c\u3001\u76ae\u819a\u786c\u5316\u306e\u6539\u5584\u3092\u898b\u306a\u304c\u30892\u9031\uff5e\u63a8\u79fb\u30f5\u6708\u3054\u3068\u306b\u7d0410\uff05\u305a\u3064\u6f38\u6e1b\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u76ee\u5b89\u3068\u3055\u308c\u308b\u30025mg\/\u65e5\u304c\u76ee\u5b89\u306e\u7dad\u6301\u91cf\u3068\u3055\u308c\u308b\u304c\u3001\u300c\u76ae\u819a\u786c\u5316\u306e\u9032\u5c55\u304c\u9577\u671f\u9593\u6b62\u307e\u308b\u300d\u3053\u3068\u3084\u300c\u840e\u7e2e\u671f\u300d\u306b\u5165\u3063\u305f\u3068\u5224\u65ad\u3067\u304d\u308c\u3070\u6f38\u6e1b\u4e2d\u6b62<\/strong>\u3057\u3066\u3088\u3044\u3002\u3000<\/p>\n\n\n\n

PSL\u306f\u814e\u30af\u30ea\u30fc\u30bc\u3092\u8a98\u767a\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u306f\u3001\u5ff5\u982d\u306b\u306f\u304a\u3044\u3066\u304a\u304f\u3053\u3068\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u25a0CY<\/p>\n\n\n\n

\u80ba\u7dda\u7dad\u75c7\u306b\u5bfe\u3059\u308bRCT\u306b\u304a\u3044\u3066CY\uff081\u338e\/\u338f\/\u65e5\uff09\u5185\u670d\u306f\u80ba\u7dda\u7dad\u75c7\u306e\u9032\u884c\u3092\u7de9\u3084\u304b\u306b\u3059\u308b\u306e\u307f\u306a\u3089\u305a\u3001\u76ae\u819a\u786c\u5316\u306b\u304a\u3044\u3066\u3082\u6709\u610f\u306a\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n\n\n\n

\uff08CY\u7fa4\uff1amRSS 15.5\u00b11.3\u219211.9\u00b11.3\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\uff1amRSS 14.6\u00b11.4\u219213.7\u00b11.4\uff09<\/p>\n\n\n\n

\u7279\u306bdsSSc\u306b\u304a\u3044\u3066\u52b9\u679c\u304c\u9ad8\u304b\u3063\u305f\uff0821.7\u00b110.1\u219215.9\u00b111.0\uff09\u3068\u3055\u308c\u308b\u304c\u300124\u30f5\u6708\u5f8c\u306e\u8a55\u4fa1\u306b\u304a\u3044\u3066\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u3057\u3066\u6709\u610f\u5dee\u306a\u3057\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

\u3000IVCY\u306b\u3088\u308b\u5831\u544a\u306f\u306a\u3057\u3002\u3057\u304b\u3057\u306a\u304c\u3089CY\u5185\u670d\u306b\u304a\u3044\u3066\u306f\u7dcf\u6295\u4e0e\u91cf\u304c\u591a\u304f\u306a\u308b\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068ICVY\u3092\u9078\u629e\u3059\u308b\u65b9\u304c\u826f\u3044\u5834\u5408\u3082\u591a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n\n

\u3000IVCY\u306f\u4e3b\u306bSSc\u306e\u80ba\u75c5\u5909\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u308b\u304c\u3001\u76ae\u819a\u786c\u5316\u306e\u6539\u5584\u3082\u793a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001GC\u7121\u52b9\u4f8b\u3084GC\u6295\u4e0e\u3067\u304d\u306a\u3044\u4f8b\u3067\u306f\u6295\u4e0e\u3092\u691c\u8a0e\u3057\u3066\u3088\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u25a0MTX<\/p>\n\n\n\n

RCT\u306f2\u5831\u3042\u308b\u3002<\/p>\n\n\n\n

\u30fb29\u4f8b\u3092\u5bfe\u8c61\u306b\u3057\u305fRCT\u3002MTX\u7b4b\u6ce8\uff0815mg\/\u9031\u300124\u9031\uff09\u306b\u3088\u308a\u76ae\u819a\u786c\u5316\u304c\u6539\u5584\u3059\u308b\u304b\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u691c\u8a0e\u3002<\/p>\n\n\n\n

\u2192\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff08p=0.06\u3001MTX\u7fa4mRSS -0.7\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4+1.2\uff09\u3002<\/p>\n\n\n\n

\u30fb73\u4f8b\u3092\u5bfe\u8c61\u306b\u3057\u305fRCT\u3002MTX\u7d4c\u53e3\u6295\u4e0e\uff0810mg\/\u9031\u300152\u9031\uff09\u306b\u3088\u308a\u76ae\u819a\u786c\u5316\u304c\u6539\u5584\u3059\u308b\u304b\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u6bd4\u8f03\u3002<\/p>\n\n\n\n

\u2192\u6709\u610f\u5dee\u306a\u3057\u3002\uff08p=0.17\u3001MTX\u7fa427.7\u219221.4\u3001\u30d7\u30e9\u30bb\u30dc\u7fa427.4\u219226.3\uff09<\/p>\n\n\n\n

\u3057\u304b\u30572RCT\u3092\u30d9\u30a4\u30ba\u7d71\u8a08\u5b66\u306b\u3088\u3063\u3066\u89e3\u6790\u3059\u308b\u3068MTX\u7fa4\u306b\u304a\u3044\u3066\u6709\u610f\u306a\u6539\u5584\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

\u3057\u305f\u304c\u3063\u3066\u3001MTX\u306e\u76ae\u819a\u786c\u5316\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u306f\u7acb\u8a3c\u3055\u308c\u3066\u3044\u306a\u3044\u3068\u8a00\u308f\u3056\u308b\u3048\u306a\u3044\u304c\u3001\u4ed6\u306e\u6cbb\u7642\u304c\u7121\u52b9\u3067\u3042\u308b\u4f8b\u306b\u5bfe\u3057\u3066\u306f\u6295\u4e0e\u3092\u691c\u8a0e\u3057\u3066\u3082\u3088\u3044\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u3002<\/p>\n\n\n\n

\u3000MTX\u306fIP\u8a98\u767a\u30ea\u30b9\u30af\u304c\u3042\u308b\u306e\u3067\u3001\u4f7f\u7528\u306b\u306f\u7dcf\u5408\u5224\u65ad\u3068\u306a\u308b\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u25a0CsA<\/p>\n\n\n\n

RCT\u3042\u308a\u3002<\/p>\n\n\n\n

CsA 2mg\/kg\/\u65e5\u306e\u5185\u670d\u306f1\u5e74\u5f8c\u306b\u76ae\u819a\u786c\u5316\u3092\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u3057\u3066\u6709\u610f\u306b\u6539\u5584\u3055\u305b\u305f\u3002<\/p>\n\n\n\n

mRSS 15.2\u00b12.0\u219211.3\u00b11.8\uff08p=0.008\uff09<\/p>\n\n\n\n

\u305f\u3060\u3057CsA\u5185\u670d\u306f\u814e\u30af\u30ea\u30fc\u30bc\u306e\u30ea\u30b9\u30af\u30fb\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u3068\u306a\u308b\u3053\u3068\u3082\u591a\u6570\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u76f8\u5bfe\u7684\u5224\u65ad\u3068\u306a\u308b\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u25a0Tac<\/p>\n\n\n\n

\u75c7\u4f8b\u5831\u544a\u30ec\u30d9\u30eb\u3002<\/p>\n\n\n\n

Tac\uff08\u5e73\u57470.07mg\/\u338f\/\u65e5\uff09\u30928\u540d\u306b\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d4\u4f8b\u306b\u304a\u3044\u3066\u76ae\u819a\u786c\u5316\u306e\u6539\u5584\u3092\u8a8d\u3081\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u25a0AZP<\/p>\n\n\n\n

CY\u306b\u5bfe\u3057\u3066\u975e\u52a3\u52e2\u3067\u3042\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u25a0MMF<\/p>\n\n\n\n

\u75c7\u4f8b\u5831\u544a\u30ec\u30d9\u30eb<\/p>\n\n\n\n

\u30fb\u65e9\u671f\u306edsSSc 15\u4f8b\u306b\u5bfe\u3057MMF\uff081g\/\u65e5\u2192\u6f38\u5897\u30013g\/\u65e5\u307e\u3067\u5897\u91cf\u53ef\uff09\u6295\u4e0e\u305712\u304b\u6708\u524d\u5411\u304d\u306b\u89b3\u5bdf\u3002<\/p>\n\n\n\n

mRSS\u306f22.4\u219213.6\u3001\u8a66\u9a13\u7d42\u4e86\u6642\u306b8.4\u307e\u3067\u6539\u5584\u3002<\/p>\n\n\n\n

\u30fb\u65e9\u671f\u3067\u672a\u6cbb\u7642\u306eSSc 25\u4f8b\u306bMMF\u3092\u5358\u72ec\u3067\u4f7f\u7528\uff08\u5e73\u57472g\/\u65e5\uff09\u3002\u524d\u5411\u304d\u89b3\u5bdf\u300218\u304b\u6708\u5f8c\u306bmRSS 24.5\u219214.5\u307e\u3067\u6539\u5584<\/p>\n\n\n\n

\u30fb\u65e9\u671fSSc 109\u4f8b\u306bMMF\u300163\u4f8b\u306b\u4ed6\u306e\u514d\u75ab\u6291\u5236\u5264\u3092\u6295\u4e0e\u30025\u5e74\u9593\u306e\u7d4c\u904e\u3092\u5f8c\u308d\u5411\u304d\u306b\u89b3\u5bdf\u3002mRSS\u306e\u5909\u5316\u306b\u306f\u4e21\u7fa4\u6709\u610f\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n

\u3000\u3000<\/p>\n\n\n\n

\u25a0RTX<\/p>\n\n\n\n

\u30fbRTX\uff08\u521d\u671f\u306f375mg\/m2\u30924\u9031\uff09\u30926\u30f5\u6708\u9593\u9694\u30672\u30af\u30fc\u30eb\u6295\u4e0e\u3092\u53d7\u3051\u305f14\u4f8b\u30671\u5e74\u5f8c\u306e\u76ae\u819a\u786c\u5316\u89b3\u5bdf\u3002<\/p>\n\n\n\n

mRSS\u304c13.5\u00b16.84\u21928.73\u00b16.45\u3078\u6539\u5584\u3057\u305f\u3002<\/p>\n\n\n\n

\u30fbRTX\u30926\u30f5\u6708\u9593\u9694\u3067\u76ae\u819a\u786c\u5316\u3092\u89b3\u5bdf\u3002<\/p>\n\n\n\n

\uff08\u30b9\u30bf\u30fc\u30c8\u6642\uff09mRSS\u306f24.8\u00b13.4<\/p>\n\n\n\n

\uff0824\u9031\u5f8c\uff09mRSS 14.4\u00b18.4<\/p>\n\n\n\n

\uff0824\u304b\u6708\u5f8c\uff09mRSS 13.0<\/p>\n\n\n\n

\u3000\u3044\u305a\u308c\u3082\u6709\u610f\u5dee\u3042\u3063\u305f\u3002<\/p>\n\n\n\n

\u30fb\u305d\u306e\u4ed6\u306b\u3082\u540c\u69d8\u306a\u75c7\u4f8b\u5831\u544a\u306f\u591a\u6570\u3042\u308a\u3002<\/p>\n\n\n\n

\u30fb63\u4f8b\u306e\u524d\u5411\u304d\u7814\u7a76\u3002<\/p>\n\n\n\n

\u3000RTX\u7fa4\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u306b\u6bd4\u3057\u3066mRSS\u306e\u6539\u5584\u7387\u304c\u6709\u610f\u306b\u5927\u304d\u304f\u3001mRSS\u306e\u5e73\u5747\u3082\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3000\uff08mRSS 26.6\u00b11.4 vs 20.3\u00b11.8\u3001p=0.0001\uff09<\/p>\n\n\n\n

\u4e0a\u8a18\u5831\u544a\u306a\u3069\u304b\u3089\u76ae\u819a\u786c\u5316\u306e\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u4e00\u65b9\u3001\u611f\u67d3\u75c7\u3092\u542b\u3081\u305fRTX\u306e\u526f\u4f5c\u7528\u306e\u61f8\u5ff5\u3082\u3042\u308a\u3001\u300c\u614e\u91cd\u306b\u4f7f\u7528\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u300d\u3068\u3055\u308c\u308b\u3002<\/p>\n\n\n\n

\u3000\u3000<\/p>\n\n\n\n

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