{"id":609,"date":"2025-11-24T05:42:19","date_gmt":"2025-11-23T20:42:19","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=609"},"modified":"2025-11-24T05:42:20","modified_gmt":"2025-11-23T20:42:20","slug":"post-609","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-609\/","title":{"rendered":"TNF\u963b\u5bb3\u85ac\u306e\u65b9\u304ccsDMARD\u306b\u6bd4\u3057\u3066\u814e\u6a5f\u80fd\u969c\u5bb3\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2025\/11\/image-5-11.jpg\" alt=\"\" class=\"wp-image-712\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2025\/11\/image-5-11.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2025\/11\/image-5-11-400x267.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u306b\u304a\u3044\u3066\u3001<strong>TNF\u963b\u5bb3\u85ac\u306fcsDMARD\uff08\u5f93\u6765\u578b\u5408\u6210\u6297\u30ea\u30a6\u30de\u30c1\u85ac\uff09\u5358\u72ec\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3001\u3042\u308b\u3044\u306f\u814e\u6a5f\u80fd\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\u53ef\u80fd\u6027\u304c\u9ad8\u3044<\/strong>\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u00a0<\/p>\n\n\n\n<p>\u4e3b\u306a\u7406\u7531\u306e\u8a73\u7d30\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u304a\u3051\u308b\u814e\u969c\u5bb3\u306e\u539f\u56e0<\/strong>: \u9577\u671f\u9593\u306b\u308f\u305f\u308b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u4e0d\u826f\u306e\u708e\u75c7\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9A\u86cb\u767d\u306e\u904e\u5270\u7523\u751f\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u3053\u308c\u304c\u814e\u81d3\u306b\u6c88\u7740\u3059\u308b\u3053\u3068\u3067\u814e\u969c\u5bb3\uff08\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>TNF\u963b\u5bb3\u85ac\u306e\u814e\u6a5f\u80fd\u3078\u306e\u5f71\u97ff<\/strong>:\n<ul class=\"wp-block-list\">\n<li>TNF\u963b\u5bb3\u85ac\u306f\u813e\u81d3\u3067\u4ee3\u8b1d\u3055\u308c\u308b\u305f\u3081\u3001\u814e\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u306f\u5c11\u306a\u304f\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\u306e\u3042\u308b\u60a3\u8005\u3067\u3082\u5b89\u5168\u306a\u6cbb\u7642\u9078\u629e\u80a2\u3068\u306a\u308a\u5f97\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u8907\u6570\u306e\u7814\u7a76\u3067\u3001TNF\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3092\u884c\u3063\u305f\u60a3\u8005\u306e\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\uff08eGFR\uff09\u306e\u5909\u5316\u306f\u3001csDMARD\u5358\u72ec\u7642\u6cd5\u3084\u975eTNF\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3092\u884c\u3063\u305f\u60a3\u8005\u3068\u6bd4\u3079\u3066\u3001\u6709\u610f\u306a\u5dee\u304c\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u3053\u308c\u306f\u3001\u5168\u8eab\u306e\u708e\u75c7\u3092\u52b9\u679c\u7684\u306b\u6291\u3048\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u306b\u4f34\u3046\u814e\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u3082\u4f4e\u6e1b\u3067\u304d\u308b\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>csDMARDs\u306e\u814e\u6a5f\u80fd\u3078\u306e\u5f71\u97ff<\/strong>:\n<ul class=\"wp-block-list\">\n<li>\u6700\u3082\u91cd\u8981\u306a\u85ac\u5264\u306e\u4e00\u3064\u3067\u3042\u308b\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\uff08MTX\uff09\u306f\u3001\u814e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u60a3\u8005\u3067\u306f\u6392\u6cc4\u304c\u9045\u308c\u3001\u526f\u4f5c\u7528\u304c\u5f37\u304f\u51fa\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u814e\u6a5f\u80fd\u306b\u5fdc\u3058\u3066\u6e1b\u91cf\u3084\u4e2d\u6b62\u304c\u5fc5\u8981\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u4ed6\u306e\u514d\u75ab\u6291\u5236\u85ac\uff08\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306a\u3069\uff09\u3082\u3001\u814e\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u00a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>TNF\u963b\u5bb3\u85ac\u306f\u814e\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u61f8\u5ff5\u304c\u5c11\u306a\u304f\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u4f34\u3046\u814e\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u4f4e\u6e1b\u306b\u5bc4\u4e0e\u3059\u308b\u3001\u307e\u305f\u306f\u5c11\u306a\u304f\u3068\u3082\u814e\u6a5f\u80fd\u306e\u60aa\u5316\u3092\u9032\u884c\u3055\u305b\u306a\u3044\u3068\u3044\u3046\u70b9\u3067\u3001csDMARDs\u3088\u308a\u3082\u6709\u5229\u306a\u5834\u5408\u304c\u591a\u3044\u3001\u3068\u3044\u3046\u7406\u89e3\u3067\u3059\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8a73\u7d30\u306b\u3064\u3044\u3066\u3082\u5171\u6709\u3057\u3066\u304a\u304d\u307e\u3059\u3002\u00a0<\/p>\n\n\n\n<p>\u4e8b\u5b9f\uff1aRA\u60a3\u8005\u306fCKD\u306b\u9032\u5c55\u3059\u308b\u30ea\u30b9\u30af\u304c\u5065\u5e38\u4eba\u3068\u6bd4\u8f03\u30571.5\u500d\u3002<\/p>\n\n\n\n<p>\u30b3\u30db\u30fc\u30c8\u7814\u7a76<\/p>\n\n\n\n<p>\u30fbeGFR&lt;60\u306eRA\u60a3\u800570\u4eba\u3092\u5bfe\u8c61\u306b\u814e\u6a5f\u80fd\u969c\u5bb3\u306e\u9032\u5c55\u5ea6\u5408\u3044\u3092\u89b3\u5bdf\u3002<\/p>\n\n\n\n<p>\u2192TNF\u963b\u5bb3\u85ac\u6295\u4e0e\u7fa4\u306fcsDMARD\u6295\u4e0e\u7fa4\u306b\u6bd4\u3057\u3066eGFR\u306e\u4f4e\u4e0b\u304c\u6709\u610f\u5dee\u3092\u3082\u3063\u3066\u898b\u3089\u308c\u306b\u304f\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u3000\uff08\u5e74\u9593\u5909\u5316\u91cf TNF\u963b\u5bb3\u85ac\uff1acsDMARD\uff1d2.0\u00b17.0 vs -1.9\u00b14.0\u3001p=0.006\uff09\u3002<\/p>\n\n\n\n<p>\u30fbADA\u6295\u4e0e\u3092\u53d7\u3051\u305fRA\u60a3\u8005\u306b\u304a\u3044\u3066eGFR&lt;60\u7fa4\uff1a39\u4eba\u3001eGFR&gt;60\u7fa4\uff1a26\u4eba\u306e\u814e\u6a5f\u80fd\u63a8\u79fb\u3092\u89b3\u5bdf\u3002<\/p>\n\n\n\n<p>\u2192\u3044\u305a\u308c\u306e\u7fa4\u3067\u3082eGFR\u306e\u4f4e\u4e0b\u3092\u8a8d\u3081\u305a\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305a\u814e\u6a5f\u80fd\u3092\u4fdd\u3064\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u30fb\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u3068\u78ba\u5b9a\u8a3a\u65ad\u3055\u308c\u305f\u900f\u6790\u4e2d\u306eRA\u60a3\u800528\u4eba\u3092\u5bfe\u8c61\u306b\u6b7b\u4ea1\u7387\u3092\u691c\u8a0e\u3002<\/p>\n\n\n\n<p>\u3000bDMARD\u4f7f\u7528\u8005\uff08n=10\uff09\u306fcsDMARD\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u6b7b\u4ea1\u7387\u306b\u6709\u610f\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u3000\uff08HR=1.03\u300195\uff05CI 0.43\uff5e2.48\uff09<\/p>\n\n\n\n<p>\u3000bDMARD\u306e\u4e3b\u306a\u6b7b\u56e0\u306f\u611f\u67d3\u75c7\uff086\u4f8b\uff09<\/p>\n\n\n\n<p>\u3000csDMARD\u306e\u4e3b\u306a\u6b7b\u56e0\u306f\u5fc3\u4e0d\u5168\uff088\u4f8b\uff09<\/p>\n\n\n\n<p>\u2192eGFR&lt;60\u306eRA\u60a3\u8005\u306b\u5bfe\u3057\u3066TNF\u963b\u5bb3\u85ac\u306feGFR\u3092\u4f4e\u4e0b\u3055\u305b\u305a\u3001csDMARD\u306b\u6bd4\u3057\u3066\u75be\u60a3\u6d3b\u52d5\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u900f\u6790\u307e\u3067\u81f3\u3063\u305f\u60a3\u8005\uff08\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u5408\u4f75\u900f\u6790\u60a3\u8005\uff09\u306b\u304a\u3044\u3066\u306fTNF\u963b\u5bb3\u85ac\u306f\u4e88\u5f8c\u3092\u6539\u5584\u3055\u305b\u306a\u3044\u3002<\/p>\n\n\n\n<p>\uff08csDMARD\u306b\u5207\u308a\u66ff\u3048\u308c\u3070\u6b7b\u56e0\u306f\u5fc3\u4e0d\u5168\u304c\u6700\u591a\u3068\u306a\u308b\uff1d\u666e\u901a\u306e\u900f\u6790\u60a3\u8005\u306e\u6b7b\u56e0\u3068\u540c\u4e00\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\uff09<\/p>\n\n\n\n<p>\u2192\u75be\u60a3\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u56f3\u308c\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u900f\u6790\u60a3\u8005\u3055\u3093\u306b\u306f\u30b3\u30b9\u30c8\u3082\u8003\u3048\u3001TNF\u963b\u5bb3\u85ac\u304b\u3089csDMARD\u3078\u5207\u308a\u66ff\u3048\u3082\u691c\u8a0e\u3067\u304d\u308b\u3001NSAIDs\u3082\u4f7f\u3063\u3066OK\u3001\u3068\u3044\u3046\u7406\u89e3\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u306b\u304a\u3044\u3066\u3001TNF\u963b\u5bb3\u85ac\u306fcsDMARD\uff08\u5f93\u6765\u578b\u5408\u6210\u6297\u30ea\u30a6\u30de\u30c1\u85ac\uff09\u5358\u72ec\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3001\u3042\u308b\u3044\u306f\u814e\u6a5f\u80fd\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,3],"class_list":["post-609","post","type-post","status-publish","format-standard","hentry","category-medical_science","category-3"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/comments?post=609"}],"version-history":[{"count":2,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/609\/revisions"}],"predecessor-version":[{"id":713,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/posts\/609\/revisions\/713"}],"wp:attachment":[{"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/media?parent=609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-json\/wp\/v2\/categories?post=609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}