{"id":6761,"date":"2026-07-14T21:47:53","date_gmt":"2026-07-14T12:47:53","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=6761"},"modified":"2026-07-14T21:47:53","modified_gmt":"2026-07-14T12:47:53","slug":"post-6761","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-6761\/","title":{"rendered":"TP53 Y220C\u5909\u7570\u816b\u760d\u306b\u5bfe\u3059\u308bp53\u518d\u6d3b\u6027\u5316\u85ac\u300c\u30ec\u30b6\u30bf\u30dd\u30d7\u30c8\uff08rezatapopt\uff09\u300d\u306e\u7b2c1\u76f8\u8a66\u9a13\uff08PYNNACLE\u8a66\u9a13\uff09\u306b\u3064\u3044\u3066\u67cf\u6211\u5b6b\u5b50\u306e\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u304c\u89e3\u8aac"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u4e0d\u53ef\u80fd\u3068\u3055\u308c\u305f\u907a\u4f1d\u5b50\u5909\u7570\u3078\u306e\u6311\u6226\u3002\u304c\u3093\u7d30\u80de\u306e\u81ea\u6ec5\u30b9\u30a4\u30c3\u30c1\u3092\u518d\u3073\u30aa\u30f3\u306b\u3059\u308b\u753b\u671f\u7684\u306a\u8a3c\u660e<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eba\u9593\u306e\u4f53\u306e\u4e2d\u306b\u306f\u3001\u7d30\u80de\u304c\u52dd\u624b\u306b\u5897\u6b96\u3057\u3066\u300c\u304c\u3093\u300d\u306b\u306a\u308b\u306e\u3092\u9632\u3050\u305f\u3081\u306e\u5f37\u529b\u306a\u30d6\u30ec\u30fc\u30ad\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u305d\u306e\u4ee3\u8868\u683c\u304c\u300cp53\u300d\u3068\u3044\u3046\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u591a\u304f\u306e\u56fa\u5f62\u304c\u3093\uff08\u534a\u5206\u4ee5\u4e0a\u306e\u304c\u3093\uff09\u3067\u306f\u3001\u3053\u306ep53\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u8d77\u3053\u308a\u3001\u30d6\u30ec\u30fc\u30ad\u304c\u58ca\u308c\u3066\u3057\u307e\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u3001\u3053\u306e\u300c\u58ca\u308c\u305fp53\u300d\u3092\u5143\u901a\u308a\u306b\u3059\u308b\u85ac\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u306f\u6975\u3081\u3066\u96e3\u3057\u304f\u3001\u6cbb\u7642\u306e\u5927\u304d\u306a\u58c1\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002 \u4eca\u56de\u3001\u6a29\u5a01\u533b\u5b66\u8a8c\u300eThe New England Journal of Medicine\uff08NEJM\uff09\u300f\u306b\u3066\u3001\u3053\u306e\u5e38\u8b58\u3092\u8986\u3059\u5168\u304f\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u98f2\u307f\u85ac\u300c\u30ec\u30b6\u30bf\u30dd\u30d7\u30c8\uff08rezatapopt\uff09\u300d\u306e\u7b2c1\u76f8\u81e8\u5e8a\u8a66\u9a13\uff08PYNNACLE\u8a66\u9a13\uff09\u306e\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u3053\u306e\u6700\u65b0\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u304d\u3001\u304c\u3093\u306e\u5897\u6b96\u3092\u6291\u3048\u308b\u300c\u4f53\u306e\u4ed5\u7d44\u307f\u300d\u3068\u3001\u907a\u4f1d\u5b50\u306e\u5f62\u3092\u4fee\u5fa9\u3059\u308b\u6700\u5148\u7aef\u306e\u500b\u5225\u5316\u533b\u7642\u306b\u3064\u3044\u3066\u67cf\u6211\u5b6b\u5b50\u306e\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u304c\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. \u58ca\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u300c\u30dd\u30b1\u30c3\u30c8\u300d\u3092\u57cb\u3081\u308b\u4f53\u306e\u4ed5\u7d44\u307f<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">p53\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306e\u4e2d\u3067\u3082\u3001\u300cTP53 Y220C\u300d\u3068\u547c\u3070\u308c\u308b\u7279\u5b9a\u306e\u5909\u7570\u306f\u3001\u5168\u56fa\u5f62\u304c\u3093\u306e\u7d041%\u306b\u898b\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u304c\u8d77\u3053\u308b\u3068\u3001\u4f5c\u3089\u308c\u305fp53\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u308a\u3001\u8868\u9762\u306b\u5c0f\u3055\u306a\u300c\u30dd\u30b1\u30c3\u30c8\uff08\u304f\u307c\u307f\uff09\u300d\u304c\u3067\u304d\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u304c\u3093\u7d30\u80de\u3092\u81ea\u6ec5\uff08\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff09\u306b\u5c0e\u304f\u672c\u6765\u306e\u6a5f\u80fd\u304c\u5931\u308f\u308c\u3066\u3057\u307e\u3044\u307e\u3059\u3002 \u4eca\u56de\u958b\u767a\u3055\u308c\u305f\u65b0\u85ac\u300c\u30ec\u30b6\u30bf\u30dd\u30d7\u30c8\u300d\u306f\u3001\u3053\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3067\u304d\u305f\u7279\u6b8a\u306a\u30dd\u30b1\u30c3\u30c8\u306b\u30d4\u30bf\u30c3\u3068\u306f\u307e\u308a\u8fbc\u307f\u3001\u4e0d\u5b89\u5b9a\u306b\u306a\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6b63\u5e38\uff08\u91ce\u751f\u578b\uff09\u306e\u69cb\u9020\u3078\u3068\u30ab\u30c1\u30c3\u3068\u5b89\u5b9a\u3055\u305b\u308b\u300c\u518d\u6d3b\u6027\u5316\uff08reactivator\uff09\u300d\u306e\u50cd\u304d\u3092\u6301\u3061\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u304c\u3093\u7d30\u80de\u306e\u4e2d\u3067\u518d\u3073\u30d6\u30ec\u30fc\u30ad\u304c\u6a5f\u80fd\u3057\u59cb\u3081\u3001\u816b\u760d\u306e\u7e2e\u5c0f\u3092\u3082\u305f\u3089\u3059\u3068\u3044\u3046\u3001\u6975\u3081\u3066\u7cbe\u5bc6\u3067\u7406\u306b\u304b\u306a\u3063\u305f\u4f53\u306e\u4ed5\u7d44\u307f\u3092\u5229\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. \u8907\u6570\u306e\u304c\u3093\u7a2e\u3067\u78ba\u8a8d\u3055\u308c\u305f\u300c\u816b\u760d\u7e2e\u5c0f\u300d\u306e\u8a3c\u660e<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u3053\u308c\u307e\u3067\u306b\u8907\u6570\u306e\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3082\u304c\u3093\u304c\u9032\u884c\u3057\u3066\u3057\u307e\u3063\u305f\u300cTP53 Y220C\u5909\u7570\u300d\u3092\u6301\u306477\u540d\u306e\u60a3\u8005\u69d8\uff08\u5375\u5de3\u304c\u3093\u3001\u4e73\u304c\u3093\u3001\u81b5\u81d3\u304c\u3093\u306a\u3069\uff09\u3092\u5bfe\u8c61\u306b\u3001\u30ec\u30b6\u30bf\u30dd\u30d7\u30c8\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002 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class=\"wp-block-paragraph\"><strong>3. \u526f\u4f5c\u7528\u306e\u7ba1\u7406\u3068\u300c\u98df\u4e8b\u300d\u306e\u610f\u5916\u306a\u52b9\u679c<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u65b0\u3057\u3044\u304a\u85ac\u3067\u3042\u308b\u305f\u3081\u3001\u526f\u4f5c\u7528\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u306e\u78ba\u8a8d\u3082\u614e\u91cd\u306b\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u6700\u3082\u591a\u304f\u898b\u3089\u308c\u305f\u526f\u4f5c\u7528\u306f\u300c\u5410\u304d\u6c17\uff0858%\uff09\u300d\u300c\u5614\u5410\uff0844%\uff09\u300d\u300c\u75b2\u52b4\uff0839%\uff09\u300d\u306a\u3069\u306e\u6d88\u5316\u5668\u75c7\u72b6\u3067\u3057\u305f\u3002 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\u81ea\u5206\u306e\u300c\u907a\u4f1d\u5b50\u300d\u3092\u77e5\u308b\u3053\u3068\u3067\u672a\u6765\u304c\u958b\u3051\u308b\u6642\u4ee3\u3078<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7814\u7a76\u306f\u3001\u304c\u3093\u6cbb\u7642\u304c\u300c\u81d3\u5668\u3054\u3068\u306e\u6cbb\u7642\u300d\u304b\u3089\u300c\u4e00\u4eba\u3072\u3068\u308a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306b\u5408\u308f\u305b\u305f\u6cbb\u7642\uff08\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\uff09\u300d\u3078\u3068\u5b8c\u5168\u306b\u30b7\u30d5\u30c8\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u7269\u8a9e\u3063\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u591a\u304f\u306e\u304c\u3093\u8a3a\u7642\u62e0\u70b9\u75c5\u9662\u3067\u300c\u304c\u3093\u30b2\u30ce\u30e0\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u691c\u67fb\u300d\u304c\u884c\u308f\u308c\u3066\u304a\u308a\u3001\u3054\u81ea\u8eab\u306e\u304c\u3093\u304c\u3069\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u306e\u7570\u5e38\uff08\u4f53\u306e\u4ed5\u7d44\u307f\u306e\u30a8\u30e9\u30fc\uff09\u306b\u3088\u3063\u3066\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u30ec\u30b6\u30bf\u30dd\u30d7\u30c8\u306e\u3088\u3046\u306a\u753b\u671f\u7684\u306a\u65b0\u85ac\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u305f\u3081\u306b\u306f\u3001\u307e\u305a\u3054\u81ea\u8eab\u306e\u300c\u6575\u306e\u6b63\u4f53\u300d\u3092\u6b63\u78ba\u306b\u77e5\u308b\u3053\u3068\u304c\u7b2c\u4e00\u6b69\u3068\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af<\/strong>\u3067\u306f\u3001\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u306e\u8996\u70b9\u304b\u3089\u3001\u907a\u4f1d\u5b50\u3084\u514d\u75ab\u306e\u7570\u5e38\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u5168\u8eab\u306e\u75c5\u6c17\u3084\u304c\u3093\u306b\u7e4b\u304c\u3063\u3066\u3044\u304f\u306e\u304b\u3068\u3044\u3046**\u300c\u4f53\u306e\u4ed5\u7d44\u307f\u300d\u3092\u4e01\u5be7\u306b\u7d10\u89e3\u304d\u306a\u304c\u3089**\u3001\u7686\u69d8\u306e\u30c8\u30fc\u30bf\u30eb\u306a\u5065\u5eb7\u7ba1\u7406\u3092\u30b5\u30dd\u30fc\u30c8\u3044\u305f\u3057\u307e\u3059\u3002\u5f53\u9662\u3067\u306f\u76f4\u63a5\u306e\u6297\u304c\u3093\u5264\u6cbb\u7642\u306f\u884c\u3063\u3066\u304a\u308a\u307e\u305b\u3093\u304c\u3001\u304c\u3093\u4e88\u9632\u306e\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3001\u304c\u3093\u6cbb\u7642\u4e2d\u306e\u514d\u75ab\u529b\u4f4e\u4e0b\u306b\u4f34\u3046\u611f\u67d3\u75c7\u4e88\u9632\uff08\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\uff09\u3001\u305d\u3057\u3066\u6297\u304c\u3093\u5264\u306e\u526f\u4f5c\u7528\u304b\u3089\u304a\u53e3\u3092\u5b88\u308b\u533b\u79d1\u6b6f\u79d1\u9023\u643a\u3092\u901a\u3058\u305f\u5fb9\u5e95\u3057\u305f\u53e3\u8154\u30b1\u30a2\u3092\u3054\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u5168\u8eab\u306e\u5065\u5eb7\u3084\u3054\u5bb6\u65cf\u306e\u75c5\u6b74\u306b\u4e0d\u5b89\u304c\u3042\u308b\u65b9\u306f\u3001\u67cf\u30fb\u6211\u5b6b\u5b50\u30a8\u30ea\u30a2\u306e\u76f8\u8ac7\u7a93\u53e3\u3067\u3042\u308b\u5f53\u9662\u3078\u304a\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u79c1\u305f\u3061\u306f\u3001\u7686\u69d8\u304c\u75c5\u6c17\u306e\u4e0d\u5b89\u304b\u3089\u89e3\u653e\u3055\u308c\u3001\u3054\u5bb6\u65cf\u63c3\u3063\u3066\u5b89\u5fc3\u3067\u5065\u3084\u304b\u306a\u6bce\u65e5\u3092\u697d\u3057\u3081\u308b\u3088\u3046\u5168\u529b\u3067\u4f34\u8d70\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u25a0 \u53d7\u8a3a\u3092\u3054\u5e0c\u671b\u306e\u65b9\u3078<br>\ud83d\udc49 \u3010\u533b\u79d1\u3011\uff08\u67cf\u6211\u5b6b\u5b50\u306e\u7dcf\u5408\u5185\u79d1\u30fb\u304b\u304b\u308a\u3064\u3051\u533b\uff09WEB\u4e88\u7d04\u306f\u3053\u3061\u3089<a href=\"https:\/\/melmo-app.com\/clinic\/673d5e08785f0f0030870bdb\/reservation?method=visit\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/melmo-app.com\/clinic\/673d5e08785f0f0030870bdb\/reservation?method=visit<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 \u3010\u6b6f\u79d1\u3011\uff08\u53e3\u8154\u5185\u6240\u898b\u30fb\u3080\u3057\u6b6f\u30fb\u6b6f\u5468\u75c5\u30fb\u6839\u7ba1\u6cbb\u7642\u30fb\u30a4\u30f3\u30d7\u30e9\u30f3\u30c8\u306a\u3069\uff09WEB\u4e88\u7d04\u306f\u3053\u3061\u3089<a href=\"http:\/\/www.gomidental-kashiwa.com\/reservation\/\" target=\"_blank\" rel=\"noopener\" title=\"\">http:\/\/www.gomidental-kashiwa.com\/reservation\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udcde \u304a\u96fb\u8a71\u3067\u306e\u3054\u4e88\u7d04\u30fb\u304a\u554f\u3044\u5408\u308f\u305b\uff08\u5065\u5eb7\u8a3a\u65ad\u30fb\u30ef\u30af\u30c1\u30f3\u306a\u3069\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3010\u533b\u79d1\u3011\uff1a04-7196-7531 \u3010\u6b6f\u79d1\u3011\uff1a04-7191-7081<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83c\udfe5 \u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af \u30a2\u30af\u30bb\u30b9 \u3012277-0902 \u5343\u8449\u770c\u67cf\u5e02\u5927\u4e95764-1 \u30d0\u30b9\u3067\u304a\u8d8a\u3057\u306e\u65b9\uff1a\u5343\u4ee3\u7530\u5e38\u78d0\u7dda \u67cf\u99c5\u6771\u53e3 \u6771\u6b66\u30d0\u30b91\u756a\u4e57\u5834\uff08\u300c\u6cbc\u5357\u8eca\u5eab\u300d\u300c\u5c0f\u91ce\u585a\u53f0\u300d\u300c\u624b\u8cc0\u306e\u4e18\u516c\u5712\u300d\u300c\u5e03\u702c\u300d\u884c\u304d\uff09\u3088\u308a\u30d0\u30b915\u5206 \u300c\u5927\u4e95\u300d\u4e0b\u8eca \u5f92\u6b691\u5206 \u8eca\u3067\u304a\u8d8a\u3057\u306e\u65b9\uff1a\u67cf\u99c5\u3088\u308a\u7d0415\u5206<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-362.jpg\" alt=\"\" class=\"wp-image-6762\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-362.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-362-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-363.jpg\" alt=\"\" class=\"wp-image-6763\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-363.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-363-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-364.jpg\" alt=\"\" class=\"wp-image-6764\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-364.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-364-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-365.jpg\" alt=\"\" class=\"wp-image-6765\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-365.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-365-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-366.jpg\" alt=\"\" class=\"wp-image-6766\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-366.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-366-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-367.jpg\" alt=\"\" class=\"wp-image-6767\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-367.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-367-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-368.jpg\" alt=\"\" class=\"wp-image-6768\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-368.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-368-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-369.jpg\" alt=\"\" class=\"wp-image-6769\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-369.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-369-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-370.jpg\" alt=\"\" class=\"wp-image-6770\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-370.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-370-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-371.jpg\" alt=\"\" class=\"wp-image-6771\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-371.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-371-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-372.jpg\" alt=\"\" class=\"wp-image-6772\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-372.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-372-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-373.jpg\" alt=\"\" class=\"wp-image-6773\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-373.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-373-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-374.jpg\" alt=\"\" class=\"wp-image-6774\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-374.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-374-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-375.jpg\" alt=\"\" class=\"wp-image-6775\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-375.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-375-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-376.jpg\" alt=\"\" class=\"wp-image-6776\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-376.jpg 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/07\/image-376-400x224.jpg 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Ecaterina E. Dumbrava, Geoffrey I. Shapiro, Aparna R. Parikh, et al. &#8220;Phase 1 Study of Rezatapopt, a p53 Reactivator, in TP53 Y220C\u2013Mutated Tumors.&#8221; <em>New England Journal of Medicine<\/em>. 2026;394:872-883.<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\u25a0\u95a2\u9023\u8a18\u4e8b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. \u304c\u3093\u6cbb\u7642\u4e2d\u306e\u300c\u304a\u53e3\u306e\u30c8\u30e9\u30d6\u30eb\u300d\u3084\u300c\u514d\u75ab\u529b\u4f4e\u4e0b\u300d\u304c\u6c17\u306b\u306a\u308b\u65b9\u3078\uff08\u533b\u79d1\u6b6f\u79d1\u9023\u643a\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u65b0\u85ac\u3067\u3082\u300c\u5410\u304d\u6c17\u300d\u306a\u3069\u306e\u526f\u4f5c\u7528\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u6297\u304c\u3093\u5264\u6cbb\u7642\u4e2d\u306f\u553e\u6db2\u304c\u6e1b\u3063\u3066\u300c\u30c9\u30e9\u30a4\u30de\u30a6\u30b9\u300d\u306b\u306a\u3063\u305f\u308a\u3001\u91cd\u3044\u53e3\u5185\u708e\u304c\u3067\u304d\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u304a\u53e3\u306e\u74b0\u5883\u304c\u60aa\u5316\u3059\u308b\u3068\u7d30\u83cc\u304c\u5168\u8eab\u306b\u56de\u308a\u3001\u81f4\u547d\u7684\u306a\u611f\u67d3\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u5371\u967a\u304c\u3042\u308a\u307e\u3059\u3002\u533b\u79d1\u6b6f\u79d1\u9023\u643a\u306e\u5f53\u9662\u3060\u304b\u3089\u3053\u305d\u3067\u304d\u308b\u3001\u304c\u3093\u6cbb\u7642\u3092\u5b89\u5168\u306b\u4e57\u308a\u5207\u308b\u305f\u3081\u306e\u5fb9\u5e95\u3057\u305f\u53e3\u8154\u30b1\u30a2\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure 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