{"id":7694,"date":"2026-08-09T17:32:17","date_gmt":"2026-08-09T08:32:17","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=7694"},"modified":"2026-08-09T17:32:17","modified_gmt":"2026-08-09T08:32:17","slug":"post-7694","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-7694\/","title":{"rendered":"\u76ae\u819a\u7b4b\u708e\u306b\u304a\u3051\u308bTYK2\/JAK1\u963b\u5bb3\u85ac\u30d6\u30ec\u30dd\u30b7\u30c1\u30cb\u30d6\u306e\u52b9\u679c\u3002NEJM2026\u30fb\u7b2c3\u76f8\u8a66\u9a13\uff08VALOR\u8a66\u9a13\uff09\u306e\u7d50\u679c\u3092\u67cf\u6211\u5b6b\u5b50\u306e\u30ea\u30a6\u30de\u30c1\u5c02\u9580\u533b\u304c\u89e3\u8aac\u3002"},"content":{"rendered":"\n<h2 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class=\"wp-block-paragraph\">\u3053\u306e\u6cbb\u7642\u306e\u58c1\u3092\u6253\u3061\u7834\u308b\u3079\u304f\u3001\u4e16\u754c\u6700\u9ad8\u5cf0\u306e\u533b\u5b66\u8a8c\u300eThe New England Journal of Medicine (NEJM)\u300f\u306b2026\u5e74\u306b\u63b2\u8f09\u3055\u308c\u305f\u6700\u65b0\u306e\u7b2c3\u76f8\u81e8\u5e8a\u8a66\u9a13\uff08VALOR\u8a66\u9a13\uff09\u304c\u3001\u6975\u3081\u3066\u753b\u671f\u7684\u306a\u89e3\u6c7a\u7b56\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u305d\u308c\u306f\u3001\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u7d30\u80de\u5185\u306e\u4f1d\u9054\u7d4c\u8def\u3092\u30d4\u30f3\u30dd\u30a4\u30f3\u30c8\u3067\u906e\u65ad\u3059\u308b\u3001\u4e16\u754c\u521d\u306e\u7d4c\u53e3\u9078\u629e\u7684\u300cTYK2\u30fbJAK1\u963b\u5bb3\u85ac\u300d\u3067\u3042\u308b\u30d6\u30ec\u30dd\u30b7\u30c1\u30cb\u30d6\uff08Brepocitinib\uff09\u306e\u81e8\u5e8a\u691c\u8a3c\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. 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class=\"wp-block-paragraph\">\u8fd1\u5e74\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u30fb\u81ea\u5df1\u514d\u75ab\u5b66\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u76ae\u819a\u7b4b\u708e\u306e\u60a3\u8005\u69d8\u306e\u4f53\u5185\u3067\u306f\u3001I\u578b\u304a\u3088\u3073II\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08IFN\uff09\u3001\u30a4\u30f3\u30bf\u30fc\u30ec\u30a6\u30ad\u30f3-6\uff08IL-6\uff09\u3001IL-12\u3001IL-23\u3068\u3044\u3063\u305f\u8907\u6570\u306e\u300c\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u300d\u304c\u7570\u5e38\u306b\u5897\u3048\u3001\u3053\u308c\u3089\u304c\u514d\u75ab\u7d30\u80de\u3092\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3066\u81ea\u5206\u81ea\u8eab\u306e\u7d44\u7e54\u3092\u653b\u6483\u3055\u305b\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002 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class=\"wp-block-paragraph\"><strong>2. \u96e3\u6cbb\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305f\u53b3\u683c\u306a\u56fd\u969b\u5171\u540c\u7b2c3\u76f8\u8a66\u9a13\uff08VALOR\u8a66\u9a13\uff09<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u8a66\u9a13\u306b\u306f\u3001\u5f93\u6765\u306e\u30b9\u30c6\u30ed\u30a4\u30c9\u3084\u5f93\u6765\u306e\u514d\u75ab\u6291\u5236\u85ac\u3001\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u7642\u6cd5\u3092\u884c\u3063\u3066\u3082\u5341\u5206\u306a\u6cbb\u7642\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u3001\u4e16\u754c20\u30ab\u56fd\u306e\u6cbb\u7642\u62b5\u6297\u6027\u306e\u6210\u4eba\u76ae\u819a\u7b4b\u708e\u60a3\u8005\u69d8241\u540d\u304c\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002\u60a3\u8005\u69d8\u306f\u3001\u30d6\u30ec\u30dd\u30b7\u30c1\u30cb\u30d6\u30921\u65e51\u56de30mg\u670d\u7528\u3059\u308b\u30b0\u30eb\u30fc\u30d7\uff0881\u540d\uff09\u300115mg\u670d\u7528\u3059\u308b\u30b0\u30eb\u30fc\u30d7\uff0881\u540d\uff09\u3001\u307e\u305f\u306f\u507d\u85ac\uff08\u30d7\u30e9\u30bb\u30dc\uff09\u3092\u670d\u7528\u3059\u308b\u30b0\u30eb\u30fc\u30d7\uff0879\u540d\uff09\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5206\u3051\u3089\u308c\u3001\u3053\u308c\u307e\u3067\u306e\u80cc\u666f\u6cbb\u7642\u3092\u7d99\u7d9a\u3057\u306a\u304c\u3089\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u91cf\u3092\u30d7\u30ed\u30c8\u30b3\u30eb\u306b\u6cbf\u3063\u3066\u6bb5\u968e\u7684\u306b\u6e1b\u91cf\uff08\u30c6\u30fc\u30d1\u30ea\u30f3\u30b0\uff09\u3057\u300152\u9031\u9593\u306b\u308f\u305f\u3063\u3066\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. 30mg\u6295\u4e0e\u7fa4\u304c\u793a\u3057\u305f\u5287\u7684\u306a\u81e8\u5e8a\u6539\u5584\u3068\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\u96e2\u8131\u300d\u306e\u9054\u6210<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">52\u9031\u306e\u6642\u70b9\u306b\u304a\u3051\u308b\u3001\u7b4b\u8089\u3084\u76ae\u819a\u306e\u6d3b\u52d5\u6027\u3001\u751f\u6d3b\u6a5f\u80fd\u306a\u3069\u3092\u7dcf\u5408\u7684\u306b\u6570\u5024\u5316\u3057\u305f\u300cTotal Improvement Score\uff08\u7dcf\u5408\u6539\u5584\u30b9\u30b3\u30a2\uff1a0\u301c100\u70b9\uff09\u300d\u306e\u5e73\u5747\u5024\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3001\u660e\u78ba\u306a\u5dee\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d6\u30ec\u30dd\u30b7\u30c1\u30cb\u30d630mg\u7fa4<\/strong>\uff1a<strong>\u5e73\u574746.5\u70b9<\/strong><\/li>\n\n\n\n<li><strong>\u30d7\u30e9\u30bb\u30dc\u7fa4<\/strong>\uff1a\u5e73\u574731.2\u70b9 \u4e21\u7fa4\u306e\u9593\u306b\u306f\u300c15.3\u70b9\u300d\u306e\u6709\u610f\u306a\u30b9\u30b3\u30a2\u5dee\uff08P&lt;0.001\uff09<strong>\u304c\u8a8d\u3081\u3089\u308c\u3001\u30d6\u30ec\u30dd\u30b7\u30c1\u30cb\u30d630mg\u306e\u5727\u5012\u7684\u306a\u6cbb\u7642\u52b9\u679c\u304c\u79d1\u5b66\u7684\u306b\u7acb\u8a3c\u3055\u308c\u307e\u3057\u305f\uff08\u306a\u304a\u300115mg\u7fa4\u3067\u306f\u6709\u610f\u306a\u5dee\u306f\u5f97\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff09\u3002\u3055\u3089\u306b\u3001\u60a3\u8005\u69d8\u306e\u534a\u6570\u306b\u8fd1\u3044\u300c46%\u300d\u304c\u3001\u6700\u91cd\u75c7\u4f8b\u3067\u3082\u300e\u8457\u660e\u306a\u6539\u5584\uff08\u4e3b\u8981\u6539\u5584\uff1a\u30b9\u30b3\u30a260\u70b9\u4ee5\u4e0a\uff09\u300f\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u7279\u7b46\u3059\u3079\u304d\u306f\u3001\u3053\u306e\u5287\u7684\u306a\u6539\u5584\u304c\u3001<\/strong>\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u91cf\u3092\u5927\u5e45\u306b\u6e1b\u3089\u3057\u306a\u304c\u3089\u9054\u6210\u3055\u308c\u305f\u300d\u3068\u3044\u3046\u70b9\u3067\u3059\u300230mg\u670d\u7528\u7fa4\u3067\u306f\u3001\u6cbb\u7642\u958b\u59cb\u524d\u306b\u4f7f\u7528\u3057\u3066\u3044\u305f\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u91cf\u3092\u6bb5\u968e\u7684\u306b\u6e1b\u3089\u3057\u300152\u9031\u306e\u6642\u70b9\u3067\u306a\u3093\u3068\u300c62%\u300d\u306e\u60a3\u8005\u69d8\u304c1\u65e5\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\u63db\u7b97\u30672.5mg\u4ee5\u4e0b\u3068\u3044\u3046\u6975\u3081\u3066\u5fae\u91cf\u307e\u3067\u6e1b\u91cf\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u3055\u3089\u306b\u300c42%\u300d\u306e\u60a3\u8005\u69d8\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u5b8c\u5168\u306b\u4e2d\u6b62\uff080mg\uff09\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff0823%\u304c\u5b8c\u5168\u4e2d\u6b62\uff09\u3092\u7d042\u500d\u4e0a\u56de\u308b\u7d50\u679c\u3067\u3042\u308a\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u6709\u5bb3\u306a\u9577\u671f\u7684\u5f71\u97ff\u304b\u3089\u60a3\u8005\u69d8\u306e\u5168\u8eab\u3092\u5b88\u308b\u3068\u3044\u3046\u300c\u771f\u306e\u6cbb\u7642\u30b4\u30fc\u30eb\u300d\u306b\u76f4\u7d50\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4. \u65e9\u671f\u306e\u76ae\u819a\u75c5\u5909\u6539\u5584\u3068\u751f\u6d3b\u6a5f\u80fd\u306e\u56de\u5fa9<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ae\u819a\u306e\u75c7\u72b6\uff08CDASI-A\u30b9\u30b3\u30a2\uff09\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306f\u3001\u6cbb\u7642\u958b\u59cb\u5f8c\u308f\u305a\u304b\u300c4\u9031\u9593\u300d\u3068\u3044\u3046\u8d85\u65e9\u671f\u304b\u3089\u9855\u8457\u306b\u73fe\u308c\u307e\u3057\u305f\u300252\u9031\u306e\u6642\u70b9\u3067\u306f\u3001\u4e2d\u7b49\u5ea6\u304b\u3089\u91cd\u75c7\u306e\u76ae\u819a\u75c5\u5909\u3092\u62b1\u3048\u3066\u3044\u305f\u60a3\u8005\u69d8\u306e44%\u304c\u3001\u76ae\u819a\u75c7\u72b6\u306e\u5b8c\u5168\u5bdb\u89e3\uff08\u307b\u307c\u6b63\u5e38\u306a\u72b6\u614b\uff09\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002 \u307e\u305f\u3001\u65e5\u5e38\u751f\u6d3b\u52d5\u4f5c\u306e\u969c\u5bb3\u5ea6\u3092\u793a\u3059HAQ-DI\u30b9\u30b3\u30a2\u306b\u304a\u3044\u3066\u3082\u3001\u81e8\u5e8a\u7684\u306b\u6975\u3081\u3066\u610f\u5473\u306e\u3042\u308b\u6a5f\u80fd\u56de\u5fa9\uff08MCID 0.22\u3092\u4e0a\u56de\u308b\u6539\u5584\uff09\u304c\u5b9f\u8a3c\u3055\u308c\u3001\u60a3\u8005\u69d8\u304c\u81ea\u5206\u306e\u529b\u3067\u5feb\u9069\u306b\u751f\u6d3b\u3092\u9001\u308b\u559c\u3073\u3092\u53d6\u308a\u623b\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>5. \u5c02\u9580\u533b\u306e\u76ee\u306b\u3088\u308b\u5fb9\u5e95\u3057\u305f\u5b89\u5168\u6027\u7ba1\u7406<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d6\u30ec\u30dd\u30b7\u30c1\u30cb\u30d630mg\u7fa4\u306b\u304a\u3044\u3066\u3001\u91cd\u7be4\u306a\u611f\u67d3\u75c7\u306e\u767a\u751f\u7387\u306f10%\u3068\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e1%\u3068\u6bd4\u8f03\u3057\u3066\u9ad8\u5024\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u611f\u67d3\u75c7\u306f\u5c02\u9580\u533b\u306b\u3088\u308b\u9069\u5207\u306a\u5185\u79d1\u7684\u6cbb\u7642\u306b\u3088\u3063\u3066\u5168\u4f8b\u304c\u901f\u3084\u304b\u306b\u56de\u5fa9\u3057\u3001\u85ac\u306e\u6cbb\u7642\u81ea\u4f53\u3092\u4e2d\u65ad\u3059\u308b\u3053\u3068\u306a\u304f\u5b8c\u4e86\u3067\u304d\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8840\u6813\u75c7\u3084\u304c\u3093\u306e\u65b0\u898f\u767a\u75c7\u306a\u3069\u306f\u30d6\u30ec\u30dd\u30b7\u30c1\u30cb\u30d6\u7fa4\u3067\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u5168\u4f53\u3068\u3057\u3066\u306e\u5b89\u5168\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u3053\u308c\u307e\u3067\u306eJAK\u963b\u5bb3\u85ac\u3068\u540c\u7b49\u3067\u3057\u305f\u3002 \u3053\u306e\u7d50\u679c\u306f\u3001\u5f37\u529b\u306b\u514d\u75ab\u306e\u4e71\u308c\u3092\u6574\u3048\u308b\u6700\u5148\u7aef\u306e\u304a\u85ac\u3067\u3042\u308b\u304b\u3089\u3053\u305d\u3001\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u3092\u719f\u77e5\u3057\u305f\u5c02\u9580\u533b\u304c\u5b9a\u671f\u7684\u306a\u63a1\u8840\u3084\u751f\u6d3b\u6307\u5c0e\u3001\u9069\u5207\u306a\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6848\u5185\u306a\u3069\u306e\u526f\u4f5c\u7528\u4e88\u9632\u3092\u53b3\u683c\u306b\u884c\u3046\u3053\u3068\u304c\u3044\u304b\u306b\u5927\u5207\u3067\u3042\u308b\u304b\u3092\u7269\u8a9e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ae\u819a\u7b4b\u708e\u3068\u3044\u3046\u3001\u76ae\u819a\u3068\u7b4b\u8089\u3092\u8755\u3080\u96e3\u75c5\u306e\u6cbb\u7642\u306f\u3001\u305f\u3060\u30b9\u30c6\u30ed\u30a4\u30c9\u3067\u708e\u75c7\u3092\u529b\u4efb\u305b\u306b\u6291\u3048\u8fbc\u3080\u6642\u4ee3\u304b\u3089\u3001\u7d30\u80de\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u30b9\u30de\u30fc\u30c8\u306b\u30d6\u30ed\u30c3\u30af\u3057\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u306a\u3044\u81ea\u7531\u306a\u65e5\u5e38\u751f\u6d3b\u3092\u5b89\u5168\u306b\u53d6\u308a\u623b\u3059\u300c\u65b0\u6642\u4ee3\u300d\u3078\u3068\u78ba\u5b9f\u306b\u30b7\u30d5\u30c8\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af<\/strong>\u3067\u306f\u3001\u30ea\u30a6\u30de\u30c1\u79d1\u5c02\u9580\u533b\u30fb\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u306e\u8996\u70b9\u304b\u3089\u3001\u95a2\u7bc0\u3084\u7b4b\u8089\u306e\u75db\u307f\u3001\u76ae\u819a\u306e\u8d64\u307f\u30fb\u305f\u3060\u308c\u304c\u3069\u306e\u3088\u3046\u306a\u300c\u4f53\u306e\u4ed5\u7d44\u307f\uff08\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\uff09\u300d\u306e\u4e71\u308c\u306b\u3088\u3063\u3066\u751f\u3058\u3066\u3044\u308b\u306e\u304b\u3092\u4e01\u5be7\u306b\u7d10\u89e3\u304d\u3001\u6700\u65b0\u306e\u6cbb\u7642\u9078\u629e\u80a2\u3084\u526f\u4f5c\u7528\u5bfe\u7b56\u3092\u8003\u616e\u3057\u305f\u5305\u62ec\u7684\u306a\u81a0\u539f\u75c5\u6cbb\u7642\u3092\u3054\u63d0\u6848\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u5f53\u9662\u306e\u5185\u79d1\uff08\u30ea\u30a6\u30de\u30c1\u30fb\u751f\u6d3b\u7fd2\u6163\u75c5\u8a3a\u7642\uff09\u30fb\u767a\u71b1\u5916\u6765\u306f\u571f\u66dc\u65e5\u306e\u5348\u5f8c\u308217\u6642\u307e\u3067\u8a3a\u7642\u3092\u884c\u3063\u3066\u304a\u308a\u3001\u5e73\u65e5\u306f\u304a\u4ed5\u4e8b\u3084\u5bb6\u4e8b\u3001\u4ecb\u8b77\u7b49\u3067\u53d7\u8a3a\u304c\u96e3\u3057\u3044\u60a3\u8005\u69d8\u3067\u3082\u3001\u9031\u672b\u306b\u3086\u3068\u308a\u3092\u6301\u3063\u3066\u5c02\u9580\u533b\u306b\u3088\u308b\u5b9a\u671f\u7684\u306a\u691c\u67fb\u3084\u8a3a\u5bdf\u3001\u4e01\u5be7\u306a\u304a\u85ac\u306e\u8aac\u660e\u3092\u53d7\u3051\u3066\u3044\u305f\u3060\u304f\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u76ae\u819a\u7b4b\u708e\u306b\u4f34\u3046\u5589\u306e\u7b4b\u529b\u4f4e\u4e0b\uff08\u56a5\u4e0b\u969c\u5bb3\uff09\u306f\u3001\u304a\u53e3\u306e\u4e2d\u306e\u7d30\u83cc\u304c\u80ba\u306b\u6d41\u308c\u8fbc\u3080\u300c\u8aa4\u56a5\u6027\u80ba\u708e\u300d\u306e\u91cd\u5927\u306a\u30ea\u30b9\u30af\u3092\u4f34\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u9577\u671f\u4f7f\u7528\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u9aa8\u7c97\u9b06\u75c7\u306b\u5bfe\u3057\u3066\u9aa8\u3092\u5f37\u304f\u3059\u308b\u304a\u85ac\uff08\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u88fd\u5264\u306a\u3069\uff09\u3092\u4f7f\u7528\u3059\u308b\u969b\u3001\u3042\u3054\u306e\u9aa8\u304c\u9732\u51fa\u3057\u3066\u58ca\u6b7b\u3057\u3066\u3057\u307e\u3046\u300c\u984e\u9aa8\u58ca\u6b7b\u300d\u3092\u9632\u3050\u305f\u3081\u306b\u306f\u3001\u6cbb\u7642\u958b\u59cb\u524d\u304b\u3089\u306e\u5fb9\u5e95\u7684\u306a\u6b6f\u79d1\u7ba1\u7406\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u5f53\u9662\u306e<strong>\u6b6f\u79d1\u306f\u571f\u66dc\u65e5\u5348\u5f8c2\u6642\uff0814\u6642\uff09\u307e\u3067<\/strong>\u8a3a\u7642\u3092\u884c\u3063\u3066\u304a\u308a\u3001\u533b\u79d1\u3067\u306e\u5148\u9032\u7684\u306a\u5168\u8eab\u7ba1\u7406\u3068\u4e26\u884c\u3057\u3066\u3001\u5c02\u9580\u7684\u306a\u53e3\u8154\u885b\u751f\u7ba1\u7406\uff08PMTC\u306b\u3088\u308b\u7d30\u83cc\u306e\u9664\u53bb\uff09\u3084\u56a5\u4e0b\u8a55\u4fa1\u3092\u540c\u4e00\u30af\u30ea\u30cb\u30c3\u30af\u5185\u3067\u5b8c\u7d50\u3067\u304d\u308b\u3001\u5f37\u529b\u306a\u300c\u533b\u79d1\u6b6f\u79d1\u9023\u643a\u300d\u306e\u4f53\u5236\u3067\u60a3\u8005\u69d8\u306e\u5065\u5eb7\u3092\u30c8\u30fc\u30bf\u30eb\u30b5\u30dd\u30fc\u30c8\u3044\u305f\u3057\u307e\u3059\u3002\u67cf\u30fb\u6211\u5b6b\u5b50\u30a8\u30ea\u30a2\u3067\u539f\u56e0\u4e0d\u660e\u306e\u7b4b\u529b\u4f4e\u4e0b\u3001\u96e3\u6cbb\u6027\u306e\u767a\u75b9\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u85ac\u306e\u670d\u7528\u306b\u95a2\u3059\u308b\u3054\u4e0d\u5b89\u3092\u304a\u6301\u3061\u306e\u65b9\u306f\u3001\u304a\u6c17\u8efd\u306b\u5f53\u9662\u307e\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u25a0 \u53d7\u8a3a\u3092\u3054\u5e0c\u671b\u306e\u65b9\u3078<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 <strong>\u3010\u533b\u79d1\u3011\uff08\u30ea\u30a6\u30de\u30c1\u79d1\u30fb\u5185\u79d1\u30fb\u767a\u71b1\u5916\u6765\u30fb\u95a2\u7bc0\u3084\u7b4b\u8089\u306e\u75db\u307f\u76f8\u8ac7\u30fb\u751f\u6d3b\u7fd2\u6163\u75c5\u306a\u3069\uff09WEB\u4e88\u7d04\u306f\u3053\u3061\u3089<\/strong> \u203b\u5f53\u9662\u306e\u5185\u79d1\u30fb\u767a\u71b1\u5916\u6765\u306f\u3001\u571f\u66dc\u65e5\u5348\u5f8c\u308217\u6642\u307e\u3067\u8a3a\u7642\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002 <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/www.google.com\/url?sa=E&amp;q=https%3A%2F%2Fmelmo-app.com%2Fclinic%2F673d5e08785f0f0030870bdb%2Freservation%3Fmethod%3Dvisit\">https:\/\/melmo-app.com\/clinic\/673d5e08785f0f0030870bdb\/reservation?method=visit<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 <strong>\u3010\u6b6f\u79d1\u3011\uff08\u304a\u53e3\u306e\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30fb\u56a5\u4e0b\u6a5f\u80fd\u76f8\u8ac7\u30fb\u6b6f\u5468\u75c5\u30fb\u81a0\u539f\u75c5\u95a2\u9023\u53e3\u8154\u30b1\u30a2\uff09WEB\u4e88\u7d04\u306f\u3053\u3061\u3089<\/strong> \u203b\u5f53\u9662\u306e\u6b6f\u79d1\u306f\u3001\u571f\u66dc\u65e5\u5348\u5f8c2\u6642\uff0814\u6642\uff09\u307e\u3067\u8a3a\u7642\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002 <a href=\"https:\/\/www.google.com\/url?sa=E&amp;q=http%3A%2F%2Fwww.gomidental-kashiwa.com%2Freservation%2F\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.gomidental-kashiwa.com\/reservation\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udcde <strong>\u304a\u96fb\u8a71\u3067\u306e\u3054\u4e88\u7d04\u30fb\u304a\u554f\u3044\u5408\u308f\u305b\uff08\u5065\u5eb7\u8a3a\u65ad\u30fb\u4e88\u9632\u63a5\u7a2e\u30fb\u304a\u85ac\u306e\u76f8\u8ac7\u306a\u3069\uff09<\/strong> \u3010\u533b\u79d1\u3011\uff1a04-7196-7531 \u3010\u6b6f\u79d1\u3011\uff1a04-7191-7081<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83c\udfe5 <strong>\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af \u30a2\u30af\u30bb\u30b9<\/strong> \u3012277-0902 \u5343\u8449\u770c\u67cf\u5e02\u5927\u4e95764-1 \u30d0\u30b9\u3067\u304a\u8d8a\u3057\u306e\u65b9\uff1a\u5343\u4ee3\u7530\u5e38\u78d0\u7dda \u67cf\u99c5\u6771\u53e3 \u6771\u6b66\u30d0\u30b91\u756a\u4e57\u5834\uff08\u300c\u6cbc\u5357\u8eca\u5eab\u300d\u300c\u5c0f\u91ce\u585a\u53f0\u300d\u300c\u624b\u8cc0\u306e\u4e18\u516c\u5712\u300d\u300c\u5e03\u702c\u300d\u884c\u304d\uff09\u3088\u308a\u30d0\u30b915\u5206 \u300c\u5927\u4e95\u300d\u4e0b\u8eca \u5f92\u6b691\u5206 \u8eca\u3067\u304a\u8d8a\u3057\u306e\u65b9\uff1a\u67cf\u99c5\u3088\u308a\u7d0415\u5206\u3001\u99d0\u8eca\u5834\u5b8c\u5099<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-41.png\" alt=\"\" class=\"wp-image-7695\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-41.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-41-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-42.png\" alt=\"\" class=\"wp-image-7696\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-42.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-42-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-43.png\" alt=\"\" class=\"wp-image-7697\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-43.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-43-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-44.png\" alt=\"\" class=\"wp-image-7698\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-44.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-44-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-45.png\" alt=\"\" class=\"wp-image-7699\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-45.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-45-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-46.png\" alt=\"\" class=\"wp-image-7700\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-46.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-46-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-47.png\" alt=\"\" class=\"wp-image-7701\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-47.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-47-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-48.png\" alt=\"\" class=\"wp-image-7702\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-48.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-48-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-49.png\" alt=\"\" class=\"wp-image-7703\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-49.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-49-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-50.png\" alt=\"\" class=\"wp-image-7704\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-50.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-50-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-51.png\" alt=\"\" class=\"wp-image-7705\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-51.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/image-51-400x224.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Ruth Ann Vleugels, Julie J. Paik, et al. &#8220;A Phase 3 Trial of Brepocitinib in Dermatomyositis.&#8221; <em>New England Journal of Medicine<\/em>. 2026; 394: 1883-1893.<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\u25a0\u95a2\u9023\u8a18\u4e8b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. \u7b4b\u8089\u306e\u75db\u307f\u3084\u3060\u308b\u3055\u304c\u3042\u308a\u3001\u4ed6\u306b\u3082\u7b4b\u8089\u3092\u653b\u6483\u3059\u308b\u81ea\u5df1\u514d\u75ab\u306e\u75c5\u6c17\u304c\u306a\u3044\u304b\u4e0d\u5b89\u306a\u65b9\u3078<\/strong><\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u76ae\u819a\u7b4b\u708e\u306a\u3069\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u4e3b\u5f79\u6cbb\u7642\u85ac\u3067\u3042\u308b\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\uff08\u526f\u814e\u76ae\u8cea\u30db\u30eb\u30e2\u30f3\uff09\u300d\u306f\u3001\u5f37\u529b\u306b\u708e\u75c7\u3092\u6291\u3048\u8fbc\u3080\u4e00\u65b9\u3067\u3001\u6613\u611f\u67d3\u6027\u3084\u7cd6\u5c3f\u75c5\u3001\u9aa8\u7c97\u9b06\u75c7\u3068\u3044\u3063\u305f\u591a\u5f69\u306a\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u3092\u4f34\u3044\u307e\u3059\u3002\u6700\u65b0\u85ac\u3067\u3042\u308b\u30d6\u30ec\u30dd\u30b7\u30c1\u30cb\u30d6\u306e\u767b\u5834\u306b\u3088\u308a\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u5b89\u5168\u306b\u6e1b\u3089\u3059\u300d\u3053\u3068\u304c\u73fe\u5b9f\u7684\u306b\u306a\u3063\u305f\u4eca\u3060\u304b\u3089\u3053\u305d\u3001\u77e5\u3063\u3066\u304a\u304f\u3079\u304d\u30b9\u30c6\u30ed\u30a4\u30c9\u7ba1\u7406\u306e\u9244\u5247\u3068\u3001\u5b89\u5168\u306b\u6e1b\u91cf\u3059\u308b\u305f\u3081\u306e\u5168\u8eab\u7ba1\u7406\u306e\u4ed5\u7d44\u307f\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure 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class=\"wp-block-embed is-type-wp-embed\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"AycXENgIxE\"><a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-6949\/\">\u3010\u67cf\u5e02\u6211\u5b6b\u5b50\u5e02\u30fb\u533b\u79d1\u6b6f\u79d1\u9023\u643a\u3011\u6301\u75c5\u304c\u3042\u3063\u3066\u3082\u5b89\u5fc3\u30fb\u5b89\u5168\u306a\u6b6f\u79d1\u6cbb\u7642\uff1a\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u3068\u6b6f\u79d1\u533b\u5e2b\u306e\u30c1\u30fc\u30e0\u533b\u7642\u304c\u5b88\u308b\u4f53\u306e\u4ed5\u7d44\u307f<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" 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