{"id":8700,"date":"2026-09-10T14:06:31","date_gmt":"2026-09-10T05:06:31","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=8700"},"modified":"2026-09-10T14:06:34","modified_gmt":"2026-09-10T05:06:34","slug":"post-8700","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-8700\/","title":{"rendered":"\u3010\u76ae\u819a\u79d1\u30fb\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u5185\u79d1\u3011\u5bdb\u89e3\u4e2d\u306e\u4e7e\u766c\u304c\u300c\u50b7\u8de1\u306b\u6cbf\u3063\u3066\u300d\u518d\u3073\u51fa\u73fe\u3002NEJM\u75c7\u4f8b\u306b\u5b66\u3076\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u3068\u76ae\u819a\u5916\u50b7\u306b\u3088\u308b\u514d\u75ab\u518d\u6d3b\u6027\u5316\u306e\u4ed5\u7d44\u307f"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\"><strong>\u30ea\u30b5\u30f3\u30ad\u30ba\u30de\u30d6\u306718\u304b\u6708\u9593\u5bdb\u89e3\u3057\u3066\u3044\u305f\u4e7e\u766c\u304c\u3001\u306a\u305c\u6e7f\u5f0f\u30ab\u30c3\u30d4\u30f3\u30b0\u5f8c\u306b\u518d\u3073\u51fa\u73fe\u3057\u305f\u306e\u304b\u3002\u76ae\u819a\u3078\u306e\u5916\u50b7\u306b\u3088\u3063\u3066\u540c\u3058\u76ae\u819a\u75be\u60a3\u306e\u75c5\u5909\u304c\u8a98\u767a\u3055\u308c\u308b\u300c\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\uff08Koebner phenomenon\uff09\u300d\u3092\u3001\u6700\u65b0NEJM\u75c7\u4f8b\u3068\u3068\u3082\u306b\u89e3\u8aac\u3057\u307e\u3059\u3002<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e7e\u766c\uff08Psoriasis\uff09\u3084\u767d\u6591\u3001\u6241\u5e73\u82d4\u766c\u306a\u3069\u306e\u76ae\u819a\u75be\u60a3\u3067\u306f\u3001\u6cbb\u7642\u306b\u3088\u3063\u3066\u75c5\u52e2\u304c\u5341\u5206\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3001\u76ae\u75b9\u304c\u307b\u3068\u3093\u3069\u6d88\u3048\u3066\u3044\u308b\u72b6\u614b\u3067\u3082\u3001<strong>\u64e6\u308a\u50b7\u3001\u5207\u308a\u50b7\u3001\u3084\u3051\u3069\u3001\u5f37\u3044\u6469\u64e6\u306a\u3069\u3092\u53d7\u3051\u305f\u5834\u6240\u306b\u3001\u65b0\u3057\u3044\u76ae\u75b9\u304c\u73fe\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306b\u3001\u3082\u3068\u3082\u3068\u76ae\u75b9\u306e\u306a\u304b\u3063\u305f\u76ae\u819a\u304c\u5916\u50b7\u3092\u53d7\u3051\u305f\u3042\u3068\u3001\u305d\u306e\u90e8\u4f4d\u306b\u5143\u306e\u76ae\u819a\u75be\u60a3\u3068\u540c\u3058\u75c5\u5909\u304c\u51fa\u73fe\u3059\u308b\u73fe\u8c61\u3092\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\uff08Koebner phenomenon\uff09\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3042\u308b\u3044\u306f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u540c\u5f62\u53cd\u5fdc\uff08isomorphic response\uff09\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e747\u670823\u65e5\u53f7\u306e\u300eThe New England Journal of Medicine\uff08NEJM\uff09\u300f\u306b\u306f\u3001\u30ea\u30b5\u30f3\u30ad\u30ba\u30de\u30d6\u306b\u3088\u3063\u306618\u304b\u6708\u9593\u5bdb\u89e3\u3092\u7dad\u6301\u3057\u3066\u3044\u305f\u4e7e\u766c\u60a3\u8005\u304c\u3001<strong>\u6e7f\u5f0f\u30ab\u30c3\u30d4\u30f3\u30b0\uff08wet cupping\uff09\u3092\u53d7\u3051\u305f\u90e8\u4f4d\u306b\u6cbf\u3063\u3066\u4e7e\u766c\u3092\u518d\u3073\u751f\u3058\u305f\u75c7\u4f8b<\/strong>\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e7e\u766c\u304c\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u3066\u3082\u3001\u76ae\u819a\u3078\u306e\u5916\u50b7\u306b\u3088\u3063\u3066\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u304c\u8d77\u3053\u308a\u3046\u308b\u3053\u3068\u3092\u3001\u975e\u5e38\u306b\u5206\u304b\u308a\u3084\u3059\u304f\u793a\u3057\u305f\u75c7\u4f8b\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\uff0e18\u304b\u6708\u9593\u306e\u5bdb\u89e3\u5f8c\u3001\u6e7f\u5f0f\u30ab\u30c3\u30d4\u30f3\u30b0\u306e\u50b7\u306b\u6cbf\u3063\u3066\u4e7e\u766c\u304c\u51fa\u73fe<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u306f35\u6b73\u306e\u7537\u6027\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e2d\u7b49\u75c7\u304b\u3089\u91cd\u75c7\u306e\u5c0b\u5e38\u6027\u4e7e\u766c\uff08plaque psoriasis\uff09\u304c\u3042\u308a\u3001IL-23\u3092\u6a19\u7684\u3068\u3059\u308b\u751f\u7269\u5b66\u7684\u88fd\u5264\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ea\u30b5\u30f3\u30ad\u30ba\u30de\u30d6\uff08risankizumab\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cbb\u7642\u52b9\u679c\u306f\u975e\u5e38\u306b\u826f\u597d\u3067\u3001<strong>\u904e\u53bb18\u304b\u6708\u9593\u306b\u308f\u305f\u308a\u4e7e\u766c\u306f\u5bdb\u89e3\u72b6\u614b\u3092\u7dad\u6301\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u53d7\u8a3a\u306e2\u9031\u9593\u524d\u3001\u8170\u75db\u3092\u548c\u3089\u3052\u308b\u76ee\u7684\u3067\u3001\u521d\u3081\u3066\u6e7f\u5f0f\u30ab\u30c3\u30d4\u30f3\u30b0\uff08wet cupping\uff09\u3092\u53d7\u3051\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6e7f\u5f0f\u30ab\u30c3\u30d4\u30f3\u30b0\u3067\u306f\u3001\u76ae\u819a\u306b\u5c0f\u3055\u306a\u5207\u958b\u3092\u8907\u6570\u52a0\u3048\u305f\u3042\u3068\u3001\u305d\u306e\u90e8\u5206\u306b\u30ab\u30c3\u30d7\u3092\u88c5\u7740\u3057\u3001\u9670\u5727\u3092\u304b\u3051\u3066\u5c11\u91cf\u306e\u8840\u6db2\u3092\u5438\u5f15\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e2\u9031\u9593\u5f8c\u3001\u80cc\u4e2d\u306b\u65b0\u3057\u3044\u76ae\u75b9\u304c\u51fa\u73fe\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8a3a\u5bdf\u3059\u308b\u3068\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u80a9<\/li>\n\n\n\n<li>\u80cc\u4e2d\u306e\u4e2d\u592e<\/li>\n\n\n\n<li>\u8170\u90e8<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3001<strong>\u30ab\u30c3\u30d4\u30f3\u30b0\u306e\u969b\u306b\u5c0f\u5207\u958b\u304c\u52a0\u3048\u3089\u308c\u305f\u5834\u6240\u3068\u4e00\u81f4\u3057\u3066\u3001\u5883\u754c\u660e\u77ad\u306a\u7d05\u6591\u6027\u306e\u4e18\u75b9\u30fb\u5c40\u9762\u3068\u9c57\u5c51\u304c\u96c6\u7c07\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u306a\u306e\u306f\u3001\u76ae\u75b9\u304c\u7121\u79e9\u5e8f\u306b\u51fa\u73fe\u3057\u305f\u306e\u3067\u306f\u306a\u304f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u76ae\u819a\u304c\u50b7\u3064\u3051\u3089\u308c\u305f\u5834\u6240\u306b\u6cbf\u3063\u3066\u4e7e\u766c\u304c\u518d\u73fe\u3055\u308c\u3066\u3044\u305f\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7279\u5fb4\u7684\u306a\u5206\u5e03\u304b\u3089\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6e7f\u5f0f\u30ab\u30c3\u30d4\u30f3\u30b0\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u305f\u4e7e\u766c\u306e\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\uff0e\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u3068\u306f\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u306f\u3001\u3082\u3068\u3082\u3068\u76ae\u75b9\u306e\u306a\u304b\u3063\u305f\u76ae\u819a\u306b\u5916\u50b7\u304c\u52a0\u308f\u3063\u305f\u3042\u3068\u3001<strong>\u305d\u306e\u60a3\u8005\u304c\u6301\u3063\u3066\u3044\u308b\u76ae\u819a\u75be\u60a3\u3068\u540c\u3058\u75c5\u5909\u304c\u5916\u50b7\u90e8\u4f4d\u306b\u51fa\u73fe\u3059\u308b\u73fe\u8c61<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e4\u5178\u7684\u306b\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e7e\u766c<\/li>\n\n\n\n<li>\u767d\u6591<\/li>\n\n\n\n<li>\u6241\u5e73\u82d4\u766c<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e7e\u766c\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u64e6\u308a\u50b7<\/li>\n\n\n\n<li>\u5207\u5275<\/li>\n\n\n\n<li>\u3084\u3051\u3069<\/li>\n\n\n\n<li>\u624b\u8853\u5275<\/li>\n\n\n\n<li>\u30bf\u30c8\u30a5\u30fc<\/li>\n\n\n\n<li>\u5f37\u3044\u6469\u64e6<\/li>\n\n\n\n<li>\u7e70\u308a\u8fd4\u3055\u308c\u308b\u63bb\u7834<\/li>\n\n\n\n<li>\u305d\u306e\u4ed6\u306e\u6a5f\u68b0\u7684\u523a\u6fc0<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u304d\u3063\u304b\u3051\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306eNEJM\u75c7\u4f8b\u3067\u7279\u306b\u91cd\u8981\u306a\u306e\u306f\u3001<strong>\u4e7e\u766c\u304c18\u304b\u6708\u9593\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u305f\u60a3\u8005\u3067\u3082\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u304c\u751f\u3058\u305f<\/strong>\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u901a\u5e38\u3001\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u306f\u6d3b\u52d5\u6027\u306e\u9ad8\u3044\u4e7e\u766c\u3067\u307f\u3089\u308c\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u75c5\u52e2\u304c\u5b89\u5b9a\u3057\u3066\u3044\u3066\u3082\u5b8c\u5168\u306b\u8d77\u3053\u3089\u306a\u304f\u306a\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\uff0e\u306a\u305c\u300c\u50b7\u3064\u3044\u305f\u5834\u6240\u300d\u306b\u4e7e\u766c\u304c\u73fe\u308c\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u73fe\u5728\u3067\u306f\u3001\u5358\u306a\u308b\u76ae\u819a\u306e\u50b7\u3067\u306f\u306a\u304f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u76ae\u819a\u640d\u50b7\u3092\u514d\u75ab\u7cfb\u304c\u691c\u77e5\u3057\u3001\u4e7e\u766c\u306b\u95a2\u4fc2\u3059\u308b\u708e\u75c7\u7d4c\u8def\u304c\u5c40\u6240\u3067\u518d\u3073\u52d5\u304d\u59cb\u3081\u308b\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3068\u304c\u91cd\u8981\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u89d2\u5316\u7d30\u80de\u304c\u50b7\u3064\u304d\u3001\u300c\u5371\u967a\u4fe1\u53f7\u300d\u304c\u653e\u51fa\u3055\u308c\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ae\u819a\u304c\u5207\u3089\u308c\u305f\u308a\u5f37\u304f\u523a\u6fc0\u3055\u308c\u305f\u308a\u3059\u308b\u3068\u3001\u8868\u76ae\u3092\u69cb\u6210\u3059\u308b\u89d2\u5316\u7d30\u80de\uff08\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\uff09\u304c\u640d\u50b7\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3059\u308b\u3068\u7d30\u80de\u304b\u3089\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u81ea\u5df1DNA<\/li>\n\n\n\n<li>\u81ea\u5df1RNA<\/li>\n\n\n\n<li>DAMPs\uff08damage-associated molecular patterns\uff1a\u50b7\u5bb3\u95a2\u9023\u5206\u5b50\u30d1\u30bf\u30fc\u30f3\uff09<\/li>\n\n\n\n<li>LL-37\u306a\u3069\u306e\u6297\u83cc\u30da\u30d7\u30c1\u30c9<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3063\u305f\u7269\u8cea\u304c\u653e\u51fa\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306f\u3001\u672c\u6765\u306f\u611f\u67d3\u3084\u7d44\u7e54\u640d\u50b7\u304b\u3089\u8eab\u4f53\u3092\u5b88\u308b\u305f\u3081\u306b\u514d\u75ab\u7cfb\u3078\u5371\u967a\u3092\u77e5\u3089\u305b\u308b\u30b7\u30b0\u30ca\u30eb\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">LL-37\u3068\u81ea\u5df1\u6838\u9178\u304c\u81ea\u7136\u514d\u75ab\u3092\u523a\u6fc0\u3059\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e7e\u766c\u3067\u306f\u3001\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306e\u4e00\u3064\u3067\u3042\u308b<strong>LL-37<\/strong>\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">LL-37\u306f\u3001\u50b7\u3064\u3044\u305f\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u305f\u81ea\u5df1DNA\u3084RNA\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3001\u76ae\u819a\u306b\u5b58\u5728\u3059\u308b\u514d\u75ab\u7d30\u80de\u3092\u523a\u6fc0\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u3001\u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de\uff08plasmacytoid dendritic cell\uff1apDC\uff09\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306a\u3069\u306e\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u304c\u7523\u751f\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">IL-23\uff0fTh17\u7d4c\u8def\u3078\u708e\u75c7\u304c\u3064\u306a\u304c\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u9aa8\u9ac4\u7cfb\u6a39\u72b6\u7d30\u80de\u306a\u3069\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>IL-23\uff0fTh17\uff0fIL-17\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u4e7e\u766c\u306b\u7279\u5fb4\u7684\u306a\u514d\u75ab\u7d4c\u8def<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3078\u708e\u75c7\u53cd\u5fdc\u304c\u3064\u306a\u304c\u3063\u3066\u3044\u304f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306e\u904e\u5270\u306a\u5897\u6b96\u3084\u89d2\u5316\u7570\u5e38<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u8d77\u3053\u308a\u3001\u3082\u3068\u3082\u3068\u6b63\u5e38\u306b\u898b\u3048\u3066\u3044\u305f\u76ae\u819a\u306b\u4e7e\u766c\u75c5\u5909\u304c\u5f62\u6210\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u76ae\u819a\u5916\u50b7<br>\u2193<br>\u640d\u50b7\u7d30\u80de\u304b\u3089\u81ea\u5df1\u6838\u9178\u30fb\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u304c\u653e\u51fa<br>\u2193<br>\u81ea\u7136\u514d\u75ab\u7cfb\u304c\u6d3b\u6027\u5316<br>\u2193<br>IL-23\uff0fTh17\u7cfb\u306a\u3069\u4e7e\u766c\u306b\u95a2\u308f\u308b\u708e\u75c7\u53cd\u5fdc\u304c\u518d\u6d3b\u6027\u5316<br>\u2193<br>\u50b7\u3064\u3044\u305f\u5834\u6240\u306b\u4e7e\u766c\u75c5\u5909\u304c\u5f62\u6210<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u6d41\u308c\u3067\u7406\u89e3\u3059\u308b\u3068\u5206\u304b\u308a\u3084\u3059\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u306e\u514d\u75ab\u7d4c\u8def\u306e\u3059\u3079\u3066\u304c\u4eca\u56de\u306e\u60a3\u8005\u3067\u76f4\u63a5\u6e2c\u5b9a\u30fb\u8a3c\u660e\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5728\u306e\u4e7e\u766c\u7814\u7a76\u304b\u3089\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3001<strong>\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u3092\u8aac\u660e\u3059\u308b\u6709\u529b\u306a\u75c5\u614b\u30e2\u30c7\u30eb<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4\uff0e\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u4f7f\u7528\u3057\u3066\u3044\u3066\u3082\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u60a3\u8005\u306f\u3001\u4e7e\u766c\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30ea\u30b5\u30f3\u30ad\u30ba\u30de\u30d6\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ea\u30b5\u30f3\u30ad\u30ba\u30de\u30d6\u306f\u3001\u4e7e\u766c\u306e\u75c5\u614b\u3067\u91cd\u8981\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b<strong>IL-23\u3092\u6a19\u7684\u3068\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u88fd\u5264<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u6cbb\u7642\u306b\u3088\u3063\u3066\u60a3\u8005\u306e\u4e7e\u766c\u306f18\u304b\u6708\u9593\u5bdb\u89e3\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u308c\u3067\u3082\u76ae\u819a\u5916\u50b7\u5f8c\u306b\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u304c\u751f\u3058\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3053\u304b\u3089\u5206\u304b\u308b\u91cd\u8981\u306a\u30dd\u30a4\u30f3\u30c8\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u751f\u7269\u5b66\u7684\u88fd\u5264\u304c\u52b9\u3044\u3066\u3044\u306a\u3044\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u306a\u3044<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b9f\u969b\u3001\u3053\u306e\u60a3\u8005\u3067\u306f\u30ea\u30b5\u30f3\u30ad\u30ba\u30de\u30d6\u305d\u306e\u3082\u306e\u304c\u5909\u66f4\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u826f\u597d\u306a\u6cbb\u7642\u52b9\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u5834\u5408\u3067\u3082\u3001\u5f37\u3044\u5c40\u6240\u523a\u6fc0\u306b\u3088\u3063\u3066\u76ae\u819a\u306e\u708e\u75c7\u53cd\u5fdc\u304c\u8a98\u767a\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u3001<strong>\u85ac\u7269\u6cbb\u7642\u3068\u540c\u6642\u306b\u76ae\u819a\u3078\u306e\u4e0d\u8981\u306a\u5916\u50b7\u3092\u907f\u3051\u308b\u3053\u3068\u3082\u91cd\u8981<\/strong>\u306a\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5\uff0e\u6cbb\u7642\u306f\u3069\u3046\u3057\u305f\u306e\u304b\uff1f\u2015\u2015\u30ea\u30b5\u30f3\u30ad\u30ba\u30de\u30d6\u306f\u305d\u306e\u307e\u307e\u7d99\u7d9a<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u60a3\u8005\u306f\u3001\u6e7f\u5f0f\u30ab\u30c3\u30d4\u30f3\u30b0\u3092\u4e2d\u6b62\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u4e7e\u766c\u306e\u57fa\u672c\u6cbb\u7642\u3067\u3042\u308b<strong>\u30ea\u30b5\u30f3\u30ad\u30ba\u30de\u30d6\u306f\u540c\u3058\u7528\u91cf\u306e\u307e\u307e\u7d99\u7d9a<\/strong>\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u304c\u8d77\u3053\u3063\u305f\u304b\u3089\u3068\u3044\u3063\u3066\u3001\u76f4\u3061\u306b\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u5897\u91cf\u3057\u305f\u308a\u3001\u5225\u306e\u85ac\u3078\u5909\u66f4\u3057\u305f\u308a\u3057\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3057\u30663\u304b\u6708\u5f8c\u306e\u518d\u8a3a\u6642\u306b\u306f\u3001<strong>\u80cc\u90e8\u306e\u76ae\u75b9\u306f\u8efd\u5feb\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7d4c\u904e\u306f\u975e\u5e38\u306b\u793a\u5506\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e7e\u766c\u60a3\u8005\u306b\u65b0\u3057\u3044\u76ae\u75b9\u304c\u73fe\u308c\u305f\u5834\u5408\u306b\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u85ac\u304c\u52b9\u304b\u306a\u304f\u306a\u3063\u305f\u306e\u3067\u306f\u306a\u3044\u304b\uff1f\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3060\u3051\u3067\u306a\u304f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u6700\u8fd1\u3001\u305d\u306e\u90e8\u4f4d\u306b\u4f55\u3089\u304b\u306e\u5916\u50b7\u3084\u523a\u6fc0\u304c\u306a\u304b\u3063\u305f\u304b\uff1f\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u8996\u70b9\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6\uff0e\u4e7e\u766c\u60a3\u8005\u304c\u65e5\u5e38\u751f\u6d3b\u3067\u6ce8\u610f\u3057\u305f\u3044\u76ae\u819a\u523a\u6fc0<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u3092\u7d4c\u9a13\u3057\u305f\u3053\u3068\u304c\u3042\u308b\u65b9\u3084\u3001\u4e7e\u766c\u306e\u6d3b\u52d5\u6027\u304c\u9ad8\u3044\u65b9\u3067\u306f\u3001\u5fc5\u8981\u4ee5\u4e0a\u306e\u76ae\u819a\u5916\u50b7\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f8b\u3048\u3070\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5f37\u304f\u76ae\u819a\u3092\u3053\u3059\u308b<\/li>\n\n\n\n<li>\u7e70\u308a\u8fd4\u3057\u63bb\u304f<\/li>\n\n\n\n<li>\u5f37\u3044\u3042\u304b\u3059\u308a<\/li>\n\n\n\n<li>\u76ae\u819a\u3092\u50b7\u3064\u3051\u308b\u65bd\u8853<\/li>\n\n\n\n<li>\u30bf\u30c8\u30a5\u30fc<\/li>\n\n\n\n<li>\u4e0d\u5fc5\u8981\u306a\u5207\u5275\u3084\u523a\u5275<\/li>\n\n\n\n<li>\u5f37\u3044\u6469\u64e6\u3092\u7e70\u308a\u8fd4\u3059<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u306f\u3001\u72b6\u6cc1\u306b\u3088\u3063\u3066\u76ae\u75b9\u3092\u8a98\u767a\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3082\u3061\u308d\u3093\u3001\u3059\u3079\u3066\u306e\u76ae\u819a\u523a\u6fc0\u3067\u5fc5\u305a\u30b1\u30d6\u30cd\u30eb\u73fe\u8c61\u304c\u8d77\u3053\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u5fc5\u8981\u306a\u624b\u8853\u30fb\u6ce8\u5c04\u30fb\u533b\u7642\u51e6\u7f6e\u3092\u4e00\u5f8b\u306b\u907f\u3051\u308b\u5fc5\u8981\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5927\u5207\u306a\u306e\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u4e7e\u766c\u3067\u306f\u76ae\u819a\u3078\u306e\u5916\u50b7\u304c\u65b0\u3057\u3044\u75c5\u5909\u306e\u304d\u3063\u304b\u3051\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308b\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u7279\u6027\u3092\u77e5\u308a\u3001\u4e0d\u5fc5\u8981\u306a\u76ae\u819a\u523a\u6fc0\u3092\u6e1b\u3089\u3059\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u65b0\u3057\u3044\u65bd\u8853\u3084\u7f8e\u5bb9\u51e6\u7f6e\u3001\u30bf\u30c8\u30a5\u30fc\u306a\u3069\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u306f\u3001\u4e7e\u766c\u306e\u6d3b\u52d5\u6027\u3084\u6cbb\u7642\u72b6\u6cc1\u3082\u542b\u3081\u3001\u4e8b\u524d\u306b\u4e3b\u6cbb\u533b\u3078\u76f8\u8ac7\u3059\u308b\u3068\u5b89\u5fc3\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">7\uff0e\u3053\u306eNEJM\u75c7\u4f8b\u304b\u3089\u5b66\u3079\u308b\u3053\u3068<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u75c7\u4f8b\u304b\u3089\u5f97\u3089\u308c\u308b\u6700\u5927\u306e\u6559\u8a13\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u76ae\u819a\u75c7\u72b6\u304c\u6d88\u3048\u3066\u3044\u308b\u3053\u3068\u300d\u3068\u300c\u76ae\u819a\u306e\u514d\u75ab\u5b66\u7684\u306a\u7d20\u56e0\u304c\u5b8c\u5168\u306b\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u300d\u306f\u540c\u3058\u3067\u306f\u306a\u3044<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e7e\u766c\u306f\u3001\u76ae\u819a\u3060\u3051\u306b\u9650\u5c40\u3057\u305f\u5358\u7d14\u306a\u300c\u767a\u75b9\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3001\u81ea\u7136\u514d\u75ab\u3001\u7372\u5f97\u514d\u75ab\u3001IL-23\uff0fTh17\u7d4c\u8def\u306a\u3069\u304c\u8907\u96d1\u306b\u95a2\u4e0e\u3059\u308b\u6162\u6027\u708e\u75c7\u6027\u75be\u60a3\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u751f\u7269\u5b66\u7684\u88fd\u5264\u306b\u3088\u3063\u3066\u75c5\u52e2\u3092\u975e\u5e38\u306b\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u6642\u4ee3\u306b\u306a\u3063\u305f\u4e00\u65b9\u3067\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u76ae\u819a\u3092\u5b88\u308b\u751f\u6d3b\u7fd2\u6163\u3082\u6cbb\u7642\u306e\u4e00\u90e8<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u4e7e\u766c\u3067\u306f\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3067\u4e7e\u766c\u6027\u95a2\u7bc0\u708e\uff08Psoriatic Arthritis\uff1aPsA\uff09\u3092\u5408\u4f75\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6307\u3084\u8db3\u8dbe\u306e\u816b\u308c\u3001\u671d\u306e\u3053\u308f\u3070\u308a\u3001\u8171\u4ed8\u7740\u90e8\u75db\u3001\u8170\u75db\u306a\u3069\u3092\u4f34\u3046\u5834\u5408\u306b\u306f\u3001\u76ae\u819a\u3060\u3051\u3067\u306a\u304f\u95a2\u7bc0\u3084\u810a\u690e\u3092\u542b\u3081\u305f\u5168\u8eab\u8a55\u4fa1\u304c\u5fc5\u8981\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u30af\u30ea\u30cb\u30c3\u30af\u304b\u3089\u306e\u30e1\u30c3\u30bb\u30fc\u30b8<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u306f\u3001\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u30fb\u30ea\u30a6\u30de\u30c1\u5c02\u9580\u533b\u304a\u3088\u3073\u809d\u81d3\u5c02\u9580\u533b\u304c\u5728\u7c4d\u3057\u3001\u75c7\u72b6\u3060\u3051\u3092\u898b\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u554f\u8a3a\u30fb\u8eab\u4f53\u6240\u898b\u30fb\u8840\u6db2\u691c\u67fb\u30fb\u753b\u50cf\u691c\u67fb\u306a\u3069\u3092\u7d44\u307f\u5408\u308f\u305b\u306a\u304c\u3089\u3001\u300c\u306a\u305c\u305d\u306e\u75c7\u72b6\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\u300d\u3092\u75c5\u614b\u751f\u7406\u304b\u3089\u8003\u3048\u308b\u8a3a\u7642\u3092\u5927\u5207\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ae\u75b9\u306b\u52a0\u3048\u3066\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u539f\u56e0\u4e0d\u660e\u306e\u95a2\u7bc0\u75db\u30fb\u95a2\u7bc0\u816b\u8139<\/li>\n\n\n\n<li>\u671d\u306e\u3053\u308f\u3070\u308a<\/li>\n\n\n\n<li>\u6307\u3084\u8db3\u8dbe\u306e\u816b\u308c<\/li>\n\n\n\n<li>\u9577\u5f15\u304f\u8170\u75db<\/li>\n\n\n\n<li>\u767a\u71b1<\/li>\n\n\n\n<li>\u5026\u6020\u611f<\/li>\n\n\n\n<li>\u305d\u306e\u4ed6\u306e\u5168\u8eab\u75c7\u72b6<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3092\u4f34\u3046\u5834\u5408\u306b\u306f\u3001\u4e7e\u766c\u6027\u95a2\u7bc0\u708e\u3084\u81a0\u539f\u75c5\u3092\u542b\u3081\u305f\u8a55\u4fa1\u304c\u5fc5\u8981\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ae\u819a\u75be\u60a3\u305d\u306e\u3082\u306e\u306b\u3064\u3044\u3066\u5c02\u9580\u7684\u306a\u76ae\u819a\u79d1\u8a3a\u7642\u304c\u5fc5\u8981\u3068\u5224\u65ad\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u9069\u5207\u306a\u76ae\u819a\u79d1\u533b\u7642\u6a5f\u95a2\u3068\u9023\u643a\u3057\u306a\u304c\u3089\u5bfe\u5fdc\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u4e7e\u766c\u3068\u6b6f\u5468\u75c5\u306f\u3044\u305a\u308c\u3082\u6162\u6027\u708e\u75c7\u3092\u80cc\u666f\u3068\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u75ab\u5b66\u7814\u7a76\u3067\u306f<strong>\u4e7e\u766c\u60a3\u8005\u3067\u6b6f\u5468\u708e\u304c\u591a\u3044\u53ef\u80fd\u6027<\/strong>\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u6b6f\u5468\u75c5\u6cbb\u7642\u306b\u3088\u3063\u3066\u4e7e\u766c\u305d\u306e\u3082\u306e\u304c\u6539\u5584\u3059\u308b\u3068\u65ad\u5b9a\u3067\u304d\u308b\u6bb5\u968e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5168\u8eab\u75be\u60a3\u306e\u6cbb\u7642\u4e2d\u3067\u3042\u3063\u3066\u3082\u3001\u3080\u3057\u6b6f\u3084\u6b6f\u5468\u75c5\u3092\u9069\u5207\u306b\u4e88\u9632\u30fb\u6cbb\u7642\u3057\u3001\u826f\u597d\u306a\u53e3\u8154\u74b0\u5883\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u306f\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u306f\u533b\u79d1\u3068\u6b6f\u79d1\u304c\u540c\u4e00\u65bd\u8a2d\u5185\u3067\u8a3a\u7642\u3057\u3066\u304a\u308a\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u60c5\u5831\u3092\u5171\u6709\u3057\u306a\u304c\u3089\u3001\u5168\u8eab\u3068\u53e3\u8154\u306e\u53cc\u65b9\u304b\u3089\u5065\u5eb7\u7ba1\u7406\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u25a0\u53d7\u8a3a\u3092\u3054\u5e0c\u671b\u306e\u65b9\u3078<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 <strong>\u3010\u533b\u79d1\u3011\u30a2\u30ec\u30eb\u30ae\u30fc\u30fb\u81a0\u539f\u75c5\u30fb\u30ea\u30a6\u30de\u30c1\u5185\u79d1\uff0f\u7dcf\u5408\u5185\u79d1\uff0f\u767a\u71b1\u5916\u6765<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc0\u75db\u3001\u95a2\u7bc0\u816b\u8139\u3001\u539f\u56e0\u4e0d\u660e\u306e\u767a\u71b1\u30fb\u76ae\u75b9\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u3001\u5404\u7a2e\u8840\u6db2\u691c\u67fb\u30fb\u753b\u50cf\u691c\u67fb\u306a\u3069\u306b\u5bfe\u5fdc\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u203b\u5f53\u9662\u306e\u5185\u79d1\u306f\u571f\u66dc\u65e5\u308217\u6642\u307e\u3067\u8a3a\u7642\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">WEB\u4e88\u7d04\uff1a<br><a href=\"https:\/\/melmo-app.com\/clinic\/673d5e08785f0f0030870bdb\/reservation?method=visit\">https:\/\/melmo-app.com\/clinic\/673d5e08785f0f0030870bdb\/reservation?method=visit<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 <strong>\u3010\u6b6f\u79d1\u3011\u6839\u7ba1\u6cbb\u7642\u30fb\u3080\u3057\u6b6f\u30fb\u6b6f\u5468\u75c5\u30fb\u4e88\u9632\u6b6f\u79d1\u30fb\u6709\u75c5\u8005\u6b6f\u79d1\u30fbPMTC\u306a\u3069<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u203b\u5f53\u9662\u306e\u6b6f\u79d1\u306f\u571f\u66dc\u65e514\u6642\u307e\u3067\u8a3a\u7642\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">WEB\u4e88\u7d04\uff1a<br><a href=\"http:\/\/www.gomidental-kashiwa.com\/reservation\/\">http:\/\/www.gomidental-kashiwa.com\/reservation\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udcde <strong>\u304a\u96fb\u8a71\u3067\u306e\u3054\u4e88\u7d04\u30fb\u304a\u554f\u3044\u5408\u308f\u305b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3010\u533b\u79d1\u301104-7196-7531<br>\u3010\u6b6f\u79d1\u301104-7191-7081<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83c\udfe5 <strong>\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3012277-0902<br>\u5343\u8449\u770c\u67cf\u5e02\u5927\u4e95764-1<br>\uff08\u5927\u4e95\u4ea4\u5dee\u70b9\u8fd1\u304f\u30fb\u99d0\u8eca\u5834\u5b8c\u5099\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u67cf\u99c5\u6771\u53e3\u3088\u308a\u6771\u6b66\u30d0\u30b9\u3067\u7d0415\u5206\u3001\u300c\u5927\u4e95\u300d\u4e0b\u8eca\u5f92\u6b691\u5206\u3002<br>\u304a\u8eca\u3067\u306f\u67cf\u99c5\u5468\u8fba\u304b\u3089\u7d0415\u5206\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u6b63\u5f0f\u306a\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Demir Y, Kutlubay Z. Koebner Phenomenon from Wet Cupping. <em>N Engl J Med.<\/em> 2026;395. doi:10.1056\/NEJMicm2603647.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-359.png\" alt=\"\" class=\"wp-image-8710\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-359.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-359-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-359-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-360.png\" alt=\"\" class=\"wp-image-8711\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-360.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-360-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-360-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-361.png\" alt=\"\" class=\"wp-image-8712\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-361.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-361-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-361-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-362.png\" alt=\"\" class=\"wp-image-8713\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-362.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-362-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-362-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-363.png\" alt=\"\" class=\"wp-image-8714\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-363.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-363-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-363-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-364.png\" alt=\"\" class=\"wp-image-8715\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-364.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-364-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-364-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-365.png\" alt=\"\" class=\"wp-image-8716\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-365.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-365-767x428.png 767w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-365-400x223.png 400w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" 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