{"id":8886,"date":"2026-09-14T18:01:01","date_gmt":"2026-09-14T09:01:01","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=8886"},"modified":"2026-09-14T18:28:23","modified_gmt":"2026-09-14T09:28:23","slug":"post-8886","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-8886\/","title":{"rendered":"\u3010NEJM2026\u3011\u8840\u5c0f\u677f\u7b2c4\u56e0\u5b50\uff08PF4\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u300c\u8840\u6813\u75c7\uff0b\u8840\u5c0f\u677f\u6e1b\u5c11\u300d\u306e\u65b0\u3057\u3044\u75be\u60a3\u6982\u5ff5\uff1a\u300c\u6297PF4\u6297\u4f53\u95a2\u9023\u75be\u60a3\u300d\u3092\u5c02\u9580\u533b\u304c\u89e3\u8aac"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>\u30d8\u30d1\u30ea\u30f3\u8d77\u56e0\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\uff08HIT\uff09\u304b\u3089VITT\u3001\u3055\u3089\u306bVITT\u69d8MGTS\u3078\u3002PF4\u3092\u6a19\u7684\u3068\u3059\u308b\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u6297\u4f53\u304c\u3001Fc\u03b3RIIa\u3092\u4ecb\u3057\u3066\u8840\u5c0f\u677f\u30fb\u5358\u7403\u30fb\u597d\u4e2d\u7403\u3092\u5dfb\u304d\u8fbc\u307f\u3001\u300c\u8840\u6813\u6027\u708e\u75c7\uff08thromboinflammation\uff09\u300d\u3092\u5f62\u6210\u3059\u308b\u4ed5\u7d44\u307f\u3092\u89e3\u8aac\u3057\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6db2\u691c\u67fb\u3067\u300c\u8840\u5c0f\u677f\u304c\u6e1b\u3063\u3066\u3044\u308b\u300d\u3068\u805e\u304f\u3068\u3001\u591a\u304f\u306e\u65b9\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u8840\u304c\u6b62\u307e\u308a\u306b\u304f\u304f\u306a\u308b\u306e\u3067\u306f\uff1f\u300d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u8003\u3048\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u306e\u4e2d\u306b\u306f\u3001\u3080\u3057\u308d\u53cd\u5bfe\u306b<strong>\u8840\u6813\u75c7\u3092\u5f37\u304f\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308b\u7279\u6b8a\u306a\u75c5\u614b<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u4ee3\u8868\u304c\u3001\u30d8\u30d1\u30ea\u30f3\u8d77\u56e0\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\uff08heparin-induced thrombocytopenia\uff1aHIT\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u8fd1\u5e74\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u81ea\u5df1\u514d\u75ab\u6027HIT\uff08autoimmune HIT\uff1aaHIT\uff09<\/li>\n\n\n\n<li>\u81ea\u767a\u6027HIT\uff08spontaneous HIT\uff1aSpHIT\uff09<\/li>\n\n\n\n<li>\u30ef\u30af\u30c1\u30f3\u8a98\u767a\u6027\u514d\u75ab\u6027\u8840\u6813\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\uff08VITT\uff09<\/li>\n\n\n\n<li>\u81ea\u7136\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5f8c\u306eVITT\u69d8\u75c5\u614b<\/li>\n\n\n\n<li>VITT\u69d8\u5358\u30af\u30ed\u30fc\u30f3\u6027\u30ac\u30f3\u30de\u30b0\u30ed\u30d6\u30ea\u30f3\u8840\u75c7\u6027\u8840\u6813\u75c7\uff08VITT-like MGTS\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u76f8\u6b21\u3044\u3067\u660e\u3089\u304b\u3068\u306a\u308a\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u8840\u5c0f\u677f\u7b2c4\u56e0\u5b50\uff08platelet factor 4\uff1aPF4\uff09\u3092\u6a19\u7684\u3068\u3059\u308b\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u6297\u4f53\u306b\u3088\u308b\u75be\u60a3\u7fa4\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u65b0\u3057\u3044\u75c5\u614b\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u3068\u3057\u3066\u6349\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e74\u3001Warkentin\u3068Greinacher\u306f <em>The New England Journal of Medicine<\/em> \u306b\u304a\u3044\u3066\u3001\u3053\u306e\u4e00\u9023\u306e\u75be\u60a3\u3092<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Platelet-Activating Anti\u2013Platelet Factor 4 Disorders<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3057\u3066\u4f53\u7cfb\u7684\u306b\u6574\u7406\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u8a18\u4e8b\u3067\u306f\u3001\u6700\u65b0\u306eNEJM\u7dcf\u8aac\u3092\u3082\u3068\u306b\u3001\u305d\u306e\u75c5\u614b\u3092\u300c\u4f53\u306e\u4ed5\u7d44\u307f\u300d\u304b\u3089\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-474.png\" alt=\"\" class=\"wp-image-8890\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-474.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-474-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-474-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1\uff0ePF4\u3068\u306f\u4f55\u304b\uff1f\u2015\u2015\u8840\u5c0f\u677f\u304b\u3089\u653e\u51fa\u3055\u308c\u308b\u5f37\u3044\u6b63\u96fb\u8377\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PF4\uff08platelet factor 4\uff09\u306f\u3001\u4e3b\u3068\u3057\u3066\u8840\u5c0f\u677f\u306e\u03b1\u9846\u7c92\u306b\u84c4\u3048\u3089\u308c\u3066\u3044\u308b\u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u4e00\u7a2e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u5c0f\u677f\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u8840\u6db2\u4e2d\u3078\u653e\u51fa\u3055\u308c\u3001\u8840\u7ba1\u5185\u76ae\u8868\u9762\u306e\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\u306a\u3069\u306b\u3082\u7d50\u5408\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PF4\u306f4\u3064\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u304b\u3089\u306a\u308b\u30c6\u30c8\u30e9\u30de\u30fc\uff084\u91cf\u4f53\uff09\u3092\u5f62\u6210\u3057\u3001\u5168\u4f53\u3068\u3057\u3066\u5f37\u3044\u6b63\u96fb\u8377\u3092\u5e2f\u3073\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u6027\u8cea\u304c\u3001HIT\u3084VITT\u306e\u75c5\u614b\u3092\u7406\u89e3\u3059\u308b\u91cd\u8981\u306a\u9375\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HIT\u3067\u306f\u300cPF4\uff0b\u30d8\u30d1\u30ea\u30f3\u300d\u304c\u6297\u539f\u306b\u306a\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d8\u30d1\u30ea\u30f3\u306f\u5f37\u3044\u9670\u6027\u8377\u96fb\u3092\u6301\u3064\u30dd\u30ea\u30a2\u30cb\u30aa\u30f3\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PF4\u3068\u30d8\u30d1\u30ea\u30f3\u304c\u9069\u5207\u306a\u6bd4\u7387\u3067\u7d50\u5408\u3059\u308b\u3068\u3001\u591a\u6570\u306ePF4\u5206\u5b50\u304c\u96c6\u5408\u3057\u305f\u9ad8\u5206\u5b50\u8907\u5408\u4f53\u304c\u5f62\u6210\u3055\u308c\u3001\u305d\u308c\u307e\u3067\u514d\u75ab\u7cfb\u304b\u3089\u898b\u3048\u306b\u304f\u304b\u3063\u305f\u6297\u539f\u90e8\u4f4d\u304c\u8a8d\u8b58\u3055\u308c\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3053\u3078IgG\u6297\u4f53\u304c\u7d50\u5408\u3059\u308b\u3068\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PF4\uff0d\u30d8\u30d1\u30ea\u30f3\uff0dIgG\u514d\u75ab\u8907\u5408\u4f53<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u5f62\u6210\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u514d\u75ab\u8907\u5408\u4f53\u304c\u3001\u8840\u5c0f\u677f\u8868\u9762\u306b\u5b58\u5728\u3059\u308bIgG\u53d7\u5bb9\u4f53<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fc\u03b3RIIa<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3092\u67b6\u6a4b\u3059\u308b\u3053\u3068\u3067\u3001\u8840\u5c0f\u677f\u3092\u5f37\u529b\u306b\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-475.png\" alt=\"\" class=\"wp-image-8892\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-475.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-475-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-475-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2\uff0e\u306a\u305c\u300c\u8840\u5c0f\u677f\u304c\u6e1b\u308b\u306e\u306b\u8840\u6813\u304c\u3067\u304d\u308b\u300d\u306e\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Anti-PF4 disorders\u3067\u6700\u3082\u91cd\u8981\u306a\u306e\u304c\u3001\u3053\u306e\u4e00\u898b\u77db\u76fe\u3057\u305f\u73fe\u8c61\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297PF4\u6297\u4f53\u306b\u3088\u3063\u3066\u8840\u5c0f\u677f\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8840\u5c0f\u677f\u51dd\u96c6<\/li>\n\n\n\n<li>\u51dd\u56fa\u4fc3\u9032\u6027\u5fae\u7c92\u5b50\u306e\u653e\u51fa<\/li>\n\n\n\n<li>\u30c8\u30ed\u30f3\u30d3\u30f3\u7523\u751f\u5897\u52a0<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u75c5\u614b\u306f\u8840\u5c0f\u677f\u3060\u3051\u306b\u306f\u3068\u3069\u307e\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5358\u7403<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Fc\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u6d3b\u6027\u5316\u3055\u308c\u3001\u7d44\u7e54\u56e0\u5b50\uff08tissue factor\uff09\u306e\u767a\u73fe\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u597d\u4e2d\u7403<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">NETosis\u304c\u8a98\u5c0e\u3055\u308c\u3001NETs\uff08\u597d\u4e2d\u7403\u7d30\u80de\u5916\u30c8\u30e9\u30c3\u30d7\uff09\u304c\u8840\u7ba1\u5185\u306b\u5f62\u6210\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8840\u7ba1\u5185\u76ae<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u708e\u75c7\u30fb\u51dd\u56fa\u53cd\u5fdc\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u8840\u6813\u5f62\u6210\u3092\u3055\u3089\u306b\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3046\u3057\u3066\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8840\u5c0f\u677f\u6d3b\u6027\u5316 \u2192 \u51dd\u56fa\u6d3b\u6027\u5316 \u2192 \u708e\u75c7 \u2192 \u3055\u3089\u306a\u308b\u8840\u5c0f\u677f\u6d3b\u6027\u5316<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u81ea\u5df1\u5897\u5e45\u30eb\u30fc\u30d7\u304c\u6210\u7acb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>thromboinflammation\uff08\u8840\u6813\u6027\u708e\u75c7\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u547c\u3070\u308c\u308b\u72b6\u614b\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u5c0f\u677f\u306f\u8840\u6813\u5f62\u6210\u306e\u904e\u7a0b\u3067\u5927\u91cf\u306b\u6d88\u8cbb\u3055\u308c\u308b\u305f\u3081\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u8840\u5c0f\u677f\u6e1b\u5c11\u300d\u3068\u300c\u5f37\u3044\u8840\u6813\u50be\u5411\u300d\u304c\u540c\u6642\u306b\u8d77\u3053\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u7279\u5fb4\u7684\u306a\u81e8\u5e8a\u50cf\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-476.png\" alt=\"\" class=\"wp-image-8893\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-476.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-476-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-476-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3\uff0e\u53e4\u5178\u7684HIT\u2015\u2015\u30d8\u30d1\u30ea\u30f3\u6295\u4e0e\u5f8c\u306b\u8d77\u3053\u308b\u4ee3\u8868\u7684Anti-PF4 disorder<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e4\u5178\u7684HIT\uff08classic HIT\uff09\u306f\u3001\u901a\u5e38\u3001\u30d8\u30d1\u30ea\u30f3\u6295\u4e0e\u958b\u59cb\u304b\u30895\uff5e10\u65e5\u524d\u5f8c\u3067\u767a\u75c7\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5178\u578b\u7684\u306b\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8840\u5c0f\u677f\u6570\u304c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308950\uff05\u4ee5\u4e0a\u4f4e\u4e0b\u3059\u308b<\/li>\n\n\n\n<li>\u9759\u8108\u8840\u6813\u75c7<\/li>\n\n\n\n<li>\u80ba\u585e\u6813\u75c7<\/li>\n\n\n\n<li>\u52d5\u8108\u8840\u6813\u75c7<\/li>\n\n\n\n<li>\u30ab\u30c6\u30fc\u30c6\u30eb\u8840\u6813\u75c7<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3092\u8a8d\u3081\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001PF4\uff0d\u30d8\u30d1\u30ea\u30f3\u6297\u4f53\u304c\u691c\u51fa\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u60a3\u8005\u306bHIT\u304c\u767a\u75c7\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297\u4f53\u304c\u5b58\u5728\u3057\u3066\u3044\u3066\u3082\u3001\u5b9f\u969b\u306b\u8840\u5c0f\u677f\u3092\u5f37\u304f\u6d3b\u6027\u5316\u3067\u304d\u308b\u6297\u4f53\u306f\u305d\u306e\u4e00\u90e8\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u95a2\u4fc2\u306f\u3057\u3070\u3057\u3070\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300cHIT\u306e\u30a2\u30a4\u30b9\u30d0\u30fc\u30b0\u30e2\u30c7\u30eb\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3057\u3066\u8aac\u660e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6c34\u9762\u4e0b\u306b\u306f\u591a\u304f\u306e\u6297PF4\uff0f\u30d8\u30d1\u30ea\u30f3\u6297\u4f53\u967d\u6027\u8005\u304c\u5b58\u5728\u3057\u3001\u305d\u306e\u4e2d\u306e\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u80fd\u306e\u5f37\u3044\u4e00\u90e8\u3060\u3051\u304c\u3001\u81e8\u5e8a\u7684\u306aHIT\u3068\u3057\u3066\u8868\u9762\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-477.png\" alt=\"\" class=\"wp-image-8894\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-477.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-477-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-477-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4\uff0e\u81ea\u5df1\u514d\u75ab\u6027HIT\uff08aHIT\uff09\u2015\u2015\u30d8\u30d1\u30ea\u30f3\u3092\u4e2d\u6b62\u3057\u3066\u3082\u75c5\u614b\u304c\u7d9a\u304f\u3053\u3068\u304c\u3042\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u90e8\u306eHIT\u6297\u4f53\u306f\u3001\u901a\u5e38\u306eHIT\u6297\u4f53\u3088\u308a\u3082\u5f37\u3044\u6027\u8cea\u3092\u6301\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3046\u3057\u305f\u6297\u4f53\u3067\u306f\u3001\u30d8\u30d1\u30ea\u30f3\u5b58\u5728\u4e0b\u3060\u3051\u3067\u306a\u304f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30d8\u30d1\u30ea\u30f3\u304c\u5b58\u5728\u3057\u306a\u304f\u3066\u3082\u8840\u5c0f\u677f\u3092\u6d3b\u6027\u5316\u3067\u304d\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u304c\u81ea\u5df1\u514d\u75ab\u6027HIT\uff08autoimmune HIT\uff1aaHIT\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d8\u30d1\u30ea\u30f3\u3092\u4e2d\u6b62\u3057\u3066\u3082\u8840\u5c0f\u677f\u6e1b\u5c11\u304c\u9032\u884c\u3059\u308b<\/li>\n\n\n\n<li>\u8840\u6813\u75c7\u304c\u9077\u5ef6\u3059\u308b<\/li>\n\n\n\n<li>\u901a\u5e38\u306eHIT\u3088\u308a\u91cd\u75c7\u5316\u3059\u308b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u300c\u30d8\u30d1\u30ea\u30f3\u975e\u4f9d\u5b58\u6027\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u80fd\u300d\u306f\u3001Anti-PF4 disorders\u306e\u91cd\u75c7\u5ea6\u3092\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u91cd\u8981\u306a\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5\uff0e\u81ea\u767a\u6027HIT\uff08SpHIT\uff09\u2015\u2015\u30d8\u30d1\u30ea\u30f3\u3092\u4f7f\u3063\u3066\u3044\u306a\u304f\u3066\u3082HIT\u69d8\u75c5\u614b\u304c\u8d77\u3053\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u8208\u5473\u6df1\u3044\u75c5\u614b\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>spontaneous HIT\uff08SpHIT\uff1a\u81ea\u767a\u6027HIT\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6587\u5b57\u901a\u308a\u3001\u660e\u3089\u304b\u306a\u30d8\u30d1\u30ea\u30f3\u66dd\u9732\u304c\u306a\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001HIT\u306b\u6975\u3081\u3066\u4f3c\u305f\u6297PF4\u6297\u4f53\u306b\u3088\u308b\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u304c\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4eba\u5de5\u819d\u95a2\u7bc0\u7f6e\u63db\u8853\u306a\u3069\u306e\u5927\u304d\u306a\u624b\u8853<\/li>\n\n\n\n<li>\u7d44\u7e54\u969c\u5bb3<\/li>\n\n\n\n<li>\u611f\u67d3\u75c7<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u5951\u6a5f\u3068\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7d44\u7e54\u969c\u5bb3\u3084\u611f\u67d3\u306b\u3088\u3063\u3066\u653e\u51fa\u3055\u308c\u308bDNA\u3001RNA\u306a\u3069\u306e\u9670\u6027\u8377\u96fb\u7269\u8cea\u304cPF4\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u30d8\u30d1\u30ea\u30f3\u306b\u4f3c\u305f\u514d\u75ab\u5b66\u7684\u74b0\u5883\u3092\u4f5c\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6\uff0eVITT\u2015\u2015\u30ef\u30af\u30c1\u30f3\u304b\u3089\u59cb\u307e\u3063\u305f\u65b0\u3057\u3044Anti-PF4 disorder<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2021\u5e74\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u30ef\u30af\u30c1\u30f3\u5c0e\u5165\u5f8c\u3001\u3054\u304f\u307e\u308c\u306b\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8840\u5c0f\u677f\u6e1b\u5c11<\/li>\n\n\n\n<li>\u8457\u660e\u306aD-dimer\u4e0a\u6607<\/li>\n\n\n\n<li>\u8133\u9759\u8108\u6d1e\u8840\u6813\u75c7\uff08CVST\uff09<\/li>\n\n\n\n<li>\u5185\u81d3\u9759\u8108\u8840\u6813\u75c7<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3092\u751f\u3058\u308b\u60a3\u8005\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>VITT\uff08vaccine-induced immune thrombocytopenia and thrombosis\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">VITT\u6297\u4f53\u306fHIT\u6297\u4f53\u3068\u306f\u7570\u306a\u308a\u3001\u30d8\u30d1\u30ea\u30f3\u3092\u5fc5\u8981\u3068\u305b\u305aPF4\u305d\u306e\u3082\u306e\u3092\u5f37\u304f\u8a8d\u8b58\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7\uff0e2026\u5e74NEJM\u304c\u660e\u3089\u304b\u306b\u3057\u305fVITT\u306e\u5206\u5b50\u6a5f\u5e8f\u2015\u2015\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9pVII\u3068PF4<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e74\u306b\u306f\u3001VITT\u306e\u6210\u7acb\u904e\u7a0b\u306b\u3064\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u306a\u7814\u7a76\u304cNEJM\u306b\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\u76ee\u3055\u308c\u305f\u306e\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u306ecore protein VII\uff08pVII\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">VITT\u60a3\u8005\u306e\u6297\u4f53\u89e3\u6790\u304b\u3089\u3001PF4\u306b\u53cd\u5fdc\u3059\u308b\u6297\u4f53\u3068pVII\u306b\u53cd\u5fdc\u3059\u308b\u6297\u4f53\u306e\u9593\u306b\u3001\u5171\u901a\u3059\u308b\u30af\u30ed\u30fc\u30f3\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001\u591a\u304f\u306eVITT\u60a3\u8005\u3067\u306f\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u8efd\u9396\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>IGLV3-21*02 \u307e\u305f\u306f *03<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3053\u3078\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>K31E<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3059\u306a\u308f\u306131\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u304c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">lysine\uff08K\uff1a\u30ea\u30b8\u30f3\uff09<br>\u2193<br>glutamic acid\uff08E\uff1a\u30b0\u30eb\u30bf\u30df\u30f3\u9178\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3078\u5909\u5316\u3059\u308b\u7279\u5b9a\u306e\u4f53\u7d30\u80de\u8d85\u5909\u7570\u304c\u52a0\u308f\u308b\u3053\u3068\u3067\u3001\u6297\u4f53\u306e\u6027\u8cea\u304c\u5927\u304d\u304f\u5909\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u6765\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9pVII\u3092\u8a8d\u8b58\u3057\u3066\u3044\u305f\u6297\u4f53\u304c\u3001\u5f37\u3044\u6b63\u96fb\u8377\u3092\u6301\u3064PF4\u3078\u9ad8\u3044\u89aa\u548c\u6027\u3092\u793a\u3059\u3088\u3046\u306b\u306a\u308b\u3068\u3044\u3046\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>molecular mimicry\uff08\u5206\u5b50\u6a21\u5023\uff09\uff0bsomatic hypermutation\uff08\u4f53\u7d30\u80de\u8d85\u5909\u7570\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u3001VITT\u5f62\u6210\u306e\u91cd\u8981\u306a\u5206\u5b50\u6a5f\u5e8f\u3068\u3057\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u304a\u3001\u3053\u308c\u306fVITT\u306e\u75c5\u614b\u3092\u8aac\u660e\u3059\u308b\u975e\u5e38\u306b\u5f37\u529b\u306a\u30e2\u30c7\u30eb\u3067\u3059\u304c\u3001\u3059\u3079\u3066\u306e\u81e8\u5e8a\u72b6\u6cc1\u3092\u5358\u4e00\u306e\u7d4c\u8def\u3060\u3051\u3067\u8aac\u660e\u3067\u304d\u308b\u3068\u65ad\u5b9a\u3059\u308b\u6bb5\u968e\u3067\u306f\u306a\u304f\u3001\u4eca\u5f8c\u3055\u3089\u306b\u7814\u7a76\u304c\u9032\u3080\u9818\u57df\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-478.png\" alt=\"\" class=\"wp-image-8895\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-478.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-478-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-478-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">8\uff0e\u81ea\u7136\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3067\u3082VITT\u69d8\u75c5\u614b\u306f\u8d77\u3053\u308a\u5f97\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">VITT\u3068\u3044\u3046\u540d\u79f0\u304b\u3089\u300c\u30ef\u30af\u30c1\u30f3\u3060\u3051\u3067\u8d77\u3053\u308b\u75c5\u6c17\u300d\u3068\u8003\u3048\u3089\u308c\u304c\u3061\u3067\u3059\u304c\u3001\u73fe\u5728\u3067\u306f\u6975\u3081\u3066\u307e\u308c\u306a\u304c\u3089\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u81ea\u7136\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5f8c\u306b\u3082VITT\u3068\u307b\u307c\u540c\u4e00\u306e\u6297PF4\u6297\u4f53\u304c\u5f62\u6210\u3055\u308c\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066VITT\u306f\u3001\u3088\u308a\u5e83\u3044\u610f\u5473\u3067\u306f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u95a2\u9023Anti-PF4 disorder<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3057\u3066\u7406\u89e3\u3059\u3079\u304d\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">9\uff0eVITT-like MGTS\u2015\u2015\u300c\u4e00\u904e\u6027\u300d\u3067\u306f\u306a\u304f\u6297\u4f53\u304c\u4f5c\u3089\u308c\u7d9a\u3051\u308b\u75c5\u614b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HIT\u3084VITT\u306e\u591a\u304f\u306f\u3001\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u75c5\u539f\u6027\u6297\u4f53\u304c\u6e1b\u5c11\u3057\u3066\u3044\u304f\u6025\u6027\u30fb\u4e00\u904e\u6027\u75be\u60a3\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u8fd1\u5e74\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>VITT-like monoclonal gammopathy of thrombotic significance\uff08VITT-like MGTS\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u65b0\u3057\u3044\u6162\u6027\u75be\u60a3\u6982\u5ff5\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MGTS\u3067\u306f\u3001\u7279\u5b9a\u306e\u5f62\u8cea\u7d30\u80de\u30af\u30ed\u30fc\u30f3\u306a\u3069\u304b\u3089\u7523\u751f\u3055\u308c\u308b\u5358\u30af\u30ed\u30fc\u30f3\u6027\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\uff08M\u30bf\u30f3\u30d1\u30af\uff09\u81ea\u4f53\u304c\u3001\u8840\u5c0f\u677f\u3092\u6d3b\u6027\u5316\u3059\u308b\u6297PF4\u6297\u4f53\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u539f\u56e0\u4e0d\u660e\u306e\u53cd\u5fa9\u6027\u8840\u6813\u75c7<\/li>\n\n\n\n<li>\u6297\u51dd\u56fa\u7642\u6cd5\u4e2d\u306b\u3082\u7e70\u308a\u8fd4\u3059\u8840\u6813\u75c7<\/li>\n\n\n\n<li>\u8840\u5c0f\u677f\u6e1b\u5c11<\/li>\n\n\n\n<li>\u6301\u7d9a\u7684D-dimer\u4e0a\u6607<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3092\u8a8d\u3081\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u975e\u5e38\u306b\u307e\u308c\u306a\u75be\u60a3\u3067\u3059\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u6297\u51dd\u56fa\u3057\u3066\u3044\u308b\u306e\u306b\u306a\u305c\u8840\u6813\u304c\u7e70\u308a\u8fd4\u3055\u308c\u308b\u306e\u304b\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u60a3\u8005\u306e\u80cc\u666f\u306b\u3001\u6297\u4f53\u3092\u4f5c\u308a\u7d9a\u3051\u308b\u8840\u6db2\u5b66\u7684\u30af\u30ed\u30fc\u30f3\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u91cd\u8981\u306a\u75c5\u614b\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-479.png\" alt=\"\" class=\"wp-image-8896\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-479.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-479-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-479-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">10\uff0eAnti-PF4 disorders\u306e\u8a3a\u65ad\u2015\u2015HIT\u3068VITT\u3067\u306f\u691c\u67fb\u306e\u6027\u8cea\u304c\u7570\u306a\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Anti-PF4 disorders\u306e\u8a3a\u65ad\u3067\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u81e8\u5e8a\u72b6\u6cc1\u3068\u691c\u67fb\u7d50\u679c\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u5224\u65ad\u3059\u308b\u3053\u3068<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HIT\u306e\u5834\u5408<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305a\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4Ts score<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3092\u7528\u3044\u3066\u81e8\u5e8a\u7684\u4e8b\u524d\u78ba\u7387\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e2d\u7b49\u5ea6\uff5e\u9ad8\u78ba\u7387\u3067\u3042\u308c\u3070\u3001PF4\uff0f\u30d8\u30d1\u30ea\u30f3\u6297\u4f53\u3092\u6e2c\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ELISA\u306a\u3069\u306e\u514d\u75ab\u6e2c\u5b9a\u6cd5\u306f\u611f\u5ea6\u304c\u9ad8\u3044\u4e00\u65b9\u3067\u3001\u6297\u4f53\u304c\u5b58\u5728\u3059\u308b\u3060\u3051\u3067\u306f\u5b9f\u969b\u306b\u8840\u5c0f\u677f\u3092\u6d3b\u6027\u5316\u3059\u308b\u304b\u3069\u3046\u304b\u307e\u3067\u306f\u5206\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SRA\uff08serotonin-release assay\uff09<\/li>\n\n\n\n<li>HIPA\uff08heparin-induced platelet activation assay\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u306e\u6a5f\u80fd\u7684\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u8a66\u9a13\u3092\u7d44\u307f\u5408\u308f\u305b\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u6a5f\u80fd\u691c\u67fb\u306f\u5c02\u9580\u65bd\u8a2d\u3067\u3057\u304b\u5b9f\u65bd\u3067\u304d\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u3001<strong>\u3059\u3079\u3066\u306e\u75c7\u4f8b\u3067\u6a5f\u80fd\u691c\u67fb\u304c\u306a\u3051\u308c\u3070\u8a3a\u65ad\u3067\u304d\u306a\u3044\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81e8\u5e8a\u78ba\u7387\u3068\u5f37\u967d\u6027\u306e\u514d\u75ab\u6e2c\u5b9a\u7d50\u679c\u304b\u3089\u8a3a\u65ad\u30fb\u6cbb\u7642\u5224\u65ad\u3092\u884c\u3046\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">VITT\u306e\u5834\u5408<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">VITT\u3067\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PF4\u4f9d\u5b58\u6027ELISA<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001HIT\u8a3a\u65ad\u3067\u4f7f\u7528\u3055\u308c\u308b\u4e00\u90e8\u306e\u8fc5\u901f\u514d\u75ab\u6e2c\u5b9a\u6cd5\uff08latex immunoassay\u3084\u4e00\u90e8\u306echemiluminescence assay\u306a\u3069\uff09\u306fVITT\u6297\u4f53\u306b\u5bfe\u3059\u308b\u611f\u5ea6\u304c\u4f4e\u304f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8fc5\u901fHIT\u691c\u67fb\u304c\u9670\u6027\u3060\u304b\u3089VITT\u3092\u5426\u5b9a\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5fc5\u8981\u306b\u5fdc\u3058\u3066PF4\u3092\u6dfb\u52a0\u3057\u305f\u6a5f\u80fd\u691c\u67fb\u306a\u3069\u3092\u5c02\u9580\u65bd\u8a2d\u3067\u884c\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306fHIT\u3068VITT\u3092\u8a3a\u65ad\u3059\u308b\u3046\u3048\u3067\u975e\u5e38\u306b\u91cd\u8981\u306a\u9055\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-480.png\" alt=\"\" class=\"wp-image-8897\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-480.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-480-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-480-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-481.png\" alt=\"\" class=\"wp-image-8898\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-481.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-481-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-481-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">11\uff0e\u6cbb\u7642\u2015\u2015\u5358\u306b\u300c\u8840\u3092\u56fa\u307e\u308a\u306b\u304f\u304f\u3059\u308b\u300d\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u306a\u3053\u3068\u304c\u3042\u308b<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u53e4\u5178\u7684HIT<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">HIT\u304c\u7591\u308f\u308c\u305f\u5834\u5408\u306b\u306f\u3001\u539f\u5247\u3068\u3057\u3066\u30d8\u30d1\u30ea\u30f3\u3092\u4e2d\u6b62\u3057\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30a2\u30eb\u30ac\u30c8\u30ed\u30d0\u30f3<\/li>\n\n\n\n<li>\u30d3\u30d0\u30ea\u30eb\u30b8\u30f3<\/li>\n\n\n\n<li>\u30c0\u30ca\u30d1\u30ed\u30a4\u30c9<\/li>\n\n\n\n<li>\u30d5\u30a9\u30f3\u30c0\u30d1\u30ea\u30cc\u30af\u30b9<\/li>\n\n\n\n<li>\u9069\u5207\u306a\u72b6\u6cc1\u3067\u306eDOAC<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3001\u975e\u30d8\u30d1\u30ea\u30f3\u7cfb\u6297\u51dd\u56fa\u85ac\u3092\u691c\u8a0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-482.png\" alt=\"\" class=\"wp-image-8899\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-482.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-482-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-482-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">aHIT\u30fbVITT\u306a\u3069<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d8\u30d1\u30ea\u30f3\u975e\u4f9d\u5b58\u7684\u306a\u5f37\u3044\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u3092\u4f34\u3046\u75c5\u614b\u3067\u306f\u3001\u6297\u51dd\u56fa\u7642\u6cd5\u3060\u3051\u3067\u306f\u75c5\u614b\u3092\u5341\u5206\u306b\u6291\u3048\u3089\u308c\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u306b\u91cd\u8981\u3068\u306a\u308b\u306e\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9ad8\u7528\u91cf\u9759\u6ce8\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u7642\u6cd5\uff08IVIG\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5927\u91cf\u306e\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u306b\u3088\u3063\u3066\u8840\u5c0f\u677fFc\u03b3RIIa\u3092\u4ecb\u3057\u305f\u75c5\u539f\u6027IgG\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u3048\u3001\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u306e\u9023\u9396\u3092\u906e\u65ad\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306bVITT\u3067\u306f\u3001\u6297\u51dd\u56fa\u7642\u6cd5\u3068\u3068\u3082\u306b\u91cd\u8981\u306a\u6cbb\u7642\u6226\u7565\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-483.png\" alt=\"\" class=\"wp-image-8900\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-483.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-483-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-483-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">12\uff0eFc\u03b3RIIa\u30b7\u30b0\u30ca\u30eb\u3092\u76f4\u63a5\u6b62\u3081\u308b\u2015\u2015BTK\u963b\u5bb3\u3068\u3044\u3046\u65b0\u3057\u3044\u6cbb\u7642\u6982\u5ff5<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u5c0f\u677fFc\u03b3RIIa\u304b\u3089\u7d30\u80de\u5185\u3078\u4f1d\u308f\u308b\u30b7\u30b0\u30ca\u30eb\u306b\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bruton\u2019s tyrosine kinase\uff08BTK\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u305f\u3081\u3001Anti-PF4\u6297\u4f53\u304c\u5b58\u5728\u3057\u3066\u3044\u3066\u3082\u3001\u305d\u306e\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u3092\u906e\u65ad\u3059\u308c\u3070\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u3092\u6291\u3048\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b9f\u969b\u3001\u96e3\u6cbb\u6027MGTS\u306b\u5bfe\u3057\u3066\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ibrutinib<\/li>\n\n\n\n<li>pirtobrutinib<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u306eBTK\u963b\u5bb3\u85ac\u3092\u4f7f\u7528\u3057\u3001\u8840\u5c0f\u677f\u6570\u3084\u51dd\u56fa\u6d3b\u6027\u5316\u3001\u8840\u6813\u30a4\u30d9\u30f3\u30c8\u304c\u6539\u5584\u3057\u305f\u75c7\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u308c\u306f\u73fe\u6642\u70b9\u3067\u306f\u6975\u3081\u3066\u307e\u308c\u306a\u75c5\u614b\u306b\u5bfe\u3059\u308b\u5c02\u9580\u7684\u6cbb\u7642\u3067\u3042\u308a\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Anti-PF4 disorders\u5168\u822c\u306b\u5bfe\u3059\u308b\u6a19\u6e96\u6cbb\u7642\u3068\u3057\u3066\u78ba\u7acb\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5f8c\u306e\u7814\u7a76\u304c\u671f\u5f85\u3055\u308c\u308b\u9818\u57df\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"446\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-486.png\" alt=\"\" class=\"wp-image-8905\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-486.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-486-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-486-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">13\uff0eAnti-PF4 disorders\u304c\u6559\u3048\u3066\u304f\u308c\u308b\u3053\u3068<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Anti-PF4 disorders\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u8840\u5c0f\u677f\u6570\u304c\u4f4e\u3044\uff1d\u51fa\u8840\u3059\u308b\u75c5\u6c17\u300d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u5358\u7d14\u306a\u7406\u89e3\u3067\u306f\u8aac\u660e\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c5\u539f\u6027\u6297\u4f53\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PF4<br>\u2193<br>IgG\u514d\u75ab\u8907\u5408\u4f53<br>\u2193<br>Fc\u03b3RIIa<br>\u2193<br>\u8840\u5c0f\u677f\u30fb\u5358\u7403\u30fb\u597d\u4e2d\u7403\u6d3b\u6027\u5316<br>\u2193<br>\u30c8\u30ed\u30f3\u30d3\u30f3\u7523\u751f<br>\u2193<br>\u8840\u6813\u6027\u708e\u75c7<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u9023\u9396\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8840\u5c0f\u677f\u3092\u6d88\u8cbb\u3057\u306a\u304c\u3089\u3001\u540c\u6642\u306b\u8840\u6813\u3092\u4f5c\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u3001\u4e00\u898b\u77db\u76fe\u3059\u308b\u75c5\u614b\u304c\u6210\u7acb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306bVITT-like MGTS\u306e\u767a\u898b\u306b\u3088\u3063\u3066\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u4e00\u6642\u7684\u306a\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u300d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3060\u3051\u3067\u306f\u306a\u304f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6297PF4\u6297\u4f53\u305d\u306e\u3082\u306e\u3092\u9577\u671f\u9593\u7523\u751f\u3057\u7d9a\u3051\u308b\u8840\u6db2\u5b66\u7684\u30af\u30ed\u30fc\u30f3<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u8840\u6813\u75c7\u306e\u539f\u56e0\u3068\u306a\u308a\u5f97\u308b\u3053\u3068\u307e\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6813\u75c7\u30fb\u514d\u75ab\u5b66\u30fb\u8840\u6db2\u5b66\u306e\u5883\u754c\u304c\u5927\u304d\u304f\u5909\u308f\u308a\u3064\u3064\u3042\u308b\u9818\u57df\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u30af\u30ea\u30cb\u30c3\u30af\u304b\u3089\u306e\u30e1\u30c3\u30bb\u30fc\u30b8<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u306f\u3001\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u30fb\u30ea\u30a6\u30de\u30c1\u5c02\u9580\u533b\u3001\u809d\u81d3\u5c02\u9580\u533b\u304c\u5728\u7c4d\u3057\u3001\u8840\u6db2\u691c\u67fb\u306e\u7570\u5e38\u3092\u5358\u72ec\u306e\u300c\u70b9\u300d\u3068\u3057\u3066\u3067\u306f\u306a\u304f\u3001\u75c7\u72b6\u3001\u670d\u85ac\u6b74\u3001\u65e2\u5f80\u6b74\u3001\u8840\u5c0f\u677f\u6570\u306e\u63a8\u79fb\u3001\u51dd\u56fa\u7cfb\u691c\u67fb\u306a\u3069\u3092\u542b\u3081\u3066\u300c\u7dda\u300d\u3068\u3057\u3066\u6349\u3048\u308b\u8a3a\u7642\u3092\u5927\u5207\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u5c0f\u677f\u6e1b\u5c11\u306b\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u611f\u67d3\u75c7<\/li>\n\n\n\n<li>\u85ac\u5264<\/li>\n\n\n\n<li>\u809d\u75be\u60a3<\/li>\n\n\n\n<li>\u81ea\u5df1\u514d\u75ab\u75be\u60a3<\/li>\n\n\n\n<li>ITP<\/li>\n\n\n\n<li>\u9aa8\u9ac4\u75be\u60a3<\/li>\n\n\n\n<li>HIT\u306a\u3069\u306e\u8840\u6813\u6027\u75be\u60a3<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u539f\u56e0\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6025\u901f\u306a\u8840\u5c0f\u677f\u6e1b\u5c11\u306b\u8840\u6813\u75c7\u3001\u547c\u5438\u56f0\u96e3\u3001\u80f8\u75db\u3001\u7247\u811a\u306e\u816b\u308c\u3001\u5f37\u3044\u982d\u75db\u3001\u795e\u7d4c\u75c7\u72b6\u306a\u3069\u3092\u4f34\u3046\u5834\u5408\u306f\u3001\u7dca\u6025\u6027\u306e\u9ad8\u3044\u75c5\u614b\u3092\u8003\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HIT\u3084VITT\u3001MGTS\u306a\u3069\u304c\u7591\u308f\u308c\u308b\u5834\u5408\u306b\u306f\u3001\u4e00\u822c\u5916\u6765\u3060\u3051\u3067\u5b8c\u7d50\u3059\u308b\u75be\u60a3\u3067\u306f\u306a\u304f\u3001\u8840\u6db2\u5185\u79d1\u30fb\u5faa\u74b0\u5668\u5185\u79d1\u30fb\u6551\u6025\u533b\u7642\u306a\u3069\u5c02\u9580\u533b\u7642\u6a5f\u95a2\u3067\u306e\u8fc5\u901f\u306a\u7cbe\u67fb\u30fb\u6cbb\u7642\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u306f\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u521d\u671f\u8a55\u4fa1\u3092\u884c\u3044\u3001\u9ad8\u6b21\u533b\u7642\u6a5f\u95a2\u3068\u9023\u643a\u3057\u3066\u9069\u5207\u306a\u8a3a\u7642\u306b\u3064\u306a\u3052\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u6297\u51dd\u56fa\u7642\u6cd5\u3084\u514d\u75ab\u6291\u5236\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u6b6f\u79d1\u6cbb\u7642\u6642\u306e\u51fa\u8840\u30ea\u30b9\u30af\u3084\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u3092\u542b\u3081\u3001\u5168\u8eab\u72b6\u614b\u3092\u628a\u63e1\u3057\u305f\u3046\u3048\u3067\u53e3\u8154\u7ba1\u7406\u3092\u884c\u3046\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u306f\u533b\u79d1\u3068\u6b6f\u79d1\u304c\u540c\u4e00\u65bd\u8a2d\u5185\u3067\u9023\u643a\u3057\u3001\u670d\u85ac\u5185\u5bb9\u3084\u5168\u8eab\u72b6\u614b\u3092\u78ba\u8a8d\u3057\u306a\u304c\u3089\u6b6f\u79d1\u8a3a\u7642\u30fb\u53e3\u8154\u885b\u751f\u7ba1\u7406\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c02\u9580\u7684\u53e3\u8154\u30b1\u30a2\u306fAnti-PF4\u6297\u4f53\u305d\u306e\u3082\u306e\u3092\u6cbb\u7642\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3080\u3057\u6b6f\u30fb\u6b6f\u5468\u75c5\u3092\u4e88\u9632\u30fb\u7ba1\u7406\u3057\u3001\u6297\u51dd\u56fa\u7642\u6cd5\u3084\u514d\u75ab\u6291\u5236\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u304c\u5b89\u5168\u306b\u6b6f\u79d1\u6cbb\u7642\u3092\u7d99\u7d9a\u3059\u308b\u305f\u3081\u306e\u57fa\u76e4\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u56e0\u306e\u5206\u304b\u3089\u306a\u3044\u8840\u5c0f\u677f\u6e1b\u5c11\u3084\u5065\u5eb7\u8a3a\u65ad\u306e\u7570\u5e38\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-487.png\" alt=\"\" class=\"wp-image-8907\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-487.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-487-400x225.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/09\/image-487-768x432.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u53d7\u8a3a\u3092\u3054\u5e0c\u671b\u306e\u65b9\u3078<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 <strong>\u3010\u533b\u79d1\u3011\u30a2\u30ec\u30eb\u30ae\u30fc\u30fb\u81a0\u539f\u75c5\u30fb\u30ea\u30a6\u30de\u30c1\u5185\u79d1\uff0f\u7dcf\u5408\u5185\u79d1\uff0f\u767a\u71b1\u5916\u6765\uff0f\u8840\u5c0f\u677f\u6e1b\u5c11\uff0f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff0f\u751f\u6d3b\u7fd2\u6163\u75c5\uff0f\u5065\u5eb7\u8a3a\u65ad\u7570\u5e38\u306a\u3069<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u5c0f\u677f\u6570\u306e\u7570\u5e38\u3084\u539f\u56e0\u4e0d\u660e\u306e\u691c\u67fb\u5024\u7570\u5e38\u306b\u3064\u3044\u3066\u3082\u3001\u75c7\u72b6\u30fb\u670d\u85ac\u6b74\u30fb\u904e\u53bb\u306e\u691c\u67fb\u7d50\u679c\u3092\u542b\u3081\u3066\u8a55\u4fa1\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u203b\u5f53\u9662\u306e\u5185\u79d1\u306f\u571f\u66dc\u65e5\u308217\u6642\u307e\u3067\u8a3a\u7642\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">WEB\u4e88\u7d04\uff1a<br><a href=\"https:\/\/melmo-app.com\/clinic\/673d5e08785f0f0030870bdb\/reservation?method=visit\">https:\/\/melmo-app.com\/clinic\/673d5e08785f0f0030870bdb\/reservation?method=visit<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 <strong>\u3010\u6b6f\u79d1\u3011\u6839\u7ba1\u6cbb\u7642\uff0f\u3080\u3057\u6b6f\uff0f\u6b6f\u5468\u75c5\uff0f\u4e88\u9632\u6b6f\u79d1\uff0f\u53e3\u8154\u30b1\u30a2\uff0f\u6709\u75c5\u8005\u6b6f\u79d1\u306a\u3069<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297\u51dd\u56fa\u85ac\u30fb\u514d\u75ab\u6291\u5236\u85ac\u306a\u3069\u3092\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u65b9\u306b\u3064\u3044\u3066\u3082\u3001\u5168\u8eab\u72b6\u614b\u306b\u914d\u616e\u3057\u306a\u304c\u3089\u8a3a\u7642\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u203b\u5f53\u9662\u306e\u6b6f\u79d1\u306f\u571f\u66dc\u65e514\u6642\u307e\u3067\u8a3a\u7642\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">WEB\u4e88\u7d04\uff1a<br><a href=\"http:\/\/www.gomidental-kashiwa.com\/reservation\/\">http:\/\/www.gomidental-kashiwa.com\/reservation\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udcde <strong>\u304a\u96fb\u8a71\u3067\u306e\u3054\u4e88\u7d04\u30fb\u304a\u554f\u3044\u5408\u308f\u305b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3010\u533b\u79d1\u301104-7196-7531<br>\u3010\u6b6f\u79d1\u301104-7191-7081<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83c\udfe5 <strong>\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3012277-0902<br>\u5343\u8449\u770c\u67cf\u5e02\u5927\u4e95764-1<br>\u5927\u4e95\u4ea4\u5dee\u70b9\u8fd1\u304f\u30fb\u99d0\u8eca\u5834\u5b8c\u5099<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u67cf\u99c5\u6771\u53e3\u3088\u308a\u6771\u6b66\u30d0\u30b9\u3067\u7d0415\u5206\u3001\u300c\u5927\u4e95\u300d\u4e0b\u8eca \u5f92\u6b69\u7d041\u5206\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u3042\u308f\u305b\u3066\u8aad\u307f\u305f\u3044\u95a2\u9023\u8a18\u4e8b<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u2460 \u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u4f34\u3046\u8840\u5c0f\u677f\u6e1b\u5c11\u306b\u3064\u3044\u3066\u77e5\u308a\u305f\u3044\u65b9\u3078<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-1973\/\" target=\"_blank\" rel=\"noopener\">\u3010\u81a0\u539f\u75c5\u30fb\u30ea\u30a6\u30de\u30c1\u5185\u79d1\u3011SLE\u306b\u4f34\u3046\u91cd\u75c7\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u306e\u9451\u5225 \u2014 \u514d\u75ab\u6027\uff08SLE-ITP\uff09\u3068\u85ac\u5264\u6027\uff08DITP\uff09\u306e\u6df7\u5728\u3068\u4f53\u306e\u4ed5\u7d44\u307f<\/a><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u5c0f\u677f\u6e1b\u5c11\u306e\u539f\u56e0\u306fHIT\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SLE\u306a\u3069\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u306f\u3001\u514d\u75ab\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\uff08ITP\uff09\u3001\u85ac\u5264\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\uff08DITP\uff09\u3001\u611f\u67d3\u75c7\u306a\u3069\u3001\u8907\u6570\u306e\u75c5\u614b\u3092\u9451\u5225\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u306a\u305c\u8840\u5c0f\u677f\u304c\u6e1b\u3063\u3066\u3044\u308b\u306e\u304b\u300d\u3092\u75c5\u614b\u3054\u3068\u306b\u6574\u7406\u3057\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2461 \u6297\u51dd\u56fa\u7642\u6cd5\u30fb\u514d\u75ab\u6291\u5236\u7642\u6cd5\u4e2d\u306e\u53e3\u8154\u7ba1\u7406\u306b\u3064\u3044\u3066\u77e5\u308a\u305f\u3044\u65b9\u3078<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-4765\/\" target=\"_blank\" rel=\"noopener\">\u3010\u4e88\u9632\u6b6f\u79d1\u3011\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u7834\u58ca\u305b\u3088\u3002\u5c02\u9580\u7684\u53e3\u8154\u30b1\u30a2\uff08PMTC\uff09\u304c\u5168\u8eab\u306e\u5065\u5eb7\u3092\u5b88\u308b\u4f53\u306e\u4ed5\u7d44\u307f<\/a><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bce\u65e5\u306e\u6b6f\u78e8\u304d\u306b\u52a0\u3048\u3066\u3001\u6b6f\u79d1\u533b\u9662\u3067\u53e3\u8154\u5185\u3092\u5b9a\u671f\u7684\u306b\u8a55\u4fa1\u3057\u3001\u3080\u3057\u6b6f\u3084\u6b6f\u5468\u75c5\u3092\u9069\u5207\u306b\u7ba1\u7406\u3059\u308b\u3053\u3068\u306f\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u6297\u51dd\u56fa\u7642\u6cd5\u3084\u514d\u75ab\u6291\u5236\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u65b9\u3067\u306f\u3001\u5168\u8eab\u72b6\u614b\u3084\u670d\u85ac\u5185\u5bb9\u3092\u628a\u63e1\u3057\u305f\u3046\u3048\u3067\u5b89\u5168\u306b\u6b6f\u79d1\u8a3a\u7642\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u884c\u3063\u3066\u3044\u308b\u533b\u79d1\u6b6f\u79d1\u9023\u643a\u3068\u5c02\u9580\u7684\u53e3\u8154\u7ba1\u7406\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2462 \u8840\u5c0f\u677f\u6570\u3092\u542b\u3080\u5065\u5eb7\u8a3a\u65ad\u30c7\u30fc\u30bf\u3092\u300c\u70b9\u3067\u306f\u306a\u304f\u7dda\u300d\u3067\u8aad\u307f\u305f\u3044\u65b9\u3078<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-4765\/\" target=\"_blank\" rel=\"noopener\">\u3010\u7dcf\u5408\u5185\u79d1\u3011\u5b9a\u671f\u5065\u8a3a\u306e\u8840\u6db2\u30c7\u30fc\u30bf\u3092\u70b9\u304b\u3089\u7dda\u3078\u3002\u81ea\u899a\u75c7\u72b6\u306e\u306a\u3044\u521d\u671f\u75c5\u614b\u3092\u898b\u9003\u3055\u306a\u3044\u5065\u5eb7\u8a3a\u65ad\u306e\u6d3b\u7528\u6cd5<\/a><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u5c0f\u677f\u6570\u3001\u767d\u8840\u7403\u6570\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3001\u809d\u6a5f\u80fd\u3001\u814e\u6a5f\u80fd\u306a\u3069\u306e\u6570\u5024\u306f\u3001\u4e00\u56de\u3060\u3051\u306e\u7570\u5e38\u5024\u3067\u306f\u5224\u65ad\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u904e\u53bb\u304b\u3089\u306e\u63a8\u79fb\u3084\u8907\u6570\u306e\u691c\u67fb\u9805\u76ee\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u5065\u5eb7\u8a3a\u65ad\u306e\u30c7\u30fc\u30bf\u3092\u75c5\u614b\u3068\u3057\u3066\u8aad\u307f\u89e3\u304f\u8003\u3048\u65b9\u3092\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Warkentin TE, Greinacher A. Platelet-Activating Anti\u2013Platelet Factor 4 Disorders. <em>N Engl J Med<\/em>. 2026;395:478-491. doi:10.1056\/NEJMra2502459.<\/li>\n\n\n\n<li>Greinacher A, et al. Adenoviral Inciting Antigen and Somatic Hypermutation in VITT. <em>N Engl J Med<\/em>. 2026;394(7). doi:10.1056\/NEJMoa2514824.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u203b\u672c\u8a18\u4e8b\u306f\u533b\u5b66\u60c5\u5831\u306e\u63d0\u4f9b\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u500b\u3005\u306e\u60a3\u8005\u3055\u3093\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u3092\u4ee3\u66ff\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6025\u6fc0\u306a\u8840\u5c0f\u677f\u6e1b\u5c11\u3001\u80f8\u75db\u3001\u547c\u5438\u56f0\u96e3\u3001\u7247\u811a\u306e\u816b\u308c\u3001\u5f37\u3044\u982d\u75db\u3001\u610f\u8b58\u969c\u5bb3\u30fb\u9ebb\u75fa\u306a\u3069\u304c\u3042\u308b\u5834\u5408\u306b\u306f\u3001\u901f\u3084\u304b\u306b\u6551\u6025\u533b\u7642\u6a5f\u95a2\u3092\u53d7\u8a3a\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained 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