{"id":9143,"date":"2026-10-07T21:57:19","date_gmt":"2026-10-07T12:57:19","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=9143"},"modified":"2026-10-07T22:48:46","modified_gmt":"2026-10-07T13:48:46","slug":"post-9143","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-9143\/","title":{"rendered":"\u96e3\u6cbb\u6027SLE\u30fb\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u30fb\u708e\u75c7\u6027\u7b4b\u75be\u60a3\u306b\u5bfe\u3059\u308bCAR-T\u7d30\u80de\u7642\u6cd5\uff5c\u9577\u671f\u7121\u85ac\u5bdb\u89e3\u3001CRS\u4e88\u6e2c\u56e0\u5b50\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u7279\u6709\u306eLICATS\u3068\u306f"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-37.png\" alt=\"\" class=\"wp-image-9147\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-37.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-37-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-37-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u91cd\u8981\u8981\u70b9<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u3084\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u3001\u76ae\u819a\u7b4b\u708e\u306a\u3069\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u306f\u3001\u514d\u75ab\u3092\u6291\u3048\u308b\u85ac\u3092\u4f55\u5e74\u3082\u7d9a\u3051\u306a\u3051\u308c\u3070\u75c5\u6c17\u3092\u6291\u3048\u3089\u308c\u306a\u3044\u60a3\u8005\u3055\u3093\u304c\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3046\u3057\u305f\u96e3\u6cbb\u4f8b\u306b\u5bfe\u3057\u3066\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001\u3082\u3068\u3082\u3068\u8840\u6db2\u304c\u3093\u306e\u6cbb\u7642\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u305f\u300cCAR-T\u7d30\u80de\u7642\u6cd5\u300d\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u3055\u3093\u81ea\u8eab\u306eT\u7d30\u80de\u3092\u7279\u6b8a\u306a\u65b9\u6cd5\u3067\u4f5c\u308a\u66ff\u3048\u3001\u75c5\u6c17\u306b\u95a2\u4fc2\u3059\u308bB\u7d30\u80de\u3092\u975e\u5e38\u306b\u6df1\u304f\u9664\u53bb\u3059\u308b\u3053\u3068\u3067\u3001\u4e71\u308c\u305f\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u305d\u306e\u3082\u306e\u3092\u4e00\u5ea6\u300c\u30ea\u30bb\u30c3\u30c8\u300d\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2025\u301c2026\u5e74\u306b\u5831\u544a\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u5f93\u6765\u6cbb\u7642\u304c\u52b9\u304d\u306b\u304f\u304b\u3063\u305fSLE\u3001\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u3001\u7279\u767a\u6027\u708e\u75c7\u6027\u7b4b\u75be\u60a3\u306a\u3069\u3067\u3001\u85ac\u3092\u4e2d\u6b62\u3057\u305f\u307e\u307e\u9577\u671f\u9593\u75c5\u6c17\u304c\u843d\u3061\u7740\u304f\u300c\u7121\u85ac\u5bdb\u89e3\u300d\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001CAR-T\u7642\u6cd5\u306b\u306f\u767a\u71b1\u3084\u8840\u5727\u4f4e\u4e0b\u3092\u4f34\u3046\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u75c7\u5019\u7fa4\uff08CRS\uff09\u306a\u3069\u306e\u526f\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u306f\u3001\u3082\u3068\u3082\u3068\u75c5\u6c17\u306b\u4fb5\u3055\u308c\u3066\u3044\u305f\u76ae\u819a\u3001\u814e\u81d3\u3001\u7b4b\u8089\u306a\u3069\u306b\u4e00\u6642\u7684\u306a\u708e\u75c7\u304c\u8d77\u3053\u308b\u300cLICATS\u300d\u3068\u3044\u3046\u65b0\u3057\u3044\u526f\u4f5c\u7528\u306e\u6982\u5ff5\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u306f\u307e\u3060\u9650\u3089\u308c\u305f\u65bd\u8a2d\u30fb\u7814\u7a76\u6bb5\u968e\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u6cbb\u7642\u3067\u3059\u304c\u3001\u300c\u9577\u671f\u9593\u85ac\u3092\u7d9a\u3051\u3066\u75c5\u6c17\u3092\u6291\u3048\u308b\u300d\u3068\u3044\u3046\u5f93\u6765\u306e\u81a0\u539f\u75c5\u6cbb\u7642\u304b\u3089\u3001\u300c\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u305d\u306e\u3082\u306e\u3092\u518d\u69cb\u7bc9\u3059\u308b\u300d\u3068\u3044\u3046\u65b0\u3057\u3044\u65b9\u5411\u6027\u3092\u793a\u3059\u6cbb\u7642\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CAR-T\u7d30\u80de\u7642\u6cd5\u3068\u306f\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\uff08Chimeric Antigen Receptor T-cell\uff1a\u30ad\u30e1\u30e9\u6297\u539f\u53d7\u5bb9\u4f53T\u7d30\u80de\uff09\u7642\u6cd5\u306f\u3001\u60a3\u8005\u3055\u3093\u81ea\u8eab\u306eT\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3001\u7279\u5b9a\u306e\u7d30\u80de\u3092\u8a8d\u8b58\u3057\u3066\u653b\u6483\u3067\u304d\u308b\u3088\u3046\u907a\u4f1d\u5b50\u6539\u5909\u3057\u305f\u3046\u3048\u3067\u4f53\u5185\u3078\u623b\u3059\u7d30\u80de\u6cbb\u7642\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3082\u3068\u3082\u3068\u306fB\u7d30\u80de\u6027\u767d\u8840\u75c5\u3084\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306a\u3069\u306e\u8840\u6db2\u60aa\u6027\u816b\u760d\u306b\u5bfe\u3057\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u306f\u3001\u591a\u304f\u306e\u75c5\u614b\u306bB\u7d30\u80de\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B\u7d30\u80de\u306f\u5358\u306b\u6297\u4f53\u3092\u4f5c\u308b\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u81ea\u5df1\u6297\u4f53\u306e\u7523\u751f<\/li>\n\n\n\n<li>\u81ea\u5df1\u6297\u539f\u306e\u63d0\u793a<\/li>\n\n\n\n<li>T\u7d30\u80de\u306e\u6d3b\u6027\u5316<\/li>\n\n\n\n<li>\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f<\/li>\n\n\n\n<li>\u81ea\u5df1\u514d\u75ab\u306e\u300c\u8a18\u61b6\u300d\u306e\u7dad\u6301<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3053\u3067CD19\u306a\u3069\u3092\u6a19\u7684\u3068\u3059\u308bCAR-T\u7d30\u80de\u3092\u5229\u7528\u3057\u3001\u5f93\u6765\u306e\u6297CD20\u6297\u4f53\u306a\u3069\u3067\u306f\u5341\u5206\u306b\u9664\u53bb\u3067\u304d\u306a\u304b\u3063\u305fB\u7d30\u80de\u96c6\u56e3\u307e\u3067\u6df1\u304f\u67af\u6e07\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u305d\u306e\u3082\u306e\u3092\u30ea\u30bb\u30c3\u30c8\u3067\u304d\u306a\u3044\u304b\u3001\u3068\u3044\u3046\u8003\u3048\u65b9\u304c\u751f\u307e\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-40.png\" alt=\"\" class=\"wp-image-9151\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-40.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-40-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-40-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">1\uff0e\u96e3\u6cbb\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u5831\u544a\u3055\u308c\u305f\u9ad8\u3044\u6cbb\u7642\u53cd\u5fdc<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e74\u306eRMD Open\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u96e3\u6cbb\u6027\u81ea\u5df1\u514d\u75ab\u6027\u30ea\u30a6\u30de\u30c1\u75be\u60a3\u306b\u5bfe\u3059\u308bCAR-T\u7642\u6cd5\u3092\u691c\u8a0e\u3057\u305f12\u7814\u7a76\u3001\u8a0844\u4f8b\u304c\u89e3\u6790\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bfe\u8c61\u306b\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u30fb\u30eb\u30fc\u30d7\u30b9\u814e\u708e<\/li>\n\n\n\n<li>\u5168\u8eab\u6027\u5f37\u76ae\u75c7\uff08SSc\uff09<\/li>\n\n\n\n<li>\u7279\u767a\u6027\u708e\u75c7\u6027\u7b4b\u75be\u60a3\uff08IIM\uff09<\/li>\n\n\n\n<li>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1<\/li>\n\n\n\n<li>\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c5<\/li>\n\n\n\n<li>\u6297ARS\u6297\u4f53\u75c7\u5019\u7fa4<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u3055\u3093\u306f\u6cbb\u7642\u62b5\u6297\u6027\u304c\u5f37\u304f\u3001CAR-T\u7642\u6cd5\u524d\u306b\u306f\u4e2d\u592e\u50245\u7a2e\u985e\u306e\u6cbb\u7642\u6b74\u3092\u6709\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5831\u544a\u3055\u308c\u305f\u5404\u7814\u7a76\u3067\u306f92\u301c100%\u3068\u3044\u3046\u9ad8\u3044\u81e8\u5e8a\u53cd\u5fdc\u7387\u304c\u8a8d\u3081\u3089\u308c\u3001\u5b8c\u5168\u594f\u52b9\u30fb\u5bdb\u89e3\u306fCAR-T\u6295\u4e0e\u5f8c\u304a\u304a\u3080\u306d2\u301c16\u9031\u9593\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u30016\u301c46\u304b\u6708\u306b\u308f\u305f\u308a\u514d\u75ab\u6291\u5236\u85ac\u3092\u4f7f\u7528\u305b\u305a\u5bdb\u89e3\u3092\u7dad\u6301\u3057\u305f\u300cDrug-Free Remission\uff08\u7121\u85ac\u5bdb\u89e3\uff09\u300d\u3082\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306f\u81a0\u539f\u75c5\u8a3a\u7642\u306b\u3068\u3063\u3066\u975e\u5e38\u306b\u91cd\u8981\u306a\u6982\u5ff5\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f93\u6765\u6cbb\u7642\u306e\u591a\u304f\u306f\u300c\u85ac\u3092\u7d99\u7d9a\u3057\u3066\u3044\u308b\u9593\u3001\u514d\u75ab\u53cd\u5fdc\u3092\u6291\u3048\u308b\u300d\u6cbb\u7642\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9CAR-T\u7642\u6cd5\u3067\u306f\u3001\u4e00\u5ea6\u306e\u7d30\u80de\u7642\u6cd5\u306b\u3088\u3063\u3066\u75c5\u7684\u306aB\u7d30\u80de\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u5927\u304d\u304f\u518d\u69cb\u7bc9\u3057\u3001\u305d\u306e\u5f8c\u85ac\u3092\u4f7f\u7528\u3057\u306a\u304f\u3066\u3082\u514d\u75ab\u5b66\u7684\u5bdb\u89e3\u304c\u7dad\u6301\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-42.png\" alt=\"\" class=\"wp-image-9153\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-42.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-42-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-42-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u81ea\u5df1\u6297\u4f53\u3082\u5927\u304d\u304f\u4f4e\u4e0b\u3059\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u75be\u60a3\u95a2\u9023\u81ea\u5df1\u6297\u4f53\u304c\u5168\u4f53\u3068\u3057\u306680\u301c99%\u7a0b\u5ea6\u4f4e\u4e0b\u3059\u308b\u306a\u3069\u3001\u5f37\u3044\u514d\u75ab\u5b66\u7684\u5909\u5316\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SLE\u3067\u306f\u6297dsDNA\u6297\u4f53\u3084\u6297\u30ea\u30f3\u8102\u8cea\u6297\u4f53\u3001\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u3067\u306f\u75be\u60a3\u7279\u7570\u7684\u81ea\u5df1\u6297\u4f53\u306a\u3069\u304c\u8457\u660e\u306b\u4f4e\u4e0b\u3001\u3042\u308b\u3044\u306f\u9670\u6027\u5316\u3057\u305f\u75c7\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u308c\u306f\u300cCAR-T\u7642\u6cd5\u306b\u3088\u3063\u3066\u3059\u3079\u3066\u306e\u81ea\u5df1\u6297\u4f53\u304c\u5fc5\u305a\u6d88\u5931\u3059\u308b\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u88fd\u5264\u306e\u6a19\u7684\u3001\u75be\u60a3\u3001\u65e2\u5b58\u306e\u5f62\u8cea\u7d30\u80de\u306e\u5bff\u547d\u306a\u3069\u306b\u3088\u3063\u3066\u53cd\u5fdc\u306f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u9577\u5bff\u547d\u5f62\u8cea\u7d30\u80de\u306fCD19\u3092\u5341\u5206\u767a\u73fe\u3057\u306a\u3044\u5834\u5408\u304c\u3042\u308b\u305f\u3081\u3001\u8fd1\u5e74\u306fCD19\u306b\u52a0\u3048\u3066BCMA\u306a\u3069\u3092\u6a19\u7684\u3068\u3059\u308b\u4e8c\u91cd\u6a19\u7684CAR-T\u7642\u6cd5\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-43.png\" alt=\"\" class=\"wp-image-9154\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-43.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-43-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-43-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u306a\u305c\u901a\u5e38\u306eB\u7d30\u80de\u9664\u53bb\u7642\u6cd5\u3088\u308a\u6df1\u3044\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u306e\u304b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297CD20\u6297\u4f53\u306a\u3069\u306e\u751f\u7269\u5b66\u7684\u88fd\u5264\u3067\u3082\u672b\u68a2\u8840\u4e2d\u306eB\u7d30\u80de\u306f\u5927\u304d\u304f\u6e1b\u5c11\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u30ea\u30f3\u30d1\u7bc0\u3001\u9aa8\u9ac4\u3001\u708e\u75c7\u7d44\u7e54\u306a\u3069\u306b\u5b58\u5728\u3059\u308bB\u7d30\u80de\u306e\u4e00\u90e8\u306f\u6b8b\u5b58\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u306f\u4f53\u5185\u3067\u5897\u6b96\u3057\u306a\u304c\u3089\u6a19\u7684\u7d30\u80de\u3092\u63a2\u7d22\u3059\u308b\u305f\u3081\u3001\u3088\u308a\u6df1\u3044B\u7d30\u80de\u9664\u53bb\u3092\u9054\u6210\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u75c5\u539f\u6027B\u7d30\u80de\u306e\u9664\u53bb\u300d<br>\u2193<br>\u300c\u81ea\u5df1\u6297\u4f53\u30fb\u6297\u539f\u63d0\u793a\u306e\u4f4e\u4e0b\u300d<br>\u2193<br>\u300cT\u7d30\u80de-B\u7d30\u80de\u9593\u306e\u7570\u5e38\u306a\u514d\u75ab\u56de\u8def\u306e\u89e3\u9664\u300d<br>\u2193<br>\u300c\u65b0\u3057\u3044B\u7d30\u80de\u96c6\u56e3\u306e\u518d\u69cb\u7bc9\u300d<br>\u2193<br>\u300c\u81ea\u5df1\u514d\u75ab\u5bdb\u5bb9\u306e\u518d\u5f62\u6210\u300d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u3001\u3044\u308f\u3070\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u300c\u518d\u8d77\u52d5\u300d\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u306e\u201cimmune reset\u201d\u306e\u8a73\u3057\u3044\u6a5f\u5e8f\u306f\u307e\u3060\u7814\u7a76\u6bb5\u968e\u3067\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u60a3\u8005\u3067\u540c\u3058\u3088\u3046\u306b\u8d77\u3053\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-52.png\" alt=\"\" class=\"wp-image-9164\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-52.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-52-400x225.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-52-768x432.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">2\uff0eCAR-T\u7642\u6cd5\u6700\u5927\u306e\u6025\u6027\u6bd2\u6027\u300cCRS\u300d<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u3067\u6700\u3082\u3088\u304f\u77e5\u3089\u308c\u308b\u526f\u4f5c\u7528\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u75c7\u5019\u7fa4\uff08Cytokine Release Syndrome\uff1aCRS\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u304c\u6a19\u7684\u7d30\u80de\u3092\u653b\u6483\u3059\u308b\u3068\u5927\u91cf\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u653e\u51fa\u3055\u308c\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u767a\u71b1<\/li>\n\n\n\n<li>\u5026\u6020\u611f<\/li>\n\n\n\n<li>\u983b\u8108<\/li>\n\n\n\n<li>\u4f4e\u8840\u5727<\/li>\n\n\n\n<li>\u4f4e\u9178\u7d20\u8840\u75c7<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6db2\u60aa\u6027\u816b\u760d\u306b\u5bfe\u3059\u308bCAR-T\u7642\u6cd5\u3067\u306f\u3001\u91cd\u75c7CRS\u304c\u96c6\u4e2d\u6cbb\u7642\u3092\u5fc5\u8981\u3068\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306eCRS\u306f\u6bd4\u8f03\u7684\u8efd\u75c7\u304c\u591a\u3044<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e74\u306bThe Lancet Rheumatology\u3067\u5831\u544a\u3055\u308c\u305f\u3001\u30c9\u30a4\u30c46\u65bd\u8a2d\u30fb\u4e2d\u56fd1\u65bd\u8a2d\u306e\u8a08108\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305f\u591a\u65bd\u8a2d\u5f8c\u308d\u5411\u304d\u7814\u7a76\u3067\u306f\u3001CAR-T\u6295\u4e0e\u5f8c\u306b86\u4f8b\uff0880%\uff09\u3067CRS\u304c\u767a\u751f\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5185\u8a33\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Grade 1\uff1a71\u4f8b\uff0866%\uff09<\/li>\n\n\n\n<li>Grade 2\uff1a14\u4f8b\uff0813%\uff09<\/li>\n\n\n\n<li>Grade 3\uff1a1\u4f8b\uff081%\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001CRS\u81ea\u4f53\u306f\u6c7a\u3057\u3066\u73cd\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u306fGrade 1\u301c2\u306e\u8efd\u75c7\u301c\u4e2d\u7b49\u75c7\u3067\u3042\u308a\u3001\u91cd\u75c7CRS\u306f\u975e\u5e38\u306b\u5c11\u306a\u3044\u3068\u3044\u3046\u7279\u5fb4\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ICANS\uff08immune effector cell-associated neurotoxicity syndrome\uff1a\u514d\u75ab\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u95a2\u9023\u795e\u7d4c\u6bd2\u6027\u75c7\u5019\u7fa4\uff09\u3082108\u4f8b\u4e2d3\u4f8b\uff083%\uff09\u306b\u3068\u3069\u307e\u308a\u3001Grade 3\u4ee5\u4e0a\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-44.png\" alt=\"\" class=\"wp-image-9155\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-44.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-44-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-44-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">CRS\u3092\u4e88\u6e2c\u3059\u308b\u300c\u6295\u4e0e\u524dB\u7d30\u80de\u6570\u300d\u3068IL-6<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e108\u4f8b\u306e\u7814\u7a76\u3067\u975e\u5e38\u306b\u8208\u5473\u6df1\u304b\u3063\u305f\u306e\u304c\u3001CAR-T\u6295\u4e0e\u524d\u306e\u72b6\u614b\u304b\u3089CRS\u767a\u75c7\u30ea\u30b9\u30af\u3092\u3042\u308b\u7a0b\u5ea6\u4e88\u6e2c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CRS\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u3067\u306f\u3001\u767a\u75c7\u3057\u306a\u304b\u3063\u305f\u60a3\u8005\u3088\u308a\u3082\u6295\u4e0e\u524d\u306e<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>B\u7d30\u80de\u6570<\/li>\n\n\n\n<li>IL-6<\/li>\n\n\n\n<li>CRP<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u9ad8\u5024\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u591a\u5909\u91cf\u89e3\u6790\u3067\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B\u7d30\u80de\u6570\u9ad8\u5024\uff1aOR 1.31<br>IL-6\u9ad8\u5024\uff1aOR 2.28<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304cCRS\u767a\u75c7\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u304c\u653b\u6483\u3059\u308b\u300c\u6a19\u7684\u3068\u306a\u308bB\u7d30\u80de\u300d\u304c\u591a\u3051\u308c\u3070\u3001\u305d\u308c\u3060\u3051CAR-T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3082\u5927\u304d\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u6cbb\u7642\u524d\u304b\u3089IL-6\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u708e\u75c7\u72b6\u614b\u304c\u5b58\u5728\u3059\u308c\u3070\u3001CAR-T\u306b\u3088\u308b\u514d\u75ab\u53cd\u5fdc\u304c\u5897\u5e45\u3055\u308c\u3084\u3059\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c06\u6765\u7684\u306b\u306f\u3053\u3046\u3057\u305f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u7528\u3044\u3066\u3001\u60a3\u8005\u3054\u3068\u306bCRS\u306e\u30ea\u30b9\u30af\u3092\u5c64\u5225\u5316\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-45.png\" alt=\"\" class=\"wp-image-9156\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-45.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-45-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-45-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">AI\u306b\u3088\u308bCRS\u4e88\u6e2c\u7814\u7a76\u3082\u9032\u3093\u3067\u3044\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5225\u306e\u8840\u6db2\u60aa\u6027\u816b\u760dCAR-T\u7814\u7a76\u3067\u306f\u3001\u4f53\u6e29\u3001\u8840\u5727\u3001CRP\u3001\u30d5\u30a3\u30d6\u30ea\u30ce\u30b2\u30f3\u3001\u8840\u6e05Na\u3001\u30ea\u30f3\u30d1\u7403\u6570\u306a\u3069\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6a5f\u68b0\u5b66\u7fd2\u30e2\u30c7\u30eb\u306b\u3088\u3063\u3066\u3001CRS\u767a\u75c7\u309224\u301c72\u6642\u9593\u524d\u304b\u3089\u4e88\u6e2c\u3059\u308b\u8a66\u307f\u3082\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u306eAI\u30e2\u30c7\u30eb\u306f\u30ea\u30f3\u30d1\u816b\u30fb\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u3042\u308a\u3001\u73fe\u6642\u70b9\u3067\u81ea\u5df1\u514d\u75ab\u75be\u60a3CAR-T\u60a3\u8005\u306b\u305d\u306e\u307e\u307e\u9069\u7528\u3067\u304d\u308b\u3068\u8a3c\u660e\u3055\u308c\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u9818\u57df\u3067\u306f\u3001\u307e\u305a\u6295\u4e0e\u524dB\u7d30\u80de\u6570\u3084IL-6\u306a\u3069\u3001\u3088\u308a\u5358\u7d14\u306a\u81e8\u5e8a\u6307\u6a19\u306b\u3088\u308b\u30ea\u30b9\u30af\u5c64\u5225\u5316\u306e\u6709\u7528\u6027\u304c\u793a\u3055\u308c\u59cb\u3081\u305f\u6bb5\u968e\u3068\u8003\u3048\u308b\u306e\u304c\u9069\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\uff0e\u81ea\u5df1\u514d\u75ab\u75be\u60a3CAR-T\u7279\u6709\u306e\u65b0\u3057\u3044\u526f\u4f5c\u7528\u300cLICATS\u300d<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306bCAR-T\u7642\u6cd5\u3092\u5fdc\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u9818\u57df\u3067\u306f\u3042\u307e\u308a\u8a8d\u8b58\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305f\u65b0\u3057\u3044\u6709\u5bb3\u4e8b\u8c61\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2025\u5e74\u3001The Lancet Rheumatology\u306b\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Local Immune Effector Cell-Associated Toxicity Syndrome\uff08LICATS\uff09<br>\u5c40\u6240\u514d\u75ab\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u95a2\u9023\u6bd2\u6027\u75c7\u5019\u7fa4<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u65b0\u3057\u3044\u6982\u5ff5\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-46.png\" alt=\"\" class=\"wp-image-9157\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-46.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-46-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-46-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">LICATS\u306f\u300c\u3082\u3068\u3082\u3068\u75c5\u5909\u304c\u3042\u3063\u305f\u81d3\u5668\u300d\u306b\u8d77\u3053\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7814\u7a76\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SLE\uff1a20\u4f8b<\/li>\n\n\n\n<li>\u5168\u8eab\u6027\u5f37\u76ae\u75c7\uff1a13\u4f8b<\/li>\n\n\n\n<li>\u7279\u767a\u6027\u708e\u75c7\u6027\u7b4b\u75be\u60a3\uff1a6\u4f8b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8a0839\u4f8b\u304c\u89e3\u6790\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u3046\u306130\u4f8b\uff0877%\uff09\u306b\u3001\u8a0854\u4ef6\u306eLICATS\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u975e\u5e38\u306b\u7279\u5fb4\u7684\u3060\u3063\u305f\u306e\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>LICATS\u304c\u3001\u305d\u306e\u60a3\u8005\u3055\u3093\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u3088\u3063\u3066\u4ee5\u524d\u304b\u3089\u969c\u5bb3\u3055\u308c\u3066\u3044\u305f\u81d3\u5668\u3060\u3051\u306b\u767a\u751f\u3057\u305f<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u3082\u591a\u304b\u3063\u305f\u306e\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u76ae\u819a\uff1a19\u4ef6\uff0835%\uff09<\/li>\n\n\n\n<li>\u814e\u81d3\uff1a12\u4ef6\uff0822%\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u4ed6\u306b\u3082\u7b4b\u9aa8\u683c\u7cfb\u306a\u3069\u3001\u65e2\u5b58\u75c5\u5909\u90e8\u4f4d\u3092\u4e2d\u5fc3\u306b\u5c40\u6240\u708e\u75c7\u304c\u751f\u3058\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u767a\u75c7\u6642\u671f\u4e2d\u592e\u5024\u306fCAR-T\u6295\u4e0e\u5f8c10\u65e5\u3067\u3001B\u7d30\u80de\u7121\u5f62\u6210\u671f\u306b\u9650\u3063\u3066\u767a\u751f\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-47.png\" alt=\"\" class=\"wp-image-9158\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-47.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-47-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-47-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">CRS\u3068\u306f\u7570\u306a\u308b\u708e\u75c7\u53cd\u5fdc<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">CRS\u306f\u5168\u8eab\u6027\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u306b\u3088\u3063\u3066\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9LICATS\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u904e\u53bb\u306b\u81ea\u5df1\u514d\u75ab\u708e\u75c7\u304c\u5b58\u5728\u3057\u305f\u81d3\u5668\u5c40\u6240\u306b\u9650\u5c40\u3059\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u70b9\u304c\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001CAR-T\u6cbb\u7642\u5f8c\u306b\u4e00\u6642\u7684\u306b<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u76ae\u75b9\u304c\u60aa\u5316\u3059\u308b<\/li>\n\n\n\n<li>\u86cb\u767d\u5c3f\u304c\u5897\u3048\u308b<\/li>\n\n\n\n<li>\u814e\u6a5f\u80fd\u304c\u5909\u52d5\u3059\u308b<\/li>\n\n\n\n<li>\u7b4b\u8089\u75db\u3084\u95a2\u7bc0\u75db\u304c\u8d77\u3053\u308b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3063\u305f\u75c7\u72b6\u304c\u51fa\u73fe\u3057\u305f\u5834\u5408\u3001\u5358\u7d14\u306b\u300c\u539f\u75be\u60a3\u304c\u518d\u71c3\u3057\u305f\u300d\u3068\u5224\u65ad\u3057\u3066\u3057\u307e\u3046\u3068\u3001\u6cbb\u7642\u65b9\u91dd\u3092\u8aa4\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u300cClean-up reaction\u300d\u3068\u3044\u3046\u4eee\u8aac<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">LICATS\u306e\u6b63\u78ba\u306a\u75c5\u614b\u306f\u307e\u3060\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5728\u63d0\u5531\u3055\u308c\u3066\u3044\u308b\u4eee\u8aac\u306e\u4e00\u3064\u304c\u3001\u75c5\u5909\u7d44\u7e54\u5185\u306b\u5b58\u5728\u3059\u308bB\u7d30\u80de\u3092CAR-T\u7d30\u80de\u304c\u6025\u901f\u306b\u9664\u53bb\u3059\u308b\u904e\u7a0b\u3067\u8d77\u3053\u308b\u5c40\u6240\u708e\u75c7\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u306b\u3088\u3063\u3066B\u7d30\u80de\u304c\u6b7b\u6ec5\u3059\u308b\u3068\u3001\u305d\u306e\u7d30\u80de\u6210\u5206\u3092\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u8caa\u98df\u7d30\u80de\u304c\u51e6\u7406\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u5c40\u6240\u7684\u306a\u300c\u514d\u75ab\u7d30\u80de\u306e\u6e05\u6383\u904e\u7a0b\u300d\u306b\u4f34\u3063\u3066\u4e00\u6642\u7684\u306a\u708e\u75c7\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3044\u308f\u3070\u201cclean-up reaction\u201d\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u308c\u306f\u73fe\u6642\u70b9\u3067\u306f\u75c5\u614b\u4eee\u8aac\u3067\u3042\u308a\u3001\u78ba\u7acb\u3057\u305f\u6a5f\u5e8f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-53.png\" alt=\"\" class=\"wp-image-9166\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-53.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-53-400x225.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-53-768x432.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">LICATS\u306e\u591a\u304f\u306f\u81ea\u7136\u8efd\u5feb\u3059\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">54\u4ef6\u306eLICATS\u306e\u3046\u3061\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Grade 1\uff1a35\u4ef6\uff0865%\uff09<\/li>\n\n\n\n<li>Grade 2\uff1a16\u4ef6\uff0830%\uff09<\/li>\n\n\n\n<li>Grade 3\uff1a3\u4ef6<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Grade 1\u306f\u81ea\u7136\u8efd\u5feb\u3057\u3001Grade 2\u3067\u306f\u75c7\u72b6\u3084\u81d3\u5668\u969c\u5bb3\u306b\u5fdc\u3058\u3066\u77ed\u671f\u9593\u306e\u526f\u814e\u76ae\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9\u6cbb\u7642\u306a\u3069\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u306a\u306e\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5168LICATS\u30a4\u30d9\u30f3\u30c8\u304c\u5f8c\u907a\u75c7\u306a\u304f\u6539\u5584\u3057\u305f<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u5f8c\u306e\u81d3\u5668\u75c7\u72b6\u3092\u3059\u3079\u3066\u539f\u75be\u60a3\u518d\u71c3\u3068\u3057\u3066\u5f37\u304f\u514d\u75ab\u6291\u5236\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u306f\u306a\u304f\u3001CRS\u3001\u611f\u67d3\u75c7\u3001\u539f\u75be\u60a3\u518d\u71c3\u3001LICATS\u3092\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-54.png\" alt=\"\" class=\"wp-image-9168\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-54.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-54-400x225.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-54-768x432.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">4\uff0eCAR-T\u7642\u6cd5\u306f\u300c\u81a0\u539f\u75c5\u3092\u6cbb\u3059\u6cbb\u7642\u300d\u306a\u306e\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u6642\u70b9\u3067\u306f\u3001\u300cCAR-T\u7642\u6cd5\u306b\u3088\u3063\u3066\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u304c\u6839\u6cbb\u3059\u308b\u300d\u3068\u65ad\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u78ba\u304b\u306b\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u5f93\u6765\u6cbb\u7642\u3067\u306f\u5f97\u306b\u304f\u304b\u3063\u305f\u9577\u671f\u9593\u306e\u7121\u85ac\u5bdb\u89e3\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u30012026\u5e74\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3067\u3082\u5bfe\u8c61\u306f44\u4f8b\u306b\u3059\u304e\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u75c7\u4f8b\u5831\u544a\u30fb\u30b1\u30fc\u30b9\u30b7\u30ea\u30fc\u30ba\u304c\u591a\u3044<\/li>\n\n\n\n<li>\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u304c\u307b\u307c\u306a\u3044<\/li>\n\n\n\n<li>\u91cd\u75c7\u30fb\u96e3\u6cbb\u4f8b\u3092\u9078\u629e\u3057\u3066\u3044\u308b<\/li>\n\n\n\n<li>CAR-T\u88fd\u5264\u3084\u6a19\u7684\u304c\u7d71\u4e00\u3055\u308c\u3066\u3044\u306a\u3044<\/li>\n\n\n\n<li>\u89b3\u5bdf\u671f\u9593\u304c\u307e\u3060\u77ed\u3044<\/li>\n\n\n\n<li>\u82e5\u5e74\u8005\u4e2d\u5fc3\u3067\u3042\u308b<\/li>\n\n\n\n<li>\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3063\u305f\u91cd\u8981\u306a\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u73fe\u5728\u306e\u4f4d\u7f6e\u3065\u3051\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u975e\u5e38\u306b\u6709\u671b\u306a\u514d\u75ab\u30ea\u30bb\u30c3\u30c8\u7642\u6cd5\u3067\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u9577\u671f\u7684\u306a\u6709\u52b9\u6027\u30fb\u5b89\u5168\u6027\u30fb\u9069\u5207\u306a\u60a3\u8005\u9078\u629e\u306b\u3064\u3044\u3066\u306f\u4eca\u5f8c\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u5fc5\u8981\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u6bb5\u968e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u9577\u671f\u5b89\u5168\u6027\u3082\u91cd\u8981<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u3067\u306fCRS\u3084LICATS\u3060\u3051\u3067\u306a\u304f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u597d\u4e2d\u7403\u6e1b\u5c11<\/li>\n\n\n\n<li>\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11<\/li>\n\n\n\n<li>\u611f\u67d3\u75c7<\/li>\n\n\n\n<li>\u4f4e\u03b3\u30b0\u30ed\u30d6\u30ea\u30f3\u8840\u75c7<\/li>\n\n\n\n<li>B\u7d30\u80de\u7121\u5f62\u6210<\/li>\n\n\n\n<li>ICANS<\/li>\n\n\n\n<li>\u30ea\u30f3\u30d1\u7403\u9664\u53bb\u5316\u5b66\u7642\u6cd5\u306b\u4f34\u3046\u6bd2\u6027<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u306b\u3082\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081CAR-T\u7642\u6cd5\u306f\u3001\u30ea\u30a6\u30de\u30c1\u30fb\u81a0\u539f\u75c5\u5185\u79d1\u3060\u3051\u3067\u5b8c\u7d50\u3059\u308b\u6cbb\u7642\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6db2\u5185\u79d1\u3001\u7d30\u80de\u6cbb\u7642\u90e8\u9580\u3001\u611f\u67d3\u75c7\u79d1\u3001\u96c6\u4e2d\u6cbb\u7642\u79d1\u3001\u814e\u81d3\u5185\u79d1\u3001\u795e\u7d4c\u5185\u79d1\u306a\u3069\u3092\u542b\u3080\u591a\u8077\u7a2e\u30fb\u591a\u8a3a\u7642\u79d1\u9023\u643a\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CAR-T\u7642\u6cd5\u304c\u793a\u3059\u300c\u81a0\u539f\u75c5\u6cbb\u7642\u306e\u672a\u6765\u300d<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u307e\u3067\u81a0\u539f\u75c5\u6cbb\u7642\u3067\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u514d\u75ab\u3092\u6291\u3048\u308b\u85ac\u3092\u9577\u671f\u9593\u7d9a\u3051\u308b\u300d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3068\u304c\u57fa\u672c\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u306f\u3001\u3053\u306e\u8003\u3048\u65b9\u305d\u306e\u3082\u306e\u3092\u5909\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6301\u7d9a\u7684\u514d\u75ab\u6291\u5236<br>\u2192 \u75c5\u539f\u6027\u514d\u75ab\u7d30\u80de\u306e\u6df1\u3044\u9664\u53bb<br>\u2192 \u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u518d\u69cb\u7bc9<br>\u2192 \u7121\u85ac\u5bdb\u89e3<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u6cbb\u7642\u6226\u7565\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5f8c\u3001\u3088\u308a\u5b89\u5168\u306aCAR-T\u3001CAR-NK\u3001in vivo CAR-T\u3001\u4e8c\u91cd\u7279\u7570\u7684\u6297\u4f53\u3084T-cell engager\u306a\u3069\u304c\u767a\u5c55\u3059\u308c\u3070\u3001\u300c\u96e3\u6cbb\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u3069\u3053\u307e\u3067\u6df1\u304f\u514d\u75ab\u5b66\u7684\u306b\u30ea\u30bb\u30c3\u30c8\u3067\u304d\u308b\u306e\u304b\u300d\u304c\u30ea\u30a6\u30de\u30c1\u5b66\u306e\u5927\u304d\u306a\u30c6\u30fc\u30de\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30af\u30ea\u30cb\u30c3\u30af\u304b\u3089\u306e\u30e1\u30c3\u30bb\u30fc\u30b8<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u3001\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u3001\u708e\u75c7\u6027\u7b4b\u75be\u60a3\u306a\u3069\u306e\u81a0\u539f\u75c5\u6cbb\u7642\u306f\u3001\u3053\u306e\u6570\u5e74\u9593\u3067\u6025\u901f\u306b\u5909\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u7642\u6cd5\u306f\u305d\u306e\u4e2d\u3067\u3082\u7279\u306b\u6ce8\u76ee\u3055\u308c\u308b\u6cbb\u7642\u3067\u3059\u304c\u3001\u73fe\u6642\u70b9\u3067\u306f\u3059\u3079\u3066\u306e\u60a3\u8005\u3055\u3093\u304c\u4e00\u822c\u8a3a\u7642\u3068\u3057\u3066\u53d7\u3051\u3089\u308c\u308b\u6cbb\u7642\u3067\u306f\u306a\u304f\u3001\u5c02\u9580\u65bd\u8a2d\u3084\u81e8\u5e8a\u7814\u7a76\u3092\u4e2d\u5fc3\u306b\u691c\u8a0e\u3055\u308c\u308b\u9ad8\u5ea6\u306a\u7d30\u80de\u6cbb\u7642\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067CAR-T\u7d30\u80de\u7642\u6cd5\u305d\u306e\u3082\u306e\u3092\u5b9f\u65bd\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u30fb\u30ea\u30a6\u30de\u30c1\u5c02\u9580\u533b\u3068\u3057\u3066\u3001\u73fe\u5728\u306e\u75c5\u6c17\u306e\u6d3b\u52d5\u6027\u3001\u81d3\u5668\u969c\u5bb3\u3001\u81ea\u5df1\u6297\u4f53\u3001\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u3001\u3053\u308c\u307e\u3067\u306e\u6cbb\u7642\u6b74\u3092\u7dcf\u5408\u7684\u306b\u8a55\u4fa1\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u9ad8\u6b21\u533b\u7642\u6a5f\u95a2\u3068\u9023\u643a\u3057\u306a\u304c\u3089\u6cbb\u7642\u65b9\u91dd\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u306f\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u85ac\u3092\u4f55\u7a2e\u985e\u4f7f\u3063\u3066\u3082\u75c5\u6c17\u304c\u5b89\u5b9a\u3057\u306a\u3044\u300d<br>\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u306a\u304b\u306a\u304b\u6e1b\u3089\u305b\u306a\u3044\u300d<br>\u300c\u73fe\u5728\u306e\u6cbb\u7642\u4ee5\u5916\u306b\u9078\u629e\u80a2\u304c\u3042\u308b\u306e\u304b\u77e5\u308a\u305f\u3044\u300d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3063\u305f\u5834\u5408\u306b\u306f\u3001\u307e\u305a\u73fe\u5728\u306e\u75c5\u614b\u3092\u6b63\u78ba\u306b\u6574\u7406\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u3092\u8003\u3048\u308b\u524d\u306b\u3082\u3001\u5f93\u6765\u6cbb\u7642\u304c\u5341\u5206\u306b\u6700\u9069\u5316\u3055\u308c\u3066\u3044\u308b\u304b\u3001\u8a3a\u65ad\u3084\u81d3\u5668\u8a55\u4fa1\u306b\u898b\u843d\u3068\u3057\u304c\u306a\u3044\u304b\u3092\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u9ad8\u5ea6\u306a\u514d\u75ab\u6291\u5236\u7642\u6cd5\u3084\u7d30\u80de\u6cbb\u7642\u3092\u53d7\u3051\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u611f\u67d3\u75c7\u5bfe\u7b56\u3082\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e3\u8154\u5185\u306e\u611f\u67d3\u5de3\u306b\u3064\u3044\u3066\u3082\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u6b6f\u79d1\u3068\u9023\u643a\u3057\u3001\u5168\u8eab\u6cbb\u7642\u3092\u5b89\u5168\u306b\u884c\u3046\u305f\u3081\u306e\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u306f\u533b\u79d1\u3068\u6b6f\u79d1\u304c\u540c\u4e00\u65bd\u8a2d\u5185\u3067\u8a3a\u7642\u3057\u3066\u304a\u308a\u3001\u5168\u8eab\u72b6\u614b\u3092\u8e0f\u307e\u3048\u305f\u53e3\u8154\u7ba1\u7406\u306b\u3064\u3044\u3066\u3082\u9023\u643a\u3057\u3066\u5bfe\u5fdc\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"447\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-51.png\" alt=\"\" class=\"wp-image-9162\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-51.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-51-400x223.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-51-767x428.png 767w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u3042\u308f\u305b\u3066\u8aad\u307f\u305f\u3044\u95a2\u9023\u8a18\u4e8b<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u2460 \u96e3\u6cbb\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u5bfe\u3059\u308bCAR-T\u7642\u6cd5\u3092\u3001\u5b9f\u969b\u306e\u6cbb\u7642\u6210\u7e3e\u304b\u3089\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308a\u305f\u3044\u65b9\u3078<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u3010\u8840\u6db2\u5185\u79d1\u30fb\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3011\u591a\u5264\u8010\u6027\u81ea\u5df1\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8ca7\u8840\uff08AIHA\uff09\u306b\u5bfe\u3059\u308bCD19 CAR-T\u7d30\u80de\u7642\u6cd5\uff5c\u6301\u7d9a\u7684\u5bdb\u89e3\u3068\u518d\u767a\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"yRamYT2Bvj\"><a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-1183\/\">\u591a\u5264\u8010\u6027\u81ea\u5df1\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8ca7\u8840(AIHA)\u306b\u5bfe\u3059\u308bCD19 CAR-T\u7d30\u80de\u7642\u6cd5\uff1a\u96e3\u6cbb\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u6301\u7d9a\u7684\u306a\u5bdb\u89e3\u3068\u518d\u767a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5206\u5b50\u7684\u89e3\u660e<\/a><\/blockquote><iframe loading=\"lazy\" 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class=\"wp-block-paragraph\">\u5f93\u6765\u306e\u6cbb\u7642\u304c\u52b9\u304d\u306b\u304f\u3044\u81ea\u5df1\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8ca7\u8840\uff08AIHA\uff09\u306b\u5bfe\u3057\u3066\u3001CD19 CAR-T\u7d30\u80de\u7642\u6cd5\u306b\u3088\u3063\u3066\u6df1\u3044B\u7d30\u80de\u9664\u53bb\u3092\u884c\u3044\u3001\u9577\u671f\u5bdb\u89e3\u3092\u76ee\u6307\u3059\u65b0\u3057\u3044\u6cbb\u7642\u6226\u7565\u3092\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u306b\u3088\u3063\u3066\u81ea\u5df1\u53cd\u5fdc\u6027B\u7d30\u80de\u3092\u3069\u3053\u307e\u3067\u9664\u53bb\u3067\u304d\u308b\u306e\u304b\u3001\u306a\u305c\u4e00\u90e8\u3067\u306f\u518d\u767a\u304c\u8d77\u3053\u308b\u306e\u304b\u3001\u9577\u5bff\u547d\u5f62\u8cea\u7d30\u80de\u306a\u3069\u304c\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e\u3059\u308b\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u300c\u514d\u75ab\u30ea\u30bb\u30c3\u30c8\u300d\u3068\u3044\u3046\u8003\u3048\u65b9\u3092\u3055\u3089\u306b\u6df1\u304f\u7406\u89e3\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">\u2461 \u300cB\u7d30\u80de\u3092\u6a19\u7684\u306b\u3059\u308b\u300d\u3068\u306f\u3069\u3046\u3044\u3046\u3053\u3068\u304b\uff5cSLE\u6cbb\u7642\u306e\u73fe\u5728\u5730\u3092\u77e5\u308a\u305f\u3044\u65b9\u3078<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u3010NEJM2026\u3011SLE\u306b\u5bfe\u3059\u308b\u30aa\u30d3\u30cc\u30c4\u30ba\u30de\u30d6\uff5cB\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u6b21\u4e16\u4ee3\u6cbb\u7642\u3068ALLEGORY\u8a66\u9a13\u3092\u5c02\u9580\u533b\u304c\u89e3\u8aac<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"fUKmIIH1uv\"><a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-8593\/\">\u3010NEJM2026\u3011SLE\u306b\u5bfe\u3059\u308b\u30aa\u30d3\u30cc\u30c4\u30ba\u30de\u30d6\uff5cB\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u6b21\u4e16\u4ee3\u6cbb\u7642\u3068ALLEGORY\u8a66\u9a13\u3092\u5c02\u9580\u533b\u304c\u89e3\u8aac<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" 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class=\"wp-block-paragraph\">\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u306e\u75c5\u614b\u3067\u306f\u3001\u81ea\u5df1\u6297\u4f53\u7523\u751f\u3060\u3051\u3067\u306a\u304f\u3001\u6297\u539f\u63d0\u793a\u3084T\u7d30\u80de\u6d3b\u6027\u5316\u306a\u3069\u3092\u901a\u3058\u3066B\u7d30\u80de\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001CD20\u967d\u6027B\u7d30\u80de\u3092\u5f37\u529b\u306b\u9664\u53bb\u3059\u308b\u30aa\u30d3\u30cc\u30c4\u30ba\u30de\u30d6\u306e\u7b2c3\u76f8ALLEGORY\u8a66\u9a13\u3092\u3082\u3068\u306b\u3001B\u7d30\u80de\u6a19\u7684\u6cbb\u7642\u306b\u3088\u308b\u75c5\u52e2\u6539\u5584\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u6e1b\u91cf\u3001\u30d5\u30ec\u30a2\u6291\u5236\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u6297CD20\u6297\u4f53\u306b\u3088\u308bB\u7d30\u80de\u9664\u53bb\u300d\u3068\u300cCD19 CAR-T\u7642\u6cd5\u306b\u3088\u308b\u3088\u308a\u6df1\u3044B\u7d30\u80de\u30ea\u30bb\u30c3\u30c8\u300d\u3092\u6bd4\u8f03\u3057\u3066\u8aad\u3080\u3053\u3068\u3067\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u5bfe\u3059\u308bB\u7d30\u80de\u6a19\u7684\u6cbb\u7642\u304c\u3069\u3053\u307e\u3067\u9032\u6b69\u3057\u3066\u304d\u305f\u306e\u304b\u304c\u7406\u89e3\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">\u2462 CAR-T\u7642\u6cd5\u306e\u5bfe\u8c61\u3068\u3057\u3066\u3082\u7814\u7a76\u304c\u9032\u3080\u300c\u708e\u75c7\u6027\u7b4b\u75be\u60a3\u300d\u306e\u73fe\u5728\u306e\u6a19\u6e96\u6cbb\u7642\u3092\u77e5\u308a\u305f\u3044\u65b9\u3078<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u3010JAMA Neurology2026\u3011\u65b0\u898f\u8a3a\u65ad\u306e\u7b4b\u708e\u306bIVIg\u3092\u65e9\u671f\u4f75\u7528\u3059\u308b\u52b9\u679c\u3068\u6ce8\u610f\u70b9\uff5cTIME IS MUSCLE\u8a66\u9a13\u3092\u5c02\u9580\u533b\u304c\u89e3\u8aac<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"m1qF0uC8sW\"><a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-9109\/\">\u3010JAMA Neurology2026\u3011\u65b0\u898f\u8a3a\u65ad\u306e\u7b4b\u708e\u306bIVIg\u3092\u65e9\u671f\u4f75\u7528\u3059\u308b\u52b9\u679c\u3068\u6ce8\u610f\u70b9\uff5cTIME IS MUSCLE\u8a66\u9a13\u3092\u5c02\u9580\u533b\u304c\u89e3\u8aac<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u201c\u3010JAMA Neurology2026\u3011\u65b0\u898f\u8a3a\u65ad\u306e\u7b4b\u708e\u306bIVIg\u3092\u65e9\u671f\u4f75\u7528\u3059\u308b\u52b9\u679c\u3068\u6ce8\u610f\u70b9\uff5cTIME IS MUSCLE\u8a66\u9a13\u3092\u5c02\u9580\u533b\u304c\u89e3\u8aac\u201d \u2014 \u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af\u30d6\u30ed\u30b0\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-9109\/embed\/#?secret=mgU55S7ch6#?secret=m1qF0uC8sW\" data-secret=\"m1qF0uC8sW\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u591a\u767a\u6027\u7b4b\u708e\u30fb\u76ae\u819a\u7b4b\u708e\u306a\u3069\u306e\u7279\u767a\u6027\u708e\u75c7\u6027\u7b4b\u75be\u60a3\uff08IIM\uff09\u306f\u3001\u4eca\u56de\u306eCAR-T\u7642\u6cd5\u7814\u7a76\u3067\u3082\u91cd\u8981\u306a\u5bfe\u8c61\u75be\u60a3\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001CAR-T\u7642\u6cd5\u306f\u73fe\u6642\u70b9\u3067\u3059\u3079\u3066\u306e\u7b4b\u708e\u60a3\u8005\u3055\u3093\u306b\u884c\u3046\u6cbb\u7642\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305a\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u3001\u514d\u75ab\u6291\u5236\u85ac\u3001IVIg\u306a\u3069\u65e2\u5b58\u6cbb\u7642\u3092\u9069\u5207\u306b\u7d44\u307f\u5408\u308f\u305b\u3001\u7b4b\u529b\u4f4e\u4e0b\u3084\u81d3\u5668\u969c\u5bb3\u3092\u65e9\u671f\u306b\u6291\u3048\u308b\u3053\u3068\u304c\u57fa\u672c\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">TIME IS MUSCLE\u8a66\u9a13\u3092\u901a\u3057\u3066\u3001\u7b4b\u708e\u306b\u5bfe\u3059\u308b\u65e9\u671fIVIg\u4f75\u7528\u306e\u610f\u7fa9\u3068\u5b89\u5168\u6027\u3092\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u306e\u6a19\u6e96\u6cbb\u7642\u3068\u3001\u5c06\u6765\u306eCAR-T\u306e\u3088\u3046\u306a\u514d\u75ab\u30ea\u30bb\u30c3\u30c8\u7642\u6cd5\u3068\u306e\u4f4d\u7f6e\u3065\u3051\u3092\u6574\u7406\u3059\u308b\u3046\u3048\u3067\u3082\u304a\u3059\u3059\u3081\u306e\u8a18\u4e8b\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Santosa A, Tan TC. CAR-T cell therapy for treatment-refractory rheumatic autoimmune diseases: a systematic review of clinical outcomes and safety profiles. RMD Open. 2026;12(1).<br>doi:10.1136\/rmdopen-2025-006417<\/li>\n\n\n\n<li>Chan SCW, Tascilar K, Wirsching A, et al. Predicting prevalence and severity of cytokine release syndrome after CAR T-cell therapy in patients with autoimmune disease: a retrospective cohort study. Lancet Rheumatol. Published online September 25, 2026.<br>doi:10.1016\/S2665-9913(26)00230-4<\/li>\n\n\n\n<li>Hagen M, M\u00fcller F, Wirsching A, et al. Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with autoimmune disease: an observational study. Lancet Rheumatol. 2025;7(6).<br>doi:10.1016\/S2665-9913(25)00091-8<\/li>\n\n\n\n<li>Zhang Y, Han W. Management of Cytokine Release Syndrome (CRS) following CAR T-cell therapy: a comprehensive review. Clin Cancer Bull. 2025;4:15.<br>doi:10.1007\/s44272-025-00044-0<\/li>\n\n\n\n<li>Paludo J, et al. Machine learning-based prediction of cytokine release syndrome post CAR-T cell therapy. J Clin Oncol. 2025;43(16_suppl).<br>doi:10.1200\/JCO.2025.43.16_suppl.e13622<\/li>\n<\/ol>\n<\/blockquote>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23%\">\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/84f9b1a365bb2c08a7e4b50359f34012-600x600.png\" alt=\"\" class=\"wp-image-8240\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/84f9b1a365bb2c08a7e4b50359f34012-600x600.png 600w, 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