{"id":9199,"date":"2026-10-15T15:25:00","date_gmt":"2026-10-15T06:25:00","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=9199"},"modified":"2026-10-15T17:12:20","modified_gmt":"2026-10-15T08:12:20","slug":"post-9199","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-9199\/","title":{"rendered":"\u6f70\u760d\u6027\u5927\u8178\u708e\u30fb\u30af\u30ed\u30fc\u30f3\u75c5\u3068\u6297IL-10\u81ea\u5df1\u6297\u4f53\uff5cIBD\u306e\u65b0\u305f\u306a\u75c5\u614b\u3010NEJM 2026\u3011"},"content":{"rendered":"\n<p 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class=\"wp-block-paragraph\">IL-10\u7523\u751f<br>\u2193<br>IL-10\u53d7\u5bb9\u4f53\u3078\u306e\u7d50\u5408<br>\u2193<br>JAK1\u30fbTYK2\u306e\u6d3b\u6027\u5316<br>\u2193<br>STAT3\u3092\u4ecb\u3057\u305f\u6297\u708e\u75c7\u6027\u5fdc\u7b54<br>\u2193<br>TNF\u30fbIL-1\u03b2\u30fbIL-6\u30fbIL-23\u306a\u3069\u306e\u904e\u5270\u306a\u708e\u75c7\u53cd\u5fdc\u306e\u6291\u5236<br>\u2193<br>\u8178\u7ba1\u514d\u75ab\u306e\u6052\u5e38\u6027\u7dad\u6301<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7d4c\u8def\u304c\u6b63\u5e38\u306b\u50cd\u304f\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u8178\u7ba1\u306f\u5927\u91cf\u306e\u7d30\u83cc\u306b\u63a5\u3057\u3066\u3044\u3066\u3082\u3001\u4e0d\u5fc5\u8981\u306a\u708e\u75c7\u3092\u8d77\u3053\u3057\u7d9a\u3051\u305a\u306b\u6e08\u307f\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">IL-10\u7d4c\u8def\u306e\u907a\u4f1d\u7684\u6b20\u640d\u3067\u306f\u91cd\u75c7\u306e\u8178\u708e\u304c\u8d77\u3053\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">IL10\u3001IL10RA\u3001IL10RB\u306a\u3069\u306e\u907a\u4f1d\u5b50\u306b\u4e21\u30a2\u30ec\u30eb\u6027\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u304c\u5b58\u5728\u3059\u308b\u3068\u3001\u4e73\u5150\u671f\u304b\u3089\u91cd\u75c7\u306e\u8178\u708e\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3046\u3057\u305f\u5358\u4e00\u907a\u4f1d\u5b50\u6027\u708e\u75c7\u6027\u8178\u75be\u60a3\u3067\u306f\u3001\u975e\u5e38\u306b\u65e9\u3044\u6642\u671f\u304b\u3089\u5f37\u3044\u708e\u75c7\u304c\u751f\u3058\u3001\u5f93\u6765\u306e\u6cbb\u7642\u306b\u62b5\u6297\u6027\u3092\u793a\u3059\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001IL-10\u7d4c\u8def\u306e\u50cd\u304d\u304c\u5931\u308f\u308c\u308b\u3053\u3068\u81ea\u4f53\u304c\u3001\u8178\u708e\u3092\u5f15\u304d\u8d77\u3053\u3057\u5f97\u308b\u3053\u3068\u306f\u3001\u4ee5\u524d\u304b\u3089\u907a\u4f1d\u6027\u75be\u60a3\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u540c\u3058\u3088\u3046\u306a\u6a5f\u80fd\u969c\u5bb3\u304c\u3001\u907a\u4f1d\u5b50\u306e\u6b20\u640d\u3067\u306f\u306a\u304f\u81ea\u5df1\u6297\u4f53\u306b\u3088\u3063\u3066\u5f8c\u5929\u7684\u306b\u751f\u3058\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u70b9\u306b\u5927\u304d\u306a\u610f\u7fa9\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\uff0e\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u3068\u306f\uff1f \u81ea\u5206\u81ea\u8eab\u306e\u300c\u708e\u75c7\u306e\u30d6\u30ec\u30fc\u30ad\u300d\u3092\u59a8\u5bb3\u3059\u308b\u6297\u4f53<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u5df1\u6297\u4f53\u3068\u306f\u3001\u672c\u6765\u306f\u5916\u90e8\u306e\u75c5\u539f\u4f53\u306a\u3069\u3092\u8a8d\u8b58\u3059\u308b\u306f\u305a\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u3001\u81ea\u5206\u81ea\u8eab\u306e\u5206\u5b50\u306b\u5bfe\u3057\u3066\u4f5c\u3063\u3066\u3057\u307e\u3046\u6297\u4f53\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u554f\u984c\u3068\u306a\u3063\u305f\u306e\u306f\u3001IL-10\u306b\u7d50\u5408\u3057\u3001\u305d\u306e\u50cd\u304d\u3092\u59a8\u5bb3\u3059\u308b\u300c\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\uff08Neutralizing Anti\u2013IL-10 Autoantibodies\uff09\u300d\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u306a\u306e\u306f\u3001IL-10\u306b\u7d50\u5408\u3059\u308b\u6297\u4f53\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3068\u3001IL-10\u306e\u50cd\u304d\u3092\u5b9f\u969b\u306b\u59a8\u5bb3\u3059\u308b\u3053\u3068\u306f\u5fc5\u305a\u3057\u3082\u540c\u3058\u3067\u306f\u306a\u3044\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u5358\u306b\u6297\u4f53\u306e\u5b58\u5728\u3092\u8abf\u3079\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u3092\u7528\u3044\u3066IL-10\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u963b\u5bb3\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u81ea\u5df1\u6297\u4f53\u304cIL-10\u3092\u4e2d\u548c\u3059\u308b\u3068\u4f55\u304c\u8d77\u3053\u308b\u306e\u304b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6297IL-10\u81ea\u5df1\u6297\u4f53\u306b\u3088\u308b\u708e\u75c7\u5897\u5e45\u30e2\u30c7\u30eb<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u306e\u5b58\u5728<br>\u2193<br>IL-10\u3078\u306e\u7d50\u5408\u30fb\u751f\u7269\u5b66\u7684\u6d3b\u6027\u306e\u963b\u5bb3<br>\u2193<br>IL-10\u53d7\u5bb9\u4f53\u3092\u4ecb\u3059\u308b\u6297\u708e\u75c7\u6027\u30b7\u30b0\u30ca\u30eb\u306e\u4f4e\u4e0b<br>\u2193<br>\u5358\u7403\u30fb\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u708e\u75c7\u5236\u5fa1\u304c\u4e0d\u5341\u5206\u306b\u306a\u308b<br>\u2193<br>IL-23\u30fbIL-1\u03b2\u30fbTNF\u30fbIL-6\u306a\u3069\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5fdc\u7b54\u304c\u5897\u5e45<br>\u2193<br>\u8178\u7ba1\u306b\u304a\u3051\u308b\u6162\u6027\u708e\u75c7\u306e\u6301\u7d9a\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306f\u3001\u708e\u75c7\u3092\u4fc3\u9032\u3059\u308b\u30a2\u30af\u30bb\u30eb\u304c\u5f37\u304f\u306a\u308b\u3068\u3044\u3046\u3088\u308a\u3082\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u30d6\u30ec\u30fc\u30ad\u304c\u6b63\u5e38\u306b\u4f5c\u52d5\u3057\u306a\u304f\u306a\u308b\u75c5\u614b\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u514d\u75ab\u5b66\u7684\u306b\u306f\u3001\u5148\u5929\u7684\u306aIL-10\u7d4c\u8def\u306e\u6b20\u640d\u306b\u4f3c\u305f\u72b6\u614b\u304c\u3001\u81ea\u5df1\u6297\u4f53\u306b\u3088\u3063\u3066\u5f8c\u5929\u7684\u306b\u5f62\u6210\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306b\u5f8c\u5929\u7684\u306a\u514d\u75ab\u7570\u5e38\u304c\u907a\u4f1d\u6027\u75be\u60a3\u3068\u4f3c\u305f\u75c5\u614b\u3092\u5f15\u304d\u8d77\u3053\u3059\u73fe\u8c61\u3092\u300c\u30d5\u30a7\u30ce\u30b3\u30d4\u30fc\uff08Phenocopy\uff1a\u8868\u73fe\u578b\u6a21\u5023\uff09\u300d\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u967d\u6027\u60a3\u8005\u304c\u5168\u54e1\u3001\u4e73\u5150\u671f\u767a\u75c7\u306eIL-10\u7d4c\u8def\u6b20\u640d\u75c7\u3068\u540c\u3058\u81e8\u5e8a\u50cf\u3092\u5448\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-63.png\" alt=\"\" class=\"wp-image-9201\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-63.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-63-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-63-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">4\uff0eNEJM 2026\uff1a\u708e\u75c7\u6027\u8178\u75be\u60a3\u60a3\u80054,909\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u306f\u3001Gharahdaghi\u3089\u306b\u3088\u308b\u300cInterleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease\u300d\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e746\u670811\u65e5\u4ed8\u306eNEJM\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u3067\u306f\u3001\u82f1\u56fd\u306e\u8907\u6570\u306eIBD\u30b3\u30db\u30fc\u30c8\u3068\u975eIBD\u5bfe\u7167\u7fa4\u3092\u7528\u3044\u3066\u3001\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u306e\u4fdd\u6709\u7387\u3001\u6a5f\u80fd\u7684\u5f71\u97ff\u3001HLA\u907a\u4f1d\u5b50\u578b\u3068\u306e\u95a2\u9023\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u306f\u3001\u8840\u6e05\u3092\u7528\u3044\u305f\u6a5f\u80fd\u7684\u81ea\u5df1\u6297\u4f53\u89e3\u6790\u3068\u3001HLA\u907a\u4f1d\u5b66\u7684\u95a2\u9023\u89e3\u6790\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u89b3\u5bdf\u7814\u7a76\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u5bfe\u8c61\u30b3\u30db\u30fc\u30c8<\/th><th class=\"has-text-align-right\" data-align=\"right\">\u5bfe\u8c61\u8005\u6570<\/th><th class=\"has-text-align-right\" data-align=\"right\">\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u967d\u6027\u8005<\/th><\/tr><tr><td>Oxford IBD Discovery<\/td><td class=\"has-text-align-right\" data-align=\"right\">847\u4eba<\/td><td class=\"has-text-align-right\" data-align=\"right\">45\u4eba\uff085.3%\uff09<\/td><\/tr><tr><td>Oxford IBD Validation<\/td><td class=\"has-text-align-right\" data-align=\"right\">715\u4eba<\/td><td class=\"has-text-align-right\" data-align=\"right\">22\u4eba\uff083.1%\uff09<\/td><\/tr><tr><td>U.K. IBD BioResource<\/td><td class=\"has-text-align-right\" data-align=\"right\">3,347\u4eba<\/td><td class=\"has-text-align-right\" data-align=\"right\">106\u4eba\uff083.2%\uff09<\/td><\/tr><tr><td><strong>IBD\u60a3\u8005\u5408\u8a08<\/strong><\/td><td class=\"has-text-align-right\" data-align=\"right\"><strong>4,909\u4eba<\/strong><\/td><td class=\"has-text-align-right\" data-align=\"right\"><strong>173\u4eba\uff083.5%\uff09<\/strong><\/td><\/tr><tr><td>\u975eIBD\u5bfe\u7167\u7fa4<\/td><td class=\"has-text-align-right\" data-align=\"right\">1,006\u4eba<\/td><td class=\"has-text-align-right\" data-align=\"right\">0\u4eba\uff080%\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bfe\u7167\u7fa4\u306f\u5c0f\u515013\u4eba\u3001\u6210\u4eba993\u4eba\u3067\u69cb\u6210\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u306e\u5224\u5b9a\u65b9\u6cd5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297IL-10\u81ea\u5df1\u6297\u4f53\u306e\u5224\u5b9a\u306b\u306f\u3001\u4e3b\u306b\u4ee5\u4e0b\u306e2\u3064\u306e\u6a5f\u80fd\u7684\u691c\u67fb\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2460 HEK-Blue IL-10\u30ec\u30dd\u30fc\u30bf\u30fc\u30a2\u30c3\u30bb\u30a4<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IL-10\u523a\u6fc0\u306b\u3088\u308b\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u3092\u6e2c\u5b9a\u3057\u3001\u60a3\u8005\u8840\u6e05\u304c\u305d\u306e\u53cd\u5fdc\u3092\u963b\u5bb3\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2461 \u7af6\u5408ELISA<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u8840\u6e05\u306b\u3088\u308bIL-10\u3078\u306e\u7d50\u5408\u963b\u5bb3\u30fb\u4e2d\u548c\u4f5c\u7528\u3092\u3001\u5225\u306e\u65b9\u6cd5\u3067\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e2\u3064\u306e\u691c\u67fb\u3067\u4e00\u81f4\u3057\u305f\u4e2d\u548c\u6d3b\u6027\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u3092\u3001\u300c\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u967d\u6027\u300d\u306e\u5224\u5b9a\u306b\u7528\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u4e00\u90e8\u306e\u60a3\u8005\u8840\u6e05\u3067\u306f\u3001\u672b\u68a2\u8840\u5358\u6838\u7403\uff08PBMC\uff09\u3092\u7528\u3044\u305f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u8a66\u9a13\u3092\u884c\u3044\u3001\u6297\u4f53\u304c\u708e\u75c7\u53cd\u5fdc\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u306b\u306f\u3001HLA\u907a\u4f1d\u5b50\u578b\u306e\u7d71\u8a08\u7684\u63a8\u5b9a\uff08imputation\uff09\u3068\u3001\u4e00\u90e8\u306e\u75c7\u4f8b\u306b\u304a\u3051\u308b\u9ad8\u89e3\u50cf\u5ea6HLA\u30b7\u30fc\u30af\u30a8\u30f3\u30b7\u30f3\u30b0\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5\uff0e\u7814\u7a76\u7d50\u679c\u2460\uff1aIBD\u60a3\u8005\u306e3.5%\u3067\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u3092\u691c\u51fa<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u306e\u6700\u3082\u57fa\u672c\u7684\u306a\u7d50\u679c\u306f\u3001\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u304cIBD\u60a3\u8005\u306e\u4e00\u90e8\u306b\u5b58\u5728\u3057\u3001\u975eIBD\u5bfe\u7167\u7fa4\u3067\u306f\u78ba\u8a8d\u3055\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IBD\u60a3\u8005\uff1a173\/4,909\u4eba\uff083.5%\uff09<\/li>\n\n\n\n<li>95%\u4fe1\u983c\u533a\u9593\uff1a3.0\uff5e4.1%<\/li>\n\n\n\n<li>\u975eIBD\u5bfe\u7167\u7fa4\uff1a0\/1,006\u4eba\uff080%\uff09<\/li>\n\n\n\n<li>95%\u4fe1\u983c\u533a\u9593\uff1a0\uff5e0.5%<\/li>\n\n\n\n<li>\u7fa4\u9593\u6bd4\u8f03\uff1aP\uff1c0.001<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001IBD\u306e\u75c5\u578b\u5225\u306b\u307f\u308b\u3068\u3001\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u306e\u967d\u6027\u7387\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>IBD\u306e\u75c5\u578b<\/th><th class=\"has-text-align-right\" data-align=\"right\">\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u967d\u6027\u7387<\/th><\/tr><tr><td>\u6f70\u760d\u6027\u5927\u8178\u708e<\/td><td class=\"has-text-align-right\" data-align=\"right\">4.4%<\/td><\/tr><tr><td>\u30af\u30ed\u30fc\u30f3\u75c5<\/td><td class=\"has-text-align-right\" data-align=\"right\">2.5%<\/td><\/tr><tr><td>\u5206\u985e\u4e0d\u80fd\u578bIBD<\/td><td class=\"has-text-align-right\" data-align=\"right\">5.9%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u6f70\u760d\u6027\u5927\u8178\u708e\u3067\u6bd4\u8f03\u7684\u9ad8\u3044\u967d\u6027\u7387\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u304c\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u3067\u3082\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u81ea\u5df1\u6297\u4f53\u306f\u6f70\u760d\u6027\u5927\u8178\u708e\u306e\u307f\u306b\u9650\u5b9a\u3055\u308c\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001IBD\u5168\u4f53\u306e\u4e00\u90e8\u306b\u5171\u901a\u3059\u308b\u514d\u75ab\u5b66\u7684\u7279\u5fb4\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001IBD\u60a3\u8005\u306e\u7d0496.5%\u306f\u4eca\u56de\u306e\u57fa\u6e96\u3067\u306f\u9670\u6027\u3067\u3042\u308a\u3001\u3059\u3079\u3066\u306eIBD\u3092\u8aac\u660e\u3059\u308b\u75c5\u614b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u4eca\u56de\u306e\u967d\u6027\u7387\u306f\u7814\u7a76\u306b\u53c2\u52a0\u3057\u305f\u82f1\u56fd\u306e\u5bfe\u8c61\u96c6\u56e3\u306b\u304a\u3051\u308b\u5024\u3067\u3042\u308a\u3001\u65e5\u672c\u4ebaIBD\u60a3\u8005\u3067\u3082\u540c\u3058\u5272\u5408\u306b\u306a\u308b\u3068\u65ad\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-64.png\" alt=\"\" class=\"wp-image-9202\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-64.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-64-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-64-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">6\uff0e\u7814\u7a76\u7d50\u679c\u2461\uff1a\u6297IL-10\u81ea\u5df1\u6297\u4f53\u306f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u53cd\u5fdc\u3092\u5897\u5e45\u3055\u305b\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7814\u7a76\u306e\u91cd\u8981\u306a\u70b9\u306f\u3001\u81ea\u5df1\u6297\u4f53\u306e\u5b58\u5728\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u306e\u6a5f\u80fd\u3092\u5b9f\u9a13\u7684\u306b\u691c\u8a3c\u3057\u305f\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u8005\u3089\u306f\u3001\u5065\u5eb7\u306a\u30c9\u30ca\u30fc\u7531\u6765\u306e\u672b\u68a2\u8840\u5358\u6838\u7403\u3092\u30ea\u30dd\u591a\u7cd6\uff08LPS\uff09\u3067\u523a\u6fc0\u3057\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u967d\u6027\u60a3\u8005\u306e\u8840\u6e05\u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001\u6297IL-10\u6d3b\u6027\u304c\u9ad8\u3044\u8840\u6e05\u306e\u5b58\u5728\u4e0b\u3067\u306f\u3001\u691c\u51fa\u53ef\u80fd\u306aIL-10\u304c\u6e1b\u5c11\u3057\u3001\u8907\u6570\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u304c\u5897\u52a0\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u305f\u4e3b\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3<\/th><th>\u4e3b\u306a\u514d\u75ab\u5b66\u7684\u5f79\u5272<\/th><th>\u5b9f\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u5909\u5316<\/th><\/tr><tr><td>IL-10<\/td><td>\u6297\u708e\u75c7\u6027\u8abf\u7bc0<\/td><td>\u691c\u51fa\u53ef\u80fd\u91cf\u304c\u4f4e\u4e0b<\/td><\/tr><tr><td>IL-23<\/td><td>\u8178\u7ba1\u708e\u75c7\u30fbTh17\u95a2\u9023\u5fdc\u7b54\u306b\u95a2\u4e0e<\/td><td>\u5897\u52a0<\/td><\/tr><tr><td>IL-1\u03b2<\/td><td>\u81ea\u7136\u514d\u75ab\u30fb\u708e\u75c7\u5897\u5e45<\/td><td>\u5897\u52a0<\/td><\/tr><tr><td>TNF<\/td><td>\u708e\u75c7\u6027\u7d30\u80de\u5fdc\u7b54\u30fb\u7d44\u7e54\u969c\u5bb3\u306b\u95a2\u4e0e<\/td><td>\u5897\u52a0<\/td><\/tr><tr><td>IL-6<\/td><td>\u6025\u6027\u671f\u53cd\u5fdc\u30fb\u708e\u75c7\u6027\u514d\u75ab\u5fdc\u7b54\u306b\u95a2\u4e0e<\/td><td>\u5897\u52a0<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u304c\u5b58\u5728\u3059\u308b\u3068\u3001\u901a\u5e38\u3067\u3042\u308c\u3070IL-10\u306b\u3088\u3063\u3066\u6291\u3048\u3089\u308c\u308b\u708e\u75c7\u53cd\u5fdc\u304c\u5f37\u304f\u306a\u308b\u3053\u3068\u3092\u652f\u6301\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306bIL-23\u3001TNF\u306a\u3069\u306f\u3001\u73fe\u5728\u306eIBD\u6cbb\u7642\u3067\u91cd\u8981\u306a\u6a19\u7684\u3068\u306a\u3063\u3066\u3044\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u306f\u3001\u65e2\u77e5\u306eIBD\u708e\u75c7\u7d4c\u8def\u3092\u4e0a\u6d41\u304b\u3089\u5897\u5e45\u3055\u305b\u308b\u56e0\u5b50\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u4eca\u56de\u306e\u5b9f\u9a13\u306f\u4e3b\u306b\u8a66\u9a13\u7ba1\u5185\u3067\u5b9f\u65bd\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u60a3\u8005\u3055\u3093\u306e\u8178\u7ba1\u7d44\u7e54\u5185\u3067\u3082\u540c\u3058\u5927\u304d\u3055\u306e\u5909\u5316\u304c\u751f\u3058\u308b\u3053\u3068\u3092\u76f4\u63a5\u8a3c\u660e\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u691c\u51fa\u53ef\u80fd\u306aIL-10\u306e\u6e1b\u5c11\u306f\u3001IL-10\u7523\u751f\u91cf\u305d\u306e\u3082\u306e\u306e\u6e1b\u5c11\u3060\u3051\u3092\u610f\u5473\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u6297\u4f53\u306b\u3088\u308b\u7d50\u5408\u30fb\u4e2d\u548c\u3084\u6e2c\u5b9a\u7cfb\u3078\u306e\u5f71\u97ff\u3082\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">7\uff0e\u7814\u7a76\u7d50\u679c\u2462\uff1a\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u306f\u9577\u671f\u9593\u6301\u7d9a\u3059\u308b\u3053\u3068\u304c\u3042\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u5df1\u6297\u4f53\u304c\u4e00\u6642\u7684\u306a\u708e\u75c7\u53cd\u5fdc\u306b\u3088\u3063\u3066\u51fa\u73fe\u3057\u305f\u3060\u3051\u306a\u306e\u304b\u3001\u305d\u308c\u3068\u3082\u9577\u671f\u9593\u6301\u7d9a\u3059\u308b\u514d\u75ab\u5b66\u7684\u7279\u5fb4\u306a\u306e\u304b\u306f\u91cd\u8981\u306a\u554f\u984c\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u3067\u306f\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u967d\u6027\u60a3\u800510\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u8840\u6e05\u4e2d\u306e\u4e2d\u548c\u6d3b\u6027\u3092\u7d4c\u6642\u7684\u306b\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5e73\u5747\u8ffd\u8de1\u671f\u9593\u306f8.6\u00b14.5\u5e74\u3067\u3001\u6700\u957714\u5e74\u9593\u306b\u53ca\u3073\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u300110\u4eba\u4e2d7\u4eba\uff0870%\uff09\u3067\u9577\u671f\u9593\u306b\u308f\u305f\u308a\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u306e\u6301\u7d9a\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u9670\u6027\u3067\u3042\u3063\u305f7\u4eba\u306f\u3001\u89b3\u5bdf\u3057\u305f\u6642\u70b9\u3092\u901a\u3058\u3066\u9670\u6027\u306e\u307e\u307e\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7d50\u679c\u306f\u3001\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u304c\u4e00\u90e8\u306eIBD\u60a3\u8005\u306b\u304a\u3044\u3066\u6bd4\u8f03\u7684\u5b89\u5b9a\u3057\u305f\u514d\u75ab\u5b66\u7684\u7279\u5fb4\u3068\u306a\u308a\u5f97\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u7e26\u65ad\u89e3\u6790\u306e\u5bfe\u8c61\u4eba\u6570\u306f\u5c11\u306a\u304f\u3001\u6297\u4f53\u4fa1\u306e\u63a8\u79fb\u3068\u5b9f\u969b\u306e\u75be\u60a3\u6d3b\u52d5\u6027\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u3001\u624b\u8853\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u3001\u3055\u3089\u306a\u308b\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">8\uff0e\u7814\u7a76\u7d50\u679c\u2463\uff1aHLA-DRB1*01:03\u3068\u6297IL-10\u81ea\u5df1\u6297\u4f53\u306e\u6975\u3081\u3066\u5f37\u3044\u95a2\u9023<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u3067\u7279\u306b\u6ce8\u76ee\u3059\u3079\u304d\u767a\u898b\u304c\u3001\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u3068HLA-DRB1*01:03\u3068\u306e\u907a\u4f1d\u5b66\u7684\u95a2\u9023\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLA\uff08Human Leukocyte Antigen\uff1a\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u306f\u3001\u514d\u75ab\u7cfb\u304c\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308b\u969b\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3064\u5206\u5b50\u7fa4\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLA\u30af\u30e9\u30b9II\u5206\u5b50\u306f\u3001\u4e3b\u306b\u7d30\u80de\u5916\u7531\u6765\u306e\u6297\u539f\u30da\u30d7\u30c1\u30c9\u3092CD4\u967d\u6027T\u7d30\u80de\u306b\u63d0\u793a\u3057\u3001\u6297\u539f\u7279\u7570\u7684\u306a\u514d\u75ab\u5fdc\u7b54\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLA-DRB1*01:03\u306f\u3001\u5f93\u6765\u304b\u3089\u6f70\u760d\u6027\u5927\u8178\u708e\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3084\u91cd\u75c7\u75c5\u578b\u3068\u306e\u95a2\u9023\u304c\u77e5\u3089\u308c\u3066\u3044\u305f\u30a2\u30ec\u30eb\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u306a\u305c\u3053\u306eHLA\u578b\u304cIBD\u3068\u5f37\u304f\u95a2\u9023\u3059\u308b\u306e\u304b\u3001\u305d\u306e\u8a73\u3057\u3044\u6a5f\u5e8f\u306f\u5341\u5206\u306b\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u305d\u306e\u80cc\u666f\u306b\u6297IL-10\u81ea\u5df1\u6297\u4f53\u306e\u7523\u751f\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HLA-DRB1*01:03\u3068\u6297IL-10\u967d\u6027\u3068\u306e\u95a2\u9023<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u89e3\u6790<\/th><th class=\"has-text-align-right\" data-align=\"right\">\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09<\/th><th>95%\u4fe1\u983c\u533a\u9593<\/th><th>P\u5024<\/th><\/tr><tr><td>Oxford\u30b3\u30db\u30fc\u30c8\uff1aHLA imputation<\/td><td class=\"has-text-align-right\" data-align=\"right\">50.0<\/td><td>16.4\uff5e152.3<\/td><td>6.14\u00d710\u207b\u00b9\u00b2<\/td><\/tr><tr><td>U.K. IBD BioResource\uff1aHLA imputation<\/td><td class=\"has-text-align-right\" data-align=\"right\">24.7<\/td><td>14.5\uff5e42.1<\/td><td>6.20\u00d710\u207b\u00b3\u00b2<\/td><\/tr><tr><td>Oxford\u30b3\u30db\u30fc\u30c8\uff1a\u9ad8\u89e3\u50cf\u5ea6HLA\u89e3\u6790<\/td><td class=\"has-text-align-right\" data-align=\"right\">29.5<\/td><td>12.2\uff5e71.1<\/td><td>4.85\u00d710\u207b\u00b9\u2074<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u7570\u306a\u308b\u30b3\u30db\u30fc\u30c8\u3068\u7570\u306a\u308b\u89e3\u6790\u65b9\u6cd5\u3067\u3001\u4e00\u8cab\u3057\u3066\u5f37\u3044\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3053\u3067\u6ce8\u610f\u3059\u3079\u304d\u306a\u306e\u306f\u3001\u3053\u308c\u3089\u306e\u30aa\u30c3\u30ba\u6bd4\u304c<strong>HLA-DRB1*01:03\u4fdd\u6709\u3068\u6297IL-10\u81ea\u5df1\u6297\u4f53\u967d\u6027\u3068\u306e\u95a2\u9023<\/strong>\u3092\u8868\u3057\u3066\u3044\u308b\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u3053\u306eHLA\u578b\u3092\u6301\u3064\u3068IBD\u309250\u500d\u767a\u75c7\u3057\u3084\u3059\u3044\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u30aa\u30c3\u30ba\u6bd4\u306f\u30ea\u30b9\u30af\u6bd4\u3068\u540c\u4e00\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u81ea\u5df1\u6297\u4f53\u967d\u6027\u60a3\u8005\u306e\u7d048\u5272\u304cHLA-DRB1*01:03\u3092\u4fdd\u6709<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Oxford\u30b3\u30db\u30fc\u30c8\u3067\u5229\u7528\u53ef\u80fd\u306aHLA\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3059\u308b\u3068\u3001\u6b21\u306e\u3088\u3046\u306a\u9055\u3044\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6297IL-10\u81ea\u5df1\u6297\u4f53\u967d\u6027IBD\u60a3\u8005\uff1a81.1%<\/li>\n\n\n\n<li>\u6297IL-10\u81ea\u5df1\u6297\u4f53\u9670\u6027IBD\u60a3\u8005\uff1a7.0%<\/li>\n\n\n\n<li>\u6bd4\u8f03\u5bfe\u8c61\u3068\u3055\u308c\u305f\u82f1\u56fd\u4e00\u822c\u96c6\u56e3\uff1a3.9%<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u5df1\u6297\u4f53\u967d\u6027\u60a3\u8005\u3067\u3001HLA-DRB1*01:03\u306e\u4fdd\u6709\u5272\u5408\u304c\u8457\u3057\u304f\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u81ea\u5df1\u6297\u4f53\u9670\u6027\u60a3\u8005\u306b\u3082HLA-DRB1*01:03\u4fdd\u6709\u8005\u306f\u5b58\u5728\u3057\u3001\u967d\u6027\u60a3\u8005\u5168\u54e1\u304c\u3053\u306e\u30a2\u30ec\u30eb\u3092\u6301\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306eHLA\u578b\u3060\u3051\u3067\u81ea\u5df1\u6297\u4f53\u306e\u6709\u7121\u3092\u78ba\u5b9f\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-65.png\" alt=\"\" class=\"wp-image-9203\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-65.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-65-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-65-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">9\uff0e\u306a\u305cHLA-DRB1*01:03\u304c\u81ea\u5df1\u6297\u4f53\u7523\u751f\u306b\u95a2\u4fc2\u3059\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HLA\u5206\u5b50\u306f\u3001\u6297\u539f\u3068\u306a\u308b\u30da\u30d7\u30c1\u30c9\u3092T\u7d30\u80de\u306b\u63d0\u793a\u3059\u308b\u969b\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u7279\u5b9a\u306eHLA\u578b\u3067\u306f\u3001\u3042\u308b\u81ea\u5df1\u6297\u539f\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u304c\u751f\u3058\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001HLA-DRB1\u5206\u5b50\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3082\u691c\u8a0e\u3055\u308c\u3001\u7279\u306b71\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u306b\u6ce8\u76ee\u3059\u3079\u304d\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HLA-DRB1\u306e71\u756a\u76ee\u306e\u30b0\u30eb\u30bf\u30df\u30f3\u9178\uff08E71\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">HLA-DRB1\u306e\u30a2\u30df\u30ce\u917871\u756a\u76ee\u306b\u304a\u3051\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\uff08Glutamic Acid\uff1aE\uff09\u306f\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u967d\u6027\u3068\u95a2\u9023\u3059\u308b\u4e3b\u8981\u306a\u914d\u5217\u4e0a\u306e\u7279\u5fb4\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLA-DR\u5206\u5b50\u306e\u6297\u539f\u7d50\u5408\u90e8\u4f4d\u3092\u69cb\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u914d\u5217\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u30da\u30d7\u30c1\u30c9\u3092\u63d0\u793a\u3057\u3084\u3059\u3044\u304b\u306b\u5f71\u97ff\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3053\u3068\u304b\u3089\u3001HLA-DRB1*01:03\u306b\u7279\u5fb4\u7684\u306a\u6297\u539f\u63d0\u793a\u304c\u3001IL-10\u306b\u5bfe\u3059\u308b\u81ea\u5df1\u514d\u75ab\u5fdc\u7b54\u306e\u6210\u7acb\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u73fe\u6642\u70b9\u3067\u60f3\u5b9a\u3055\u308c\u308b\u75c5\u614b\u4eee\u8aac<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLA-DRB1*01:03\u306a\u3069\u306e\u907a\u4f1d\u7684\u7d20\u56e0<br>\u2193<br>\u7279\u5b9a\u306e\u81ea\u5df1\u6297\u539f\u306b\u5bfe\u3059\u308b\u6297\u539f\u63d0\u793a\u306e\u5909\u5316<br>\u2193<br>\u514d\u75ab\u5bdb\u5bb9\u306e\u7834\u7dbb<br>\u2193<br>IL-10\u306b\u53cd\u5fdc\u3059\u308bT\u7d30\u80de\u30fbB\u7d30\u80de\u5fdc\u7b54\u306e\u5f62\u6210<br>\u2193<br>\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u306e\u7523\u751f<br>\u2193<br>IL-10\u306b\u3088\u308b\u6297\u708e\u75c7\u6027\u5236\u5fa1\u306e\u4f4e\u4e0b<br>\u2193<br>IBD\u95a2\u9023\u708e\u75c7\u306e\u5897\u5e45<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u306e\u4e00\u9023\u306e\u904e\u7a0b\u3059\u3079\u3066\u304c\u5b9f\u9a13\u7684\u306b\u8a3c\u660e\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u3001IL-10\u7531\u6765\u30da\u30d7\u30c1\u30c9\u304cHLA-DRB1*01:03\u306b\u3088\u3063\u3066\u3069\u306e\u3088\u3046\u306b\u63d0\u793a\u3055\u308c\u308b\u306e\u304b\u3001\u3069\u306eT\u7d30\u80de\u304c\u53cd\u5fdc\u3059\u308b\u306e\u304b\u3001\u81ea\u5df1\u6297\u4f53\u7523\u751f\u306e\u76f4\u63a5\u7684\u306a\u8a98\u56e0\u304c\u4f55\u306a\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u306e\u306f\u3001\u5f37\u3044HLA\u95a2\u9023\u3068\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u306b\u3088\u308b\u6a5f\u80fd\u7684\u306a\u4e2d\u548c\u4f5c\u7528\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">10\uff0e\u907a\u4f1d\u6027\u8178\u708e\u3068\u5f8c\u5929\u6027\u81ea\u5df1\u514d\u75ab\u6027\u8178\u708e\u3092\u3064\u306a\u3050\u300c\u30d5\u30a7\u30ce\u30b3\u30d4\u30fc\u300d\u3068\u3044\u3046\u6982\u5ff5<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">IL-10\u7d4c\u8def\u306e\u7570\u5e38\u306b\u306f\u3001\u5927\u304d\u304f\u5206\u3051\u30662\u3064\u306e\u5f62\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u7279\u5fb4<\/th><th>\u907a\u4f1d\u6027IL-10\u7d4c\u8def\u6b20\u640d<\/th><th>\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u95a2\u9023IBD<\/th><\/tr><tr><td>\u4e3b\u306a\u539f\u56e0<\/td><td>IL10\u30fbIL10RA\u30fbIL10RB\u306a\u3069\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570<\/td><td>IL-10\u3092\u4e2d\u548c\u3059\u308b\u81ea\u5df1\u6297\u4f53<\/td><\/tr><tr><td>\u7570\u5e38\u306e\u6210\u7acb<\/td><td>\u5148\u5929\u7684<\/td><td>\u5f8c\u5929\u7684\u306a\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc<\/td><\/tr><tr><td>\u5178\u578b\u7684\u306a\u767a\u75c7\u6642\u671f<\/td><td>\u4e73\u5150\u671f\u30fb\u5e7c\u5150\u671f<\/td><td>\u5c0f\u5150\u304b\u3089\u6210\u4eba\u307e\u3067\u5831\u544a<\/td><\/tr><tr><td>\u514d\u75ab\u5b66\u7684\u5f71\u97ff<\/td><td>IL-10\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u969c\u5bb3<\/td><td>IL-10\u306e\u6a5f\u80fd\u7684\u4e2d\u548c<\/td><\/tr><tr><td>\u75c5\u614b\u306e\u5171\u901a\u70b9<\/td><td>\u708e\u75c7\u6291\u5236\u6a5f\u69cb\u306e\u969c\u5bb3<\/td><td>\u708e\u75c7\u6291\u5236\u6a5f\u69cb\u306e\u969c\u5bb3<\/td><\/tr><tr><td>\u6cbb\u7642\u7814\u7a76<\/td><td>\u91cd\u75c7\u4f8b\u3067\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u306a\u3069<\/td><td>\u81ea\u5df1\u6297\u4f53\u9664\u53bb\u30fbB\u7d30\u80de\u6a19\u7684\u7642\u6cd5\u306a\u3069\u304c\u7814\u7a76\u8ab2\u984c<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e2\u3064\u306f\u539f\u56e0\u304c\u7570\u306a\u308a\u307e\u3059\u304c\u3001IL-10\u306b\u3088\u308b\u708e\u75c7\u6291\u5236\u304c\u5341\u5206\u306b\u50cd\u304b\u306a\u304f\u306a\u308b\u3068\u3044\u3046\u70b9\u3067\u5171\u901a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u6027\u514d\u75ab\u7570\u5e38\u3068\u5f8c\u5929\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u304c\u3001\u540c\u3058\u5206\u5b50\u7d4c\u8def\u306e\u969c\u5bb3\u3092\u4ecb\u3057\u3066\u985e\u4f3c\u306e\u75c5\u614b\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u306f\u3001\u514d\u75ab\u5b66\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u8003\u3048\u65b9\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u5e74\u3001\u6297\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u81ea\u5df1\u6297\u4f53\u306f\u514d\u75ab\u4e0d\u5168\u75c7\u3084\u611f\u67d3\u75c7\u3060\u3051\u3067\u306a\u304f\u3001\u3055\u307e\u3056\u307e\u306a\u708e\u75c7\u6027\u30fb\u81ea\u5df1\u514d\u75ab\u6027\u75be\u60a3\u3068\u306e\u95a2\u4fc2\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u305d\u306e\u6982\u5ff5\u3092\u708e\u75c7\u6027\u8178\u75be\u60a3\u306b\u5e83\u3052\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-67.png\" alt=\"\" class=\"wp-image-9207\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-67.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-67-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-67-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56f3\uff1aHLA-DRB1*01:03\u3068\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u306b\u95a2\u9023\u3059\u308b\u63a8\u5b9a\u75c5\u614b\u30e2\u30c7\u30eb\u3002<\/strong> \u672c\u7814\u7a76\u3067\u306f\u3001HLA-DRB1*01:03\u3068\u81ea\u5df1\u6297\u4f53\u967d\u6027\u3068\u306e\u5f37\u3044\u95a2\u9023\u3001\u304a\u3088\u3073IL-10\u306e\u6a5f\u80fd\u7684\u4e2d\u548c\u3068\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5fdc\u7b54\u306e\u5897\u5e45\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u4e00\u65b9\u3001\u81ea\u5df1\u6297\u4f53\u5f62\u6210\u306b\u81f3\u308b\u6297\u539f\u63d0\u793a\u30fb\u514d\u75ab\u5bdb\u5bb9\u7834\u7dbb\u306e\u6a5f\u5e8f\u3084\u3001\u5b9f\u969b\u306e\u8178\u7ba1\u708e\u75c7\u3078\u306e\u56e0\u679c\u7684\u5bc4\u4e0e\u306b\u3064\u3044\u3066\u306f\u4eca\u5f8c\u306e\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">11\uff0e\u6297IL-10\u81ea\u5df1\u6297\u4f53\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u306f\u53ef\u80fd\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u7d50\u679c\u3092\u8e0f\u307e\u3048\u308b\u3068\u3001\u6297IL-10\u4e2d\u548c\u81ea\u5df1\u6297\u4f53\u304c\u75c5\u614b\u306b\u95a2\u4e0e\u3059\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u81ea\u5df1\u6297\u4f53\u305d\u306e\u3082\u306e\u3001\u3042\u308b\u3044\u306f\u81ea\u5df1\u6297\u4f53\u3092\u7523\u751f\u3059\u308b\u514d\u75ab\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u8005\u3089\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u306b\u8a00\u53ca\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2460 B\u7d30\u80de\u6a19\u7684\u7642\u6cd5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297CD20\u6297\u4f53\u3084\u6297CD19\u6297\u4f53\u306a\u3069\u306b\u3088\u3063\u3066\u3001\u81ea\u5df1\u6297\u4f53\u7523\u751f\u306b\u3064\u306a\u304c\u308bB\u7d30\u80de\u96c6\u56e3\u3092\u6e1b\u5c11\u3055\u305b\u308b\u6226\u7565\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u904e\u53bb\u306b\u5831\u544a\u3055\u308c\u305f\u5c0f\u5150IBD\u75c7\u4f8b\u3067\u306f\u3001\u6297CD20\u7642\u6cd5\u306b\u4f34\u3046\u6297IL-10\u81ea\u5df1\u6297\u4f53\u4fa1\u3068\u75be\u60a3\u6d3b\u52d5\u6027\u306e\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u308c\u306f\u9650\u5b9a\u7684\u306a\u75c7\u4f8b\u7d4c\u9a13\u3067\u3042\u308a\u3001IBD\u60a3\u8005\u5168\u4f53\u3001\u3042\u308b\u3044\u306f\u6297IL-10\u81ea\u5df1\u6297\u4f53\u967d\u6027\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u304c\u78ba\u7acb\u3057\u305f\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2461 \u5f62\u8cea\u7d30\u80de\u6a19\u7684\u7642\u6cd5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CD38\u306a\u3069\u3092\u6a19\u7684\u3068\u3057\u3066\u3001\u6297\u4f53\u3092\u7523\u751f\u3059\u308b\u5f62\u8cea\u7d30\u80de\u3092\u6e1b\u5c11\u3055\u305b\u308b\u65b9\u6cd5\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9577\u671f\u9593\u6301\u7d9a\u3059\u308b\u81ea\u5df1\u6297\u4f53\u306b\u5bfe\u3057\u3066\u306f\u3001B\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u5f62\u8cea\u7d30\u80de\u3078\u306e\u4ecb\u5165\u304c\u91cd\u8981\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2462 \u8840\u6f3f\u4ea4\u63db\u30fbFcRn\u963b\u5bb3<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6f3f\u4ea4\u63db\u306f\u3001\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308b\u6297\u4f53\u3092\u7269\u7406\u7684\u306b\u9664\u53bb\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u65b0\u751f\u5150Fc\u53d7\u5bb9\u4f53\uff08Neonatal Fc Receptor\uff1aFcRn\uff09\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001IgG\u306e\u518d\u5229\u7528\u3092\u6291\u5236\u3057\u3001\u8840\u4e2dIgG\u6fc3\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u6226\u7565\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u81ea\u5df1\u6297\u4f53\u304c\u518d\u3073\u7523\u751f\u3055\u308c\u308b\u5834\u5408\u306b\u306f\u3001\u52b9\u679c\u306e\u6301\u7d9a\u6027\u304c\u8ab2\u984c\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2463 CAR-T\u7d30\u80de\u7642\u6cd5\u30fbCAAR-T\u7d30\u80de\u7642\u6cd5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u7642\u6cd5\u306f\u3001\u907a\u4f1d\u5b50\u6539\u5909\u3057\u305fT\u7d30\u80de\u3092\u7528\u3044\u3066\u7279\u5b9a\u306e\u7d30\u80de\u96c6\u56e3\u3092\u9664\u53bb\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u306f\u3001CD19\u306a\u3069\u3092\u6a19\u7684\u3068\u3057\u305fB\u7d30\u80de\u9664\u53bb\u306b\u3088\u3063\u3066\u3001\u75c5\u7684\u306a\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u3092\u5927\u304d\u304f\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001CAAR-T\uff08Chimeric Autoantibody Receptor T-cell\uff09\u7642\u6cd5\u306f\u3001\u81ea\u5df1\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308bB\u7d30\u80de\u3092\u9078\u629e\u7684\u306b\u9664\u53bb\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u6280\u8853\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u8457\u8ad6\u6587\u3067\u3082\u3001\u6297\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u81ea\u5df1\u6297\u4f53\u3092\u7523\u751f\u3059\u308bB\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u524d\u81e8\u5e8a\u7814\u7a76\u306b\u8a00\u53ca\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u95a2\u9023IBD\u306b\u5bfe\u3059\u308bCAR-T\u7642\u6cd5\u3084CAAR-T\u7642\u6cd5\u306e\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u30fb\u5b89\u5168\u6027\u306f\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306f\u4eca\u5f8c\u306e\u7814\u7a76\u5bfe\u8c61\u3067\u3042\u308a\u3001\u73fe\u6642\u70b9\u306e\u6a19\u6e96\u6cbb\u7642\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">12\uff0e\u5b89\u5168\u6027\u3068\u6cbb\u7642\u4e0a\u306e\u8ab2\u984c\uff1a\u81ea\u5df1\u6297\u4f53\u3092\u53d6\u308a\u9664\u3051\u3070\u3088\u3044\u3068\u306f\u9650\u3089\u306a\u3044<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297IL-10\u81ea\u5df1\u6297\u4f53\u3092\u9664\u53bb\u3059\u308b\u6cbb\u7642\u306f\u3001\u7406\u8ad6\u7684\u306b\u306f\u75c5\u614b\u306e\u6839\u672c\u306b\u4ecb\u5165\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u81ea\u5df1\u6297\u4f53\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u514d\u75ab\u7d30\u80de\u3092\u9664\u53bb\u3059\u308b\u6cbb\u7642\u3067\u306f\u3001\u514d\u75ab\u9632\u5fa1\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u3082\u8003\u616e\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f8b\u3048\u3070\u3001B\u7d30\u80de\u3084\u5f62\u8cea\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u3067\u306f\u3001\u6cbb\u7642\u6cd5\u306b\u5fdc\u3058\u3066\u4ee5\u4e0b\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u554f\u984c\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u91cd\u75c7\u611f\u67d3\u75c7\u3084\u611f\u67d3\u75c7\u306e\u518d\u6d3b\u6027\u5316<\/li>\n\n\n\n<li>\u4f4e\u30ac\u30f3\u30de\u30b0\u30ed\u30d6\u30ea\u30f3\u8840\u75c7<\/li>\n\n\n\n<li>\u30ef\u30af\u30c1\u30f3\u306b\u5bfe\u3059\u308b\u6297\u4f53\u5fdc\u7b54\u306e\u4f4e\u4e0b<\/li>\n\n\n\n<li>\u8840\u7403\u6e1b\u5c11<\/li>\n\n\n\n<li>\u7d30\u80de\u7642\u6cd5\u306b\u4f34\u3046\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u75c7\u5019\u7fa4\u306a\u3069<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u8840\u6f3f\u4ea4\u63db\u3067\u306f\u8840\u5727\u4f4e\u4e0b\u3001\u51fa\u8840\u50be\u5411\u3001\u8840\u7ba1\u30a2\u30af\u30bb\u30b9\u306b\u95a2\u9023\u3059\u308b\u5408\u4f75\u75c7\u306a\u3069\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u306a\u306e\u306f\u3001<strong>\u3053\u308c\u3089\u306f\u5019\u88dc\u3068\u306a\u308b\u6cbb\u7642\u6cd5\u304b\u3089\u60f3\u5b9a\u3055\u308c\u308b\u5b89\u5168\u6027\u4e0a\u306e\u8ab2\u984c\u3067\u3042\u308a\u3001\u4eca\u56de\u306eIBD\u7814\u7a76\u3067\u78ba\u8a8d\u3055\u308c\u305f\u6cbb\u7642\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u3067\u306f\u306a\u3044<\/strong>\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u539f\u8457\u306f\u89b3\u5bdf\u7814\u7a76\u3068\u6a5f\u80fd\u5b9f\u9a13\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u6297\u4f53\u9664\u53bb\u6cbb\u7642\u306e\u6709\u52b9\u6027\u30fb\u5b89\u5168\u6027\u3092\u6bd4\u8f03\u691c\u8a3c\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u8ad6\u6587\u3092\u6839\u62e0\u3068\u3057\u3066\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u967d\u6027\u60a3\u8005\u306b\u5bfe\u3059\u308bB\u7d30\u80de\u9664\u53bb\u7642\u6cd5\u3084\u7d30\u80de\u7642\u6cd5\u3092\u901a\u5e38\u8a3a\u7642\u3068\u3057\u3066\u63a8\u5968\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u6bb5\u968e\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u6cbb\u7642\u306f\u7814\u7a76\u7684\u306a\u53ef\u80fd\u6027\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">13\uff0e\u7814\u7a76\u306e\u9650\u754c\uff1a\u975e\u5e38\u306b\u5f37\u3044\u95a2\u9023\u304c\u3042\u3063\u3066\u3082\u3001\u56e0\u679c\u95a2\u4fc2\u306e\u8a3c\u660e\u3068\u306f\u7570\u306a\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u8907\u6570\u306e\u72ec\u7acb\u3057\u305f\u30b3\u30db\u30fc\u30c8\u3001\u6a5f\u80fd\u7684\u4e2d\u548c\u8a66\u9a13\u3001HLA\u89e3\u6790\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u8cea\u306e\u9ad8\u3044\u7814\u7a76\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u3001\u81ea\u5df1\u6297\u4f53\u3092\u5358\u306b\u691c\u51fa\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001IL-10\u306e\u50cd\u304d\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u8907\u6570\u306e\u5b9f\u9a13\u3067\u78ba\u8a8d\u3057\u305f\u70b9\u306f\u5927\u304d\u306a\u5f37\u307f\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u4ee5\u4e0b\u306e\u9650\u754c\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2460 \u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308a\u3001\u75c5\u6c17\u306e\u767a\u75c7\u306b\u5148\u884c\u3057\u3066\u81ea\u5df1\u6297\u4f53\u304c\u5b58\u5728\u3057\u305f\u304b\u306f\u4e0d\u660e<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297IL-10\u81ea\u5df1\u6297\u4f53\u304cIBD\u767a\u75c7\u306e\u539f\u56e0\u3068\u3057\u3066\u50cd\u304f\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u65e2\u306b\u5b58\u5728\u3059\u308b\u8178\u7ba1\u708e\u75c7\u3084\u611f\u67d3\u306a\u3069\u3092\u5951\u6a5f\u306b\u81ea\u5df1\u6297\u4f53\u304c\u5f62\u6210\u3055\u308c\u305f\u53ef\u80fd\u6027\u3082\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u81ea\u5df1\u6297\u4f53\u3068IBD\u3068\u306e\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u305f\u3053\u3068\u3060\u3051\u3067\u3001\u56e0\u679c\u95a2\u4fc2\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2461 \u81ea\u5df1\u6297\u4f53\u967d\u6027\u304c\u81e8\u5e8a\u7684\u4e88\u5f8c\u3092\u3069\u3053\u307e\u3067\u4e88\u6e2c\u3059\u308b\u304b\u306f\u4e0d\u660e<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5f8c\u3001\u7279\u306b\u91cd\u8981\u3068\u306a\u308b\u306e\u306f\u6b21\u306e\u3088\u3046\u306a\u81e8\u5e8a\u7684\u30a2\u30a6\u30c8\u30ab\u30e0\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5185\u8996\u93e1\u7684\u708e\u75c7\u306e\u91cd\u75c7\u5ea6<\/li>\n\n\n\n<li>\u30b9\u30c6\u30ed\u30a4\u30c9\u4f9d\u5b58\u6027\u30fb\u62b5\u6297\u6027<\/li>\n\n\n\n<li>\u751f\u7269\u5b66\u7684\u88fd\u5264\u306b\u5bfe\u3059\u308b\u53cd\u5fdc<\/li>\n\n\n\n<li>\u5165\u9662\u30fb\u624b\u8853\u30fb\u5927\u8178\u5207\u9664\u306e\u30ea\u30b9\u30af<\/li>\n\n\n\n<li>\u8178\u7ba1\u5916\u75c7\u72b6\u3068\u306e\u95a2\u9023<\/li>\n\n\n\n<li>\u9577\u671f\u5bdb\u89e3\u7387<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u3046\u3057\u305f\u81e8\u5e8a\u7684\u4e88\u5f8c\u3092\u4e88\u6e2c\u3059\u308b\u691c\u67fb\u3068\u3057\u3066\u306e\u6027\u80fd\u304c\u5341\u5206\u306b\u78ba\u7acb\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLA-DRB1*01:03\u304c\u5f93\u6765\u304b\u3089\u91cd\u75c7IBD\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3068\u3001\u6297IL-10\u81ea\u5df1\u6297\u4f53\u81ea\u4f53\u304c\u91cd\u75c7\u5316\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u3001\u533a\u5225\u3057\u3066\u8003\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2462 \u5bfe\u7167\u7fa4\u306e\u4eba\u6570\u30fb\u69cb\u6210\u3068\u9078\u629e\u30d0\u30a4\u30a2\u30b9<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u975eIBD\u5bfe\u7167\u7fa4\u306f1,006\u4eba\u3067\u3059\u304c\u3001\u5c0f\u5150\u306f13\u4eba\u306e\u307f\u3067\u3042\u308a\u3001\u6210\u4eba\u5bfe\u7167\u7fa4\u306f\u533b\u7642\u5f93\u4e8b\u8005\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u4e00\u822c\u4eba\u53e3\u5168\u4f53\u3084\u5c0f\u5150\u96c6\u56e3\u306b\u304a\u3051\u308b\u6297\u4f53\u4fdd\u6709\u7387\u3092\u7cbe\u5bc6\u306b\u63a8\u5b9a\u3067\u304d\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2463 \u907a\u4f1d\u5b66\u7684\u89e3\u6790\u306e\u4e00\u822c\u5316\u53ef\u80fd\u6027<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">HLA\u30a2\u30ec\u30eb\u983b\u5ea6\u306f\u96c6\u56e3\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u708e\u75c7\u6027\u8178\u75be\u60a3\u304c\u7591\u308f\u308c\u308b\u5834\u5408\u3084\u3001\u5c02\u9580\u7684\u306a\u5185\u8996\u93e1\u691c\u67fb\u30fb\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u5834\u5408\u306b\u306f\u3001\u9069\u5207\u306a\u6d88\u5316\u5668\u5c02\u9580\u533b\u7642\u6a5f\u95a2\u3068\u306e\u9023\u643a\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u6162\u6027\u708e\u75c7\u6027\u75be\u60a3\u3067\u514d\u75ab\u6291\u5236\u85ac\u3084\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u4f7f\u7528\u3059\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u611f\u67d3\u75c7\u4e88\u9632\u3084\u5168\u8eab\u72b6\u614b\u306e\u7ba1\u7406\u3082\u6b20\u304b\u305b\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u306f\u533b\u79d1\u3068\u6b6f\u79d1\u304c\u4f75\u8a2d\u3055\u308c\u3066\u304a\u308a\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u53e3\u8154\u5185\u306e\u611f\u67d3\u5de3\u3084\u6b6f\u5468\u75c5\u306a\u3069\u306b\u3064\u3044\u3066\u3082\u9023\u643a\u3057\u3066\u5bfe\u5fdc\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u708e\u75c7\u6027\u8178\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3092\u76f4\u3061\u306b\u78ba\u7acb\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001<strong>\u300c\u306a\u305c\u708e\u75c7\u304c\u6b62\u307e\u3089\u306a\u3044\u306e\u304b\u300d\u3068\u3044\u3046\u554f\u3044\u306b\u5bfe\u3057\u3066\u3001\u300c\u708e\u75c7\u3092\u6291\u3048\u308b\u4ed5\u7d44\u307f\u304c\u81ea\u5df1\u6297\u4f53\u306b\u3088\u3063\u3066\u59a8\u5bb3\u3055\u308c\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u65b0\u3057\u3044\u8996\u70b9\u3092\u52a0\u3048\u305f<\/strong>\u3053\u3068\u306b\u3001\u5927\u304d\u306a\u533b\u5b66\u7684\u610f\u7fa9\u304c\u3042\u308b\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5f8c\u3001\u3053\u3046\u3057\u305f\u514d\u75ab\u5b66\u7684\u767a\u898b\u304c\u3001\u60a3\u8005\u3055\u3093\u3054\u3068\u306e\u75c5\u614b\u306b\u9069\u3057\u305f\u7cbe\u5bc6\u533b\u7642\u3078\u3068\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Gharahdaghi N, Yeh PJ, Ceron-Gutierrez L, et al. Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>N Engl J Med.<\/em> 2026;394:2212-2222.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DOI: 10.1056\/NEJMoa2513654<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u8457\u8ad6\u6587\uff1a<a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2513654\">https:\/\/doi.org\/10.1056\/NEJMoa2513654<\/a><\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\u3042\u308f\u305b\u3066\u8aad\u307f\u305f\u3044\u95a2\u9023\u8a18\u4e8b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2460 \u30af\u30ed\u30fc\u30f3\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u81ea\u5df1\u514d\u75ab\u6027\u809d\u708e\u306e\u9855\u5728\u5316\uff5c\u611f\u67d3\u75c7\u3068\u514d\u75ab\u7570\u5e38\u3092\u8aad\u307f\u89e3\u304f\u81e8\u5e8a\u63a8\u8ad6<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed\"><div class=\"wp-block-embed__wrapper\">\n<blockquote 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class=\"wp-block-paragraph\">\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u65e2\u5f80\u3092\u6301\u3064\u60a3\u8005\u3055\u3093\u306b\u304a\u3044\u3066\u3001\u611f\u67d3\u75c7\u6cbb\u7642\u4e2d\u306b\u81ea\u5df1\u514d\u75ab\u6027\u809d\u708e\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u75c7\u4f8b\u3067\u3059\u3002IBD\u3068\u81ea\u5df1\u514d\u75ab\u7570\u5e38\u3001\u85ac\u5264\u3001\u81d3\u5668\u969c\u5bb3\u306e\u95a2\u4fc2\u3092\u8003\u3048\u308b\u3046\u3048\u3067\u53c2\u8003\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2461 \u96e3\u6cbb\u6027SLE\u30fb\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u30fb\u708e\u75c7\u6027\u7b4b\u75be\u60a3\u306b\u5bfe\u3059\u308bCAR-T\u7d30\u80de\u7642\u6cd5\uff5c\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u518d\u69cb\u7bc9\u3068\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" 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