{"id":9213,"date":"2026-10-15T20:45:50","date_gmt":"2026-10-15T11:45:50","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=9213"},"modified":"2026-10-15T21:00:56","modified_gmt":"2026-10-15T12:00:56","slug":"post-9213","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-9213\/","title":{"rendered":"\u3010NEJM 2026\u3011\u9ad8\u5ea6HLA\u611f\u4f5c\u60a3\u8005\u3078\u306eCAR-T\u7d30\u80de\u7642\u6cd5\uff5c\u6297HLA\u6297\u4f53\u3092\u6e1b\u3089\u3057\u814e\u79fb\u690d\u3092\u5b9f\u73fe\u3057\u305f\u7b2c1\u76f8\u8a66\u9a13"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>\u3010\u814e\u81d3\u5185\u79d1\u30fb\u79fb\u690d\u533b\u7642\u30fb\u8840\u6db2\u5185\u79d1\u30fb\u514d\u75ab\u5b66\u3011CD19\/BCMA\u4e8c\u91cd\u6a19\u7684CAR-T\u7d30\u80de\u7642\u6cd5\u306b\u3088\u308b\u9ad8\u5ea6HLA\u611f\u4f5c\u60a3\u8005\u306e\u8131\u611f\u4f5c\u6226\u7565\u3002\u6297HLA\u6297\u4f53\u306e\u7523\u751f\u6e90\u3067\u3042\u308bB\u7d30\u80de\u30fb\u5f62\u8cea\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u3001\u814e\u79fb\u690d\u306e\u6a5f\u4f1a\u3092\u62e1\u5927\u3057\u305fNEJM 2026\u5e74\u7b2c1\u76f8\u8a66\u9a13<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u514d\u75ab\u306e\u8a18\u61b6\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u79fb\u690d\u304c\u96e3\u3057\u304b\u3063\u305f\u60a3\u8005\u3055\u3093\u306b\u65b0\u3057\u3044\u53ef\u80fd\u6027<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u814e\u79fb\u690d\u306f\u3001\u814e\u81d3\u306e\u6a5f\u80fd\u304c\u5931\u308f\u308c\u305f\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u6cbb\u7642\u306e\u4e00\u3064\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u904e\u53bb\u306b\u79fb\u690d\u3092\u53d7\u3051\u305f\u7d4c\u9a13\u3084\u8f38\u8840\u3001\u598a\u5a20\u306a\u3069\u306b\u3088\u3063\u3066\u3001\u4ed6\u4eba\u306e\u7d44\u7e54\u3092\u653b\u6483\u3059\u308b\u300c\u6297HLA\u6297\u4f53\u300d\u304c\u4f5c\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u6297\u4f53\u304c\u591a\u3044\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u9069\u5408\u3059\u308b\u814e\u81d3\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u975e\u5e38\u306b\u96e3\u3057\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e74\u3001\u533b\u5b66\u8a8cNEJM\u306b\u3001\u514d\u75ab\u7d30\u80de\u3092\u5229\u7528\u3057\u305f\u300cCAR-T\u7d30\u80de\u7642\u6cd5\u300d\u306b\u3088\u3063\u3066\u6297HLA\u6297\u4f53\u3092\u6e1b\u3089\u3057\u3001\u79fb\u690d\u304c\u6975\u3081\u3066\u56f0\u96e3\u3060\u3063\u305f2\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u814e\u79fb\u690d\u3092\u5b9f\u65bd\u3067\u304d\u305f\u7814\u7a76\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u7642\u6cd5\u306f\u3001\u3053\u308c\u307e\u3067\u4e3b\u306b\u8840\u6db2\u304c\u3093\u3084\u96e3\u6cbb\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u7814\u7a76\u3055\u308c\u3066\u304d\u305f\u6cbb\u7642\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u6297\u4f53\u3092\u751f\u307f\u51fa\u3059B\u7d30\u80de\u3068\u5f62\u8cea\u7d30\u80de\u306e\u4e21\u65b9\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u79fb\u690d\u3092\u59a8\u3052\u308b\u514d\u75ab\u53cd\u5fdc\u3092\u5f31\u3081\u308b\u3053\u3068\u304c\u8a66\u307f\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306f\u3001\u5358\u306b\u8840\u6db2\u4e2d\u306e\u6297\u4f53\u3092\u53d6\u308a\u9664\u304f\u306e\u3067\u306f\u306a\u304f\u3001\u6297\u4f53\u3092\u4f5c\u308b\u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u6e1b\u3089\u3059\u3068\u3044\u3046\u65b0\u3057\u3044\u767a\u60f3\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2\u4eba\u3068\u3082\u814e\u79fb\u690d\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u5831\u544a\u6642\u70b9\u3067\u306f\u79fb\u690d\u3057\u305f\u814e\u81d3\u306b\u5bfe\u3059\u308b\u6297\u4f53\u306e\u518d\u4e0a\u6607\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u7814\u7a76\u5bfe\u8c61\u306f\u308f\u305a\u304b2\u4eba\u3067\u3042\u308a\u3001\u6a19\u6e96\u6cbb\u7642\u3068\u3057\u3066\u78ba\u7acb\u3055\u308c\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4eca\u5f8c\u3001\u3055\u3089\u306b\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u3067\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\uff0e\u306a\u305c\u6297HLA\u6297\u4f53\u304c\u3042\u308b\u3068\u814e\u79fb\u690d\u304c\u96e3\u3057\u304f\u306a\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u814e\u79fb\u690d\u3067\u306f\u3001\u79fb\u690d\u3055\u308c\u308b\u814e\u81d3\u3092\u60a3\u8005\u3055\u3093\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u7570\u7269\u3068\u3057\u3066\u8a8d\u8b58\u3057\u3001\u653b\u6483\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u514d\u75ab\u53cd\u5fdc\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046\u306e\u304c\u3001\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff08Human Leukocyte Antigen\uff1aHLA\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLA\u306f\u7d30\u80de\u8868\u9762\u306b\u767a\u73fe\u3059\u308b\u5206\u5b50\u3067\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u81ea\u5df1\u3068\u975e\u81ea\u5df1\u3092\u8b58\u5225\u3059\u308b\u3046\u3048\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u3055\u3093\u304c\u904e\u53bb\u306e\u814e\u79fb\u690d\u3001\u8f38\u8840\u3001\u598a\u5a20\u306a\u3069\u3092\u7d4c\u9a13\u3059\u308b\u3068\u3001\u81ea\u5206\u3068\u306f\u7570\u306a\u308bHLA\u3092\u8a8d\u8b58\u3057\u3001\u305d\u308c\u306b\u5bfe\u3059\u308b\u6297\u4f53\uff08\u6297HLA\u6297\u4f53\uff09\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u72b6\u614b\u3092\u300cHLA\u611f\u4f5c\uff08HLA sensitization\uff09\u300d\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6297HLA\u6297\u4f53\u304c\u814e\u79fb\u690d\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u79fb\u690d\u3055\u308c\u308b\u814e\u81d3\u306eHLA\u306b\u5bfe\u5fdc\u3059\u308b\u6297\u4f53\u304c\u60a3\u8005\u3055\u3093\u306e\u4f53\u5185\u306b\u5b58\u5728\u3059\u308b\u3068\u3001\u305d\u306e\u6297\u4f53\u304c\u79fb\u690d\u814e\u306e\u8840\u7ba1\u5185\u76ae\u306a\u3069\u306b\u7d50\u5408\u3057\u3001\u88dc\u4f53\u6d3b\u6027\u5316\u3084\u708e\u75c7\u7d30\u80de\u306e\u52d5\u54e1\u3092\u901a\u3058\u3066\u814e\u81d3\u3092\u969c\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u91cd\u8981\u306a\u306e\u304c\u3001\u6297\u4f53\u95a2\u9023\u578b\u62d2\u7d76\u53cd\u5fdc\uff08Antibody-Mediated Rejection\uff1aABMR\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ABMR\u306f\u79fb\u690d\u814e\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3084\u79fb\u690d\u814e\u55aa\u5931\u306b\u3064\u306a\u304c\u308b\u91cd\u8981\u306a\u5408\u4f75\u75c7\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u305f\u3081\u3001\u814e\u79fb\u690d\u524d\u306b\u306f\u6297HLA\u6297\u4f53\u3084\u30c9\u30ca\u30fc\u3068\u306e\u514d\u75ab\u5b66\u7684\u9069\u5408\u6027\u3092\u614e\u91cd\u306b\u8a55\u4fa1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\uff0ecPRA 99.9%\u4ee5\u4e0a\u3068\u306f\u4f55\u3092\u610f\u5473\u3059\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HLA\u611f\u4f5c\u306e\u7a0b\u5ea6\u3092\u8a55\u4fa1\u3059\u308b\u6307\u6a19\u306e\u4e00\u3064\u304c\u3001cPRA\uff08Calculated Panel-Reactive Antibody\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">cPRA\u306f\u3001\u60a3\u8005\u3055\u3093\u306e\u6297HLA\u6297\u4f53\u306b\u3088\u3063\u3066\u514d\u75ab\u5b66\u7684\u306b\u4e0d\u9069\u5408\u3068\u5224\u65ad\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u30c9\u30ca\u30fc\u306e\u5272\u5408\u3092\u3001\u96c6\u56e3\u306eHLA\u983b\u5ea6\u306a\u3069\u306b\u57fa\u3065\u3044\u3066\u63a8\u5b9a\u3057\u305f\u6307\u6a19\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f8b\u3048\u3070\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>cPRA 80%\uff1a\u7d0480%\u306e\u30c9\u30ca\u30fc\u304c\u514d\u75ab\u5b66\u7684\u306b\u4e0d\u9069\u5408\u3068\u63a8\u5b9a\u3055\u308c\u308b<\/li>\n\n\n\n<li>cPRA 99%\uff1a\u7d0499%\u306e\u30c9\u30ca\u30fc\u304c\u4e0d\u9069\u5408\u3068\u63a8\u5b9a\u3055\u308c\u308b<\/li>\n\n\n\n<li>cPRA 99.9%\uff1a\u7d0499.9%\u306e\u30c9\u30ca\u30fc\u304c\u4e0d\u9069\u5408\u3068\u63a8\u5b9a\u3055\u308c\u308b<\/li>\n\n\n\n<li>cPRA 99.99%\uff1a\u7d0499.99%\u306e\u30c9\u30ca\u30fc\u304c\u4e0d\u9069\u5408\u3068\u63a8\u5b9a\u3055\u308c\u308b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u610f\u5473\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">cPRA\u304c99.9%\u4ee5\u4e0a\u306b\u306a\u308b\u3068\u3001\u9069\u5408\u3059\u308b\u30c9\u30ca\u30fc\u306e\u5019\u88dc\u306f\u975e\u5e38\u306b\u9650\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001ABO\u8840\u6db2\u578b\u9069\u5408\u6027\u3084\u81d3\u5668\u914d\u5206\u306e\u6761\u4ef6\u306a\u3069\u3082\u95a2\u4fc2\u3059\u308b\u305f\u3081\u3001\u5b9f\u969b\u306b\u814e\u79fb\u690d\u3092\u53d7\u3051\u308b\u6a5f\u4f1a\u306f\u3055\u3089\u306b\u5236\u9650\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u6cbb\u7642\u958b\u59cb\u6642\u306ecPRA\u304c\u305d\u308c\u305e\u308c99.998%\u300199.995%\u3068\u3044\u3046\u6975\u3081\u3066\u9ad8\u5ea6\u306a\u611f\u4f5c\u72b6\u614b\u306b\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f93\u6765\u306e\u814e\u79fb\u690d\u533b\u7642\u3067\u306f\u3001\u3053\u3046\u3057\u305f\u60a3\u8005\u3055\u3093\u306b\u5341\u5206\u306a\u79fb\u690d\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u5927\u304d\u306a\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\uff0e\u5f93\u6765\u306e\u8131\u611f\u4f5c\u7642\u6cd5\u306b\u306f\u3069\u306e\u3088\u3046\u306a\u9650\u754c\u304c\u3042\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ad8\u5ea6HLA\u611f\u4f5c\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306f\u3001\u79fb\u690d\u524d\u306b\u6297HLA\u6297\u4f53\u3092\u6e1b\u3089\u3059\u300c\u8131\u611f\u4f5c\u7642\u6cd5\uff08Desensitization\uff09\u300d\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f93\u6765\u306e\u4e3b\u306a\u6cbb\u7642\u306b\u306f\u4ee5\u4e0b\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8840\u6f3f\u4ea4\u63db\u7642\u6cd5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308b\u6297HLA\u6297\u4f53\u3092\u7269\u7406\u7684\u306b\u9664\u53bb\u3059\u308b\u6cbb\u7642\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5faa\u74b0\u8840\u4e2d\u306e\u6297\u4f53\u3092\u6bd4\u8f03\u7684\u901f\u3084\u304b\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u304c\u3001\u6297\u4f53\u3092\u4f5c\u308b\u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u5341\u5206\u306b\u9664\u53bb\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u9759\u6ce8\u7642\u6cd5\uff08IVIG\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u514d\u75ab\u53cd\u5fdc\u306e\u8abf\u7bc0\u306a\u3069\u3092\u76ee\u7684\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u9ad8\u5ea6\u611f\u4f5c\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u6297HLA\u6297\u4f53\u306e\u6301\u7d9a\u7684\u306a\u6e1b\u5c11\u3092\u5b89\u5b9a\u3057\u3066\u9054\u6210\u3067\u304d\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">B\u7d30\u80de\u30fb\u5f62\u8cea\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297CD20\u6297\u4f53\u3001\u6297CD38\u6297\u4f53\u3001\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u85ac\u306a\u3069\u3082\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u6210\u719f\u3057\u305f\u6297\u4f53\u7523\u751f\u7d30\u80de\u306e\u4e00\u90e8\u306fCD20\u3092\u767a\u73fe\u3057\u306a\u3044\u305f\u3081\u3001B\u7d30\u80de\u3092\u9664\u53bb\u3059\u308b\u3060\u3051\u3067\u306f\u9577\u671f\u9593\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u6297\u4f53\u7523\u751f\u3092\u5341\u5206\u306b\u6291\u3048\u3089\u308c\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u6297\u4f53\u304c\u4e00\u5ea6\u6e1b\u5c11\u3057\u3066\u3082\u3001\u6b8b\u5b58\u3059\u308b\u5f62\u8cea\u7d30\u80de\u306a\u3069\u304b\u3089\u518d\u3073\u7523\u751f\u3055\u308c\u308b\u300c\u6297\u4f53\u30ea\u30d0\u30a6\u30f3\u30c9\uff08Antibody Rebound\uff09\u300d\u304c\u554f\u984c\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5f93\u6765\u306e\u8131\u611f\u4f5c\u7642\u6cd5\u306e\u91cd\u8981\u306a\u8ab2\u984c\u306f\u3001\u8840\u6db2\u4e2d\u306e\u6297\u4f53\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3068\u3001\u6297\u4f53\u3092\u4f5c\u308a\u7d9a\u3051\u308b\u7d30\u80de\u3092\u5341\u5206\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5fc5\u305a\u3057\u3082\u4e00\u81f4\u3057\u306a\u3044\u70b9\u3067\u3059\u3002<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4\uff0eCD19\/BCMA\u4e8c\u91cd\u6a19\u7684CAR-T\u7642\u6cd5\u306e\u4f5c\u7528\u6a5f\u5e8f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001CD19\u3092\u6a19\u7684\u3068\u3059\u308bCAR-T\u7d30\u80de\u3068\u3001BCMA\u3092\u6a19\u7684\u3068\u3059\u308bCAR-T\u7d30\u80de\u3092\u4f75\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u7642\u6cd5\u3068\u306f\u3001\u60a3\u8005\u3055\u3093\u306eT\u7d30\u80de\u306b\u7279\u5b9a\u306e\u6a19\u7684\u3092\u8a8d\u8b58\u3059\u308b\u4eba\u5de5\u7684\u306a\u53d7\u5bb9\u4f53\u3092\u767a\u73fe\u3055\u305b\u3001\u305d\u306e\u7d30\u80de\u3092\u4f53\u5185\u306b\u623b\u3057\u3066\u6a19\u7684\u7d30\u80de\u3092\u653b\u6483\u3055\u305b\u308b\u6cbb\u7642\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">CD19\uff1aB\u7d30\u80de\u7cfb\u7d71\u3092\u6a19\u7684\u3068\u3059\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CD19\u306f\u3001\u591a\u304f\u306eB\u7d30\u80de\u306e\u767a\u9054\u6bb5\u968e\u3067\u767a\u73fe\u3059\u308b\u5206\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CD19\u6a19\u7684CAR-T\u7d30\u80de\u306f\u3001B\u7d30\u80de\u3084\u4e00\u90e8\u306e\u5f62\u8cea\u82bd\u7d30\u80de\u30fb\u5f62\u8cea\u7d30\u80de\u3092\u9664\u53bb\u3057\u3001\u6297\u4f53\u7523\u751f\u306b\u95a2\u308f\u308bB\u7d30\u80de\u7cfb\u7d71\u3092\u6df1\u304f\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u514d\u75ab\u8a18\u61b6\u3092\u62c5\u3046\u30e1\u30e2\u30ea\u30fcB\u7d30\u80de\u306e\u9664\u53bb\u306f\u3001\u65b0\u305f\u306a\u6297\u4f53\u7523\u751f\u53cd\u5fdc\u3092\u6291\u3048\u308b\u3046\u3048\u3067\u91cd\u8981\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">BCMA\uff1a\u5f62\u8cea\u7d30\u80de\u7cfb\u7d71\u3092\u6a19\u7684\u3068\u3059\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">BCMA\uff08B-cell Maturation Antigen\uff09\u306f\u3001\u5f62\u8cea\u82bd\u7d30\u80de\u3084\u5f62\u8cea\u7d30\u80de\u306a\u3069\u306b\u767a\u73fe\u3059\u308b\u5206\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f62\u8cea\u7d30\u80de\u306f\u3001\u6297\u4f53\u3092\u5927\u91cf\u306b\u7523\u751f\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u90e8\u306e\u9577\u5bff\u547d\u5f62\u8cea\u7d30\u80de\u306f\u3001\u6297\u539f\u3078\u306e\u518d\u66dd\u9732\u304c\u306a\u304f\u3066\u3082\u9577\u671f\u9593\u6297\u4f53\u3092\u4f5c\u308a\u7d9a\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3046\u3057\u305f\u7d30\u80de\u304c\u6297HLA\u6297\u4f53\u3092\u7dad\u6301\u3059\u308b\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BCMA\u6a19\u7684CAR-T\u7d30\u80de\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001CD19\u6a19\u7684CAR-T\u7d30\u80de\u3060\u3051\u3067\u306f\u5341\u5206\u306b\u9664\u53bb\u3067\u304d\u306a\u3044\u6297\u4f53\u7523\u751f\u7d30\u80de\u306b\u3082\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e8c\u91cd\u6a19\u7684\u5316\u306e\u610f\u7fa9<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CD19\u6a19\u7684CAR-T\u7d30\u80de\u3068BCMA\u6a19\u7684CAR-T\u7d30\u80de\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>\u6297\u4f53\u7523\u751f\u3092\u62c5\u3046\u30e1\u30e2\u30ea\u30fcB\u7d30\u80de\u3092\u6e1b\u3089\u3059<\/li>\n\n\n\n<li>\u6297\u4f53\u3092\u7523\u751f\u3059\u308b\u5f62\u8cea\u7d30\u80de\u3092\u6e1b\u3089\u3059<\/li>\n\n\n\n<li>\u6297HLA\u6297\u4f53\u306e\u7523\u751f\u6e90\u3092\u8907\u6570\u306e\u6bb5\u968e\u3067\u6291\u3048\u308b<\/li>\n\n\n\n<li>\u6297\u4f53\u4fa1\u306e\u6301\u7d9a\u7684\u306a\u4f4e\u4e0b\u3092\u4fc3\u3059<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u6226\u7565\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u6cbb\u7642\u306f\u3001\u6297\u4f53\u3092\u5358\u7d14\u306b\u8840\u6db2\u4e2d\u304b\u3089\u53d6\u308a\u9664\u304f\u5f93\u6765\u7642\u6cd5\u3068\u306f\u7570\u306a\u308a\u3001\u6297\u4f53\u7523\u751f\u30b7\u30b9\u30c6\u30e0\u306e\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u518d\u69cb\u7bc9\u3092\u76ee\u6307\u3059\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001B\u7d30\u80de\u3084\u5f62\u8cea\u7d30\u80de\u304c\u5b8c\u5168\u304b\u3064\u6c38\u4e45\u306b\u9664\u53bb\u3055\u308c\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u4eca\u56de\u306e2\u4f8b\u304b\u3089\u4e8c\u91cd\u6a19\u7684\u5316\u304c\u5358\u4e00\u6a19\u7684CAR-T\u7642\u6cd5\u3088\u308a\u512a\u308c\u3066\u3044\u308b\u3068\u65ad\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-73.png\" alt=\"\" class=\"wp-image-9220\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-73.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-73-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-73-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56f31\uff0e\u9ad8\u5ea6HLA\u611f\u4f5c\u60a3\u8005\u306b\u5bfe\u3059\u308bCD19\/BCMA\u4e8c\u91cd\u6a19\u7684CAR-T\u7d30\u80de\u7642\u6cd5\u306e\u4f5c\u7528\u6a5f\u5e8f<\/strong><br>CD19\u6a19\u7684CAR-T\u7d30\u80de\u306b\u3088\u308bB\u7d30\u80de\u7cfb\u7d71\u306e\u9664\u53bb\u3068\u3001BCMA\u6a19\u7684CAR-T\u7d30\u80de\u306b\u3088\u308b\u5f62\u8cea\u7d30\u80de\u7cfb\u7d71\u306e\u9664\u53bb\u3092\u793a\u3059\u6a21\u5f0f\u56f3\u3002\u4e21\u8005\u306e\u4f75\u7528\u306b\u3088\u308a\u3001\u6297HLA\u6297\u4f53\u306e\u7523\u751f\u306b\u95a2\u4e0e\u3059\u308b\u7d30\u80de\u96c6\u56e3\u3092\u8907\u6570\u306e\u5206\u5316\u6bb5\u968e\u3067\u6a19\u7684\u3068\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5\uff0eNEJM 2026\uff1a\u7b2c1\u76f8\u81e8\u5e8a\u8a66\u9a13\u306e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u5831\u544a\u3055\u308c\u305f\u306e\u306f\u3001\u591a\u65bd\u8a2d\u5171\u540c\u7b2c1\u76f8\u8a66\u9a13\uff08NCT06056102\uff09\u306e\u5b89\u5168\u6027\u5148\u884c\u8a55\u4fa1\u30b3\u30db\u30fc\u30c8\uff08Safety Run-in Cohort\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u5bfe\u8c61\u306f\u3001cPRA 99.9%\u4ee5\u4e0a\u306e\u9ad8\u5ea6HLA\u611f\u4f5c\u60a3\u80052\u4eba\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e21\u60a3\u8005\u3068\u3082\u904e\u53bb2\u56de\u306e\u814e\u79fb\u690d\u6b74\u304c\u3042\u308a\u3001\u3044\u305a\u308c\u3082\u6297\u4f53\u95a2\u9023\u578b\u62d2\u7d76\u53cd\u5fdc\u306b\u3088\u3063\u3066\u79fb\u690d\u814e\u3092\u5931\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6cbb\u7642\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305a\u3001\u60a3\u8005\u3055\u3093\u304b\u3089T\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3066CAR-T\u7d30\u80de\u3092\u88fd\u9020\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u5f8c\u3001\u30ea\u30f3\u30d1\u7403\u9664\u53bb\u3092\u76ee\u7684\u3068\u3059\u308b\u524d\u51e6\u7f6e\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\uff1a375 mg\/m\u00b2\/\u65e5\u30923\u65e5\u9593<\/li>\n\n\n\n<li>CD19\u6a19\u7684CAR-T\u7d30\u80de\uff1a5\u00d710\u2077 CAR\u967d\u6027\u7d30\u80de<\/li>\n\n\n\n<li>BCMA\u6a19\u7684CAR-T\u7d30\u80de\uff1a5\u00d710\u2077 CAR\u967d\u6027\u7d30\u80de<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306eCAR-T\u6295\u4e0e\u91cf\u306f\u3001\u5148\u884c\u3059\u308b\u816b\u760d\u9818\u57df\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u4f7f\u7528\u3055\u308c\u305f\u91cf\u306e10\u5206\u306e1\u306b\u76f8\u5f53\u3057\u3001\u524d\u51e6\u7f6e\u3082\u6bd4\u8f03\u7684\u8efd\u6e1b\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001CAR-T\u7d30\u80de\u6295\u4e0e\u306e\u7d041\u304b\u6708\u5f8c\u304b\u3089\u30012\u4eba\u3068\u3082\u8840\u6f3f\u4ea4\u63db\u7642\u6cd5\u30925\u56de\u53d7\u3051\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5404\u8840\u6f3f\u4ea4\u63db\u306e\u5f8c\u306b\u306f\u3001100 mg\/kg\u306e\u4f4e\u7528\u91cfIVIG\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306f\u3001\u6b8b\u5b58\u3059\u308b\u5faa\u74b0\u8840\u4e2d\u306e\u6297HLA\u6297\u4f53\u306e\u9664\u53bb\u3092\u4fc3\u9032\u3059\u308b\u76ee\u7684\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8a55\u4fa1\u9805\u76ee<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b89\u5168\u6027\u306b\u52a0\u3048\u3001\u4ee5\u4e0b\u306e\u9805\u76ee\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6297HLA\u6297\u4f53\u306e\u5909\u5316<\/li>\n\n\n\n<li>cPRA\u306e\u5909\u5316<\/li>\n\n\n\n<li>CAR-T\u7d30\u80de\u306e\u4f53\u5185\u5897\u6b96\u3068\u6301\u7d9a\u6027<\/li>\n\n\n\n<li>B\u7d30\u80de\u30fb\u5f62\u8cea\u7d30\u80de\u306e\u6e1b\u5c11<\/li>\n\n\n\n<li>\u814e\u79fb\u690d\u306e\u5b9f\u73fe<\/li>\n\n\n\n<li>\u79fb\u690d\u5f8c\u306e\u30c9\u30ca\u30fc\u7279\u7570\u7684\u6297\u4f53\uff08DSA\uff09\u306e\u518d\u4e0a\u6607<\/li>\n\n\n\n<li>\u79fb\u690d\u814e\u6a5f\u80fd\u3068\u62d2\u7d76\u53cd\u5fdc<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297HLA\u6297\u4f53\u306f\u5358\u4e00\u6297\u539f\u30d3\u30fc\u30ba\u6cd5\u3067\u8a55\u4fa1\u3055\u308c\u3001MFI\uff08Mean Fluorescence Intensity\uff09\u304c1000\u672a\u6e80\u3068\u306a\u3063\u305f\u6297\u4f53\u306b\u3064\u3044\u3066\u3001\u5bfe\u5fdc\u3059\u308bHLA\u6297\u539f\u3092\u79fb\u690d\u5f85\u6a5f\u30ea\u30b9\u30c8\u4e0a\u306e\u300c\u4e0d\u9069\u5408\u6297\u539f\u300d\u304b\u3089\u9664\u5916\u3059\u308b\u3053\u3068\u304c\u691c\u8a0e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306eMFI 1000\u3068\u3044\u3046\u57fa\u6e96\u306f\u672c\u7814\u7a76\u306e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306b\u57fa\u3065\u304f\u3082\u306e\u3067\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u79fb\u690d\u65bd\u8a2d\u30fb\u3059\u3079\u3066\u306e\u60a3\u8005\u306b\u5171\u901a\u3059\u308b\u7d76\u5bfe\u7684\u306a\u5b89\u5168\u57fa\u6e96\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-74.png\" alt=\"\" class=\"wp-image-9221\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-74.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-74-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-74-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56f32\uff0e\u9ad8\u5ea6HLA\u611f\u4f5c\u60a3\u80052\u4f8b\u306b\u5bfe\u3059\u308b\u8131\u611f\u4f5c\u7642\u6cd5\u306e\u6cbb\u7642\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb<\/strong><br>\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\uff08375 mg\/m\u00b2\/\u65e5\u30013\u65e5\u9593\uff09\u306b\u3088\u308b\u524d\u51e6\u7f6e\u5f8c\u3001CD19\u6a19\u7684\u304a\u3088\u3073BCMA\u6a19\u7684CAR-T\u7d30\u80de\u3092\u54045\u00d710\u2077\u500b\u6295\u4e0e\u3057\u305f\u3002\u7d041\u304b\u6708\u5f8c\u304b\u3089\u8840\u6f3f\u4ea4\u63db5\u56de\u3068\u5404\u65bd\u884c\u5f8c\u306e\u4f4e\u7528\u91cfIVIG\uff08100 mg\/kg\uff09\u3092\u4f75\u7528\u3057\u3001\u6297HLA\u6297\u4f53\u304a\u3088\u3073\u79fb\u690d\u9069\u5408\u6027\u306e\u5909\u5316\u3092\u7d4c\u6642\u7684\u306b\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6\uff0e\u75c7\u4f8b\u2460\uff1acPRA 99.998%\u304b\u308999.516%\u3078\u4f4e\u4e0b\u3057\u30013\u56de\u76ee\u306e\u814e\u79fb\u690d\u304c\u5b9f\u73fe<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u521d\u306e\u60a3\u8005\u306f54\u6b73\u7537\u6027\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672b\u671f\u814e\u4e0d\u5168\u306b\u5bfe\u3057\u3066\u904e\u53bb2\u56de\u306e\u814e\u79fb\u690d\u3092\u53d7\u3051\u307e\u3057\u305f\u304c\u3001\u3044\u305a\u308c\u3082\u6297\u4f53\u95a2\u9023\u578b\u62d2\u7d76\u53cd\u5fdc\u306b\u3088\u308a\u79fb\u690d\u814e\u3092\u5931\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\u56de\u76ee\u306e\u814e\u79fb\u690d\u3092\u5f85\u6a5f\u3057\u3066\u3044\u305f\u6642\u70b9\u3067\u3001cPRA\u306f99.998%\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u8005\u3089\u306f\u30c9\u30ca\u30fc\u814e\u306e\u5e74\u9593\u4f9b\u7d66\u6570\u3084ABO\u9069\u5408\u6027\u3092\u8003\u616e\u3057\u3001\u3053\u306e\u60a3\u8005\u306b\u9069\u5408\u3059\u308b\u81d3\u5668\u306e\u671f\u5f85\u6570\u3092\u5e74\u9593\u7d040.1\u500b\u3068\u63a8\u8a08\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b9f\u969b\u3001\u7814\u7a76\u767b\u9332\u524d\u306e\u7d043\u5e74\u9593\u3001\u814e\u81d3\u306e\u63d0\u4f9b\u7533\u3057\u51fa\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">CAR-T\u7642\u6cd5\u5f8c\u306e\u6297HLA\u6297\u4f53\u306e\u5909\u5316<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u6295\u4e0e\u5f8c\u3001\u6297HLA\u6297\u4f53\u306f\u8907\u6570\u306e\u6297\u539f\u306b\u5bfe\u3057\u3066\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6295\u4e0e\u304b\u3089\u7d041\u304b\u6708\u4ee5\u5185\u3001\u8840\u6f3f\u4ea4\u63db\u5b9f\u65bd\u524d\u306e\u6bb5\u968e\u3067\u300112\u7a2e\u985e\u306eHLA\u6297\u539f\u306b\u5bfe\u3059\u308b\u6297\u4f53\u304cMFI 1000\u672a\u6e80\u307e\u3067\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u6295\u4e0e2\u304b\u6708\u5f8c\u307e\u3067\u306b6\u7a2e\u985e\u306e\u6297\u539f\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3082\u57fa\u6e96\u672a\u6e80\u3068\u306a\u308a\u3001\u79fb\u690d\u5019\u88dc\u3092\u5236\u9650\u3057\u3066\u3044\u305f\u6297\u539f\u306e\u4e00\u90e8\u3092\u30ea\u30b9\u30c8\u304b\u3089\u9664\u5916\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u5f8c\u3082\u6297HLA\u6297\u4f53\u306e\u6e1b\u5c11\u304c\u78ba\u8a8d\u3055\u308c\u3001\u6295\u4e0e\u7d047\u304b\u6708\u5f8c\u306b\u306fcPRA\u304c99.516%\u307e\u3067\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u898b\u3059\u308b\u306899.998%\u304b\u308999.516%\u3078\u306e\u5909\u5316\u306f\u5c0f\u3055\u304f\u611f\u3058\u3089\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u7406\u8ad6\u4e0a\u306e\u9069\u5408\u5019\u88dc\u5272\u5408\u3067\u6bd4\u8f03\u3059\u308b\u3068\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6cbb\u7642\u524d\uff1a0.002%<\/li>\n\n\n\n<li>\u6cbb\u7642\u5f8c\uff1a0.484%<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5358\u7d14\u306a\u6bd4\u3067\u306f\u9069\u5408\u5019\u88dc\u5272\u5408\u304c\u7d04242\u500d\u3068\u306a\u308b\u8a08\u7b97\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u308c\u306fcPRA\u304b\u3089\u6c42\u3081\u305f\u7406\u8ad6\u7684\u306a\u5272\u5408\u306e\u6bd4\u8f03\u3067\u3042\u308a\u3001\u5b9f\u969b\u306e\u814e\u79fb\u690d\u5b9f\u65bd\u78ba\u7387\u304c242\u500d\u306b\u306a\u3063\u305f\u3053\u3068\u3092\u793a\u3059\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u814e\u79fb\u690d\u5f8c\u306e\u7d4c\u904e<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u6295\u4e0e\u304b\u3089229\u65e5\u5f8c\u3001\u4ea4\u5dee\u9069\u5408\u8a66\u9a13\u3067\u9069\u5408\u304c\u78ba\u8a8d\u3055\u308c\u305f\u732e\u814e\u79fb\u690d\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30c9\u30ca\u30fc\u814e\u306eKDPI\uff08Kidney Donor Profile Index\uff09\u306f8%\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79fb\u690d\u5f8c\u306f\u6297\u80f8\u817a\u7d30\u80de\u30b0\u30ed\u30d6\u30ea\u30f3\u306b\u3088\u308b\u5c0e\u5165\u7642\u6cd5\u3068\u3001\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u3001\u30df\u30b3\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u30e2\u30d5\u30a7\u30c1\u30eb\u3001\u30d7\u30ec\u30c9\u30cb\u30be\u30f3\u306b\u3088\u308b\u7dad\u6301\u514d\u75ab\u6291\u5236\u7642\u6cd5\u3092\u53d7\u3051\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79fb\u690d\u5f8c12\u304b\u6708\u6642\u70b9\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u5024\u306f\u5b89\u5b9a<\/li>\n\n\n\n<li>\u30c9\u30ca\u30fc\u7279\u7570\u7684\u6297\u4f53\u306e\u518d\u4e0a\u6607\u306a\u3057<\/li>\n\n\n\n<li>\u79fb\u690d\u5f8c2\u304b\u6708\u306e\u814e\u751f\u691c\u3067\u514d\u75ab\u4ecb\u5728\u6027\u62d2\u7d76\u53cd\u5fdc\u306a\u3057<\/li>\n\n\n\n<li>C4d\u67d3\u8272\u9670\u6027<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u7d4c\u904e\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6975\u3081\u3066\u9ad8\u5ea6\u306aHLA\u611f\u4f5c\u306b\u3088\u308a\u79fb\u690d\u6a5f\u4f1a\u304c\u9650\u3089\u308c\u3066\u3044\u305f\u60a3\u8005\u3067\u3001\u518d\u79fb\u690d\u3068\u305d\u306e\u5f8c\u306e\u79fb\u690d\u814e\u6a5f\u80fd\u306e\u7dad\u6301\u304c\u5831\u544a\u3055\u308c\u305f\u3053\u3068\u306f\u6ce8\u76ee\u3059\u3079\u304d\u7d50\u679c\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">7\uff0e\u75c7\u4f8b\u2461\uff1acPRA 99.995%\u304b\u308999.567%\u3078\u4f4e\u4e0b\u3057\u300193\u65e5\u5f8c\u306b\u814e\u79fb\u690d<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2\u4eba\u76ee\u306f47\u6b73\u7537\u6027\u3067\u3001\u5de3\u72b6\u5206\u7bc0\u6027\u7cf8\u7403\u4f53\u786c\u5316\u75c7\uff08FSGS\uff09\u306e\u65e2\u5f80\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u6295\u4e0e\u5f8c\u7d041\u304b\u6708\u4ee5\u5185\u3001\u8840\u6f3f\u4ea4\u63db\u524d\u306e\u6bb5\u968e\u3067\u30016\u7a2e\u985e\u306eHLA\u6297\u539f\u306b\u5bfe\u3059\u308b\u6297\u4f53\u304cMFI 1000\u672a\u6e80\u307e\u3067\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u6295\u4e0e2\u304b\u6708\u5f8c\u307e\u3067\u306b15\u7a2e\u985e\u306e\u6297\u539f\u306b\u5bfe\u3059\u308b\u6297\u4f53\u304c\u57fa\u6e96\u672a\u6e80\u3068\u306a\u308a\u3001cPRA\u306f99.567%\u307e\u3067\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u79fb\u690d\u5b9f\u65bd\u3068\u305d\u306e\u5f8c\u306e\u7d4c\u904e<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u6295\u4e0e\u304b\u308993\u65e5\u5f8c\u3001\u4ea4\u5dee\u9069\u5408\u8a66\u9a13\u3067\u9069\u5408\u3059\u308b\u30c9\u30ca\u30fc\u814e\u304c\u898b\u3064\u304b\u308a\u3001\u732e\u814e\u79fb\u690d\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30c9\u30ca\u30fc\u814e\u306eKDPI\u306f64%\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79fb\u690d\u5f8c\u306e\u814e\u6a5f\u80fd\u306f\u5f90\u3005\u306b\u6539\u5584\u3057\u3001\u79fb\u690d\u5f8c\u900f\u6790\u306f\u5fc5\u8981\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79fb\u690d\u5f8c23\u65e5\u76ee\u306e\u814e\u751f\u691c\u3067\u306f\u3001\u6297\u4f53\u95a2\u9023\u578b\u62d2\u7d76\u53cd\u5fdc\u30fb\u7d30\u80de\u6027\u62d2\u7d76\u53cd\u5fdc\u306e\u3044\u305a\u308c\u3082\u8a8d\u3081\u3089\u308c\u305a\u3001C4d\u67d3\u8272\u3082\u9670\u6027\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79fb\u690d\u5f8c7\u304b\u6708\u6642\u70b9\u3067\u3082\u30c9\u30ca\u30fc\u7279\u7570\u7684\u6297\u4f53\u306e\u518d\u4e0a\u6607\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u79fb\u690d\u5f8c\u306b\u306fBK\u30a6\u30a4\u30eb\u30b9\u8840\u75c7\u304c\u767a\u751f\u3057\u3001\u514d\u75ab\u6291\u5236\u85ac\u306e\u6e1b\u91cf\u306b\u3088\u308b\u5bfe\u5fdc\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u70b9\u306f\u3001\u65b0\u3057\u3044\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u3092\u79fb\u690d\u533b\u7642\u306b\u5fdc\u7528\u3059\u308b\u969b\u306e\u611f\u67d3\u75c7\u30ea\u30b9\u30af\u3092\u8003\u3048\u308b\u3046\u3048\u3067\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-75.png\" alt=\"\" class=\"wp-image-9223\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-75.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-75-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-75-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56f33\uff0eCAR-T\u7d30\u80de\u7642\u6cd5\u3092\u542b\u3080\u8131\u611f\u4f5c\u524d\u5f8c\u306ecPRA\u5909\u5316\u3068\u814e\u79fb\u690d\u306e\u5b9f\u65bd<\/strong><br>\u75c7\u4f8b1\u3067\u306fcPRA\u304c99.998%\u304b\u308999.516%\u3001\u75c7\u4f8b2\u3067\u306f99.995%\u304b\u308999.567%\u306b\u4f4e\u4e0b\u3057\u305f\u3002CAR-T\u7d30\u80de\u6295\u4e0e\u5f8c\u3001\u305d\u308c\u305e\u308c229\u65e5\u76ee\u304a\u3088\u307393\u65e5\u76ee\u306b\u4ea4\u5dee\u9069\u5408\u8a66\u9a13\u3067\u9069\u5408\u304c\u78ba\u8a8d\u3055\u308c\u305f\u732e\u814e\u79fb\u690d\u304c\u5b9f\u65bd\u3055\u308c\u305f\u3002cPRA\u306f\u79fb\u690d\u5019\u88dc\u30c9\u30ca\u30fc\u3068\u306e\u514d\u75ab\u5b66\u7684\u4e0d\u9069\u5408\u5272\u5408\u3092\u63a8\u5b9a\u3059\u308b\u6307\u6a19\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">8\uff0eCAR-T\u7642\u6cd5\u306f\u5b9f\u969b\u306bB\u7d30\u80de\u3068\u5f62\u8cea\u7d30\u80de\u3092\u6e1b\u3089\u3057\u3066\u3044\u305f\u306e\u304b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u306e\u91cd\u8981\u6027\u306f\u3001\u5358\u306b\u6297HLA\u6297\u4f53\u304c\u4f4e\u4e0b\u3057\u3066\u79fb\u690d\u3067\u304d\u305f\u3068\u3044\u3046\u81e8\u5e8a\u7d50\u679c\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u306b\u3088\u308b\u514d\u75ab\u7d30\u80de\u3078\u306e\u4f5c\u7528\u3092\u3001\u8840\u6db2\u30fb\u9aa8\u9ac4\u30fb\u30ea\u30f3\u30d1\u7bc0\u306a\u3069\u3067\u8a73\u3057\u304f\u8a55\u4fa1\u3057\u3066\u3044\u305f\u70b9\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">CAR-T\u7d30\u80de\u306e\u4f53\u5185\u5897\u6b96<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c7\u4f8b\u2460\u3067\u306f\u3001CD19\u6a19\u7684CAR-T\u7d30\u80de\u3068BCMA\u6a19\u7684CAR-T\u7d30\u80de\u304c\u305d\u308c\u305e\u308c\u4f53\u5185\u3067\u5897\u6b96\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CD19\u6a19\u7684CAR-T\u7d30\u80de\u306f\u6295\u4e0e14\u65e5\u76ee\u3001BCMA\u6a19\u7684CAR-T\u7d30\u80de\u306f\u6295\u4e0e7\u65e5\u76ee\u306b\u6e2c\u5b9a\u4e0a\u306e\u30d4\u30fc\u30af\u306b\u9054\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u5f8c\u3001\u4e21\u8005\u3068\u3082\u5f90\u3005\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u304c\u4f53\u5185\u3067\u5897\u6b96\u3057\u3001\u6a19\u7684\u7d30\u80de\u306b\u4f5c\u7528\u3057\u305f\u3053\u3068\u3092\u793a\u3059\u85ac\u529b\u5b66\u7684\u306a\u7d50\u679c\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">B\u7d30\u80de\u306e\u4e00\u6642\u7684\u306a\u67af\u6e07<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c7\u4f8b\u2460\u3067\u306f\u6295\u4e0e13\u301c53\u65e5\u76ee\u3001\u75c7\u4f8b\u2461\u3067\u306f\u6295\u4e0e15\u301c50\u65e5\u76ee\u306b\u3001\u672b\u68a2\u8840\u3067B\u7d30\u80de\u304c\u691c\u51fa\u3055\u308c\u306a\u3044\u671f\u9593\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u75c7\u4f8b\u2460\u3067\u306f\u6295\u4e0e2\u304b\u6708\u5f8c\u306e\u30ea\u30f3\u30d1\u7bc0\u7a7f\u523a\u691c\u4f53\u304b\u3089B\u7d30\u80de\u304c\u691c\u51fa\u3055\u308c\u305a\u3001\u7d44\u7e54\u30ec\u30d9\u30eb\u3067\u3082B\u7d30\u80de\u306e\u67af\u6e07\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u518d\u51fa\u73fe\u3057\u305fB\u7d30\u80de\u306e\u7279\u5fb4<\/h3>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u300cCRS\u304c\u306a\u304b\u3063\u305f\u300d\u3068\u3044\u3046\u7d50\u679c\u3092\u3001\u708e\u75c7\u6027\u306e\u6709\u5bb3\u53cd\u5fdc\u304c\u5168\u304f\u306a\u304b\u3063\u305f\u3053\u3068\u3068\u540c\u4e00\u8996\u3059\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8840\u7403\u6e1b\u5c11<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c7\u4f8b\u2460\u3067\u306f\u3001\u79fb\u690d\u524d\u306bGrade 3\u4ee5\u4e0a\u306e\u4e00\u904e\u6027\u597d\u4e2d\u7403\u6e1b\u5c11\u304c\u8a8d\u3081\u3089\u308c\u3001G-CSF\u3067\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c7\u4f8b\u2461\u3067\u306f\u3001Grade 3\u306e\u767d\u8840\u7403\u6e1b\u5c11\u3068Grade 4\u306e\u597d\u4e2d\u7403\u6e1b\u5c11\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u7642\u6cd5\u306e\u9032\u6b69\u306f\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u3082\u306e\u3067\u3059\u304c\u3001\u65e2\u5b58\u306e\u814e\u81d3\u75c5\u6cbb\u7642\u3084\u81a0\u539f\u75c5\u6cbb\u7642\u3092\u7f6e\u304d\u63db\u3048\u308b\u6bb5\u968e\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u307e\u3068\u3081<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e74\u306eNEJM\u306b\u5831\u544a\u3055\u308c\u305f\u7b2c1\u76f8\u8a66\u9a13\u3067\u306f\u3001\u9ad8\u5ea6HLA\u611f\u4f5c\u306b\u3088\u308a\u814e\u79fb\u690d\u304c\u6975\u3081\u3066\u56f0\u96e3\u3060\u3063\u305f2\u4eba\u306b\u5bfe\u3057\u3001CD19\/BCMA\u4e8c\u91cd\u6a19\u7684CAR-T\u7d30\u80de\u7642\u6cd5\u3092\u542b\u3080\u8131\u611f\u4f5c\u6226\u7565\u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2\u4eba\u3068\u3082\u6297HLA\u6297\u4f53\u304c\u6e1b\u5c11<\/li>\n\n\n\n<li>cPRA\u306f99.998%\u304b\u308999.516%\u300199.995%\u304b\u308999.567%\u3078\u4f4e\u4e0b<\/li>\n\n\n\n<li>CAR-T\u6295\u4e0e\u304b\u3089229\u65e5\u5f8c\u304a\u3088\u307393\u65e5\u5f8c\u306b\u814e\u79fb\u690d\u3092\u5b9f\u65bd<\/li>\n\n\n\n<li>\u79fb\u690d\u5f8c12\u304b\u6708\u304a\u3088\u30737\u304b\u6708\u6642\u70b9\u3067\u30c9\u30ca\u30fc\u7279\u7570\u7684\u6297\u4f53\u306e\u518d\u4e0a\u6607\u306a\u3057<\/li>\n\n\n\n<li>\u8a55\u4fa1\u3055\u308c\u305f\u814e\u751f\u691c\u3067\u306f\u62d2\u7d76\u53cd\u5fdc\u3092\u8a8d\u3081\u305a<\/li>\n\n\n\n<li>CRS\u30fbICANS\u306f\u8a3a\u65ad\u3055\u308c\u306a\u304b\u3063\u305f\u4e00\u65b9\u3001\u91cd\u5ea6\u8840\u7403\u6e1b\u5c11\u3084BK\u30a6\u30a4\u30eb\u30b9\u8840\u75c7\u306a\u3069\u306e\u5b89\u5168\u6027\u4e0a\u306e\u554f\u984c\u3092\u8a8d\u3081\u305f<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7d50\u679c\u306f\u3001\u6297\u4f53\u7523\u751f\u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u306b\u3088\u3063\u3066\u3001\u9ad8\u5ea6HLA\u611f\u4f5c\u60a3\u8005\u306e\u79fb\u690d\u6a5f\u4f1a\u3092\u62e1\u5927\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u6cbb\u7642\u306b\u306f\u8840\u6f3f\u4ea4\u63db\u30fbIVIG\u304c\u4f75\u7528\u3055\u308c\u3001\u79fb\u690d\u5f8c\u3082\u514d\u75ab\u6291\u5236\u7642\u6cd5\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u5358\u72ec\u306e\u52b9\u679c\u3001\u6700\u9069\u306a\u6a19\u7684\u3001\u5b89\u5168\u6027\u3001\u9577\u671f\u7684\u306a\u79fb\u690d\u814e\u751f\u7740\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u3001\u4eca\u5f8c\u306e\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CAR-T\u7d30\u80de\u7642\u6cd5\u306f\u300c\u6297\u4f53\u3092\u9664\u53bb\u3059\u308b\u6cbb\u7642\u300d\u304b\u3089\u300c\u6297\u4f53\u3092\u4f5c\u308b\u514d\u75ab\u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u5236\u5fa1\u3059\u308b\u6cbb\u7642\u300d\u3078\u306e\u767a\u5c55\u3092\u793a\u3059\u3001\u91cd\u8981\u306a\u7814\u7a76\u9818\u57df\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af\u304b\u3089\u306e\u30e1\u30c3\u30bb\u30fc\u30b8<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u814e\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306b\u306f\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u6162\u6027\u814e\u81d3\u75c5\u3060\u3051\u3067\u306a\u304f\u3001\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306a\u3069\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u304c\u95a2\u4e0e\u3059\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u7dcf\u5408\u5185\u79d1\u5c02\u9580\u533b\u30fb\u30ea\u30a6\u30de\u30c1\u5c02\u9580\u533b\u306e\u7acb\u5834\u304b\u3089\u3001\u814e\u6a5f\u80fd\u7570\u5e38\u3084\u86cb\u767d\u5c3f\u3001\u8840\u5c3f\u306a\u3069\u306e\u8a55\u4fa1\u3068\u3001\u81a0\u539f\u75c5\u30fb\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u4f34\u3046\u814e\u969c\u5bb3\u306e\u8a3a\u7642\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u814e\u6a5f\u80fd\u306e\u7570\u5e38\u3092\u6307\u6458\u3055\u308c\u305f\u65b9\u3084\u3001\u539f\u56e0\u306e\u5206\u304b\u3089\u306a\u3044\u95a2\u7bc0\u75db\u3001\u767a\u71b1\u3001\u76ae\u75b9\u3001\u3080\u304f\u307f\u306a\u3069\u304c\u7d9a\u304f\u65b9\u306f\u3001\u65e9\u3081\u306e\u533b\u7642\u6a5f\u95a2\u3078\u306e\u76f8\u8ac7\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7cbe\u5bc6\u306a\u814e\u75be\u60a3\u8a3a\u65ad\u3084\u814e\u751f\u691c\u3001\u814e\u4ee3\u66ff\u7642\u6cd5\u30fb\u814e\u79fb\u690d\u306e\u691c\u8a0e\u304c\u5fc5\u8981\u306a\u5834\u5408\u306b\u306f\u3001\u814e\u81d3\u5185\u79d1\u30fb\u79fb\u690d\u5c02\u9580\u65bd\u8a2d\u3068\u9023\u643a\u3057\u3066\u9069\u5207\u306a\u8a3a\u7642\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<p 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\u67cf\u4e94\u5473\u6b6f\u79d1\u5185\u79d1\u30ea\u30a6\u30de\u30c1\u30af\u30ea\u30cb\u30c3\u30af\u30d6\u30ed\u30b0\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-9143\/embed\/#?secret=IQqwlghvWn#?secret=86cnRSkNeP\" data-secret=\"86cnRSkNeP\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u7642\u6cd5\u306e\u4f5c\u7528\u6a5f\u5e8f\u3084\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3078\u306e\u5fdc\u7528\u3001\u5b89\u5168\u6027\u306e\u8ab2\u984c\u3092\u8a73\u3057\u304f\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u814e\u79fb\u690d\u7814\u7a76\u3068\u5171\u901a\u3059\u308bB\u7d30\u80de\u9664\u53bb\u30fb\u514d\u75ab\u518d\u69cb\u7bc9\u3068\u3044\u3046\u6982\u5ff5\u3092\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2461 <strong>\u3010NEJM 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class=\"wp-block-paragraph\">\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u306b\u3088\u308b\u814e\u969c\u5bb3\u3092\u65e9\u671f\u306b\u5236\u5fa1\u3057\u3001\u814e\u6a5f\u80fd\u3092\u9577\u671f\u7684\u306b\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306e\u6cbb\u7642\u6226\u7565\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<h2 class=\"wp-block-heading\">\u539f\u8457\u8ad6\u6587<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Bhoj VG, Kaminski M, Zhao H, et al.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>New England Journal of Medicine.<\/em> 2026;394:2117\u20132125.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DOI\uff1a10.1056\/NEJMoa2513428<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u8457\u8ad6\u6587\uff1a<a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2513428\">https:\/\/doi.org\/10.1056\/NEJMoa2513428<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ClinicalTrials.gov\uff1aNCT06056102<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8a66\u9a13\u767b\u9332\uff1a<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06056102\">https:\/\/clinicaltrials.gov\/study\/NCT06056102<\/a><\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u8a18\u4e8b\u306f\u4e0a\u8a18\u539f\u8457\u8ad6\u6587\u306b\u57fa\u3065\u304d\u3001\u81e8\u5e8a\u514d\u75ab\u5b66\u30fb\u814e\u81d3\u75c5\u5b66\u30fb\u79fb\u690d\u533b\u7642\u306e\u89b3\u70b9\u304b\u3089\u7814\u7a76\u7d50\u679c\u3092\u89e3\u8aac\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u7814\u7a76\u6bb5\u968e\u306e\u6cbb\u7642\u3092\u4e00\u822c\u8a3a\u7642\u3068\u3057\u3066\u63a8\u5968\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container 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