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class=\"wp-block-paragraph\">RGX-111\u306f\u3001IDUA\u907a\u4f1d\u5b50\u3092\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u5c0e\u5165\u3057\u3001\u795e\u7d4c\u7d44\u7e54\u306b\u304a\u3051\u308b\u4e0d\u8db3\u9175\u7d20\u306e\u767a\u73fe\u3092\u76ee\u6307\u3059\u6cbb\u7642\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6295\u4e0e\u306b\u306f\u3001\u5927\u69fd\u5185\u6295\u4e0e\uff08intracisternal magna administration\uff1aICM\uff09\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5927\u69fd\u306f\u5c0f\u8133\u3068\u5ef6\u9ac4\u306e\u8fd1\u304f\u306b\u3042\u308b\u8133\u810a\u9ac4\u6db2\u8154\u3067\u3042\u308a\u3001\u3053\u306e\u90e8\u4f4d\u306b\u30d9\u30af\u30bf\u30fc\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u907a\u4f1d\u5b50\u9001\u9054\u3092\u56f3\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u75c7\u4f8b\u306e\u6295\u4e0e\u91cf\u306f3.8\u00d710\u00b9\u00b3 vector genomes\uff08vg\uff09\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\uff0e\u907a\u4f1d\u5b50\u6cbb\u7642\u304b\u3089\u7d044\u5e74\u5f8c\u3001\u8133\u5ba4\u5185\u816b\u760d\u304c\u767a\u898b\u3055\u308c\u305f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u75c7\u4f8b\u3067\u306f\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u304b\u3089\u7d044\u5e74\u5f8c\u3001MPS I\u306e\u5b9a\u671f\u7684\u306a\u982d\u90e8MRI\u3067\u8133\u5ba4\u5185\u816b\u7624\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u816b\u760d\u306e\u5927\u304d\u3055\u306f\u7d044\u00d72\u00d72 cm\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MRI\u3067\u306f\u53f3\u5074\u8133\u5ba4\u4f53\u90e8\u3092\u5360\u62e0\u30fb\u62e1\u5f35\u3059\u308b\u816b\u7624\u304c\u8a8d\u3081\u3089\u308c\u3001\u8133\u5ba4\u306f\u5de6\u65b9\u3078\u504f\u4f4d\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u816b\u760d\u306f\u5b9a\u671f\u753b\u50cf\u691c\u67fb\u3067\u767a\u898b\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u795e\u7d4c\u75c7\u72b6\u306e\u51fa\u73fe\u3092\u5951\u6a5f\u306b\u8a3a\u65ad\u3055\u308c\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u8133\u810a\u9ac4\u6db2\u306e\u8a55\u4fa1\u3067\u306f\u816b\u760d\u306e\u64ad\u7a2e\u3092\u793a\u3059\u6240\u898b\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-112.png\" alt=\"\u30e0\u30b3\u591a\u7cd6\u75c7I\u578b\u7537\u5150\u306e\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u3001AAV9\u907a\u4f1d\u5b50\u6cbb\u7642\u3001\u8133\u5ba4\u5185\u816b\u760d\u767a\u898b\u3068\u5207\u9664\u307e\u3067\u306e\u6642\u7cfb\u5217\u56f3\" class=\"wp-image-9323\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-112.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-112-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-112-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56f31\uff0e\u91cd\u75c7\u30e0\u30b3\u591a\u7cd6\u75c7I\u578b\uff08Hurler\u75c7\u5019\u7fa4\uff09\u60a3\u8005\u306b\u304a\u3051\u308b\u6cbb\u7642\u6b74\u3068\u8133\u5ba4\u5185\u816b\u760d\u8a3a\u65ad\u307e\u3067\u306e\u7d4c\u904e\u3002\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u5f8c\u306b\u30c9\u30ca\u30fc\u30ad\u30e1\u30ea\u30ba\u30e0\u306e\u4f4e\u4e0b\u3092\u8a8d\u3081\u3001\u751f\u5f8c13\u304b\u6708\u306bAAV9-IDUA\u907a\u4f1d\u5b50\u6cbb\u7642RGX-111\u3092\u5927\u69fd\u5185\u6295\u4e0e\u3057\u305f\u3002\u751f\u5f8c61\u304b\u6708\u306b\u5b9a\u671f\u982d\u90e8MRI\u3067\u816b\u760d\u304c\u767a\u898b\u3055\u308c\u300163\u304b\u6708\u6642\u306b\u8089\u773c\u7684\u5168\u6458\u51fa\u304c\u5b9f\u65bd\u3055\u308c\u305f\u3002\u5358\u4e00\u75c7\u4f8b\u306e\u6642\u7cfb\u5217\u3067\u3042\u308a\u3001\u816b\u760d\u767a\u751f\u7387\u3092\u793a\u3059\u3082\u306e\u3067\u306f\u306a\u3044\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"712\" height=\"393\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-115.png\" alt=\"AAV9\u907a\u4f1d\u5b50\u6cbb\u7642\u5f8c\u306b\u767a\u898b\u3055\u308c\u305f\u53f3\u5074\u8133\u5ba4\u5185\u816b\u760d\u306e\u4f4d\u7f6e\u3068\u8133\u5ba4\u504f\u4f4d\u3092\u793a\u3059\u982d\u90e8MRI\u89e3\u5256\u5b66\u7684\u56f3\" class=\"wp-image-9329\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-115.png 712w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-115-400x221.png 400w\" sizes=\"auto, (max-width: 712px) 100vw, 712px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56f3\uff0eAAV9\u907a\u4f1d\u5b50\u6cbb\u7642\u5f8c\u306b\u767a\u898b\u3055\u308c\u305f\u8133\u5ba4\u5185\u816b\u760d\u306eMRI\u6240\u898b<\/strong>\u3000\u3000\u91cd\u75c7\u30e0\u30b3\u591a\u7cd6\u75c7I\u578b\u306e\u7537\u5150\u306b\u5bfe\u3059\u308bAAV9\u907a\u4f1d\u5b50\u6cbb\u7642\u304b\u3089\u7d044\u5e74\u5f8c\u3001\u5b9a\u671f\u982d\u90e8MRI\u3067\u767a\u898b\u3055\u308c\u305f\u8133\u5ba4\u5185\u816b\u760d\u3002\u8ef8\u4f4dT2\u5f37\u8abf\u753b\u50cf\uff08C\uff09\u304a\u3088\u3073\u51a0\u72b6\u65ad\u753b\u50cf\uff08D\uff09\u3067\u306f\u3001\u53f3\u5074\u8133\u5ba4\u4f53\u90e8\u3092\u62e1\u5f35\u3059\u308b\u7d044\u00d72\u00d72 cm\u306e\u816b\u7624\u3092\u8a8d\u3081\u3001\u8133\u5ba4\u69cb\u9020\u306f\u5de6\u65b9\u3078\u504f\u4f4d\u3057\u3066\u3044\u308b\uff08\u9ec4\u8272\u77e2\u5370\uff09\u3002\u539f\u8457Figure 1C\u30fb1D\u3088\u308a\u5f15\u7528\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d44\u7e54\u8a3a\u65ad\u3068\u816b\u760d\u306e\u7279\u5fb4<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u521d\u56de\u751f\u691c\u3067\u306f\u3001\u7d44\u7e54\u5b66\u7684\u6240\u898b\u3060\u3051\u3067\u816b\u760d\u306e\u6027\u8cea\u3092\u660e\u78ba\u306b\u5206\u985e\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ki-67\u5897\u6b96\u6307\u6570\u306f5\u301c10%\u3067\u3042\u308a\u3001\u4e00\u5b9a\u306e\u7d30\u80de\u5897\u6b96\u6d3b\u6027\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81e8\u5e8a\u7684\u30b2\u30ce\u30e0\u89e3\u6790\u3067\u306f\u3001\u816b\u760d\u304c\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u30c9\u30ca\u30fc\u7531\u6765\u3067\u306f\u306a\u3044\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DNA\u30e1\u30c1\u30eb\u5316\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3067\u306f\u3001\u5f53\u521dPLAGL1\u95a2\u9023\u816b\u760d\u3092\u793a\u5506\u3059\u308b\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u304c\u3001PLAGL1\u878d\u5408\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8ffd\u52a0\u306e\u5206\u5b50\u89e3\u6790\u306b\u3088\u3063\u3066PLAG1\u907a\u4f1d\u5b50\u306e\u8457\u660e\u306a\u6d3b\u6027\u5316\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3001\u6700\u7d42\u7684\u306b\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PLAG1-driven neuroepithelial tumor, not elsewhere classified\uff08PLAG1\u99c6\u52d5\u6027\u795e\u7d4c\u4e0a\u76ae\u6027\u816b\u760d\u3001\u4ed6\u306b\u5206\u985e\u3055\u308c\u306a\u3044\u3082\u306e\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u8a3a\u65ad\u540d\u306f\u3001\u4e00\u822c\u7684\u306a\u795e\u7d4c\u81a0\u816b\u306a\u3069\u306b\u5358\u7d14\u306b\u7f6e\u304d\u63db\u3048\u3089\u308c\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u672c\u75c7\u4f8b\u306e\u5206\u5b50\u75c5\u7406\u5b66\u7684\u7279\u5fb4\u3092\u53cd\u6620\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4\uff0e\u6700\u5927\u306e\u767a\u898b\uff5cAAV\u7531\u6765DNA\u304cPLAG1\u907a\u4f1d\u5b50\u306b\u7d44\u307f\u8fbc\u307e\u308c\u3066\u3044\u305f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7814\u7a76\u306e\u6838\u5fc3\u306f\u3001\u816b\u760d\u7d30\u80de\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u8005\u3089\u306f\u3001\u816b\u760d\u7d44\u7e54\u3092\u7528\u3044\u3066RNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3001\u9577\u9396DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3001RT-PCR\u3001\u6a19\u7684PCR\u306a\u3069\u306e\u8907\u6570\u306e\u691c\u67fb\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001AAV\u7531\u6765DNA\u304c\u30d2\u30c88\u756a\u67d3\u8272\u4f53\u4e0a\u306ePLAG1\u907a\u4f1d\u5b50\u306b\u7d44\u307f\u8fbc\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">PLAG1\u3068\u306f\u4f55\u304b\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">PLAG1\uff08Pleomorphic adenoma gene 1\uff09\u306f\u3001\u8ee2\u5199\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8ee2\u5199\u56e0\u5b50\u3068\u306f\u3001\u4ed6\u306e\u907a\u4f1d\u5b50\u304c\u3069\u306e\u7a0b\u5ea6\u50cd\u304f\u304b\u3092\u5236\u5fa1\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PLAG1\u306f\u901a\u5e38\u3001\u4e3b\u3068\u3057\u3066\u80ce\u751f\u671f\u306b\u767a\u73fe\u3057\u307e\u3059\u304c\u3001\u7570\u5e38\u306a\u6d3b\u6027\u5316\u304c\u8d77\u3053\u308b\u3068\u3001\u7d30\u80de\u5897\u6b96\u3092\u4fc3\u3059\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4ea2\u9032\u3055\u305b\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081PLAG1\u306f\u3001\u304c\u3093\u539f\u907a\u4f1d\u5b50\uff08proto-oncogene\uff09\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d44\u8fbc\u307f\u90e8\u4f4d\u306fPLAG1\u306e\u30a4\u30f3\u30c8\u30ed\u30f34<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u9577\u9396DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08PacBio\uff09\u3067\u306f\u3001AAV\u30d9\u30af\u30bf\u30fc\u7531\u6765\u306e\u518d\u69cb\u6210DNA\u304cPLAG1\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f34\u306b\u7d44\u307f\u8fbc\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7d44\u307f\u8fbc\u307e\u308c\u305fDNA\u306f\u3001\u6b63\u5e38\u306aRGX-111\u30d9\u30af\u30bf\u30fc\u914d\u5217\u304c\u305d\u306e\u307e\u307e\u633f\u5165\u3055\u308c\u305f\u5358\u7d14\u306a\u69cb\u9020\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5177\u4f53\u7684\u306b\u306f\u3001CMV\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u3001CBA\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u30fb\u30b9\u30d7\u30e9\u30a4\u30b9\u4f9b\u4e0e\u90e8\u4f4d\u3001IDUA\u5c0e\u5165\u907a\u4f1d\u5b50\u306e\u65ad\u7247\u3001\u30d2\u30c810\u756a\u67d3\u8272\u4f53\u7531\u6765DNA\u65ad\u7247\u3001PLAG1\u30a4\u30f3\u30c8\u30ed\u30f34\u306e\u77ed\u3044\u91cd\u8907\u914d\u5217\u306a\u3069\u3092\u542b\u3080\u8907\u96d1\u306a\u518d\u69cb\u6210\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u30fb\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u9818\u57df\u306b\u306f\u91cd\u8907\u30fb\u9006\u5411\u304d\u914d\u7f6e\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u70b9\u306f\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u30d9\u30af\u30bf\u30fc\u306e\u5b9f\u969b\u306e\u7d44\u8fbc\u307f\u304c\u3001\u5358\u7d14\u306aDNA\u65ad\u7247\u306e\u633f\u5165\u3060\u3051\u3067\u306f\u8aac\u660e\u3067\u304d\u306a\u3044\u5834\u5408\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u816b\u760dDNA\u306e\u7d0440%\u306e\u30ea\u30fc\u30c9\u3067\u7d44\u8fbc\u307f\u69cb\u9020\u3092\u78ba\u8a8d<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u9577\u9396DNA\u89e3\u6790\u3067\u306f\u3001PLAG1\u9818\u57df\u306e\u89e3\u6790\u30ea\u30fc\u30c9\u306e\u3046\u3061\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7d0440%\u304cAAV\u7531\u6765\u914d\u5217\u3092\u542b\u3080\u7d44\u8fbc\u307f\u30a2\u30ec\u30eb<\/li>\n\n\n\n<li>\u7d0460%\u304c\u7d44\u8fbc\u307f\u3092\u8a8d\u3081\u306a\u3044\u30a2\u30ec\u30eb<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306b\u76f8\u5f53\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u6240\u898b\u306f\u3001\u816b\u760d\u306e\u8d77\u6e90\u3068\u306a\u3063\u305f\u7d30\u80de\u3067\u3001PLAG1\u306e2\u3064\u306e\u30a2\u30ec\u30eb\u306e\u3046\u3061\u4e00\u65b9\u306b\u7d44\u8fbc\u307f\u304c\u751f\u3058\u305f\u3068\u3044\u3046\u89e3\u91c8\u3068\u6574\u5408\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u306a\u306e\u306f\u3001\u3053\u306e40%\u3068\u3044\u3046\u5024\u304c\u3001\u60a3\u8005\u306e\u5168\u8eab\u7d30\u80de\u306e40%\u306bAAV\u304c\u7d44\u307f\u8fbc\u307e\u308c\u305f\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u816b\u760d\u7d44\u7e54\u306eDNA\u89e3\u6790\u306b\u304a\u3051\u308b\u76f8\u5bfe\u7684\u306a\u30ea\u30fc\u30c9\u6bd4\u7387\u3067\u3042\u308a\u3001\u816b\u760d\u7d14\u5ea6\u3084\u7d30\u80de\u96c6\u56e3\u306e\u69cb\u6210\u306a\u3069\u306e\u5f71\u97ff\u3082\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-114.png\" alt=\"PLAG1\u30a4\u30f3\u30c8\u30ed\u30f34\u306b\u7d44\u307f\u8fbc\u307e\u308c\u305fAAV\u7531\u6765DNA\u306e\u518d\u69cb\u6210\u69cb\u9020\u3068AAV\u2013PLAG1\u878d\u5408RNA\u306e\u5f62\u6210\u6a5f\u5e8f\" class=\"wp-image-9327\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-114.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-114-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-114-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56f33\uff0ePLAG1\u907a\u4f1d\u5b50\u3078\u306e\u518d\u69cb\u6210AAV\u30d9\u30af\u30bf\u30fc\u914d\u5217\u306e\u7d44\u8fbc\u307f\u3002PacBio\u9577\u9396DNA\u89e3\u6790\u3067\u306f\u30018\u756a\u67d3\u8272\u4f53\u306ePLAG1\u30a4\u30f3\u30c8\u30ed\u30f34\u306b\u3001AAV\u7531\u6765\u8ee2\u5199\u5236\u5fa1\u914d\u5217\u3001IDUA\u5c0e\u5165\u907a\u4f1d\u5b50\u65ad\u7247\u300110\u756a\u67d3\u8272\u4f53\u7531\u6765DNA\u65ad\u7247\u306a\u3069\u3092\u542b\u3080\u8907\u96d1\u306a\u7d44\u8fbc\u307f\u69cb\u9020\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u89e3\u6790\u30ea\u30fc\u30c9\u306e\u7d0440%\u304c\u7d44\u8fbc\u307f\u30a2\u30ec\u30eb\u306b\u5bfe\u5fdc\u3057\u305f\u3002AAV\u306eCBA\u30b9\u30d7\u30e9\u30a4\u30b9\u4f9b\u4e0e\u90e8\u4f4d\u3068PLAG1\u30a8\u30af\u30bd\u30f35\u306e\u30b9\u30d7\u30e9\u30a4\u30b9\u53d7\u5bb9\u90e8\u4f4d\u306e\u7d50\u5408\u306b\u3088\u308a\u878d\u5408\u8ee2\u5199\u7523\u7269\u304c\u5f62\u6210\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5\uff0eAAV\u2013PLAG1\u878d\u5408RNA\u306e\u767a\u73fe\u3092\u78ba\u8a8d<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">AAV\u7531\u6765DNA\u304cPLAG1\u306e\u8fd1\u304f\u306b\u5b58\u5728\u3059\u308b\u3060\u3051\u3067\u306f\u3001\u5b9f\u969b\u306b\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u306b\u5f71\u97ff\u3057\u305f\u3053\u3068\u307e\u3067\u306f\u8a3c\u660e\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3053\u3067\u7814\u7a76\u8005\u3089\u306f\u3001RNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u3063\u3066\u816b\u760d\u7d30\u80de\u3067\u767a\u73fe\u3057\u3066\u3044\u308bRNA\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001AAV\u30d9\u30af\u30bf\u30fc\u306eCBA\u30b9\u30d7\u30e9\u30a4\u30b9\u4f9b\u4e0e\u90e8\u4f4d\u3068\u3001PLAG1\u30a8\u30af\u30bd\u30f35\u306e\u30b9\u30d7\u30e9\u30a4\u30b9\u53d7\u5bb9\u90e8\u4f4d\u304c\u7d50\u5408\u3057\u305f\u878d\u5408RNA\u304c\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u72ec\u7acb\u3057\u305f2\u3064\u306e\u816b\u760dRNA\u8a66\u6599\u3067\u3082\u3001RT-PCR\u306b\u3088\u3063\u3066\u540c\u3058\u878d\u5408\u63a5\u5408\u90e8\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u5bfe\u7167\u3068\u3057\u305f\u975e\u816b\u760d\u6027\u8133\u7d44\u7e54\u3067\u306f\u3001\u3053\u306e\u878d\u5408\u8ee2\u5199\u7523\u7269\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u3069\u306e\u3088\u3046\u306a\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u751f\u3058\u308b\u306e\u304b\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u691c\u51fa\u3055\u308c\u305f\u878d\u5408RNA\u306f\u3001PLAG1\u306e5\u3064\u306e\u30b8\u30f3\u30af\u30d5\u30a3\u30f3\u30ac\u30fc\u578bDNA\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u3068\u3001C\u672b\u7aef\u306e\u8ee2\u5199\u6d3b\u6027\u5316\u30c9\u30e1\u30a4\u30f3\u3092\u4fdd\u6301\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306aPLAG1\u8a98\u5c0e\u4f53\u306f\u3001\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u672c\u7814\u7a76\u3067\u793a\u3055\u308c\u305f\u306e\u306f\u3001\u878d\u5408RNA\u306e\u5b58\u5728\u3068\u4e88\u6e2c\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u3067\u3042\u308a\u3001\u5f53\u8a72\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u3092\u500b\u5225\u306b\u76f4\u63a5\u5b9f\u8a3c\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u878d\u5408RNA\u304c\u751f\u3058\u305f\u3053\u3068\u3068\u3001\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8ee2\u5199\u6d3b\u6027\u3092\u5b9f\u9a13\u7684\u306b\u5b8c\u5168\u8a3c\u660e\u3057\u305f\u3053\u3068\u306f\u533a\u5225\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6\uff0ePLAG1\u306e\u767a\u73fe\u91cf\u306f\u4ed6\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u816b\u760d\u306e\u7d04298\u500d<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">RNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3067\u306f\u3001\u4eca\u56de\u306e\u816b\u760d\u306b\u304a\u3051\u308bPLAG1\u306e\u767a\u73fe\u91cf\u304c\u3001Children\u2019s Hospital of Philadelphia\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u816b\u760d\u30b3\u30db\u30fc\u30c8\u3068\u6bd4\u8f03\u3057\u3066\u3001298\u500d\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001PLAG1\u306e\u5404\u30a8\u30af\u30bd\u30f3\u306e\u767a\u73fe\u3092\u8abf\u3079\u308b\u3068\u3001\u30a8\u30af\u30bd\u30f31\u301c4\u3067\u306f\u767a\u73fe\u304c\u4e4f\u3057\u3044\u4e00\u65b9\u3001\u30a8\u30af\u30bd\u30f35\u3067\u306f\u8457\u660e\u306a\u767a\u73fe\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PLAG1\u30a8\u30af\u30bd\u30f35\u306e\u4e0a\u6d41\u914d\u5217\u3092\u542b\u3080RNA\u30ea\u30fc\u30c9\u306e93%\u306b\u306f\u3001\u901a\u5e38\u306ePLAG1\u30a8\u30af\u30bd\u30f34\u3067\u306f\u306a\u304fAAV\u7531\u6765\u914d\u5217\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u306f\u3001AAV\u306b\u7531\u6765\u3059\u308b\u8ee2\u5199\u5236\u5fa1\u9818\u57df\u304cPLAG1\u30a8\u30af\u30bd\u30f35\u304b\u3089\u306e\u8ee2\u5199\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u6a5f\u5e8f\u3092\u5f37\u304f\u652f\u6301\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">PLAG1\u4e0b\u6d41\u306e\u816b\u760d\u95a2\u9023\u907a\u4f1d\u5b50\u3082\u6d3b\u6027\u5316<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u8005\u3089\u306f\u3001PLAG1\u95a2\u9023\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u816b\u760d\u3067\u767a\u73fe\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b5\u3064\u306e\u907a\u4f1d\u5b50\u306b\u3064\u3044\u3066\u3082\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bfe\u8c61\u3068\u306a\u3063\u305f\u907a\u4f1d\u5b50\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u907a\u4f1d\u5b50<\/th><th>\u4e3b\u306a\u751f\u7269\u5b66\u7684\u5f79\u5272<\/th><\/tr><tr><td>IGF2<\/td><td>\u7d30\u80de\u306e\u6210\u9577\u30fb\u5897\u6b96\u30b7\u30b0\u30ca\u30eb<\/td><\/tr><tr><td>DLK1<\/td><td>\u767a\u751f\u30fb\u5206\u5316\u306b\u95a2\u9023\u3059\u308b\u8abf\u7bc0<\/td><\/tr><tr><td>DES<\/td><td>\u7d30\u80de\u9aa8\u683c\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea<\/td><\/tr><tr><td>CYP2W1<\/td><td>\u30b7\u30c8\u30af\u30ed\u30e0P450\u95a2\u9023\u9175\u7d20<\/td><\/tr><tr><td>RET<\/td><td>\u5897\u6b96\u30fb\u751f\u5b58\u30b7\u30b0\u30ca\u30eb\u306b\u95a2\u4e0e\u3059\u308b\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u30895\u907a\u4f1d\u5b50\u306f\u3059\u3079\u3066\u3001\u540c\u3058\u60a3\u8005\u306e\u6b63\u5e38\u5927\u8133\u76ae\u8cea\u8a66\u6599\u3068\u6bd4\u8f03\u3057\u3066\u767a\u73fe\u304c\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u767a\u73fe\u5909\u5316\u500d\u7387\u306e\u4e2d\u592e\u5024\u306f629\u500d\u3001\u7bc4\u56f2\u306f131\u301c13,006\u500d\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u6570\u5024\u306f5\u907a\u4f1d\u5b50\u3092\u307e\u3068\u3081\u305f\u767a\u73fe\u5909\u5316\u306e\u6307\u6a19\u3067\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u907a\u4f1d\u5b50\u304c629\u500d\u306b\u306a\u3063\u305f\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AAV\u7531\u6765\u914d\u5217\u306e\u7d44\u8fbc\u307f\u3001PLAG1\u878d\u5408RNA\u306e\u767a\u73fe\u3001PLAG1\u306e\u8457\u660e\u306a\u6d3b\u6027\u5316\u3001\u4e0b\u6d41\u907a\u4f1d\u5b50\u7fa4\u306e\u767a\u73fe\u4e0a\u6607\u304c\u4e00\u8cab\u3057\u3066\u8a8d\u3081\u3089\u308c\u305f\u70b9\u304c\u3001\u672c\u7814\u7a76\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u306b\u91cd\u8981\u306a\u6240\u898b\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-116.png\" alt=\"AAV\u7d44\u8fbc\u307f\u5f8c\u306ePLAG1\u30a8\u30af\u30bd\u30f35\u767a\u73fe\u4ea2\u9032\u3068IGF2\u306a\u30695\u3064\u306e\u816b\u760d\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u4e0a\u6607\" class=\"wp-image-9331\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-116.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-116-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-116-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56f34\uff0eRNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u308bPLAG1\u304a\u3088\u3073\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u89e3\u6790\u3002PLAG1\u30a8\u30af\u30bd\u30f35\u3067\u9078\u629e\u7684\u306a\u767a\u73fe\u4ea2\u9032\u304c\u8a8d\u3081\u3089\u308c\u3001PLAG1\u5168\u4f53\u306e\u767a\u73fe\u91cf\u306f\u5916\u90e8\u4e2d\u67a2\u795e\u7d4c\u7cfb\u816b\u760d\u30b3\u30db\u30fc\u30c8\u3068\u306e\u6bd4\u8f03\u3067\u7d04298\u500d\u3067\u3042\u3063\u305f\u3002\u307e\u305fIGF2\u3001DLK1\u3001DES\u3001CYP2W1\u3001RET\u306e\u767a\u73fe\u306f\u540c\u4e00\u60a3\u8005\u306e\u6b63\u5e38\u5927\u8133\u76ae\u8cea\u8a66\u6599\u3068\u6bd4\u8f03\u3057\u3066\u4e0a\u6607\u3057\u3066\u3044\u305f\u3002298\u500d\u3068\u3044\u3046\u5024\u30685\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5909\u5316\u306f\u3001\u6bd4\u8f03\u5bfe\u8c61\u304c\u7570\u306a\u308b\u305f\u3081\u76f4\u63a5\u6bd4\u8f03\u3067\u304d\u306a\u3044\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">7\uff0eAAV\u7d44\u8fbc\u307f\u304b\u3089\u816b\u760d\u5f62\u6210\u3078\uff5c\u8003\u3048\u3089\u308c\u308b\u5206\u5b50\u6a5f\u5e8f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7d50\u679c\u304b\u3089\u3001\u6b21\u306e\u3088\u3046\u306a\u767a\u304c\u3093\u6a5f\u5e8f\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2460 AAV9\u30d9\u30af\u30bf\u30fc\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u6295\u4e0e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">RGX-111\u3001\u5927\u69fd\u5185\u6295\u4e0e\u3001\u751f\u5f8c13\u304b\u6708<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2461 AAV\u7531\u6765DNA\u306e\u5bbf\u4e3b\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u8fbc\u307f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">8\u756a\u67d3\u8272\u4f53\u30fbPLAG1\u30a4\u30f3\u30c8\u30ed\u30f34<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2462 AAV\u8ee2\u5199\u5236\u5fa1\u914d\u5217\u306b\u3088\u308bPLAG1\u306e\u7570\u5e38\u767a\u73fe<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AAV\u2013PLAG1\u878d\u5408RNA\u3092\u691c\u51fa<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2463 \u816b\u760d\u95a2\u9023\u907a\u4f1d\u5b50\u7fa4\u306e\u8ee2\u5199\u4ea2\u9032<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IGF2\u3001DLK1\u3001DES\u3001CYP2W1\u3001RET<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2464 PLAG1\u99c6\u52d5\u6027\u795e\u7d4c\u4e0a\u76ae\u6027\u816b\u760d\u306e\u5f62\u6210<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5206\u5b50\u6240\u898b\u306f\u767a\u304c\u3093\u3078\u306e\u5bc4\u4e0e\u3092\u5f37\u304f\u652f\u6301\u3002\u305f\u3060\u3057\u5168\u6bb5\u968e\u306e\u76f4\u63a5\u7684\u56e0\u679c\u5b9f\u8a3c\u3067\u306f\u306a\u3044<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306b\u3001AAV\u7531\u6765\u306e\u5f37\u529b\u306a\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u30fb\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u914d\u5217\u304c\u3001\u5bbf\u4e3b\u306e\u304c\u3093\u539f\u907a\u4f1d\u5b50\u3092\u7570\u5e38\u306b\u6d3b\u6027\u5316\u3057\u305f\u3053\u3068\u304c\u3001\u816b\u760d\u5f62\u6210\u306b\u5bc4\u4e0e\u3057\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u4eca\u56de\u306e\u7814\u7a76\u306f\u6a5f\u80fd\u7684\u306a\u767a\u304c\u3093\u5b9f\u9a13\u3067\u306f\u306a\u304f\u3001\u60a3\u8005\u816b\u760d\u7d44\u7e54\u306e\u8a73\u7d30\u306a\u5206\u5b50\u89e3\u6790\u306b\u3088\u308b\u75c7\u4f8b\u5831\u544a\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u300cAAV\u7d44\u8fbc\u307f\u304c\u552f\u4e00\u306e\u539f\u56e0\u3060\u3063\u305f\u300d\u3068\u307e\u3067\u306f\u65ad\u5b9a\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u5358\u306a\u308b\u5076\u7136\u306e\u7d44\u8fbc\u307f\u306b\u6bd4\u3079\u3001\u767a\u304c\u3093\u306b\u5bc4\u4e0e\u3057\u305f\u3068\u3044\u3046\u4eee\u8aac\u3092\u652f\u6301\u3059\u308b\u8a3c\u62e0\u304c\u8907\u6570\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-117.png\" alt=\"AAV\u7531\u6765DNA\u306ePLAG1\u7d44\u8fbc\u307f\u304b\u3089\u7570\u5e38\u8ee2\u5199\u3001\u816b\u760d\u95a2\u9023\u907a\u4f1d\u5b50\u6d3b\u6027\u5316\u3001\u795e\u7d4c\u4e0a\u76ae\u6027\u816b\u760d\u5f62\u6210\u306b\u81f3\u308b\u4eee\u8aac\u30e2\u30c7\u30eb\" class=\"wp-image-9332\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-117.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-117-400x300.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-117-768x576.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56f35\uff0eAAV\u30d9\u30af\u30bf\u30fc\u306e\u5bbf\u4e3b\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u8fbc\u307f\u3092\u4ecb\u3057\u305fPLAG1\u99c6\u52d5\u6027\u816b\u760d\u5f62\u6210\u306e\u4eee\u8aac\u30e2\u30c7\u30eb\u3002\u672c\u75c7\u4f8b\u3067\u306fAAV\u7531\u6765\u914d\u5217\u306ePLAG1\u907a\u4f1d\u5b50\u3078\u306e\u7d44\u8fbc\u307f\u3001\u878d\u5408RNA\u306e\u767a\u73fe\u3001PLAG1\u304a\u3088\u3073\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u4ea2\u9032\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u5206\u5b50\u7570\u5e38\u304c\u7d30\u80de\u30af\u30ed\u30fc\u30f3\u5897\u6b96\u3068\u816b\u760d\u5f62\u6210\u306b\u5bc4\u4e0e\u3057\u305f\u3068\u8003\u3048\u3089\u308c\u308b\u304c\u3001\u3059\u3079\u3066\u306e\u56e0\u679c\u6bb5\u968e\u304c\u5b9f\u9a13\u7684\u306b\u76f4\u63a5\u8a3c\u660e\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u306a\u3044<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">8\uff0e\u6cbb\u7642\u7d4c\u904e\uff5c\u816b\u760d\u5207\u9664\u5f8c\u3082\u795e\u7d4c\u5b66\u7684\u72b6\u614b\u306f\u5b89\u5b9a<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u8457Figure 1\u306e\u81e8\u5e8a\u7d4c\u904e\u3067\u306f\u3001\u751f\u5f8c61\u304b\u6708\u306b\u816b\u760d\u304c\u8a3a\u65ad\u3055\u308c\u3001\u90e8\u5206\u5207\u9664\u304c\u5b9f\u65bd\u3055\u308c\u305f\u5f8c\u3001\u751f\u5f8c63\u304b\u6708\u306b\u8089\u773c\u7684\u5168\u6458\u51fa\uff08gross total resection\uff09\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8853\u5f8cMRI\u3067\u306f\u30012\u5e74\u524d\u306eMRI\u3067\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f1 cm\u672a\u6e80\u306e\u5c0f\u7d50\u7bc0\u304c3\u304b\u6240\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u30b7\u30b9\u30c1\u30f3\u75c7\u306f\u3001\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u5185\u306b\u30b7\u30b9\u30c1\u30f3\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3067\u3001\u814e\u81d3\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u5168\u8eab\u306e\u81d3\u5668\u306b\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u907a\u4f1d\u6027\u75be\u60a3\u3067\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u60a3\u8005\u81ea\u8eab\u306e\u9020\u8840\u5e79\u7d30\u80de\u306b\u6cbb\u7642\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3057\u3001\u79fb\u690d\u5f8c\u306b\u9577\u671f\u7684\u306a\u6cbb\u7642\u52b9\u679c\u3092\u5f97\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u907a\u4f1d\u5b50\u6cbb\u7642\u306b\u3064\u3044\u3066\u3001\u7b2c1\/2\u76f8\u8a66\u9a13\u306e\u7d50\u679c\u3092\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u4f7f\u7528\u3055\u308c\u308b\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306f\u3001\u5bbf\u4e3b\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u8fbc\u307f\u3092\u6cbb\u7642\u6a5f\u5e8f\u306e\u4e00\u90e8\u3068\u3057\u3066\u5229\u7528\u3059\u308b\u70b9\u3067\u3001\u4e3b\u3068\u3057\u3066\u67d3\u8272\u4f53\u5916\u306b\u5b58\u5728\u3059\u308bAAV\u30d9\u30af\u30bf\u30fc\u3068\u306f\u7570\u306a\u308a\u307e\u3059\u3002\u4eca\u56de\u306ePLAG1\u907a\u4f1d\u5b50\u3078\u306eAAV\u7d44\u8fbc\u307f\u306e\u5831\u544a\u3068\u4f75\u305b\u3066\u8aad\u3080\u3053\u3068\u3067\u3001\u7570\u306a\u308b\u907a\u4f1d\u5b50\u5c0e\u5165\u6280\u8853\u306b\u304a\u3051\u308b\u6cbb\u7642\u52b9\u679c\u3001\u633f\u5165\u5909\u7570\u306e\u30ea\u30b9\u30af\u3001\u9577\u671f\u5b89\u5168\u6027\u76e3\u8996\u306e\u8003\u3048\u65b9\u3092\u6bd4\u8f03\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">16\uff0e\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u539f\u8457<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ahrens-Nicklas RC, Kotch C, Roche AM, et al. Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery. N Engl J Med. 2026;394:2126\u20132133.<a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2601608?utm_source=chatgpt.com\">https:\/\/doi.org\/10.1056\/NEJMoa2601608<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u9023\u6587\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Keck MK, et al. PLAG1 fusions define a third subtype of CNS embryonal tumor with PLAG family gene alteration. Acta Neuropathologica. 2025;150:12.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Chandler RJ, et al. Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy. J Clin Invest. 2015;125:870\u2013880.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nault JC, et al. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet. 2015;47:1187\u20131193.<\/p>\n<\/blockquote>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23%\">\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/84f9b1a365bb2c08a7e4b50359f34012-600x600.png\" alt=\"\" class=\"wp-image-8240\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/84f9b1a365bb2c08a7e4b50359f34012-600x600.png 600w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/08\/84f9b1a365bb2c08a7e4b50359f34012-150x150.png 150w, 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