{"id":9553,"date":"2026-10-27T14:48:48","date_gmt":"2026-10-27T05:48:48","guid":{"rendered":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/?p=9553"},"modified":"2026-10-27T15:10:55","modified_gmt":"2026-10-27T06:10:55","slug":"pembrolizumab-hlh-fever-cytopenia","status":"publish","type":"post","link":"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/pembrolizumab-hlh-fever-cytopenia\/","title":{"rendered":"\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u6cbb\u7642\u4e2d\u306e\u767a\u71b1\u3068\u8840\u7403\u6e1b\u5c11\uff5c\u8840\u7403\u8caa\u98df\u75c7\u5019\u7fa4\u3092\u898b\u629c\u304f"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u304c\u3093\u306e\u514d\u75ab\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u65b9\u306b\u767a\u71b1\u304c\u7d9a\u3044\u305f\u5834\u5408\u3001\u307e\u305a\u6ce8\u610f\u3059\u308b\u306e\u306f\u611f\u67d3\u75c7\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u611f\u67d3\u75c7\u306e\u691c\u67fb\u3084\u6297\u83cc\u85ac\u6cbb\u7642\u3092\u9032\u3081\u3066\u3082\u539f\u56e0\u304c\u660e\u3089\u304b\u306b\u306a\u3089\u305a\u3001\u8840\u6db2\u4e2d\u306e\u7d30\u80de\u304c\u6e1b\u5c11\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u306f\u3001\u514d\u75ab\u53cd\u5fdc\u305d\u306e\u3082\u306e\u304c\u904e\u5270\u306b\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u8003\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u4e00\u3064\u304c\u3001\u8840\u7403\u8caa\u98df\u6027\u30ea\u30f3\u30d1\u7d44\u7e54\u7403\u75c7\uff08hemophagocytic lymphohistiocytosis\uff1aHLH\uff09\u3067\u3059\u3002\u300c\u8840\u7403\u8caa\u98df\u75c7\u5019\u7fa4\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u514d\u75ab\u7d30\u80de\u306e\u7570\u5e38\u306a\u6d3b\u6027\u5316\u306b\u3088\u3063\u3066\u5168\u8eab\u306b\u5f37\u3044\u708e\u75c7\u304c\u8d77\u3053\u308a\u3001\u91cd\u75c7\u5316\u3059\u308b\u3068\u8840\u5727\u4f4e\u4e0b\u3084\u591a\u81d3\u5668\u969c\u5bb3\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e74\u306e\u300eNew England Journal of Medicine\u300f\u306b\u306f\u3001\u4e73\u304c\u3093\u306b\u5bfe\u3057\u3066\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\uff08\u30ad\u30a4\u30c8\u30eb\u30fc\u30c0\ud83c\udd2c\uff09\u3092\u4f7f\u7528\u3057\u3066\u3044\u305f60\u6b73\u5973\u6027\u304c\u3001\u6301\u7d9a\u3059\u308b\u767a\u71b1\u3068\u8840\u7403\u6e1b\u5c11\u3092\u304d\u3063\u304b\u3051\u306bHLH\u3068\u8a3a\u65ad\u3055\u308c\u305f\u75c7\u4f8b\u304c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u5831\u544a\u306f\u3001\u5b9f\u969b\u306e\u60a3\u8005\u3055\u3093\u306e\u7d4c\u904e\u3092\u6bb5\u968e\u7684\u306b\u63d0\u793a\u3057\u3001\u8a3a\u65ad\u306b\u81f3\u308b\u8003\u3048\u65b9\u3092\u89e3\u8aac\u3059\u308b\u300cClinical Problem-Solving\u300d\u5f62\u5f0f\u306e\u8a18\u4e8b\u3067\u3042\u308a\u3001\u6cbb\u7642\u52b9\u679c\u3092\u6bd4\u8f03\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\uff0e\u4e73\u304c\u3093\u306e\u514d\u75ab\u7642\u6cd5\u4e2d\u306b\u7d9a\u3044\u305f\u767a\u71b1<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u3055\u3093\u306f\u3001\u30b9\u30c6\u30fc\u30b8\u2161\u306e\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\u306b\u5bfe\u3057\u3066\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u305f60\u6b73\u5973\u6027\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53d7\u8a3a\u306e\u7d042\u304b\u6708\u524d\u306b\u8853\u524d\u5316\u5b66\u7642\u6cd5\u3092\u7d42\u4e86\u3057\u3001\u7d041\u304b\u6708\u524d\u306b\u306f\u5de6\u4e73\u623f\u306e\u90e8\u5206\u5207\u9664\u3068\u30bb\u30f3\u30c1\u30cd\u30eb\u30ea\u30f3\u30d1\u7bc0\u751f\u691c\u3092\u53d7\u3051\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u4e00\u74b0\u3068\u3057\u3066\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306e\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u304c\u6295\u4e0e\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u521d\u56de\u6295\u4e0e\u306f\u53d7\u8a3a\u306e\u7d046\u304b\u6708\u524d\u3001\u6700\u7d42\u6295\u4e0e\u306f\u53d7\u8a3a\u306e6\u65e5\u524d\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u53d7\u8a3a\u306b\u3064\u306a\u304c\u3063\u305f\u306e\u306f\u3001\u7d041\u9031\u9593\u7d9a\u3044\u305f\u767a\u71b1\u3001\u60aa\u5bd2\u3001\u5026\u6020\u611f\u3001\u75f0\u3092\u4f34\u308f\u306a\u3044\u54b3\u3001\u5410\u304d\u6c17\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6765\u9662\u6642\u306e\u4f53\u6e29\u306f38.9\u2103\u3001\u8108\u62cd\u306f\u6bce\u5206120\u56de\u3001\u8840\u5727\u306f100\/63 mmHg\u3067\u3057\u305f\u3002\u5ba4\u5185\u6c17\u3067\u306e\u9178\u7d20\u98fd\u548c\u5ea6\u306f99\uff05\u3067\u3001\u80ba\u306e\u8074\u8a3a\u3084\u795e\u7d4c\u5b66\u7684\u8a3a\u5bdf\u306b\u660e\u3089\u304b\u306a\u7570\u5e38\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u8840\u6db2\u691c\u67fb\u3067\u306f\u30011\u304b\u6708\u524d\u3068\u6bd4\u8f03\u3057\u3066\u767d\u8840\u7403\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3001\u8840\u5c0f\u677f\u304c\u3044\u305a\u308c\u3082\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u9805\u76ee<\/th><th>1\u304b\u6708\u524d<\/th><th>\u53d7\u8a3a\u6642<\/th><\/tr><\/thead><tbody><tr><td>\u767d\u8840\u7403\u6570<\/td><td>4,670\/\u03bcL<\/td><td>1,860\/\u03bcL<\/td><\/tr><tr><td>\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3<\/td><td>11.2 g\/dL<\/td><td>9.2 g\/dL<\/td><\/tr><tr><td>\u8840\u5c0f\u677f\u6570<\/td><td>16.2\u4e07\/\u03bcL<\/td><td>6.6\u4e07\/\u03bcL<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">CRP\u306f248.9 mg\/L\u3067\u3001\u65e5\u672c\u3067\u3088\u304f\u7528\u3044\u3089\u308c\u308b\u5358\u4f4d\u3067\u306f\u7d0424.9 mg\/dL\u306b\u76f8\u5f53\u3059\u308b\u9ad8\u5024\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6301\u7d9a\u3059\u308b\u767a\u71b1\u306b\u3001\u6025\u901f\u306a\u8840\u7403\u6e1b\u5c11\u3068\u5f37\u3044\u708e\u75c7\u53cd\u5fdc\u304c\u91cd\u306a\u3063\u3066\u3044\u305f\u3053\u3068<\/strong>\u304c\u3001\u3053\u306e\u75c7\u4f8b\u306e\u91cd\u8981\u306a\u51fa\u767a\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"400\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-181.png\" 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class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u547c\u5438\u5668\u611f\u67d3\u75c7\u3001\u624b\u8853\u90e8\u4f4d\u306e\u611f\u67d3\u3001\u8840\u6d41\u611f\u67d3\u306a\u3069\u304c\u691c\u8a0e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53d7\u8a3a\u6642\u306e\u597d\u4e2d\u7403\u6570\u306f1,390\/\u03bcL\u3067\u3001\u8efd\u5ea6\u306e\u597d\u4e2d\u7403\u6e1b\u5c11\u306b\u5f53\u305f\u308a\u307e\u3059\u3002\u9ad8\u5ea6\u306a\u597d\u4e2d\u7403\u6e1b\u5c11\u3068\u540c\u3058\u30ea\u30b9\u30af\u3068\u3057\u3066\u6271\u3046\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001\u6700\u8fd1\u306e\u6cbb\u7642\u6b74\u3084\u5168\u8eab\u72b6\u614b\u3092\u8e0f\u307e\u3048\u3001\u611f\u67d3\u75c7\u3092\u614e\u91cd\u306b\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6db2\u57f9\u990a\u3084\u547c\u5438\u5668\u30a6\u30a4\u30eb\u30b9\u691c\u67fb\u306b\u52a0\u3048\u3001\u66dd\u9732\u6b74\u306b\u5fdc\u3058\u305f\u611f\u67d3\u75c7\u306e\u691c\u67fb\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u751f\u306e\u30e4\u30ae\u8089\u30fb\u7f8a\u8089\u3092\u6271\u3063\u305f\u7d4c\u9a13\u304b\u3089\u30d6\u30eb\u30bb\u30e9\u75c7\u3084\u30c8\u30ad\u30bd\u30d7\u30e9\u30ba\u30de\u611f\u67d3\u75c7\u3001\u5c45\u4f4f\u5730\u57df\u3084\u5c4b\u5916\u6d3b\u52d5\u6b74\u304b\u3089\u30c0\u30cb\u5a92\u4ecb\u611f\u67d3\u75c7\u306a\u3069\u3082\u691c\u8a0e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5e83\u57df\u6297\u83cc\u85ac\u306b\u3088\u308b\u6cbb\u7642\u304c\u958b\u59cb\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u767a\u71b1\u306f\u7d9a\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001<strong>\u6297\u83cc\u85ac\u304c\u52b9\u304b\u306a\u3044\u3053\u3068\u3084\u691c\u67fb\u304c\u9670\u6027\u3067\u3042\u308b\u3053\u3068\u3060\u3051\u3067\u3001\u611f\u67d3\u75c7\u3092\u5426\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/strong> \u63a1\u53d6\u6642\u671f\u3001\u691c\u67fb\u611f\u5ea6\u3001\u6297\u83cc\u85ac\u6295\u4e0e\u306e\u5f71\u97ff\u306a\u3069\u3092\u8003\u616e\u3057\u306a\u304c\u3089\u3001\u611f\u67d3\u75c7\u4ee5\u5916\u306e\u539f\u56e0\u3082\u4e26\u884c\u3057\u3066\u691c\u8a0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\uff0eCT\u3067\u898b\u3064\u304b\u3063\u305f\u300c\u611f\u67d3\u3092\u793a\u3057\u306b\u304f\u3044\u6db2\u4f53\u8caf\u7559\u300d\u3068\u813e\u816b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9020\u5f71CT\u3067\u306f\u3001\u5de6\u814b\u7aa9\u306e\u624b\u8853\u90e8\u4f4d\u306b\u7d044\u00d73 cm\u306e\u6db2\u4f53\u8caf\u7559\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u81bf\u760d\u3092\u7591\u3046\u58c1\u80a5\u539a\u3084\u9020\u5f71\u5897\u5f37\u3001\u5185\u90e8\u306e\u30ac\u30b9\u3001\u5468\u56f2\u8102\u80aa\u7e54\u306e\u708e\u75c7\u6027\u5909\u5316\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5c40\u6240\u306e\u767a\u8d64\u3084\u5727\u75db\u3082\u76ee\u7acb\u305f\u305a\u3001\u7a4d\u6975\u7684\u306b\u611f\u67d3\u3092\u793a\u3059\u6240\u898b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u813e\u81d3\u306f\u9577\u5f8413.7 cm\u306b\u816b\u5927\u3057\u3066\u3044\u307e\u3057\u305f\u30021\u304b\u6708\u524d\u306f11.5 cm\u672a\u6e80\u3067\u3042\u308a\u3001\u7d4c\u904e\u4e2d\u306b\u813e\u816b\u304c\u51fa\u73fe\u3057\u3066\u3044\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u813e\u816b\u3060\u3051\u3067\u75c5\u540d\u306f\u6c7a\u307e\u308a\u307e\u305b\u3093\u3002\u611f\u67d3\u75c7\u3001\u8840\u6db2\u60aa\u6027\u816b\u760d\u3001\u5168\u8eab\u6027\u708e\u75c7\u306a\u3069\u3067\u8a8d\u3081\u3089\u308c\u308b\u6240\u898b\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u3053\u3053\u306b\u767a\u71b1\u3068\u8840\u7403\u6e1b\u5c11\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001HLH\u3092\u542b\u3080\u5168\u8eab\u6027\u306e\u904e\u5270\u708e\u75c7\u3092\u8003\u3048\u308b\u624b\u304c\u304b\u308a\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4\uff0e\u8a3a\u65ad\u3092\u524d\u306b\u9032\u3081\u305f\u8457\u660e\u306a\u30d5\u30a7\u30ea\u30c1\u30f3\u9ad8\u5024<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5165\u9662\u5f8c\u3082\u767a\u71b1\u3068\u8840\u7403\u6e1b\u5c11\u304c\u7d9a\u304d\u3001\u7b2c4\u75c5\u65e5\u306b\u306f\u75c7\u72b6\u3092\u4f34\u3046\u8840\u5727\u4f4e\u4e0b\u304c\u51fa\u73fe\u3057\u307e\u3057\u305f\u3002\u8840\u5727\u306f\u8f38\u6db2\u306b\u3088\u3063\u3066\u6539\u5584\u3057\u307e\u3057\u305f\u304c\u3001\u75c5\u614b\u306e\u9032\u884c\u3092\u7591\u308f\u305b\u308b\u7d4c\u904e\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8ffd\u52a0\u691c\u67fb\u3067\u306f\u3001\u6b21\u306e\u7570\u5e38\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u9805\u76ee<\/th><th>\u75c7\u4f8b\u3067\u5831\u544a\u3055\u308c\u305f\u5024<\/th><th>\u89e3\u91c8<\/th><\/tr><\/thead><tbody><tr><td>\u30d5\u30a7\u30ea\u30c1\u30f3<\/td><td>37,956 \u03bcg\/L<\/td><td>\u8457\u660e\u306a\u9ad8\u5024\u3002\u6570\u5024\u4e0a\u306f37,956 ng\/mL\u3068\u540c\u3058<\/td><\/tr><tr><td>\u4e2d\u6027\u8102\u80aa<\/td><td>296 mg\/dL<\/td><td>\u9ad8\u5024<\/td><\/tr><tr><td>\u30d5\u30a3\u30d6\u30ea\u30ce\u30b2\u30f3<\/td><td>222 mg\/dL<\/td><td>HLH-2004\u306e\u4f4e\u5024\u57fa\u6e96\u306b\u306f\u8a72\u5f53\u3057\u306a\u3044<\/td><\/tr><tr><td>\u53ef\u6eb6\u6027CD25<\/td><td>4,268.1 pg\/mL<\/td><td>\u6e2c\u5b9a\u65bd\u8a2d\u306e\u57fa\u6e96\u7bc4\u56f2\u3092\u8d85\u3048\u308b\u9ad8\u5024<\/td><\/tr><tr><td>IL-6<\/td><td>56.2 pg\/mL<\/td><td>\u9ad8\u5024<\/td><\/tr><tr><td>\u767d\u8840\u7403\u6570\u306e\u6700\u4f4e\u5024<\/td><td>1,010\/\u03bcL<\/td><td>\u8840\u7403\u6e1b\u5c11\u304c\u9032\u884c<\/td><\/tr><tr><td>\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306e\u6700\u4f4e\u5024<\/td><td>7.0 g\/dL<\/td><td>\u8ca7\u8840\u304c\u9032\u884c<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d5\u30a7\u30ea\u30c1\u30f3\u306f\u9244\u306e\u8caf\u8535\u306b\u95a2\u308f\u308b\u86cb\u767d\u3067\u3059\u304c\u3001\u5f37\u3044\u708e\u75c7\u3067\u3082\u4e0a\u6607\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8457\u660e\u306a\u9ad8\u5024\u306fHLH\u3092\u7591\u3046\u91cd\u8981\u306a\u624b\u304c\u304b\u308a\u3067\u3059\u3002\u305f\u3060\u3057\u3001\u6210\u4eba\u3067\u306f\u91cd\u75c7\u611f\u67d3\u75c7\u3001\u809d\u969c\u5bb3\u3001\u60aa\u6027\u816b\u760d\u306a\u3069\u3067\u3082\u9ad8\u5024\u3068\u306a\u308a\u3001\u30d5\u30a7\u30ea\u30c1\u30f3\u3060\u3051\u3067HLH\u3092\u78ba\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u75c7\u4f8b\u3067\u306f\u3001\u767a\u71b1\u3001\u813e\u816b\u3001\u9032\u884c\u3059\u308b\u8840\u7403\u6e1b\u5c11\u3001\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3001\u8457\u660e\u306a\u30d5\u30a7\u30ea\u30c1\u30f3\u9ad8\u5024\u3092\u4e00\u3064\u306e\u75c5\u614b\u3068\u3057\u3066\u8aac\u660e\u3067\u304d\u308b\u304b\u304c\u91cd\u8981\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5\uff0eHLH\u3068\u306f\u3001\u514d\u75ab\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u304c\u6301\u7d9a\u3059\u308b\u75c5\u614b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HLH\u3067\u306f\u3001T\u7d30\u80de\u3084\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u514d\u75ab\u7d30\u80de\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u304c\u6301\u7d9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001\u767a\u71b1\u3001\u8840\u7403\u6e1b\u5c11\u3001\u809d\u813e\u816b\u3001\u51dd\u56fa\u7570\u5e38\u306a\u3069\u304c\u8d77\u3053\u308a\u3001\u91cd\u75c7\u4f8b\u3067\u306f\u5faa\u74b0\u4e0d\u5168\u3084\u591a\u81d3\u5668\u969c\u5bb3\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u7403\u6e1b\u5c11\u306b\u306f\u3001\u708e\u75c7\u306b\u3088\u308b\u9020\u8840\u6291\u5236\u3001\u813e\u81d3\u3067\u306e\u8840\u7403\u306e\u6355\u6349\u3001\u8840\u7403\u8caa\u98df\u306a\u3069\u3001\u8907\u6570\u306e\u8981\u56e0\u304c\u95a2\u308f\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c5\u540d\u306b\u300c\u8840\u7403\u8caa\u98df\u300d\u3068\u3042\u308a\u307e\u3059\u304c\u3001<strong>\u9aa8\u9ac4\u306a\u3069\u3067\u8840\u7403\u8caa\u98df\u50cf\u304c\u78ba\u8a8d\u3055\u308c\u306a\u3051\u308c\u3070\u8a3a\u65ad\u3067\u304d\u306a\u3044\u3001\u3068\u3044\u3046\u75c5\u6c17\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong> \u9006\u306b\u3001\u8840\u7403\u8caa\u98df\u50cf\u304c\u3042\u3063\u3066\u3082\u3001\u305d\u308c\u3060\u3051\u3067HLH\u3068\u306f\u8a3a\u65ad\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLH\u306b\u306f\u907a\u4f1d\u7684\u80cc\u666f\u304c\u5f37\u3044\u75c5\u578b\u3068\u3001\u611f\u67d3\u75c7\u3001\u60aa\u6027\u816b\u760d\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3001\u85ac\u5264\u306a\u3069\u306b\u95a2\u9023\u3057\u3066\u751f\u3058\u308b\u75c5\u578b\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u6210\u4eba\u4f8b\u3067\u3082\u907a\u4f1d\u7684\u7d20\u56e0\u304c\u95a2\u4e0e\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u3001\u5358\u7d14\u306a\u4e8c\u5206\u6cd5\u3067\u306f\u6349\u3048\u304d\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ea\u30a6\u30de\u30c1\u30fb\u81a0\u539f\u75c5\u9818\u57df\u306eMAS\u3068\u306e\u95a2\u4fc2<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08SLE\uff09\u3001\u6210\u4eba\u767a\u75c7Still\u75c5\u3001\u5168\u8eab\u578b\u82e5\u5e74\u6027\u7279\u767a\u6027\u95a2\u7bc0\u708e\u306a\u3069\u306e\u708e\u75c7\u6027\u75be\u60a3\u3092\u80cc\u666f\u306b\u751f\u3058\u308bHLH\u69d8\u306e\u75c5\u614b\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u6d3b\u6027\u5316\u75c7\u5019\u7fa4\uff08MAS\uff09\u3068\u547c\u3070\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001HLH\u306f\u8840\u6db2\u5185\u79d1\u3060\u3051\u3067\u306a\u304f\u3001\u30ea\u30a6\u30de\u30c1\u30fb\u81a0\u539f\u75c5\u8a3a\u7642\u3067\u3082\u91cd\u8981\u306a\u75c5\u614b\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SLE\u306e\u81d3\u5668\u969c\u5bb3\u3084\u6cbb\u7642\u8a55\u4fa1\u306b\u3064\u3044\u3066\u306f\u3001<a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/lupus-nephritis-belimumab-deep-renal-response\/\" target=\"_blank\" rel=\"noopener\">\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u3068\u30d9\u30ea\u30e0\u30de\u30d6\u6cbb\u7642\u306e\u8a18\u4e8b<\/a>\u3067\u3082\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u540c\u8a18\u4e8b\u306fMAS\u6cbb\u7642\u3092\u691c\u8a0e\u3057\u305f\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u75be\u60a3\u6d3b\u52d5\u6027\u3084\u6cbb\u7642\u30ea\u30b9\u30af\u3092\u7dcf\u5408\u7684\u306b\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u95a2\u9023\u60c5\u5831\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-182.png\" alt=\"PD-1\u963b\u5bb3\u5f8c\u306eT\u7d30\u80de\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u904e\u5270\u6d3b\u6027\u5316\u3001\u304a\u3088\u3073HLH\u306e\u767a\u71b1\u30fb\u8840\u7403\u6e1b\u5c11\u30fb\u30d5\u30a7\u30ea\u30c1\u30f3\u4e0a\u6607\u3068\u306e\u95a2\u4fc2\u3092\u793a\u3059\u6a21\u5f0f\u56f3\u3002\" class=\"wp-image-9557\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-182.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-182-400x267.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-182-768x512.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56f3\u8aac\uff1a<\/strong>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u95a2\u9023HLH\u306e\u7406\u89e3\u3092\u52a9\u3051\u308b\u6982\u5ff5\u56f3\u3002PD-1\u3092\u4ecb\u3059\u308b\u6291\u5236\u306e\u89e3\u9664\u306b\u7d9a\u304d\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306fT\u7d30\u80de\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u304c\u6301\u7d9a\u3057\u3001\u767a\u71b1\u3001\u8840\u7403\u6e1b\u5c11\u3001\u30d5\u30a7\u30ea\u30c1\u30f3\u4e0a\u6607\u3001\u51dd\u56fa\u7570\u5e38\u306a\u3069\u3092\u4f34\u3046\u5168\u8eab\u6027\u708e\u75c7\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u500b\u3005\u306e\u691c\u67fb\u7570\u5e38\u306f\u8907\u6570\u306e\u6a5f\u5e8f\u3067\u751f\u3058\u3001\u672c\u75c7\u4f8b\u3067\u5404\u7d4c\u8def\u304c\u76f4\u63a5\u691c\u8a3c\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u306a\u3044\u3002HLH\uff1a\u8840\u7403\u8caa\u98df\u6027\u30ea\u30f3\u30d1\u7d44\u7e54\u7403\u75c7\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6\uff0eHLH\u306e\u8a3a\u65ad\u57fa\u6e96\u306f\u3001\u6570\u5024\u306e\u5358\u4f4d\u307e\u3067\u78ba\u8a8d\u3059\u308b<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HLH\u306e\u8a3a\u65ad\u88dc\u52a9\u3068\u3057\u3066\u3001HLH-2004\u8a3a\u65ad\u57fa\u6e96\u304c\u3088\u304f\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLH\u306b\u5408\u81f4\u3059\u308b\u5206\u5b50\u907a\u4f1d\u5b66\u7684\u8a3a\u65ad\u304c\u3042\u308b\u5834\u5408\u3001\u307e\u305f\u306f\u4ee5\u4e0b\u306e8\u9805\u76ee\u4e2d5\u9805\u76ee\u3092\u6e80\u305f\u3059\u5834\u5408\u304c\u3001\u8a3a\u65ad\u306e\u67a0\u7d44\u307f\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u9805\u76ee<\/th><th>\u4e3b\u306a\u57fa\u6e96<\/th><\/tr><\/thead><tbody><tr><td>\u767a\u71b1<\/td><td>38.5\u2103\u4ee5\u4e0a\u3092\u76ee\u5b89\u3068\u3059\u308b\u767a\u71b1<\/td><\/tr><tr><td>\u813e\u816b<\/td><td>\u813e\u81d3\u306e\u816b\u5927<\/td><\/tr><tr><td>2\u7cfb\u7d71\u4ee5\u4e0a\u306e\u8840\u7403\u6e1b\u5c11<\/td><td>Hb 9 g\/dL\u672a\u6e80\u3001\u8840\u5c0f\u677f10\u4e07\/\u03bcL\u672a\u6e80\u3001\u597d\u4e2d\u74031,000\/\u03bcL\u672a\u6e80\u306e\u3046\u30612\u7cfb\u7d71\u4ee5\u4e0a<\/td><\/tr><tr><td>\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u307e\u305f\u306f\u4f4e\u30d5\u30a3\u30d6\u30ea\u30ce\u30b2\u30f3\u8840\u75c7<\/td><td>\u7a7a\u8179\u6642\u4e2d\u6027\u8102\u80aa265 mg\/dL\u4ee5\u4e0a\u3001\u307e\u305f\u306f\u30d5\u30a3\u30d6\u30ea\u30ce\u30b2\u30f3150 mg\/dL\u4ee5\u4e0b<\/td><\/tr><tr><td>\u8840\u7403\u8caa\u98df\u50cf<\/td><td>\u9aa8\u9ac4\u3001\u813e\u81d3\u3001\u30ea\u30f3\u30d1\u7bc0\u306a\u3069\u3067\u78ba\u8a8d<\/td><\/tr><tr><td>NK\u7d30\u80de\u6d3b\u6027<\/td><td>\u4f4e\u4e0b\u307e\u305f\u306f\u6d88\u5931<\/td><\/tr><tr><td>\u30d5\u30a7\u30ea\u30c1\u30f3\u9ad8\u5024<\/td><td>500 ng\/mL\u4ee5\u4e0a<\/td><\/tr><tr><td>\u53ef\u6eb6\u6027CD25\u9ad8\u5024<\/td><td>2,400 U\/mL\u4ee5\u4e0a<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306f\u6210\u4eba\u3067\u3082\u53c2\u8003\u306b\u3055\u308c\u307e\u3059\u304c\u3001\u81e8\u5e8a\u7d4c\u904e\u3068\u5408\u308f\u305b\u3066\u5224\u65ad\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u91cd\u75c7\u5316\u304c\u7591\u308f\u308c\u308b\u60a3\u8005\u3055\u3093\u3067\u3001\u3059\u3079\u3066\u306e\u691c\u67fb\u304c\u305d\u308d\u3046\u307e\u3067\u5bfe\u5fdc\u3092\u5f85\u3064\u305f\u3081\u306e\u57fa\u6e96\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<a href=\"https:\/\/doi.org\/10.1182\/blood.2018894618\" target=\"_blank\" rel=\"noopener\">American Society of Hematology<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u3053\u306e\u75c7\u4f8b\u3067\u306f\u3001\u4f55\u304c\u78ba\u8a8d\u3067\u304d\u305f\u306e\u304b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u75c7\u4f8b\u3067\u306f\u767a\u71b1\u3001\u813e\u816b\u3001\u30d5\u30a7\u30ea\u30c1\u30f3\u9ad8\u5024\u304c\u3042\u308a\u3001\u4e2d\u6027\u8102\u80aa\u3082\u6570\u5024\u4e0a\u306f\u57fa\u6e96\u3092\u8d85\u3048\u3066\u3044\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u672c\u6587\u306b\u306f\u7a7a\u8179\u6642\u63a1\u8840\u304b\u3069\u3046\u304b\u306e\u8a18\u8f09\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u7403\u6e1b\u5c11\u306b\u3064\u3044\u3066\u306f\u3001\u53d7\u8a3a\u6642\u306e\u30d8\u30e2\u30b0\u30ed\u30d3\u30f39.2 g\/dL\u3001\u597d\u4e2d\u74031,390\/\u03bcL\u306f\u3044\u305a\u308c\u3082\u4e0a\u8a18\u306e\u95be\u5024\u306b\u306f\u9054\u3057\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u306e\u5f8c\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306f7.0 g\/dL\u307e\u3067\u4f4e\u4e0b\u3057\u3066\u304a\u308a\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u3068\u5408\u308f\u305b\u3001\u7d4c\u904e\u4e2d\u306e\u8840\u7403\u6e1b\u5c11\u3068\u3057\u3066\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3053\u3067\u3001\u7dcf\u767d\u8840\u7403\u6570\u3068\u597d\u4e2d\u7403\u6570\u3092\u6df7\u540c\u3057\u306a\u3044\u3053\u3068\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u53ef\u6eb6\u6027CD25\u306e\u300cpg\/mL\u300d\u3068\u300cU\/mL\u300d\u306f\u76f4\u63a5\u6bd4\u8f03\u3067\u304d\u306a\u3044<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u75c7\u4f8b\u306e\u53ef\u6eb6\u6027CD25\u306f\u3001ELISA\u306b\u3088\u3063\u30664,268.1 pg\/mL\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001HLH-2004\u306e\u57fa\u6e96\u306f2,400 U\/mL\u3067\u3059\u3002\u6e2c\u5b9a\u6cd5\u3068\u5358\u4f4d\u304c\u7570\u306a\u308a\u3001\u78ba\u7acb\u3057\u305f\u63db\u7b97\u4fc2\u6570\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u6570\u5b57\u306e\u5927\u5c0f\u3060\u3051\u3092\u6bd4\u8f03\u3057\u3066\u300c\u53ef\u6eb6\u6027CD25\u306e\u8a3a\u65ad\u57fa\u6e96\u3082\u6e80\u305f\u3057\u305f\u300d\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002\u539f\u8457\u3067\u3082\u3001\u3053\u306e\u70b9\u306f\u660e\u78ba\u306b\u7559\u4fdd\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9aa8\u9ac4\u306e\u8840\u7403\u8caa\u98df\u50cf\u3084NK\u7d30\u80de\u6d3b\u6027\u306e\u7d50\u679c\u3082\u672c\u6587\u306b\u306f\u793a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u539f\u8457\u306e\u8457\u8005\u3089\u306f\u3001\u691c\u67fb\u7d50\u679c\u3068\u81e8\u5e8a\u7d4c\u904e\u3092\u7dcf\u5408\u3057\u3066HLH\u3068\u8a3a\u65ad\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HScore\u3082\u6210\u4eba\u306e\u8a3a\u65ad\u88dc\u52a9\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u672c\u8a18\u4e8b\u3067\u306f\u6b20\u6e2c\u60c5\u5831\u3092\u63a8\u6e2c\u3057\u3066\u70b9\u6570\u3084\u8a3a\u65ad\u78ba\u7387\u3092\u63d0\u793a\u3059\u308b\u3053\u3068\u306f\u3057\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-183.png\" alt=\"HLH\u75c7\u4f8b\u306e\u691c\u67fb\u5024\u3068\u8a3a\u65ad\u4e0a\u306e\u7559\u610f\u70b9\u3092\u307e\u3068\u3081\u305f\u8868\u3002\u53ef\u6eb6\u6027CD25\u306e\u5358\u4f4d\u306e\u9055\u3044\u3001\u7a7a\u8179\u6761\u4ef6\u306e\u4e0d\u660e\u3001\u8840\u7403\u6570\u306e\u6e2c\u5b9a\u6642\u70b9\u3092\u660e\u793a\u3002\" class=\"wp-image-9559\" srcset=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-183.png 800w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-183-400x267.png 400w, https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-183-768x512.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56f3\u8aac\uff1a<\/strong>\u672c\u75c7\u4f8b\u306e\u81e8\u5e8a\u30fb\u691c\u67fb\u6240\u898b\u3068HLH-2004\u8a3a\u65ad\u57fa\u6e96\u3068\u306e\u95a2\u4fc2\u3002\u30d5\u30a7\u30ea\u30c1\u30f3\u306f37,956 \u03bcg\/L\u3001\u4e2d\u6027\u8102\u80aa\u306f296 mg\/dL\u3067\u3042\u3063\u305f\u304c\u3001\u4e2d\u6027\u8102\u80aa\u63a1\u8840\u6642\u306e\u7a7a\u8179\u6761\u4ef6\u306f\u672c\u6587\u306b\u660e\u8a18\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u30d5\u30a3\u30d6\u30ea\u30ce\u30b2\u30f3222 mg\/dL\u306f\u4f4e\u30d5\u30a3\u30d6\u30ea\u30ce\u30b2\u30f3\u8840\u75c7\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3055\u306a\u3044\u3002\u53ef\u6eb6\u6027CD25\u306f4,268.1 pg\/mL\u3068\u9ad8\u5024\u3067\u3042\u3063\u305f\u304c\u3001\u8a3a\u65ad\u57fa\u6e96\u306eU\/mL\u3068\u306f\u76f4\u63a5\u6bd4\u8f03\u3067\u304d\u306a\u3044\u3002\u8840\u7403\u6570\u306f\u63a1\u8840\u6642\u70b9\u3092\u533a\u5225\u3057\u3066\u8868\u793a\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">7\uff0e\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u304cHLH\u306b\u95a2\u4fc2\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u7406\u7531<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u306f\u3001T\u7d30\u80de\u306e\u6291\u5236\u6027\u53d7\u5bb9\u4f53\u3067\u3042\u308bPD-1\u3092\u6a19\u7684\u3068\u3059\u308b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PD-1\u3092\u4ecb\u3059\u308b\u6291\u5236\u3092\u89e3\u9664\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u306b\u5bfe\u3059\u308b\u514d\u75ab\u53cd\u5fdc\u3092\u9ad8\u3081\u307e\u3059\u3002\u4e00\u65b9\u3001\u305d\u306e\u4f5c\u7528\u306b\u4f34\u3063\u3066\u514d\u75ab\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\uff08irAE\uff09\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HLH\u306f\u307e\u308c\u3067\u3059\u304c\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306b\u95a2\u9023\u3057\u3066\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u5168\u8eab\u6027\u306e\u904e\u5270\u708e\u75c7\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u75c7\u4f8b\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u7d4c\u904e\u304b\u3089\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u3068\u306e\u95a2\u9023\u304c\u5f37\u304f\u7591\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul 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rel=\"noopener\">\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u5bfe\u3059\u308bCAR-T\u7d30\u80de\u7642\u6cd5\u306e\u8a18\u4e8b<\/a>\u3067\u3082\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001CAR-T\u7642\u6cd5\u3068\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306f\u7570\u306a\u308b\u6cbb\u7642\u3067\u3042\u308a\u3001\u6bd2\u6027\u306e\u5206\u985e\u3084\u6cbb\u7642\u6cd5\u3092\u305d\u306e\u307e\u307e\u76f8\u4e92\u306b\u5f53\u3066\u306f\u3081\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/wp-content\/uploads\/2026\/10\/image-184.png\" 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target=\"_blank\" rel=\"noopener\">\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u306e\u30d9\u30ea\u30e0\u30de\u30d6\u6cbb\u7642\uff5c\u5b8c\u5168\u814e\u594f\u52b9\u3092\u8d85\u3048\u308b\u300c\u6df1\u3044\u814e\u594f\u52b9\u300d\u3068\u306f<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">SLE\u306b\u4f34\u3046\u81d3\u5668\u969c\u5bb3\u3068\u3001\u6cbb\u7642\u52b9\u679c\u3092\u8907\u6570\u306e\u6307\u6a19\u3067\u8a55\u4fa1\u3059\u308b\u8003\u3048\u65b9\u3092\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u53d6\u308a\u4e0a\u3052\u305fMAS\u306e\u80cc\u666f\u75be\u60a3\u306e\u4e00\u3064\u3067\u3042\u308bSLE\u3078\u306e\u7406\u89e3\u3092\u88dc\u3046\u8a18\u4e8b\u3067\u3059\u3002MAS\u81ea\u4f53\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u3092\u6271\u3063\u305f\u7814\u7a76\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u2462 <a href=\"https:\/\/kashiwa-gomi-shikanaika.com\/blog\/post-3488\/\" target=\"_blank\" rel=\"noopener\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u30ac\u30a4\u30c9\uff1a\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30fb\u80ba\u708e\u7403\u83cc\u30fb\u5e2f\u72b6\u75b1\u75b9\u3078\u306e\u5bfe\u5fdc<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u514d\u75ab\u6291\u5236\u6cbb\u7642\u4e2d\u306e\u611f\u67d3\u4e88\u9632\u3068\u3001\u30ef\u30af\u30c1\u30f3\u306e\u7a2e\u985e\u30fb\u63a5\u7a2e\u6642\u671f\u306e\u8003\u3048\u65b9\u3092\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u75c7\u4f8b\u3067\u306f\u5e2f\u72b6\u75b1\u75b9\u304c\u4f75\u5b58\u3057\u3066\u304a\u308a\u3001\u708e\u75c7\u3092\u6291\u3048\u308b\u6cbb\u7642\u3068\u611f\u67d3\u75c7\u3078\u306e\u5bfe\u5fdc\u3092\u4e21\u7acb\u3055\u305b\u308b\u8996\u70b9\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e00\u6b21\u6587\u732e\u30fb\u51fa\u5178<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Cho HL, Berliner N, Babcock S, Sun YP, Levy B.<\/strong> Consumed with Inflammation. <em>N Engl J Med.<\/em> 2026;395:593\u2013598.<br>DOI\uff1a<a href=\"https:\/\/doi.org\/10.1056\/NEJMcps2516922\">10.1056\/NEJMcps2516922<\/a><br>\u672c\u8a18\u4e8b\u306e\u4e2d\u5fc3\u3068\u306a\u308b\u75c7\u4f8b\u30fb\u8a3a\u65ad\u63a8\u8ad6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Henter JI, Horne A, Aric\u00f3 M, et al.<\/strong> HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. <em>Pediatr Blood Cancer.<\/em> 2007;48:124\u2013131.<br>DOI\uff1a<a href=\"https:\/\/doi.org\/10.1002\/pbc.21039\">10.1002\/pbc.21039<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fardet L, Galicier L, Lambotte O, et al.<\/strong> Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. <em>Arthritis Rheumatol.<\/em> 2014;66:2613\u20132620.<br>DOI\uff1a<a href=\"https:\/\/doi.org\/10.1002\/art.38690\">10.1002\/art.38690<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>La Ros\u00e9e P, Horne A, Hines M, et al.<\/strong> Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. <em>Blood.<\/em> 2019;133:2465\u20132477.<br>DOI\uff1a<a href=\"https:\/\/doi.org\/10.1182\/blood.2018894618\">10.1182\/blood.2018894618<\/a><\/p>\n<\/blockquote>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:23%\">\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" 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